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Showing 1–50 of 97 results

Advanced filters: Author: Ignacio Blanco Clear advanced filters

Two major ecological shifts shaped 60 million years of ungulate faunal evolution

Here, the authors analyze a fossil dataset spanning 60 million years to investigate ecological stability. Their network analysis identifies prolonged stability interrupted by two major functional transitions in ungulate assemblages linked to tectonic and climatic events.

Fernando Blanco
Ignacio A. Lazagabaster
Juan L. Cantalapiedra
ResearchOpen Access05 Jun 2025
Nature Communications

Volume: 16, P: 1-11
Everyday norms have become more permissive over time and vary across cultures

A survey across 90 societies reveals that variation and change in everyday norms are explained by a single value dimension: the priority societies place on individualizing versus binding moral concerns.

Kimmo Eriksson
Pontus Strimling
Paul A. M. Van Lange
ResearchOpen Access07 Oct 2025
Communications Psychology

Volume: 3, P: 1-14
Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Clinical studies have suggested that the therapeutic potential of polyclonal convalescent plasma is highest in the first days of symptoms. Here, the authors present results from a pooled analysis of two clinical trials in COVID-19 outpatients that did not provide conclusive evidence in favor of convalescent plasma.

Pere Millat-Martinez
Arvind Gharbharan
Michael Marks
ResearchOpen Access11 May 2022
Nature Communications

Volume: 13, P: 1-9
The role of mitochondria in osteoarthritis

Recent experimental evidence has indicated that mitochondrial function is impaired in chondrocytes from patients with osteoarthritis (OA). In this Review, the authors discuss how this mitochondrial dysfunction might affect pathogenetic pathways in OA, such as cartilage degradation, and whether the mitochondria might provide useful prognostic or diagnostic biomarkers or act as potential targets for therapy in patients with OA.

Francisco J. Blanco
Ignacio Rego
Cristina Ruiz-Romero
Reviews04 Jan 2011
Nature Reviews Rheumatology

Volume: 7, P: 161-169
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Author Correction: Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients

Pere Millat-Martinez
Arvind Gharbharan
Michael Marks
Amendments and CorrectionsOpen Access22 May 2024
Nature Communications

Volume: 15, P: 1
KLRG1 identifies regulatory T cells with mitochondrial alterations that accumulate with aging

T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate with age in both mice and humans and exhibit features including mitochondrial decline and an inflammatory phenotype.

Gonzalo Soto-Heredero
Enrique Gabandé-Rodríguez
María Mittelbrunn
ResearchOpen Access30 Apr 2025
Nature Aging

Volume: 5, P: 799-815
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer

Stig Bojesen, Georgia Chenevix-Trench, Alison Dunning and colleagues report common variants at the TERT-CLPTM1L locus associated with mean telomere length measured in whole blood. They also identify associations at this locus to breast or ovarian cancer susceptibility and report functional studies in breast and ovarian cancer tissue and cell lines.

Stig E Bojesen
Karen A Pooley
Alison M Dunning
Research27 Mar 2013
Nature Genetics

Volume: 45, P: 371-384
Monitoring SARS-CoV-2 variant transitions using differences in diagnostic cycle threshold values of target genes

Antoni E. Bordoy
Verónica Saludes
Ignacio Blanco
ResearchOpen Access17 Dec 2022
Scientific Reports

Volume: 12, P: 1-7
Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

An analysis of 2,954 genomes from 38 cancer subtypes identified 19,166 retrotransposition events in 35% of samples. Aberrant LINE-1 retrotranspositions can lead to the deletion of tumor-suppressor genes as well as the amplification of oncogenes.

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 306-319
Diverse values of nature for sustainability

Following a wide-ranging review of studies, reports and policies about nature’s multiple values, combinations of values-centred approaches are proposed to improve valuation of nature, address barriers to uptake in decision-making, and make transformative changes towards more just and sustainable futures.

Unai Pascual
Patricia Balvanera
Eglee Zent
ResearchOpen Access09 Aug 2023
Nature

Volume: 620, P: 813-823
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Spontaneous reperfusion enhances succinate concentration in peripheral blood from stemi patients but its levels does not correlate with myocardial infarct size or area at risk

Marta Consegal
Ignasi Barba
Antonio Rodríguez-Sinovas
ResearchOpen Access27 Apr 2023
Scientific Reports

Volume: 13, P: 1-7
Single cell derived mRNA signals across human kidney tumors

Transcriptomic analysis may provide information about the differentiation state and cell of origin of a cancer. Here, the authors assess mRNA signals in 1300 childhood and adult renal tumors and report a fetal origin of childhood tumors and no dedifferentiation of adult tumors.

Matthew D. Young
Thomas J. Mitchell
Sam Behjati
ResearchOpen Access23 Jun 2021
Nature Communications

Volume: 12, P: 1-19
A tumor-targeted trimeric 4-1BB-agonistic antibody induces potent anti-tumor immunity without systemic toxicity

Cancer therapy using systemically administrated 4-1BB-targeting antibodies is often associated with severe toxicity due to the nonspecific activation of autoreactive T cells. Here, the authors have developed a trimeric antibody targeting both 4-1BB and EGFR, which activates T cells effectively and shows negligible cytotoxicity.

Marta Compte
Seandean Lykke Harwood
Luis Alvarez-Vallina
ResearchOpen Access15 Nov 2018
Nature Communications

Volume: 9, P: 1-13
Association of accelerated dynamics of telomere sequence loss in peripheral blood leukocytes with incident knee osteoarthritis in Osteoarthritis Initiative cohort

Rebeca Guillén
Fátima Otero
José Luis Fernández
ResearchOpen Access05 Aug 2021
Scientific Reports

Volume: 11, P: 1-6
A Newcastle disease virus expressing a stabilized spike protein of SARS-CoV-2 induces protective immune responses

Here the authors show that a Newcastle disease virus based COVID-19 vaccine expressing a stabilized spike protein induces protective immunity in small animal models and reduces replication of variants of concerns. This vaccine candidate can be produced by influenza virus vaccine manufactures around the world.

Weina Sun
Yonghong Liu
Peter Palese
ResearchOpen Access27 Oct 2021
Nature Communications

Volume: 12, P: 1-14
Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial

Alejandro Rodríguez-Molinero
Carlos Pérez-López
Antonio Miñarro
ResearchOpen Access20 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-9
Early NT-proBNP levels as a screening tool for the detection of hemodynamically significant patent ductus arteriosus during the first week of life in very low birth weight infants

Silvia Rodriguez-Blanco
Ignacio Oulego-Erroz
Maria Luz Couce-Pico
Research22 May 2018
Journal of Perinatology

Volume: 38, P: 881-888
Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection

Laura Prieto-Pérez
José Fortes
Miguel A. Piris
Research03 Jul 2020
Modern Pathology

Volume: 33, P: 2139-2146
Cancer Surveillance Guideline for individuals with PTEN hamartoma tumour syndrome

Marc Tischkowitz
Chrystelle Colas
Marja Hietala
ResearchOpen Access12 Jun 2020
European Journal of Human Genetics

Volume: 28, P: 1387-1393
Early assessment of lung aeration using an ultrasound score as a biomarker of developing bronchopulmonary dysplasia: a prospective observational study

Ignacio Oulego-Erroz
Paula Alonso-Quintela
Silvia Rodríguez-Blanco
Research14 Jul 2020
Journal of Perinatology

Volume: 41, P: 62-68
Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses

Genome-wide analysis identifies 32 loci associated with breast cancer susceptibility, accounting for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade.

Haoyu Zhang
Thomas U. Ahearn
Montserrat García-Closas
Research18 May 2020
Nature Genetics

Volume: 52, P: 572-581
Role of Engrailed-2 (EN2) as a prostate cancer detection biomarker in genetically high risk men

Emma Killick
Richard Morgan
Hardev Pandha
ResearchOpen Access24 Jun 2013
Scientific Reports

Volume: 3, P: 1-5
In vitro antisense therapeutics for a deep intronic mutation causing Neurofibromatosis type 2

Elisabeth Castellanos
Imma Rosas
Eduard Serra
Research28 Nov 2012
European Journal of Human Genetics

Volume: 21, P: 769-773
Evidence of linkage to chromosomes 10p15.3–p15.1, 14q24.3–q31.1 and 9q33.3–q34.3 in non-syndromic colorectal cancer families

Ian W Saunders
Jason Ross
Garry N Hannan
Research10 Aug 2011
European Journal of Human Genetics

Volume: 20, P: 91-96
Ghrelin Facilitates GLUT2-, SGLT1- and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus)

Ayelén Melisa Blanco
Juan Ignacio Bertucci
Suraj Unniappan
ResearchOpen Access24 Mar 2017
Scientific Reports

Volume: 7, P: 1-16
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
Identification of six new susceptibility loci for invasive epithelial ovarian cancer

Georgia Chenevix-Trench and colleagues report meta-analyses of genome-wide association studies identifying six loci newly associated with epithelial ovarian cancer (EOC). They also test variants at the 12 known and 6 new EOC susceptibility loci for association in BRCA1 and BRCA2 mutation carriers.

Karoline B Kuchenbaecker
Susan J Ramus
Georgia Chenevix-Trench
Research12 Jan 2015
Nature Genetics

Volume: 47, P: 164-171
Nesfatin-1-Like Peptide Encoded in Nucleobindin-1 in Goldfish is a Novel Anorexigen Modulated by Sex Steroids, Macronutrients and Daily Rhythm

Lakshminarasimhan Sundarrajan
Ayelén Melisa Blanco
Suraj Unniappan
ResearchOpen Access22 Jun 2016
Scientific Reports

Volume: 6, P: 1-14
Confirmation of the topology of the Wendelstein 7-X magnetic field to better than 1:100,000

Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

T. Sunn Pedersen
M. Otte
Sandor Zoletnik
ResearchOpen Access30 Nov 2016
Nature Communications

Volume: 7, P: 1-10
Mid-term outcomes of percutaneous pulmonary valve replacement with Edwards-Sapien bioprosthesis in native right ventricular outflow tract

Yassin Belahnech
Gerard Martí-Aguasca
Ignacio Ferreira-González
ResearchOpen Access01 Feb 2025
Scientific Reports

Volume: 15, P: 1-11
mtDNA haplogroup A enhances the effect of obesity on the risk of knee OA in a Mexican population

Paula Ramos-Louro
Rubén Daniel Arellano Pérez Vertti
Ignacio Rego-Pérez
ResearchOpen Access25 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Author Correction: Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

Bernardo Rodriguez-Martin
Eva G. Alvarez
Christian von Mering
Amendments and CorrectionsOpen Access21 Mar 2023
Nature Genetics

Volume: 55, P: 1080
MYC directly transactivates CR2/CD21, the receptor of the Epstein–Barr virus, enhancing the viral infection of Burkitt lymphoma cells

Ester Molina
Lucía García-Gutiérrez
Javier León
Research29 Sept 2023
Oncogene

Volume: 42, P: 3358-3370
Deferiprone protects against photoreceptor degeneration by inhibiting parthanatos

Beatriz Villarejo-Zori
Juan Zapata-Muñoz
Patricia Boya
ResearchOpen Access19 May 2025
Cell Death & Disease

Volume: 16, P: 1-13
Discovering HIV related information by means of association rules and machine learning

Lourdes Araujo
Juan Martinez-Romo
Pablo Telleria
ResearchOpen Access28 Oct 2022
Scientific Reports

Volume: 12, P: 1-12
Shaping current European mitochondrial haplogroup frequency in response to infection: the case of SARS-CoV-2 severity

Genetic and Structural analysis of COVID patients cohort reveals a correlation between mitochondrial haplogroup and SARS-CoV-2 severity.

José Luis Cabrera-Alarcon
Raquel Cruz
José Antonio Enriquez
ResearchOpen Access09 Jan 2025
Communications Biology

Volume: 8, P: 1-12
Cross-cultural data on romantic love and mate preferences from 117,293 participants across 175 countries

Marta Kowal
Piotr Sorokowski
Filipe Prazeres
ResearchOpen Access01 Jul 2025
Scientific Data

Volume: 12, P: 1-12
Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort

Maite Silva-Díaz
Sonia Pértega-Díaz
Natividad Oreiro
ResearchOpen Access12 Mar 2024
Scientific Reports

Volume: 14, P: 1-9
Guidelines for the Li–Fraumeni and heritable TP53-related cancer syndromes

Thierry Frebourg
Svetlana Bajalica Lagercrantz
Marja Hietala
ResearchOpen Access26 May 2020
European Journal of Human Genetics

Volume: 28, P: 1379-1386
Mitochondrial DNA variation and the pathogenesis of osteoarthritis phenotypes

Mitochondrial dysfunction and mitochondrial DNA (mtDNA) influence several molecular processes underlying the pathogenesis of osteoarthritis (OA), and mtDNA variants are associated with the development and progression of knee OA, pointing to a role for mtDNA variation in OA pathogenesis and its phenotypic presentation.

Francisco J. Blanco
Ana M. Valdes
Ignacio Rego-Pérez
Reviews18 Apr 2018
Nature Reviews Rheumatology

Volume: 14, P: 327-340
Nuclear and mitochondrial data reveal high genetic divergence among Atlantic and Mediterranean populations of the Iberian killifish Aphanius iberus (Teleostei: Cyprinodontidae)

Anabel Perdices
José A Carmona
Ignacio Doadrio
Research01 Sept 2001
Heredity

Volume: 87, P: 314-324
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor–negative breast cancer in the general population

Fergus Couch and colleagues report a genome-wide association study for modifiers of breast cancer susceptibility in BRCA1 mutation carriers. They identify a locus at 19p13 associated with breast cancer risk in BRCA1 mutation carriers, and further replication studies identify this locus as associated with estrogen receptor–negative breast cancer in the general population.

Antonis C Antoniou
Xianshu Wang
Fergus J Couch
Research19 Sept 2010
Nature Genetics

Volume: 42, P: 885-892
SETD8 inhibition targets cancer cells with increased rates of ribosome biogenesis

Matilde Murga
Gema Lopez-Pernas
Oscar Fernández-Capetillo
ResearchOpen Access28 Sept 2024
Cell Death & Disease

Volume: 15, P: 1-11
ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer

Thaidy Moreno
Beatriz Monterde
Ignacio Varela
Research19 Mar 2021
Oncogene

Volume: 40, P: 2923-2935
Residual normal B-cell profiles in monoclonal B-cell lymphocytosis versus chronic lymphocytic leukemia

Ignacio Criado
Elena Blanco
Alberto Orfao
ResearchOpen Access21 Jun 2018
Leukemia

Volume: 32, P: 2701-2705

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