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Scientific Reports (33)
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Showing 1–50 of 72 results

Advanced filters: Author: Hirofumi Toyama Clear advanced filters

Factors affecting insulation failure in reusable surgical devices

Takahiro Homma
Hirofumi Uehara
Hisashi Saji
ResearchOpen Access22 Aug 2023
Scientific Reports

Volume: 13, P: 1-6
CD11c+ M1-like macrophages (MΦs) but not CD206+ M2-like MΦ are involved in folliculogenesis in mice ovary

Yosuke Ono
Miwako Nagai
Shigeru Saito
ResearchOpen Access25 May 2018
Scientific Reports

Volume: 8, P: 1-10
Orchestrated ensemble activities constitute a hippocampal memory engram

The brain stores memories through a set of neurons known as engram cells. Here, the authors show that engram cells in the mouse hippocampus are organized into sub-ensembles representing distinct pieces of information, which are then orchestrated to constitute an entire memory.

Khaled Ghandour
Noriaki Ohkawa
Kaoru Inokuchi
ResearchOpen Access14 Jun 2019
Nature Communications

Volume: 10, P: 1-14
Simultaneous visualization of multiple radionuclides in vivo

Multiple radionuclides can be simultaneously visualized in vivo by an imaging system providing high-resolution spectra that are then fitted to an X-ray analysis model of the emission lines of the radionuclides in the chosen energy band.

Atsushi Yagishita
Shin’ichiro Takeda
Hirofumi Fujii
Research04 Apr 2022
Nature Biomedical Engineering

Volume: 6, P: 640-647
Cellular tagging as a neural network mechanism for behavioural tagging

Short-term memories (STM) can become long-term memories when occurring alongside novel experiences. Here, the authors investigate the neural mechanisms behind such 'behavioural tagging' and find STM neural populations are preferentially incorporated into the ensembles encoding novel experiences.

Masanori Nomoto
Noriaki Ohkawa
Kaoru Inokuchi
ResearchOpen Access01 Aug 2016
Nature Communications

Volume: 7, P: 1-11
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Refractive outcomes after immediate primary phacoemulsification for acute primary angle closure

Takafumi Suzuki
Yoshiki Ueta
Hirofumi Sasajima
ResearchOpen Access16 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches

Methodologies to study the mechanisms of cell–cell interactions in metastatic niches remain scarce. Here, the authors develop a secretory GFP reconstitution-based system to tag tissue-resident cells neighboring on cancer cells within the metastatic niche.

Misa Minegishi
Takahiro Kuchimaru
Satoshi Nishimura
ResearchOpen Access05 Dec 2023
Nature Communications

Volume: 14, P: 1-12
Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts

Keiichi Hirono
Yukiko Hata
Fukiko Ichida
ResearchOpen Access16 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
High-throughput materials exploration system for the anomalous Hall effect using combinatorial experiments and machine learning

Ryo Toyama
Yuma Iwasaki
Yuya Sakuraba
ResearchOpen Access03 Sept 2025
npj Computational Materials

Volume: 11, P: 1-9
CAR T or NK cells targeting mismatched HLA-DR molecules in acute myeloid leukemia after allogeneic hematopoietic stem cell transplant

Ikeda et al. report that HLA-DRB1 can serve as a leukemia-specific target for CAR T or natural killer cell-based therapy in patients with AML after allogeneic hematopoietic stem cell transplantation.

Shunya Ikeda
Kana Hasegawa
Naoki Hosen
Research24 Mar 2025
Nature Cancer

Volume: 6, P: 595-611
PDGFRα plays a crucial role in connective tissue remodeling

Shinjiro Horikawa
Yoko Ishii
Masakiyo Sasahara
ResearchOpen Access07 Dec 2015
Scientific Reports

Volume: 5, P: 1-14
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Metabolites from thermophilic bacteria I: N-propionylanthranilic acid, a co-metabolite of the bacillamide class antibiotics and tryptophan metabolites with herbicidal activity from Laceyella sacchari

Hirofumi Akiyama
Naoya Oku
Yasuhiro Igarashi
Research28 May 2014
The Journal of Antibiotics

Volume: 67, P: 795-798
Gilteritinib enhances graft-versus-leukemia effects against FLT3-ITD mutant leukemia after allogeneic hematopoietic stem cell transplantation

Zixuan Zhang
Yuta Hasegawa
Takanori Teshima
Research28 Feb 2022
Bone Marrow Transplantation

Volume: 57, P: 775-780
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis

Post-translational modifications, such as glycosylation and sialylation, are thought to confer disease modifying effects on autoimmune-associated antibodies, including anti-citrullinated protein antibodies in rheumatoid arthritis. Here the authors show that sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis in mice.

Yuhsuke Ohmi
Wataru Ise
Koichi Furukawa
ResearchOpen Access05 Apr 2016
Nature Communications

Volume: 7, P: 1-12
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
The clinical outcomes of combination chemotherapy in elderly patients with advanced biliary tract cancer: an exploratory analysis of JCOG1113

Ikuhiro Yamada
Chigusa Morizane
Junji Furuse
ResearchOpen Access19 Jan 2022
Scientific Reports

Volume: 12, P: 1-9
The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age

Repeated cell divisions induce DNA damage in haematopoietic stem cells (HSC) and telomeres are sensitive to this damage. Here, the authors show in murine HSCs that the telomere binding protein POT1a inhibited the production of reactive oxygen species, and rejuvenated aged HSCs.

Kentaro Hosokawa
Ben D. MacArthur
Fumio Arai
ResearchOpen Access06 Oct 2017
Nature Communications

Volume: 8, P: 1-15
The significance of adding posterior decompression to spine stabilization in metastatic spinal surgery: a multicenter prospective study

Hiroyuki Tominaga
Ichiro Kawamura
Takeo Furuya
ResearchOpen Access29 Jul 2025
Scientific Reports

Volume: 15, P: 1-15
Smooth borders between inner nuclear layer and outer plexiform layer predict fewer macular edema recurrences in branch retinal vein occlusion

Hirofumi Sasajima
Kotaro Tsuboi
Motohiro Kamei
ResearchOpen Access06 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin

Kenji Tsuchihashi
Hitoshi Kusaba
Eishi Baba
ResearchOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1-6
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Ki-67 response-guided preoperative chemotherapy for HER2-positive breast cancer: results of a randomised Phase 2 study

Hirofumi Mukai
Takeshi Yamaguchi
Yukari Uemura
ResearchOpen Access02 Apr 2020
British Journal of Cancer

Volume: 122, P: 1747-1753
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Immune responses to Mycobacterial heat shock protein 70 accompany self-reactivity to human BiP in rheumatoid arthritis

Hirofumi Shoda
Norio Hanata
Kazuhiko Yamamoto
ResearchOpen Access01 Mar 2016
Scientific Reports

Volume: 6, P: 1-10
Quantitative and qualitative characterization of expanded CD4⁺ T cell clones in rheumatoid arthritis patients

Kazuyoshi Ishigaki
Hirofumi Shoda
Kazuhiko Yamamoto
ResearchOpen Access06 Aug 2015
Scientific Reports

Volume: 5, P: 1-9
Atypicality of Several Antipsychotics on the Basis of In Vivo Dopamine-D₂ and Serotonin-5HT₂ Receptor Occupancy

Tomiki Sumiyoshi
Kimiko Suzuki
Koichi Yokogawa
Research25 Jul 2003
Neuropsychopharmacology

Volume: 12, P: 57-64
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
TGF-β3-expressing CD4⁺CD25⁻LAG3⁺ regulatory T cells control humoral immune responses

B cells reactive against self antigens can cause autoimmune disease, but are normally suppressed by regulatory T cells (Tregs). Here the authors show that a subset of Tregs can suppress lupus in a mouse model by making TGF-β3 cytokine and by engaging an inhibitory PD-1 receptor on B cells.

Tomohisa Okamura
Shuji Sumitomo
Kazuhiko Yamamoto
ResearchOpen Access19 Feb 2015
Nature Communications

Volume: 6, P: 1-14
Facilitation of adenoviral wild-type p53-induced apoptotic cell death by overexpression of p33^ING1 in T.Tn human esophageal carcinoma cells

Hideaki Shimada
Tian-Ling Liu
Takaki Hiwasa
Research20 Feb 2002
Oncogene

Volume: 21, P: 1208-1216
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Comparison of gemcitabine-based chemotherapies for advanced biliary tract cancers by renal function: an exploratory analysis of JCOG1113

Makoto Ueno
Chigusa Morizane
Junji Furuse
ResearchOpen Access18 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice

Fumikiyo Nagawa
Natsuko Kishishita
Hitoshi Sakano
Research24 Dec 2006
Nature Immunology

Volume: 8, P: 206-213
Acute exacerbation predicting poor outcomes in idiopathic interstitial pneumonia and advanced lung cancer patients undergoing cytotoxic chemotherapy

Atsushi Miyamoto
Hirofumi Michimae
I. Honda
ResearchOpen Access03 May 2024
Scientific Reports

Volume: 14, P: 1-14
A nonsynonymous variant of IL1A is associated with endometriosis in Japanese population

Yuki Hata
Hirofumi Nakaoka
Kenichi Tanaka
Research02 May 2013
Journal of Human Genetics

Volume: 58, P: 517-520
High–Level Expression of Human Lipocortin I in the Fission Yeast Schizosaccharomyces pombe Using a Novel Expression Vector

Yuko Giga-Hama
Hideki Tohda
Hiromichi Kumagai
Research01 Apr 1994
Bio/Technology

Volume: 12, P: 400-404
Incidence of endophthalmitis after intravitreal injection of an anti-VEGF agent with or without topical antibiotics

Masakazu Morioka
Yoshihiro Takamura
Masaru Inatani
ResearchOpen Access17 Dec 2020
Scientific Reports

Volume: 10, P: 1-6
Innate immunity in diabetes and diabetic nephropathy

Pattern recognition receptors and danger-associated molecular patterns of the innate immune system contribute to the initiation of an inflammatory response in diabetes mellitus and diabetic nephropathy. In this Review, Jun Wada and Hirofumi Makino discuss how these components of the innate immune system can lead to insulin resistance, diabetes mellitus, and renal failure and describe signalling mediators and pathways that could be targeted for treatment.

Jun Wada
Hirofumi Makino
Reviews16 Nov 2015
Nature Reviews Nephrology

Volume: 12, P: 13-26
Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration

Hydrogen sulfide anion reacts with cellular electrophiles, including 8-nitro-cGMP, and sulfhydration products inhibit S-guanylation–dependent H-Ras activation in cardiac inflammatory injury models.

Motohiro Nishida
Tomohiro Sawa
Takaaki Akaike
Research01 Jul 2012
Nature Chemical Biology

Volume: 8, P: 714-724
Dual-radionuclide in vivo imaging of micro-metastasis and lymph tract with submillimetre resolution

Atsushi Yagishita
Shin’ichiro Takeda
Tadayuki Takahashi
ResearchOpen Access09 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
Association of ETS1 polymorphism with granulomatosis with polyangiitis and proteinase 3-anti-neutrophil cytoplasmic antibody positive vasculitis in a Japanese population

Aya Kawasaki
Keita Yamashita
Naoyuki Tsuchiya
Research05 Oct 2017
Journal of Human Genetics

Volume: 63, P: 55-62
Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura

Hirofumi Akiyama
Naoya Oku
Yasuhiro Igarashi
Research03 Sept 2019
The Journal of Antibiotics

Volume: 73, P: 60-65
Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I

Hideki Hasegawa
Hirofumi Sawa
William W Hall
Research19 Mar 2006
Nature Medicine

Volume: 12, P: 466-472
Novel disease-modifying anti-rheumatic drug iguratimod suppresses chronic experimental autoimmune encephalomyelitis by down-regulating activation of macrophages/microglia through an NF-κB pathway

Guangrui Li
Ryo Yamasaki
Jun-ichi Kira
ResearchOpen Access31 Jan 2018
Scientific Reports

Volume: 8, P: 1-16
Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats: continuous glucose telemetry analysis

Hiroyuki Iuchi
Masaya Sakamoto
Kazunori Utsunomiya
ResearchOpen Access19 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Structure and biological function of ENPP6, a choline-specific glycerophosphodiester-phosphodiesterase

Junko Morita
Kuniyuki Kano
Junken Aoki
ResearchOpen Access18 Feb 2016
Scientific Reports

Volume: 6, P: 1-14

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