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Showing 1–50 of 52 results

Advanced filters: Author: Hitoshi Fujiwara Clear advanced filters

Why is a minor planet minor?

TAKAFUMI MATSUI
HITOSHI MIZUTANI
Research08 Dec 1977
Nature

Volume: 270, P: 506-507
Chemical catalyst manipulating cancer epigenome and transcription

Here, the authors develop a cell-permeable chemical catalyst that acetylates histone H2BK120 in leukemia cells, attenuates NELFE chromatin binding, reprograms transcription, and reduces the tumorigenic potential of leukemia cells in mice.

Yuki Yamanashi
Shinpei Takamaru
Motomu Kanai
ResearchOpen Access24 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Positive lymph node ratio as a nodal staging system to avoid stage migration between remnant and primary proximal gastric cancers

Daiki Matsubara
Shuhei Komatsu
Atsushi Shiozaki
ResearchOpen Access05 Aug 2025
Scientific Reports

Volume: 15, P: 1-8
Staphylococcus aureus ST764-SCCmecII high-risk clone in bloodstream infections revealed through national genomic surveillance integrating clinical data

Authors present results from a national surveillance in Japan that found MRSA strains causing bloodstream infections are predominantly from three clonal lineages. They also identified the emergence of highest 30-day-mortality MRSA clone ST764-SCCmecII and traced its evolutionary path.

Junzo Hisatsune
Shoko Kutsuno
Motoyuki Sugai
ResearchOpen Access19 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial

In view of previous work suggesting that low-voltage areas may promote atrial fibrillation, a multicenter, randomized controlled trial tested the hypothesis that ablation of low-voltage areas in addition to pulmonary vein isolation might reduce the recurrence of atrial arrhythmic events, but found no significant benefit to the combined procedure.

Masaharu Masuda
Akihiro Sunaga
Takuya Ohashi
ResearchOpen Access30 Apr 2025
Nature Medicine

Volume: 31, P: 1661-1667
Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes

Barrier-to-autointegration factor (BAF) binds to mitotic chromosomes and promotes nuclear assembly. It also anchors chromatin to the nuclear lamina through Lamin A/C. Here, the authors present cryo-EM structures of BAF-Lamin A/C-nucleosome complexes.

Naoki Horikoshi
Ryosuke Miyake
Hitoshi Kurumizaka
ResearchOpen Access10 Feb 2025
Nature Communications

Volume: 16, P: 1-10
Over-Expression of TSC-22 (TGF-β Stimulated Clone-22) Markedly Enhances 5-Fluorouracil-Induced Apoptosis in a Human Salivary Gland Cancer Cell Line

Daisuke Uchida
Hitoshi Kawamata
Mitsunobu Sato
Research01 Jun 2000
Laboratory Investigation

Volume: 80, P: 955-963
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Berry curvature contributions of kagome-lattice fragments in amorphous Fe–Sn thin films

The topological character of solids is usually revealed by considering the Berry curvature of electronic bands in a periodic crystal. Here, authors demonstrate the influence of the Berry curvature on the electronic properties of an amorphous thin film.

Kohei Fujiwara
Yasuyuki Kato
Atsushi Tsukazaki
ResearchOpen Access13 Jun 2023
Nature Communications

Volume: 14, P: 1-7
descSPIM: an affordable and easy-to-build light-sheet microscope optimized for tissue clearing techniques

Poor access to suitable light-sheet microscopes remains a big obstacle for many end-users in biomedical research. Here, the authors present descSPIM, a low-cost, low-expertise light-sheet microscope for routine 3D imaging of cleared samples.

Kohei Otomo
Takaki Omura
Etsuo A. Susaki
ResearchOpen Access12 Jun 2024
Nature Communications

Volume: 15, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection

The synthesis of NPY and its receptor Y1R increases in lung phagocytes during severe influenza virus infection, leading to the induction of SOCS3 and impaired antiviral response and increased pro-inflammatory cytokine production.

Seiki Fujiwara
Midori Hoshizaki
Yumiko Imai
Research19 Nov 2018
Nature Microbiology

Volume: 4, P: 258-268
Risk factors for liver dysfunction and their clinical importance after gastric cancer surgery

Shutaro Sumiyoshi
Takeshi Kubota
Eigo Otsuji
ResearchOpen Access06 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene

Tomoya O. Akama
Kohji Nishida
Michiko N. Fukuda
Research01 Oct 2000
Nature Genetics

Volume: 26, P: 237-241
Differences of clinical features and outcomes between male and female elderly patients in gastric cancer

Hiroshi Arakawa
Shuhei Komatsu
Eigo Otsuji
ResearchOpen Access11 Oct 2023
Scientific Reports

Volume: 13, P: 1-8
Obesity paradox as a new insight from postoperative complications in gastric cancer

Hajime Kamiya
Shuhei Komatsu
Eigo Otsuji
ResearchOpen Access21 Jun 2023
Scientific Reports

Volume: 13, P: 1-9
Low levels of tumor suppressor miR-3619 in plasma contribute to malignant outcomes and a target for nucleic acid therapy in esophageal cancer

Hiroshi Arakawa
Shuhei Komatsu
Eigo Otsuji
ResearchOpen Access27 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Changes in cross-sectional areas of posterior extensor muscles in thoracic spine: a 10-year longitudinal MRI study

Hitoshi Umezawa
Kenshi Daimon
Kota Watanabe
ResearchOpen Access30 Aug 2022
Scientific Reports

Volume: 12, P: 1-8
Phosphate starvation response precedes abscisic acid response under progressive mild drought in plants

Even mild drought impacts crop production significantly. Here, the authors develop an experimental mild drought system induced by ridges in the field and find that phosphate starvation response occurs before ABA response in early mild drought.

Yukari Nagatoshi
Kenta Ikazaki
Yasunari Fujita
ResearchOpen Access19 Aug 2023
Nature Communications

Volume: 14, P: 1-16
Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin

Kenji Tsuchihashi
Hitoshi Kusaba
Eishi Baba
ResearchOpen Access01 Dec 2020
Scientific Reports

Volume: 10, P: 1-6
Discovery of a colossal slickhead (Alepocephaliformes: Alepocephalidae): an active-swimming top predator in the deep waters of Suruga Bay, Japan

Yoshihiro Fujiwara
Masaru Kawato
Shinji Tsuchida
ResearchOpen Access25 Jan 2021
Scientific Reports

Volume: 11, P: 1-16
Randomised phase II trial of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab as first-line treatment for colorectal liver metastasis (ATOM trial)

Eiji Oki
Yasunori Emi
Yoshihiko Maehara
ResearchOpen Access09 Jul 2019
British Journal of Cancer

Volume: 121, P: 222-229
REV-ERBα and REV-ERBβ function as key factors regulating Mammalian Circadian Output

Ryosuke Ikeda
Yoshiki Tsuchiya
Kazuhiro Yagita
ResearchOpen Access15 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Heparanase Expression Correlates with Invasion and Poor Prognosis in Gastric Cancers

Munenori Takaoka
Yoshio Naomoto
Minoru Haisa
Research01 May 2003
Laboratory Investigation

Volume: 83, P: 613-622
Longitudinal MRI study over 20 years of cervical posterior extensor muscle area in asymptomatic subjects

Hiroyuki Izumida
Kenshi Daimon
Kota Watanabe
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Re-examining the optimal extent of lymph node dissection for colon cancer using the lymphadenectomy index

Yuta Marunaka
Jun Kiuchi
Eigo Otsuji
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Publisher Correction: Defective Epstein–Barr virus in chronic active infection and haematological malignancy

Yusuke Okuno
Takayuki Murata
Hiroshi Kimura
Amendments and Corrections30 Jan 2019
Nature Microbiology

Volume: 4, P: 544
Defective Epstein–Barr virus in chronic active infection and haematological malignancy

Genome sequencing of fractionated T-, B- and natural killer cells from patients with chronic active Epstein–Barr virus (EBV) infection sheds light on the nature of the EBV-infected progenitor and suggests a link between intragenic EBV deletions and EBV-associated neoplastic proliferations.

Yusuke Okuno
Takayuki Murata
Hiroshi Kimura
Research21 Jan 2019
Nature Microbiology

Volume: 4, P: 404-413
Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia

Kana Yamamoto
Toshihiko Kuriu
Takanobu Nakazawa
ResearchOpen Access25 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-8
Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine

Norio Horiguchi
Hisashi Takayama
Masatomo Mori
Research13 Mar 2002
Oncogene

Volume: 21, P: 1791-1799
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Author Correction: Differences of clinical features and outcomes between male and female elderly patients in gastric cancer

Hiroshi Arakawa
Shuhei Komatsu
Eigo Otsuji
Amendments and CorrectionsOpen Access23 Jan 2024
Scientific Reports

Volume: 14, P: 1
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Is chloroplastic class IIA aldolase a marine enzyme?

Hitoshi Miyasaka
Takeru Ogata
Kazumasa Hirata
Research08 Apr 2016
The ISME Journal

Volume: 10, P: 2767-2772
Correction: PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis

Wenjie Zuo
Mai Wakimoto
Takashi Fujita
Amendments and CorrectionsOpen Access19 Sept 2022
Cell Death & Disease

Volume: 13, P: 1
Low blood level of tumour suppressor miR-5193 as a target of immunotherapy to PD-L1 in gastric cancer

Hajime Kamiya
Shuhei Komatsu
Eigo Otsuji
Research26 Dec 2023
British Journal of Cancer

Volume: 130, P: 671-681
Scalp attached tangential magnetoencephalography using tunnel magneto-resistive sensors

Akitake Kanno
Nobukazu Nakasato
Yasuo Ando
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-9
PKR and TLR3 trigger distinct signals that coordinate the induction of antiviral apoptosis

Wenjie Zuo
Mai Wakimoto
Takashi Fujita
ResearchOpen Access15 Aug 2022
Cell Death & Disease

Volume: 13, P: 1-15
House mouse Mus musculus dispersal in East Eurasia inferred from 98 newly determined complete mitochondrial genome sequences

Yue Li
Kazumichi Fujiwara
Hitoshi Suzuki
ResearchOpen Access15 Sept 2020
Heredity

Volume: 126, P: 132-147
The expression and role of TRPV2 in esophageal squamous cell carcinoma

Michihiro Kudou
Atsushi Shiozaki
Eigo Otsuji
ResearchOpen Access05 Nov 2019
Scientific Reports

Volume: 9, P: 1-12
Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer

Keiji Nishibeppu
Shuhei Komatsu
Eigo Otsuji
ResearchOpen Access21 Feb 2020
Scientific Reports

Volume: 10, P: 1-11
Comparison of reduced-intensity/toxicity conditioning regimens for umbilical cord blood transplantation for lymphoid malignancies

Nobuhiko Imahashi
Seitaro Terakura
Takaya Mitsuyoshi
Research21 May 2020
Bone Marrow Transplantation

Volume: 55, P: 2098-2108
Nucleosome destabilization by nuclear non-coding RNAs

The Eleanor cluster of non-coding RNAs is localised upstream of estrogen receptor-α (ESR1) gene locus in estrogen-deprived breast cancer cells. Fujita et al find that RNA fragments of Eleanor2 and of other non-coding RNAs are able to destabilise nucleosomes in vitro, suggesting a role in transcriptional regulation.

Risa Fujita
Tatsuro Yamamoto
Hitoshi Kurumizaka
ResearchOpen Access11 Feb 2020
Communications Biology

Volume: 3, P: 1-11
Utility of a rapid assay for prostaglandin E-major urinary metabolite as a biomarker in pediatric ulcerative colitis

Shin-ichiro Hagiwara
Naoki Abe
Yuri Etani
ResearchOpen Access19 Jun 2023
Scientific Reports

Volume: 13, P: 1-10
Overexpression of PBK/TOPK relates to tumour malignant potential and poor outcome of gastric carcinoma

Takuma Ohashi
Shuhei Komatsu
Eigo Otsuji
ResearchOpen Access29 Nov 2016
British Journal of Cancer

Volume: 116, P: 218-226
Suppression of peritoneal implantation of gastric cancer cells by adenovirus vector-mediated NK4 expression

Hitoshi Fujiwara
Takeshi Kubota
Hisakazu Yamagishi
Research15 Oct 2004
Cancer Gene Therapy

Volume: 12, P: 206-216
Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-κB signaling

Macus Tien Kuo
Zesheng Liu
Hitoshi Unate
Research22 Mar 2002
Oncogene

Volume: 21, P: 1945-1954
Novel urinary glycan profiling by lectin array serves as the biomarkers for predicting renal prognosis in patients with IgA nephropathy

Chieko Kawakita
Koki Mise
Jun Wada
ResearchOpen Access09 Feb 2021
Scientific Reports

Volume: 11, P: 1-11
Stem cell self-renewal factors Bmi1 and HMGA2 in head and neck squamous cell carcinoma: clues for diagnosis

Hiroshi Yamazaki
Taisuke Mori
Yae Kanai
Research21 Oct 2013
Laboratory Investigation

Volume: 93, P: 1331-1338

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