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Showing 101–150 of 546 results

Advanced filters: Author: Hiroshi Yoshida Clear advanced filters

Multicentre retrospective observational study for development and validation of MAC prognostic score model

Kazuaki Takeda
Takahiro Takazono
Hiroshi Mukae
ResearchOpen Access05 Aug 2025
Scientific Reports

Volume: 15, P: 1-11
Impact of shear wave dispersion slope analysis for assessing the severity of myocarditis

Naofumi Amioka
Yoichi Takaya
Hiroshi Ito
ResearchOpen Access24 May 2022
Scientific Reports

Volume: 12, P: 1-9
Absorption of Iodine by Polymers and Electrochemical Response of Polymer Film in Aqueous Solution of Iodine

Hiroshi Sukawa
Yukihiro Yoda
Masakazu Nishinuma
Research01 May 1989
Polymer Journal

Volume: 21, P: 403-408
Preparation of Layer-by-layer Thin Films Containing Insulin and its pH-Sensitive Decomposition

Kentaro Yoshida
Hiroshi Sato
Jun-ichi Anzai
Research11 Dec 2007
Polymer Journal

Volume: 40, P: 90-91
Role of phlebotomy in the treatment of liver damage related to erythropoietic porphyria

Satoru Hagiwara
Naoshi Nishida
Masatoshi Kudo
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-8
Impact of drainage retinotomy on surgical outcomes of retinal detachment: insights from the Japan-Retinal Detachment Registry

Hisashi Fukuyama
Hiroto Ishikawa
Shin Yamane
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Predicting exacerbation of renal function by DNA methylation clock and DNA damage of urinary shedding cells: a pilot study

Akihito Hishikawa
Erina Sugita Nishimura
Kaori Hayashi
ResearchOpen Access21 May 2024
Scientific Reports

Volume: 14, P: 1-10
Mortality and exacerbation risk according to GOLD and STAR severity stages of COPD: a 5-year multicenter prospective cohort study

Hiroaki Ogata
Kazuya Tsubouchi
Isamu Okamoto
ResearchOpen Access30 May 2025
Scientific Reports

Volume: 15, P: 1-11
Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

Although type I phosphatidylinositol 3-kinases (PI3Ks) are well studied signaling proteins, the functions of other PI3Ks are more enigmatic. Kazuaki Yoshioka et al. find that the type II PI3K-2α isoform regulates endosomal trafficking and cell signaling in endothelial cells. Angiogenic and vascular permeability responses are attenuated in mice lacking PI3K-2α, pointing to this enzyme as a potential target for treating vascular disease.

Kazuaki Yoshioka
Kotaro Yoshida
Yoh Takuwa
Research16 Sept 2012
Nature Medicine

Volume: 18, P: 1560-1569
Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex

Takuji Iwasato
Akash Datwani
Shigeyoshi Itohara
Research17 Aug 2000
Nature

Volume: 406, P: 726-731
Particle–hole symmetry breaking in the pseudogap state of Bi2201

Photoemission studies in the pseudogap state of a cuprate superconductor show differences depending on whether a particle is added or removed, revealing broken translational symmetry. Moreover, this particle–hole asymmetry coincides with the opening of the pseudogap.

Makoto Hashimoto
Rui-Hua He
Zhi-Xun Shen
Research04 Apr 2010
Nature Physics

Volume: 6, P: 414-418
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population

Michiaki Kubo and colleagues report a genome-wide association study for age-related macular degeneration in individuals of Japanese ancestry. They identify two genetic loci newly associated with this disease.

Satoshi Arakawa
Atsushi Takahashi
Michiaki Kubo
Research11 Sept 2011
Nature Genetics

Volume: 43, P: 1001-1004
New reference values for ultrasound fetal biometry in Japanese population and comparison with other studies

Sumito Nagasaki
Keisuke Ishii
Hirokazu Yorioka
ResearchOpen Access20 Aug 2025
Scientific Reports

Volume: 15, P: 1-12
Erect leaves caused by brassinosteroid deficiency increase biomass production and grain yield in rice

Tomoaki Sakamoto
Yoichi Morinaka
Makoto Matsuoka
Research20 Dec 2005
Nature Biotechnology

Volume: 24, P: 105-109
The prevalence and clinical features of MYO7A-related hearing loss including DFNA11, DFNB2 and USH1B

Kizuki Watanabe
Shin-ya Nishio
Shunsuke Kondo
ResearchOpen Access09 Apr 2024
Scientific Reports

Volume: 14, P: 1-19
Deregulation of a Ca²⁺/calmodulin-dependent kinase leads to spontaneous nodule development

Leïla Tirichine
Haruko Imaizumi-Anraku
Jens Stougaard
Research29 Jun 2006
Nature

Volume: 441, P: 1153-1156
Direct spectroscopic evidence for phase competition between the pseudogap and superconductivity in Bi₂Sr₂CaCu₂O_8+δ

Photoelectron spectroscopy measurements uncover a singularity over a wide doping range in the cuprate superconductor Bi₂Sr₂CaCu₂O_8+δ, suggesting a competition between the charge-ordering and the superconducting phases.

Makoto Hashimoto
Elizabeth A. Nowadnick
Zhi-Xun Shen
Research02 Nov 2014
Nature Materials

Volume: 14, P: 37-42
Glucose values from the same continuous glucose monitoring sensor significantly differ among readers with different generations of algorithm

Naru Babaya
Shinsuke Noso
Hiroshi Ikegami
ResearchOpen Access01 Mar 2024
Scientific Reports

Volume: 14, P: 1-8
Perinatal outcomes in RhD-negative pregnant women in Japan

Ken Takahashi
Susumu Yoshida
Osamu Samura
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-10
Asymmetric shape of distal phalanx of human finger improves precision grasping

Ayane Kumagai
Yoshinobu Obata
Shunta Togo
ResearchOpen Access17 May 2021
Scientific Reports

Volume: 11, P: 1-10
Superconductivity in a 122-type Fe-based compound (La,Na,K)Fe₂As₂

Kenji Kawashima
Shigeyuki Ishida
Akira Iyo
ResearchOpen Access14 Nov 2018
Scientific Reports

Volume: 8, P: 1-7
Single-cell multi-omics analysis identifies two distinct phenotypes of newly-onset microscopic polyangiitis

Autoimmune vasculitis can be heterogeneous in terms of immune cell involvement. Here the authors use a single cell transcriptomics approach to characterise a group of microscopic polyangiitis patients that could be split into two groups typified by monocyte or Interferon associated gene expression.

Masayuki Nishide
Kei Nishimura
Atsushi Kumanogoh
ResearchOpen Access11 Oct 2023
Nature Communications

Volume: 14, P: 1-14
Selective inhibition of the kinase DYRK1A by targeting its folding process

Kinase inhibitors are important drugs and usually target the ATP binding pocket of kinases. Here, Kii et al.report a completely new type of kinase inhibitor that specifically targets the protein folding intermediate state, but not the mature form, of the protein kinase DYRK1A.

Isao Kii
Yuto Sumida
Masatoshi Hagiwara
ResearchOpen Access22 Apr 2016
Nature Communications

Volume: 7, P: 1-14
Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches

Methodologies to study the mechanisms of cell–cell interactions in metastatic niches remain scarce. Here, the authors develop a secretory GFP reconstitution-based system to tag tissue-resident cells neighboring on cancer cells within the metastatic niche.

Misa Minegishi
Takahiro Kuchimaru
Satoshi Nishimura
ResearchOpen Access05 Dec 2023
Nature Communications

Volume: 14, P: 1-12
Attitudes toward and current status of disclosure of secondary findings from next-generation sequencing: a nation-wide survey of clinical genetics professionals in Japan

Mio Tsuchiya
Takahiro Yamada
Shinji Kosugi
Research13 Jul 2020
Journal of Human Genetics

Volume: 65, P: 1045-1053
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

This study identifies TTTCA- and TTTTA-repeat expansions in benign adult familial myoclonic epilepsy. Cortical neurons from affected people exhibit RNA foci containing these expanded repeats, suggesting RNA toxicity as the mechanism underlying disease pathogenesis.

Hiroyuki Ishiura
Koichiro Doi
Shoji Tsuji
Research05 Mar 2018
Nature Genetics

Volume: 50, P: 581-590
Allograft inflammatory factor 1 is a regulator of transcytosis in M cells

M cells are intestinal epithelial cells that are specialized to transcytose antigens and bacteria from the intestinal lumen to antigen presenting cells on the other side. Here the authors show that the actin-binding protein Aif1 is highly expressed by intestinal M cells and regulates this transcytosis.

Sari Kishikawa
Shintaro Sato
Hiroshi Kiyono
ResearchOpen Access22 Feb 2017
Nature Communications

Volume: 8, P: 1-10
Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi

Miyuki Takiya
Yasutaka Fushimi
Yuji Nakamoto
ResearchOpen Access30 Sept 2023
Scientific Reports

Volume: 13, P: 1-8
Decreasing undesirable absorbed radiation to the intestine after administration of radium-223 dichloride for treatment of bone metastases

Kazuma Ogawa
Takuma Higashi
Seigo Kinuya
ResearchOpen Access17 Jul 2020
Scientific Reports

Volume: 10, P: 1-8
Disturbance of deep-sea environments induced by the M9.0 Tohoku Earthquake

Shinsuke Kawagucci
Yukari T. Yoshida
Ken Takai
ResearchOpen Access16 Feb 2012
Scientific Reports

Volume: 2, P: 1-7
Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

CD44 is a cell surface protein that is a marker for stem cell-like cancer cells and has a role in invasion and metastasis. Here, epithelial splicing regulatory protein 1 is shown to generate a CD44 variant protein that enhances metastasis in a mouse model and protects cells from oxidative stress.

Toshifumi Yae
Kenji Tsuchihashi
Osamu Nagano
Research06 Jun 2012
Nature Communications

Volume: 3, P: 1-9
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice

Sasako et al. show that disruption of the insulin/IGF-1 signaling by suppressing Akt activity in mouse skeletal muscle can accelerate osteosarcopenia and shortens lifespan, which is reversed by inactivation of FoxOs rather than activation of mTOR, suggesting FoxOs as therapeutic targets.

Takayoshi Sasako
Toshihiro Umehara
Kohjiro Ueki
ResearchOpen Access05 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Exploring spin-polarization in Bi-based high-T_c cuprates

Hideaki Iwasawa
Kazuki Sumida
Taichi Okuda
ResearchOpen Access18 Aug 2023
Scientific Reports

Volume: 13, P: 1-7
Ornithine Transcarbamylase (OTC) in White Blood Cells

Noriyuki Nagata
Izumi Akaboshi
Takato Katsuki
Research01 Dec 1980
Pediatric Research

Volume: 14, P: 1370-1373
Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells

Cytotoxic CAR T cells derived from human induced pluripotent stem cells can be genetically engineered for enhanced proliferation and persistency in solid tumours.

Tatsuki Ueda
Sara Shiina
Shin Kaneko
ResearchOpen Access12 Dec 2022
Nature Biomedical Engineering

Volume: 7, P: 24-37
Identification of a tomato UDP-arabinosyltransferase for airborne volatile reception

Volatiles from herbivore-infested plants can function as chemical warning signals to neighbouring plants. Here the authors show that a tomato UDP-glycosyltransferase can convert a volatile signal emitted by infested plants to promote plant defense.

Koichi Sugimoto
Eiichiro Ono
Junji Takabayashi
ResearchOpen Access08 Feb 2023
Nature Communications

Volume: 14, P: 1-10
Long-term activation of anti-tumor immunity in pancreatic cancer by a p53-expressing telomerase-specific oncolytic adenovirus

Masashi Hashimoto
Shinji Kuroda
Toshiyoshi Fujiwara
ResearchOpen Access05 Feb 2024
British Journal of Cancer

Volume: 130, P: 1187-1195
Long-Term Plasma Levels and Dose Modulation of Alacepril in Patients with Chronic Renal Failure

Hiroshi Nonoguchi
Shigeru Kiyama
Kimio Tomita
Research01 Jan 2008
Hypertension Research

Volume: 31, P: 29-36
Experimental gene therapy against subcutaneously implanted glioma with a herpes simplex virus-defective vector expressing interferon-γ

Hiroshi Kanno
Satoshi Hattori
Micheal G Kaplitt
Research22 Oct 1999
Cancer Gene Therapy

Volume: 6, P: 147-155
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells

Regulatory T cells proliferate robustly in gut lymphoid tissues. Hase et al. show that this proliferation requires their expression of the epigenetic regulator Uhrf1, which is increased in response to IL-2 produced by effector T cells.

Yuuki Obata
Yukihiro Furusawa
Koji Hase
Research28 Apr 2014
Nature Immunology

Volume: 15, P: 571-579
Contribution of Retzius-sparing robot-assisted radical prostatectomy to the mechanism of urinary continence as demonstrated by dynamic MRI

Yoshifumi Kadono
Takahiro Nohara
Atsushi Mizokami
ResearchOpen Access18 Feb 2023
Scientific Reports

Volume: 13, P: 1-9
Significance of podocyte DNA damage and glomerular DNA methylation in CKD patients with proteinuria

This study suggested the association of podocyte DNA damage and subsequent DNA methylation with proteinuria in minor glomerular abnormalities (MGA) patients and those with eGFR declines in diabetic nephropathy (DN) patients, respectively.

Norifumi Yoshimoto
Kaori Hayashi
Hiroshi Itoh
Research17 Jan 2023
Hypertension Research

Volume: 46, P: 1000-1008
Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts

Plasma membrane damage (PMD) can induce cell death or be repaired, whereas other cell fates are not well explored. In this study, the authors found that PMD induces senescence in yeast and human fibroblasts in a manner that is distinct from DNA damage-dependent senescence. They present transcriptomic data suggesting that this PMD response may explain the origins of senescent cells near cutaneous wounds.

Kojiro Suda
Yohsuke Moriyama
Keiko Kono
ResearchOpen Access22 Feb 2024
Nature Aging

Volume: 4, P: 319-335
Selective Alkylation of Aromatic Hydrocarbons with Styrene by Solid Polymeric Oxo Acids

Hiroshi Hasegawa
Toshinobu Higashimura
Research01 Jun 1980
Polymer Journal

Volume: 12, P: 407-409
An NcoI polymorphism in the human complement component 7 (C7) gene

T. Horiuchi
Hiroaki Nishizaka
Yoshiyuki Niho
Research01 Jul 1999
Journal of Human Genetics

Volume: 44, P: 270-271
Ferromagnetism and giant magnetoresistance in zinc-blende FeAs monolayers embedded in semiconductor structures

In this manuscript, the authors grow very thin layers of FeAs in a matrix of InAs. The resulting superlattice displays ferromagnetism, with the Curie temperature varying depending on the layer thickness. These results further illustrate the wide array of intriguing ground states of materials with tetrahedral FeAs bonds

Le Duc Anh
Taiki Hayakawa
Masaaki Tanaka
ResearchOpen Access07 Jul 2021
Nature Communications

Volume: 12, P: 1-10
Palladium(0)-catalyzed Synthesis of Unsaturated Polyethers from Bifunctional Vinyloxiranes and Bisphenol Analogues

Toshio Koizumi
Tadayoshi Akita
Takeshi Endo
Research10 Aug 2004
Polymer Journal

Volume: 36, P: 647-651
Alignment and Micropatterning of Carbon Nanotubes in Polymer Composites Using Modulated Magnetic Field

Guangzhe Piao
Fumiko Kimura
Tsunehisa Kimura
Research23 Apr 2007
Polymer Journal

Volume: 39, P: 589-592
Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers

Pataer Abujiang
Tomoharu J Mori
Hiroshi Hiai
Research09 Dec 1998
Oncogene

Volume: 17, P: 3029-3033
Chip-scale high-peak-power semiconductor/solid-state vertically integrated laser

Here the authors demonstrate chip-scale high-peak-power lasers by vertical integration of semiconductor and solid state laser gain mediums to reach the same maturity level as existing semiconductor lasers, which are suitable for miniaturization and cost-effective mass production.

Jianglin Yue
Kenji Tanaka
Masanao Kamata
ResearchOpen Access01 Oct 2022
Nature Communications

Volume: 13, P: 1-9

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