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Showing 1–50 of 75 results

Advanced filters: Author: Hyemin Lee Clear advanced filters

Vitamin C insufficiency causes the stress-induced sudden death through the induction of extensive heart injury.

Jae Seung Kang
Sung Joon Kim
Wang Jae Lee
ResearchOpen Access01 Apr 2010
Nature Precedings

P: 1
Whole-genome sequencing analyses suggest novel genetic factors associated with Alzheimer’s disease and a cumulative effects model for risk liability

Here the authors reveal via whole genome sequencing of an East Asian AD cohort a common variant locus (APCDD1), rare noncoding variants in excitatory neurons, and short tandem repeat expansions, suggesting a cumulative effects model for Alzheimer’s risk.

Jun Pyo Kim
Minyoung Cho
Hong-Hee Won
ResearchOpen Access26 May 2025
Nature Communications

Volume: 16, P: 1-18
Shared genetic architectures of educational attainment in East Asian and European populations

The authors conducted a genome-wide association study of educational attainment in an East Asian ancestry cohort, and a cross-ancestry meta-analysis with earlier genome-wide association studies from European ancestry populations, providing new insights into correlations and transferability between ancestries.

Tzu-Ting Chen
Jaeyoung Kim
Hong-Hee Won
ResearchOpen Access05 Jan 2024
Nature Human Behaviour

Volume: 8, P: 562-575
Erratum: Map-based Cloning and Characterization of the BPH18 Gene from Wild Rice Conferring Resistance to Brown Planthopper (BPH) Insect Pest

Hyeonso Ji
Sung-Ryul Kim
Kshirod K. Jena
Amendments and CorrectionsOpen Access11 Nov 2016
Scientific Reports

Volume: 6, P: 1
Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition

A cross-ancestry GWAS meta-analysis of β-amyloid deposition in East Asian and European populations identifies a novel SORL1 locus and highlights its differential expression in microglia associated with β-amyloid positivity.

Jun Pyo Kim
Sang-Hyuk Jung
Hong-Hee Won
ResearchOpen Access02 Apr 2025
Nature Communications

Volume: 16, P: 1-12
Low excess noise and high quantum efficiency avalanche photodiodes for beyond 2 µm wavelength detection

Photodetectors for monitoring greenhouse gas emissions must cover the extended short-wavelength infrared range. Here, antimonide-based materials on a InP substrate enable a high-performance avalanche photodiode with detectivity beyond 2 µm wavelength.

Hyemin Jung
Seunghyun Lee
Sanjay Krishna
ResearchOpen Access09 Oct 2024
Communications Materials

Volume: 5, P: 1-7
Energy-stress-mediated AMPK activation inhibits ferroptosis

Lee et al. show that energy stress inhibits ferroptosis through AMPK activation and demonstrate a role for AMPK in ferroptosis-associated renal ischaemia–reperfusion injury in vivo.

Hyemin Lee
Fereshteh Zandkarimi
Boyi Gan
Research06 Feb 2020
Nature Cell Biology

Volume: 22, P: 225-234
Prion-like domain mediated phase separation of ARID1A promotes oncogenic potential of Ewing’s sarcoma

ARID1A is a chromatin remodeling protein frequently mutated in cancer. Here the authors report that ARID1A plays a role in forming membraneless organelles through liquid-liquid phase separation (LLPS). ARID1A condensates were elevated in Ewing’s sarcoma patients.

Yong Ryoul Kim
Jaegeon Joo
Sung Hee Baek
ResearchOpen Access03 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao
Xiaoguang Liu
Boyi Gan
Amendments and Corrections02 Aug 2021
Nature

Volume: 596, P: E13
Diagonal Earlobe Crease is a Visible Sign for Cerebral Small Vessel Disease and Amyloid-β

Jin San Lee
Seongbeom Park
Sang Won Seo
ResearchOpen Access17 Oct 2017
Scientific Reports

Volume: 7, P: 1-7
Generation, transport and detection of valley-locked spin photocurrent in WSe₂–graphene–Bi₂Se₃ heterostructures

Lateral TMD–graphene–topological insulator hetero-devices enable room-temperature optoelectronic transport of the valley-locked spin polarization degree of freedom.

Soonyoung Cha
Minji Noh
Hyunyong Choi
Research23 Jul 2018
Nature Nanotechnology

Volume: 13, P: 910-914
Dual-mode action of scalable, high-quality engineered stem cell-derived SIRPα-extracellular vesicles for treating acute liver failure

Acute liver failure arises from rapid cell death and impaired liver regeneration. Here, the authors show that scalable, high-purity engineered extracellular vesicles derived from stem cells promote the clearance of dying hepatocytes and drive liver repair through in vivo macrophage reprogramming.

Seohyun Kim
Yoon Kyoung Kim
In-San Kim
ResearchOpen Access23 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Clinical application of whole-genome sequencing of solid tumors for precision oncology

Ryul Kim
Seokhwi Kim
Minsuk Kwon
ResearchOpen Access13 Aug 2024
Experimental & Molecular Medicine

Volume: 56, P: 1856-1868
Predictors of galcanezumab response in a real-world study of Korean patients with migraine

Seung Ae Kim
Hyemin Jang
Mi Ji Lee
ResearchOpen Access08 Sept 2023
Scientific Reports

Volume: 13, P: 1-7
Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

How cell cycling coordinates with cell survival and death remains unclear. Here, the authors reveal a suppressive effect of cell cycle arrest on ferroptosis and propose a ferroptosis-inducing approach to treat slow-cycling, therapy-resistant cancers.

Hyemin Lee
Amber Horbath
Boyi Gan
ResearchOpen Access02 Jan 2024
Nature Communications

Volume: 15, P: 1-13
Farnesiferol c induces apoptosis via regulation of L11 and c-Myc with combinational potential with anticancer drugs in non-small-cell lung cancers

Ji Hoon Jung
Moon Joon Kim
Sung-Hoon Kim
ResearchOpen Access27 May 2016
Scientific Reports

Volume: 6, P: 1-9
Antibodies against endogenous retroviruses promote lung cancer immunotherapy

In lung adenocarcinoma, antibodies against endogenous retroviruses promote anti-tumour activity, and expression of endogenous retroviruses can predict outcomes of immunotherapy.

Kevin W. Ng
Jesse Boumelha
George Kassiotis
ResearchOpen Access12 Apr 2023
Nature

Volume: 616, P: 563-573
IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis

The endoplasmic reticulum (ER) is a major site of lipid peroxidation during ferroptosis. Here authors show that the ER protein IRE1α determines ferroptosis induction via regulating glutathione synthesis independent of the unfolded protein response.

Dadi Jiang
Youming Guo
Albert C. Koong
ResearchOpen Access15 May 2024
Nature Communications

Volume: 15, P: 1-16
Re-evaluation of arterial dissection as a possible major cause of lateral medullary infarction in a single-center study from South Korea

Jiyeon Ha
Wookjin Yang
Seung-Hoon Lee
ResearchOpen Access19 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Anomalous excess noise behavior in thick Al_0.85Ga_0.15As_0.56Sb_0.44 avalanche photodiodes

Harry I. J. Lewis
Xiao Jin
John P. R. David
ResearchOpen Access19 Jun 2023
Scientific Reports

Volume: 13, P: 1-9
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

DHO dehydrogenase regulates ferroptosis by preventing mitochondrial lipid peroxidation and its inhibition suppresses growth in tumours with low levels of GPX4.

Chao Mao
Xiaoguang Liu
Boyi Gan
Research12 May 2021
Nature

Volume: 593, P: 586-590
Effect modification by cardiovascular and metabolic disease onset on long-term PM_2.5 exposure and mortality: a nationwide cohort study

Hyemin Jang
Jinah Park
Whanhee Lee
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-14
Evaluation of roadside air quality using deep learning models after the application of the diesel vehicle policy (Euro 6)

Hyemin Hwang
Sung Rak Choi
Jae Young Lee
ResearchOpen Access01 Dec 2022
Scientific Reports

Volume: 12, P: 1-9
Sustainable lead management in halide perovskite solar cells

The most-efficient solar cells use Pb-based halide perovskites; however, their toxicity poses environmental and health risks. Here, the authors report an adsorbent that allows for sustainable Pb management in these devices.

So Yeon Park
Ji-Sang Park
Hyun Suk Jung
Research03 Aug 2020
Nature Sustainability

Volume: 3, P: 1044-1051
Automated classification of chondroid tumor using 3D U-Net and radiomics with deep features

Tuan Le Dinh
Seungeun Lee
Joon-Yong Jung
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress

Liu et al. show that, in response to energy stress, the NBR2 long non-coding RNA binds AMPK and promotes its activity to reduce cancer cell proliferation. Conversely, loss of NBR2 inhibits AMPK, leading to mTOR activation and tumour growth.

Xiaowen Liu
Zhen-Dong Xiao
Boyi Gan
Research21 Mar 2016
Nature Cell Biology

Volume: 18, P: 431-442
Unusually efficient photocurrent extraction in monolayer van der Waals heterostructure by tunnelling through discretized barriers

Vertical integration of two-dimensional materials can open unprecedented possibilities towards design of efficient optoelectronic devices. Here, the authors investigate the photoresponse properties of a graphene/MoS₂/graphene heterostructure, revealing promising quantum efficiency performances.

Woo Jong Yu
Quoc An Vu
Xiangfeng Duan
ResearchOpen Access09 Nov 2016
Nature Communications

Volume: 7, P: 1-9
Long noncoding RNA MALAT1 suppresses breast cancer metastasis

Targeted inactivation, restoration and overexpression of MALAT1 in multiple in vivo models demonstrate that the lncRNA MALAT1 suppresses breast cancer metastasis through binding and inactivation of the pro-metastatic transcription factor TEAD.

Jongchan Kim
Hai-Long Piao
Li Ma
Research22 Oct 2018
Nature Genetics

Volume: 50, P: 1705-1715
RNA-binding motif protein 10 induces apoptosis and suppresses proliferation by activating p53

Ji Hoon Jung
Hyemin Lee
Hua Lu
Research07 Oct 2019
Oncogene

Volume: 39, P: 1031-1040
Haematopoietic stem cell-dependent Notch transcription is mediated by p53 through the Histone chaperone Supt16h

Espanola et al. show in zebrafish that Supt16h, a component of the FACT complex, regulates HSC development through an increase of p53, which promotes expression of phc1, a transcriptional repressor of Notch.

Sophia G. Espanola
Hyemin Song
Yoonsung Lee
Research23 Nov 2020
Nature Cell Biology

Volume: 22, P: 1411-1422
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Glutathione peroxidase 4 (GPX4) inhibits ferroptosis, but protein synthesis is inefficient and costly. Here, the authors reveal that cystine uptake promotes GPX4 synthesis by activating mTORC1 and show that cancer cells are sensitized to ferroptosis by mTORC1 inhibition.

Yilei Zhang
Robert V. Swanda
Boyi Gan
ResearchOpen Access11 Mar 2021
Nature Communications

Volume: 12, P: 1-14
Clinical spectrum of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia in individuals of Korean ancestry

Jae Rim Kim
Suin Lee
Hee Jin Kim
ResearchOpen Access13 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer

Liu et al. show that cancer cells with high levels of SLC7A11 have increased dependency on the pentose phosphate pathway and consequently accumulate disulfide, and can be therapeutically targeted by limiting glucose supply.

Xiaoguang Liu
Kellen Olszewski
Boyi Gan
Research30 Mar 2020
Nature Cell Biology

Volume: 22, P: 476-486
Comparison of accumulation rates of beta-amyloid tracers and their relationship with cognitive changes

Soo Hyun Cho
Heekyoung Kang
Jun Pyo Kim
ResearchOpen Access27 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development

FoxO are commonly down-regulated transcription factors and tumor suppressors in renal cell cancer (RCC). Here, the authors show that upon energy stress FoxOs induce the expression of the long non-coding RNA FILNC1, which inhibits survival of RCC by downregulating c-Myc and c-Myc-dependent metabolic rewiring.

Zhen-Dong Xiao
Leng Han
Boyi Gan
ResearchOpen Access04 Oct 2017
Nature Communications

Volume: 8, P: 1-13
BAP1 links metabolic regulation of ferroptosis to tumour suppression

Zhang et al. show that BAP1 suppresses SLC7A11 expression and cystine uptake, thereby promoting ferroptosis and inhibiting tumour growth.

Yilei Zhang
Jiejun Shi
Boyi Gan
Research10 Sept 2018
Nature Cell Biology

Volume: 20, P: 1181-1192
Comprehensive profiling of phenolic compounds and triterpenoid saponins from Acanthopanax senticosus and their antioxidant, α-glucosidase inhibitory activities

Ryeong Ha Kwon
Hyemin Na
Heon-Woong Kim
ResearchOpen Access01 Nov 2024
Scientific Reports

Volume: 14, P: 1-30
Multifunctional materials for implantable and wearable photonic healthcare devices

Multifunctional materials are critical to enable next-generation implantable and wearable photonic healthcare devices. This Review examines these emerging materials and discusses the path for their clinical translation, along with the future research directions for the field, particularly regarding mobile healthcare and personalized medicine.

Geon-Hui Lee
Hanul Moon
Sei Kwang Hahn
Reviews07 Jan 2020
Nature Reviews Materials

Volume: 5, P: 149-165
Correlations between Gray Matter and White Matter Degeneration in Pure Alzheimer’s Disease, Pure Subcortical Vascular Dementia, and Mixed Dementia

Hyemin Jang
Hunki Kwon
Jong-Min Lee
ResearchOpen Access25 Aug 2017
Scientific Reports

Volume: 7, P: 1-9
Author Correction: Clinical spectrum of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia in individuals of Korean ancestry

Jae Rim Kim
Suin Lee
Hee Jin Kim
Amendments and CorrectionsOpen Access18 Mar 2025
Scientific Reports

Volume: 15, P: 1
Genomic hypomethylation in cell-free DNA predicts responses to checkpoint blockade in lung and breast cancer

Kyeonghui Kim
Hyemin Kim
Jung Kyoon Choi
ResearchOpen Access18 Dec 2023
Scientific Reports

Volume: 13, P: 1-15
Coiled-coil domain containing 3 suppresses breast cancer growth by protecting p53 from proteasome-mediated degradation

Caiyue Li
Hyemin Lee
Hua Lu
Research17 Nov 2022
Oncogene

Volume: 42, P: 154-164
Author Correction: Distinctive Clinical Effects of Haemorrhagic Markers in Cerebral Amyloid Angiopathy

Young Kyoung Jang
Hee Jin Kim
Sang Won Seo
Amendments and CorrectionsOpen Access21 Mar 2018
Scientific Reports

Volume: 8, P: 1
Author Correction: Non-alcoholic fatty liver disease and cerebral small vessel disease in Korean cognitively normal individuals

Hyemin Jang
Danbee Kang
Sang Won Seo
Amendments and CorrectionsOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1
Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer

Dong-Hyeon Ha
Ahrum Min
Seock-Ah Im
ResearchOpen Access18 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Distinct amyloid distribution patterns in amyloid positive subcortical vascular cognitive impairment

Hyemin Jang
Jong-Yun Park
Sang Won Seo
ResearchOpen Access01 Nov 2018
Scientific Reports

Volume: 8, P: 1-8
Non-alcoholic fatty liver disease and cerebral small vessel disease in Korean cognitively normal individuals

Hyemin Jang
Danbee Kang
Sang Won Seo
ResearchOpen Access12 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Zinc finger protein 746 promotes colorectal cancer progression via c-Myc stability mediated by glycogen synthase kinase 3β and F-box and WD repeat domain-containing 7

Ji Hoon Jung
Deok-Beom Jung
Sung-Hoon Kim
Research09 Apr 2018
Oncogene

Volume: 37, P: 3715-3728
Localization-adjusted diagnostic performance and assistance effect of a computer-aided detection system for pneumothorax and consolidation

Sun Yeop Lee
Sangwoo Ha
Jong Mun Choi
ResearchOpen Access30 Jul 2022
npj Digital Medicine

Volume: 5, P: 1-11
Comprehensive characterization of flavonoid derivatives in young leaves of core-collected soybean (Glycine max L.) cultivars based on high-resolution mass spectrometry

Suji Lee
Heon-Woong Kim
Sang Hoon Lee
ResearchOpen Access29 Aug 2022
Scientific Reports

Volume: 12, P: 1-19

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