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Showing 51–82 of 82 results
Advanced filters: Author: Isabel Lokody Clear advanced filters

  • Eswarappaet al. have identified a novel anti-angiogenic form of vascular endothelial growth factor A (VEGFA) that is produced by programmed translational readthrough.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 514-515

  • A new study has shown that intratumoural injection of attenuated bacteria can reduce tumour volume.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 648

  • Mouwet al. show that increased extracellular matrix stiffness induces tumorigenic signalling circuits.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 296-297

  • Two new studies in mice have shown that disrupting the microbial balance in the gut through the use of antibiotics can affect the response to cancer therapy.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 11

  • Ayteset al. identify forkhead box M1 (FOXM1) and centromere protein F (CENPF) as synergistic drivers and prognostic markers of prostate cancer.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 451

  • A novelin vivogenome-wide RNAi screening method in mice provides insights into the biology of skin growth and skin carcinogenesis.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 683

  • Ganemet al. elucidate the mechanisms underlying cell cycle arrest in tetraploid cells in vitro and in vivo.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 647

  • A new study by Emerling and colleagues has shown that phosphatidylinositol 5-phosphate 4-kinase type-2α (PIP4K2α) and PIP4K2β are essential for the growth of p53-null cells and may represent a pharmaceutical target for cancers that have non-functional p53.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 9

  • Chenet al. have shown that growth of isocitrate dehydrogenase 1 (IDH1)-mutant gliomas is promoted by expression of glutamate dehydrogenase 2 (GLUD2) protein.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 706-707

  • A new study identifies the tumour suppressor folliculin as a GTPase-activating protein that regulates the nucleotide status of the RAG proteins, which are important regulators of mTOR complex 1 kinase activity.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 825

  • Goodarziet al. highlight the regulation of RNA stability as a crucial mechanism in breast cancer metastasis.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 579

  • Zhuet al. identified mutations in the histone-lysine N-methyltransferase SETD2and showed that these mutations cooperate with other genetic aberrations to promote acute leukaemia.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 215

  • Paolinoet al. have shown that deletion or inhibition of casitas B-lineage lymphoma-b (Cbl-b) decreases metastasis in various mouse tumour models by activating natural killer cells.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 218

    • Isabel Lokody
    Research Highlights
    Nature Reviews Genetics
    Volume: 14, P: 823

  • A new study has shown that mice with an activating β-catenin mutation that is specifically expressed in osteoblasts develop acute myeloid leukaemia.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 14, P: 154

  • Mutations in the metabolic gene isocitrate dehydrogenase 2 (IDH2) drive the development of leukaemia and sarcoma in vivo.

    • Isabel Lokody
    Research Highlights
    Nature Reviews Cancer
    Volume: 13, P: 757