Nature Search

NAT10-mediated mRNA N⁴-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia

Zhang, Huang, Wang, Long et al. report that NAT10 enhances serine uptake and biosynthesis in an ac4C-dependent mechanism, thereby promoting stemness and progression in acute myeloid leukaemia.

Subo Zhang
Feng Huang
Huilin Huang
ResearchOpen Access06 Nov 2024
Nature Cell Biology

Volume: 26, P: 2168-2182
Publisher Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang
Hengyou Weng
Jianjun Chen
Amendments and Corrections27 Aug 2020
Nature Cell Biology

Volume: 22, P: 1288
Histone H3 trimethylation at lysine 36 guides m⁶A RNA modification co-transcriptionally

METTL14 recognizes the trimethyl mark on lysine 36 of histone H3 that directs m⁶A modifications co-transcriptionally.

Huilin Huang
Hengyou Weng
Jianjun Chen
Research13 Mar 2019
Nature

Volume: 567, P: 414-419
Author Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang
Hengyou Weng
Jianjun Chen
Amendments and Corrections07 Jun 2018
Nature Cell Biology

Volume: 20, P: 1098
m⁶A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability

Serine metabolism is essential for leukemogenesis and stemness in acute myeloid leukemia (AML). Here the authors show that targeting IGF2BP3 disrupts the serine synthesis pathway in AML cells in an RNA N⁶-Methyladenosine modification dependent manner, sensitizing AML cells to serine and glycine deprivation.

Feng Huang
Yushuai Wang
Hengyou Weng
ResearchOpen Access06 May 2025
Nature Communications

Volume: 16, P: 1-18
Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huang et al. identify IGF2BPs as an additional class of N⁶-methyladenosine (m⁶A) reader proteins. They find that IGF2BPs selectively bind to m⁶A-containing mRNAs and promote their stability.

Huilin Huang
Hengyou Weng
Jianjun Chen
Research23 Feb 2018
Nature Cell Biology

Volume: 20, P: 285-295
Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Xi Jiang
Chao Hu
Jianjun Chen
Amendments and CorrectionsOpen Access09 Feb 2018
Nature Communications

Volume: 9, P: 1
miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes and that restoring mir-22 expression suppresses AML progression.

Xi Jiang
Chao Hu
Jianjun Chen
ResearchOpen Access26 Apr 2016
Nature Communications

Volume: 7, P: 1-15
Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Ten-eleven translocation 1 (TET1) is a critical oncoprotein in AML. Here, the authors identify 2 compounds that target the binding of STAT3/5 specifically to the TET1 promoter, inhibiting its expression and AML cell viability.

Xi Jiang
Chao Hu
Jianjun Chen
ResearchOpen Access13 Dec 2017
Nature Communications

Volume: 8, P: 1-13
Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia

Huilin Huang
Hengyou Weng
Lianghu Qu
ResearchOpen Access27 Jan 2017
Scientific Reports

Volume: 7, P: 1-12
ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia

Yungui Wang
Jennifer R. Skibbe
Xi Jiang
ResearchOpen Access12 May 2017
Scientific Reports

Volume: 7, P: 1-11
RNA N⁶-methyladenosine modification in cancers: current status and perspectives

Xiaolan Deng
Rui Su
Jianjun Chen
ReviewsOpen Access23 Apr 2018
Cell Research

Volume: 28, P: 507-517

Search

NAT10-mediated mRNA N⁴-acetylcytidine reprograms serine metabolism to drive leukaemogenesis and stemness in acute myeloid leukaemia

Publisher Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Histone H3 trimethylation at lysine 36 guides m⁶A RNA modification co-transcriptionally

Author Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

m⁶A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability

Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Author Correction: Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

miR-22 has a potent anti-tumour role with therapeutic potential in acute myeloid leukaemia

Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia

Oridonin Triggers Chaperon-mediated Proteasomal Degradation of BCR-ABL in Leukemia

ALOX5 exhibits anti-tumor and drug-sensitizing effects in MLL-rearranged leukemia

RNA N⁶-methyladenosine modification in cancers: current status and perspectives

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