The transcription factor OASIS was previously implicated in the ER stress response. BMP2 signalling, which is required for bone formation, induces OASIS expression and activation. Mice lacking OASIS show severe defects in bone formation and in response to BMP2 signalling. OASIS directly induces expression of Col1a1, a component of type 1 collagen.
- Tomohiko Murakami
- Atsushi Saito
- Kazunori Imaizumi