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Greenwald, Nederlof and colleagues developed a computational pipeline analyzing multiplex imaging data and established spatial patterns within breast cancer microenvironment that are predictive of immune checkpoint blockade response across treatment time course.

The systemic discovery of metal–small-molecule complexes from biological samples is a difficult challenge. Now, a method based on liquid chromatography and native electrospray ionization mass spectrometry has been developed. The approach uses post-column pH adjustment and metal infusion combined with ion identity molecular networking, and a rule-based informatics workflow, to interrogate small-molecule–metal binding.

Polymer thin films that emit and absorb circularly polarised light are promising in achieving important technological advances, but the origin of the large chiroptical effects in such films has remained elusive. Here the authors demonstrate that in non-aligned polymer thin films, large chiroptical effects are caused by magneto-electric coupling, not structural chirality as previously assumed.

HIV-1 integrase forms an RNA-binding module on the luminal side of the mature capsid lattice.

An outbreak of MPXV in sooty mangabeys in Côte d’Ivoire was linked to MPXV-infected fire-footed rope squirrels, providing direct evidence of interspecies transmission and indicating risk for zoonotic transmission of MPXV from both hosts.

Biodiversity loss threatens deep time evolutionary history. Here, the authors describe patterns of Evolutionarily Distinct and Globally Endangered species across all tetrapod groups and identify 25 priority zones which are insufficiently protected and exposed to high human pressure.

Owing to electron localization, two-dimensional materials are not expected to be metallic at low temperatures, but a field-induced quantum metal phase emerges in NbSe₂, whose behaviour is consistent with the Bose-metal model.

Janus graphene nanoribbons with localized states on a single zigzag edge are fabricated by introducing a topological defect array of benzene motifs on the opposite zigzag edge, to break the structural symmetry.

Study and identification of the actinide electronic structure is complicated and crucial. Here the authors probe the hybridization between 5f to 6d orbitals in uranium compounds using X-ray magnetic circular dichroism near U-L3 edge through the dipolar and quadrupolar spectral contributions.

JWST imaged three of the gas giants orbiting the star HR 8799 to study their atmospheres. The uniform enrichment of heavy elements, including sulfur, indicates that they formed like Jupiter and Saturn by accreting a lot of icy and rocky solids.

Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence in mice.

Single iron atoms on nitrogen-doped carbon catalysts are a promising alternative to platinum for the oxygen reduction reaction on fuel cell cathodes, but commonly suffer from low stability. Here an in situ chemical vapour deposition synthetic approach is presented, enabling high iron active site dispersion and reducing surface porosity, which mitigates demetallation and carbon corrosion, ensuring high activity and stability.

Here the authors introduce VACmap, a nonlinear long-read aligner that improves detection of complex structural variations like duplications, inversions, and gene conversions. It enhances SV callers’ performance on benchmarks and resolves clinically relevant loci in LPA, GBA1, and STRC genes.

The development of advanced electrocatalysts with high efficiency and longevity is essential to alleviate the energy crisis. Here, the authors report an atomic editing strategy to access atomically dispersed, heteronuclear triatomic Fe and Co sites to endow improved activity and stability.

Edge-localized plasma modes in a tokamak can damage its innermost wall. Simulations now show that fast ions can modify the spatio-temporal structure of these modes. These effects need to be considered in the optimization of control techniques.

Angle-resolved photoemission spectroscopy shows that Weyl semimetal PtBi₂ harbours nodes in its superconducting gap, implying unconventional i-wave pairing symmetry.

The properties of electronic transport through edge states of three-dimensional quantum Hall-like states are not yet resolved. Now, increasing the surface area of the edges is shown to produce increased conductance, suggesting that chiral surface states are present.

In a phase 1 trial, personalized mRNA vaccines tailored to individual tumour mutations in triple-negative breast cancer induced robust, long-lasting T cell responses and improved prognosis.

Tokamak walls suffer erosion from steady and bursty heat loads. Here, the authors demonstrate that optimizing 3D magnetic field and cooling gas injection can tame destructive plasma bursts while enabling cooler, safer exhaust conditions.

Here the authors spatially map tuberculosis granulomas from nonhuman primates to link structure and immune organization with bacterial control. They find that a conserved hypoxic myeloid core is associated with dysfunctional immunity, restricted lymphocyte access and increased bacterial burden.

Biochemical and structural studies show that the bacterial dGTPase CloA is activated by virally produced dTTP and inhibited by 5′-triphosphothymidyl-3′5′-thymidine produced by its regulatory partner CloB, and thereby balances antiviral defence and immune-mediated toxicity.

Thermal imaging lenses are typically made from expensive materials such as germanium and silicon. Here, the authors synthesise a sulfur-based polymer with high mid-wave infrared and long-wave infrared transparencies, presenting a high-performing, low-cost alternative to traditional thermal imaging lens materials.

The suppression of edge-localized modes in tokamak plasmas is crucial to prevent them from damaging the walls of the chamber. Now experiments confirm the role that magnetic islands play in suppressing these detrimental modes.

An Fe^III/V redox mechanism in Li₄FeSbO₆ on delithiation without Fe^IV or oxygen formation with resistance to aging, high operating potential and low voltage hysteresis is demonstrated, with implications for Fe-based high-voltage applications.

Energy gaps can be induced by spatial modulation of the electronic potential. Here, the authors demonstrate a large and robust energy gap in a free-standing carbon nanotube utilizing a 15-gate keyboard that spatially modulates the local potential.

Comparative genomics and high-resolution mass spectrometry reveal the biosynthetic gene clusters, and vast chemical diversity of natural products that they encode, in Photorhabdus and Xenorhabdus, bacteria that interact with hosts as symbionts and entomopathogens.

Single-cell technologies generate complex datasets, but effective cell alignment across studies—within and across modalities—remains challenging. Here, the authors introduce scGALA, a graph-based self-supervised framework that advances cell alignment to improve data integration and harmonization.

Nanoscale imaging of edge currents in charge-neutral graphene shows that charge accumulation can explain various exotic nonlocal transport measurements, bringing into question some theories about their origins.

This study uses single-cell DNA sequencing to analyze genomic evolution in pancreatic cancer using a cohort of multiregionally and longitudinally sampled patients’ tissues across various clinical contexts.

An artificial Kitaev chain is realized by engineering three coupled quantum dots in a two-dimensional electron gas, which enables the manipulation and observation of both the edge and bulk states.

Topological edge states can emerge not only in a fermionic electron system but also in a bosonic system. Here, Nawa et al. report topologically nontrivial triplon bands in a two-dimensional dimerized quantum antiferromagnet Ba₂CuSi₂O₆Cl₂, suggesting a bosonic realization of the coupled Su-Schrieffer-Heeger model.

Synthetic dimensions, states of a system engineered to act as if they were a reconfigurable extra spatial dimension, have been demonstrated with different systems previously. Here the authors create a synthetic dimension using Rydberg atoms and configure it to support topological edge states.

Oriented growth is an important pathway for crystal growth. Here, the authors show that gibbsite nanoplates form mesocrystals through directed sliding and staggered stacking, as demonstrated by in situ microscopy and molecular simulations.

An architecture inspired by Hopfield networks based on a programmable, stable, room-temperature optoelectronic oscillator-based photonics Ising machine is introduced that can be used to efficiently address optimization and combinatorics problems.

This study analyses whole-genome sequencing data of cancer samples from 10,983 patients and explores relationships among mutational signatures, various biomarkers and clinical outcomes.

How superconducting states with different order parameter symmetries can interact with each other is not well understood. Now, the edge mode of a Weyl superconductor serves as a probe for competing condensates.

Vanishing Chern numbers usually mean that a system is topologically trivial, but this rule may be violated for periodically driven systems. Here, Maczewskyet al.report topologically protected edge modes in a periodically driven photonic lattice with all bands of zero Chern number.

Edge modes are a key feature of topological materials, but their propagation is difficult to directly observe in condensed matter systems. The controlled injection and propagation of chiral edge modes has now been shown in a rotating ultracold gas.

MultiCell is a deep learning method to capture complex cell dynamics during multicellular development.

Bright electron bunches power particle physics and photon science. Here, reproducible bunches were generated in a plasma with simultaneous high charge per unit energy and low emittance, advancing a scheme to produce ultra-bright bunches in future.

A plasma lens capable of focusing broadband extreme-ultraviolet attosecond pulses is demonstrated.

Current catalysts for water-splitting electrolyzers are scarce and unstable under acidic conditions. Here, the authors report that cobalt oxyhydroxide works across all pH levels, delivering stable industrial-scale current for 400 h while its redox behavior adapts with acidity.

Superconductivity induced on a topological insulator’s surface may realize Majorana modes. Here, Herbrych et al. predict that a large Coulomb interaction helps develop a spiral spin order, which is a topological state at the edge of a canonical superconductor with orbital degrees of freedom.

Genomic analyses of DNA from modern individuals show that, about 800 years ago, pre-European contact occurred between Polynesian individuals and Native American individuals from near present-day Colombia, while remote Pacific islands were still being settled.

WIN332 is an HIV-1 Env protein designed to elicit a new class of Asn332-glycan-independent antibodies (type II) to the V3-glycan site of Env. WIN332 immunization rapidly induces type-II V3-glycan antibodies with low inhibitory activity indicative of a neutralization activity in macaques.

This study examines long-term changes in species richness across tropical forests in the Andes and Amazon. Hotter, drier and more seasonal forests in the eastern and southern Amazon are losing species, while Northern Andean forests are accumulating species, acting as a refuge for climate-displaced species.