In nematodes, the extracellular molecule UNC6/netrin is required both in the vicinity of dendrites to prevent mislocalization of axonal proteins there, and sufficient to exclude synaptic proteins from axon terminals if artificially provided close to these. The results extend to another extracellular protein, Wnt, and suggest that axon guidance cues also control local exclusion of axon terminal components from dendrites.
- Vivian Y. Poon
- Matthew P. Klassen
- Kang Shen
