Nature Search

Unravelling the drivers of marine biodiversity across the Phanerozoic

There is no consensus on a potential primary cause of spatio-temporal biodiversity patterns. Here the authors combine a macroecological model and global climate simulations to suggest that niche-environment interaction may have driven marine biodiversity trajectory during the Phanerozoic.

Alexis Balembois
Alexandre Pohl
Grégory Beaugrand
ResearchOpen Access26 Sept 2025
Nature Communications

Volume: 16, P: 1-12
Deep microbial colonization during impact-generated hydrothermal circulation at the Lappajärvi impact structure, Finland

Meteorite impacts can create long-lived hydrothermal systems that may spark onset of microbial life. At Finland’s Lappajärvi crater, minerals in fractures contain biosignatures of microbial life related to the hydrothermal circulation, offering clues to deep microbial colonization of Earth and beyond.

Jacob Gustafsson
Gordon R. Osinski
Henrik Drake
ResearchOpen Access17 Sept 2025
Nature Communications

Volume: 16, P: 1-14
Lymphocyte predominant cells detect Moraxella catarrhalis-derived antigens in nodular lymphocyte-predominant Hodgkin lymphoma

Nodular lymphocyte-predominant Hodgkin lymphoma with IgD+ lymphocyte-predominant (LP) cells is a rare clinical distinct lymphoma subset of B-cell origin. Here the authors show that antigens expressed by Moraxella catarrhalis are recognized by B cell receptors of IgD+ LP cells, suggesting the contribution of chronic antigen stimulation to lymphomagenesis.

Lorenz Thurner
Sylvia Hartmann
Michael Pfreundschuh
ResearchOpen Access18 May 2020
Nature Communications

Volume: 11, P: 1-12
Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations

Skeletal muscle cells contain hundreds of nuclei, but can also add new nuclei in response to various stimuli. Here, the authors perform lineage tracing on the newly fused nuclei showing that these exhibit unique transcriptional states depending on the stimulus.

Chengyi Sun
Casey O. Swoboda
Douglas P. Millay
ResearchOpen Access30 Oct 2024
Nature Communications

Volume: 15, P: 1-19
Intracranial directed connectivity links subregions of the prefrontal cortex to major depression

Low frequency brain waves convey information between regions. Here, the authors demonstrate that for patients with major depression, mood becomes more negative as low frequency waves increase intensity across the prefrontal cortex.

John Myers
Jiayang Xiao
Sameer A. Sheth
ResearchOpen Access09 Jul 2025
Nature Communications

Volume: 16, P: 1-15
Rapid brain tumor classification from sparse epigenomic data

MethyLYZR, an epigenetic classifier of brain tumors, provides clinically relevant cancer classification results within 15 min of sequencing, with potential applications for neurosurgical intraoperative use.

Björn Brändl
Mara Steiger
Franz-Josef Müller
ResearchOpen Access28 Feb 2025
Nature Medicine

Volume: 31, P: 840-848
Distinct Hodgkin lymphoma subtypes defined by noninvasive genomic profiling

The potential use of circulating tumour DNA in classic Hodgkin lymphoma detection, classification and monitoring is defined.

Stefan K. Alig
Mohammad Shahrokh Esfahani
Ash A. Alizadeh
Research11 Dec 2023
Nature

Volume: 625, P: 778-787
Cholecystokinin produces bait shyness in rats

J. A. DEUTSCH
W. T. HARDY
Research10 Mar 1977
Nature

Volume: 266, P: 196
Cholecystokinin produces bait shyness in rats (reply)

J. GIBBS
G. P. SMITH
Research10 Mar 1977
Nature

Volume: 266, P: 196
Faricimab at 6 and 12 mg reduces pigment epithelium detachment in treatment-resistant macular neovascularization: an OCT and AI analysis

Ines D. Nagel
Melanie D. Tran
William R. Freeman
ResearchOpen Access30 Sept 2025
Scientific Reports

Volume: 15, P: 1-8
Synergy between transcription factors DBP and C/EBP compensates for a haemophilia B Leyden factor IX mutation

David J. Picketts
David P. Lillicrap
Christopher R. Mueller
Research01 Feb 1993
Nature Genetics

Volume: 3, P: 175-179
A reinvestigation of the role of the grey crescent in axis formation in Xenopus laevis

J. Gerhart
G. Ubbels
M. Kirschner
Research06 Aug 1981
Nature

Volume: 292, P: 511-516
Gain of function mutations in p53

Dirk Dittmer
Sibani Pati
Arnold J. Levine
Research01 May 1993
Nature Genetics

Volume: 4, P: 42-46
Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation

The molecular basis underlying infection infection-mediated lung pathology is not fully revealed. Here the authors report that SPARCL1 expressed in pulmonary capillary endothelial cells contributes to immune pathology in mouse model via pro-inflammatory macrophage induction, while circulating SPARCL1 levels corelate with COVID-19 lethality.

Gan Zhao
Maria E. Gentile
Andrew E. Vaughan
ResearchOpen Access18 May 2024
Nature Communications

Volume: 15, P: 1-19
The p21 cyclin–dependent kinase inhibitor suppresses tumorigenicity in vivo

Zhi-Yong Yang
Neil D. Perkins
Gary J. Nabel
Research01 Oct 1995
Nature Medicine

Volume: 1, P: 1052-1056
A community approach to mortality prediction in sepsis via gene expression analysis

Sepsis is characterized by deregulated host response to infection. Efficient therapies are still needed but a limitation for sepsis treatment is the heterogeneity in patients. Here Sweeney et al. generate prognostic models based on gene expression to improve risk stratification classification and prediction for 30-day mortality of patients.

Timothy E. Sweeney
Thanneer M. Perumal
Raymond J. Langley
ResearchOpen Access15 Feb 2018
Nature Communications

Volume: 9, P: 1-10
High prevalence of multi-drug-resistant bacteria in faecal samples from UK passerine birds

Jenny C. Dunn
Simon R. Clegg
ResearchOpen Access01 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Structural models of genome-wide covariance identify multiple common dimensions in autism

Studying individuals with autism only, this study investigated the genomic architecture of autism-related phenotypes using a multivariate modelling framework. This work identified distinct genomic factors linked to language performance, behaviour and developmental motor delay.

Lucía de Hoyos
Maria T. Barendse
Beate St Pourcain
ResearchOpen Access27 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Disruption of the ATP-dependent unfoldase ClpX reverses antifungal resistance in Cryptococcus neoformans

Here, the authors reveal that the ATP-dependent unfoldase ClpX is a key driver of fluconazole resistance in Cryptococcus neoformans, and show that targeting ClpX restores drug susceptibility, offering a potential therapeutic strategy to reverse antifungal resistance and to render current drugs effective.

M. Woods
A. Bermas
J. Geddes-McAlister
ResearchOpen Access07 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Prefrontal and striatal dopaminergic genes predict individual differences in exploration and exploitation

The exploration/exploitation dilemma describes the choice between maintaining the current strategy, or trying new strategies, to maximize rewards. The authors show that genes controlling striatal dopamine function are associated with exploitative learning. In contrast, a gene controlling prefrontal dopamine function is predictive of exploration when the value of alternative strategies is uncertain.

Michael J Frank
Bradley B Doll
Francisco Moreno
Research20 Jul 2009
Nature Neuroscience

Volume: 12, P: 1062-1068
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
Activin signalling and response to a morphogen gradient

J. B. Gurdon
P. Harger
P. Lemaire
Research06 Oct 1994
Nature

Volume: 371, P: 487-492
Crystal structure of a yeast TFIIA/TBP/DNA complex

Song Tan
Yvonne Hunziker
Timothy J. Richmond
Research09 May 1996
Nature

Volume: 381, P: 127-134
Understanding the scaling of transport energy use with operational density

Anupriya
Emma McCoy
Daniel J. Graham
ResearchOpen Access01 Sept 2025
npj Sustainable Mobility and Transport

Volume: 2, P: 1-11
Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene

Jaeseob Kim
Angela Sebring
Sean B. Carroll
Research11 Jul 1996
Nature

Volume: 382, P: 133-138
Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism

Mark W. Sornson
Wei Wu
Michael G. Rosenfeld
Research28 Nov 1996
Nature

Volume: 384, P: 327-333
Vortex rectenna powered by environmental fluctuations

Devices that generate electricity from electric fluctuations are promising for wireless power transmission as well as energy harvesting from environmental radio waves. Here the authors report the electric power generation from environmental fluctuations by using superconducting vortex strings in MoGe/YIG bilayer system.

J. Lustikova
Y. Shiomi
E. Saitoh
ResearchOpen Access22 Nov 2018
Nature Communications

Volume: 9, P: 1-6
A subset of p53-deficient embryos exhibit exencephaly

Valerie P. Sah
Laura D. Attardi
Tyler Jacks
Research01 Jun 1995
Nature Genetics

Volume: 10, P: 175-180
Spatial transcriptomics reveals human cortical layer and area specification

Multiplexed error-robust fluorescence in situ hybridization (MERFISH) together with deep-learning-based nucleus segmentation enabled the construction of a highly detailed and informative spatially resolved single-cell atlas of human fetal cortical development.

Xuyu Qian
Kyle Coleman
Christopher A. Walsh
ResearchOpen Access14 May 2025
Nature

Volume: 644, P: 153-163
wingless refines its own expression domain on the Drosophila wing margin

Eric J. Rulifson
Craig A. Micchelli
Seth S. Blair
Research07 Nov 1996
Nature

Volume: 384, P: 72-74
A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo

Mitchell H. Rosner
M. Alessandra Vigano
Louis M. Staudt
Research21 Jun 1990
Nature

Volume: 345, P: 686-692
Development of the Thymus in the Human Fœtus and its Relation to Immunological Potential

H. E. M. KAY
J. H. L. PLAYFAIR
P. K. HOPPER
Research20 Oct 1962
Nature

Volume: 196, P: 238-240
Estimates of total quantity of meteorites in the East Antarctic ice cap

Edward J. Olsen
Research06 Aug 1981
Nature

Volume: 292, P: 516-518
Specific interaction between HPV-16 E1–E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network

J. Doorbar
S. Ely
L. Crawford
Research29 Aug 1991
Nature

Volume: 352, P: 824-827
Structural variation in 1,019 diverse humans based on long-read sequencing

Intermediate-coverage long-read sequencing in 1,019 diverse humans from the 1000 Genomes Project, representing 26 populations, enables the generation of comprehensive population-scale structural variant catalogues comprising common and rare alleles.

Siegfried Schloissnig
Samarendra Pani
Jan O. Korbel
ResearchOpen Access23 Jul 2025
Nature

Volume: 644, P: 442-452
Genomic imprinting of Mash2, a mouse gene required for trophoblast development

François Guillemot
Tamara Caspary
András Nagy
Research01 Mar 1995
Nature Genetics

Volume: 9, P: 235-242
Wide-field calcium imaging of cortical activation and functional connectivity in externally- and internally-driven locomotion

How the cerebral cortex controls internally- versus sensory-driven movements remains unclear. Here the authors show that the differences in these two classes of movements are represented in cortex-wide activation and functional connectivity patterns.

Sarah L. West
Morgan L. Gerhart
Timothy J. Ebner
ResearchOpen Access06 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice

Tariq Enver
Natacha Raich
George Stamatoyannopoulos
Research22 Mar 1990
Nature

Volume: 344, P: 309-313
A transcriptional partner for MAD proteins in TGF-β signalling

Xin Chen
Melissa J. Rubock
Malcolm Whitman
Research24 Oct 1996
Nature

Volume: 383, P: 691-696
Using deep learning to annotate the protein universe

A deep learning model predicts protein functional annotations for unaligned amino acid sequences.

Maxwell L. Bileschi
David Belanger
Lucy J. Colwell
Research21 Feb 2022
Nature Biotechnology

Volume: 40, P: 932-937
Fast Spectrophotometric Measurement of H⁺ Changes in Chromatium Chromatophores activated by a Liquid Dye Laser

B. CHANCE
J. A. McCRAY
J. BUNKENBURG
Research21 Feb 1970
Nature

Volume: 225, P: 705-708
Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome

Elena V. Semina
Rebecca Reiter
Jeffrey C. Murray
Research01 Dec 1996
Nature Genetics

Volume: 14, P: 392-399
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening

Human brain organoids are plagued by heterogeneity and poor reproducibility, critical parameters for reliable disease modeling and drug testing. Here, the authors report on Hi-Q organoids which solve these limitations and can be cryopreserved in large quantities.

Anand Ramani
Giovanni Pasquini
Jay Gopalakrishnan
ResearchOpen Access19 Dec 2024
Nature Communications

Volume: 15, P: 1-20
Serological indication of chronic inflammatory demyelinating polyneuropathy as an extrahepatic manifestation of hepatitis E virus infection

S. Pischke
A. Kjasimov
M. Gelderblom
ResearchOpen Access20 Aug 2024
Scientific Reports

Volume: 14, P: 1-8
Interactions of the LIM-domain-binding factor Ldbl with LIM homeodomain proteins

Alan D. Agulnick
Masanori Taira
Heiner Westphal
Research21 Nov 1996
Nature

Volume: 384, P: 270-272
Benthic diel oxygen variability and stress as potential drivers for animal diversification in the Neoproterozoic-Palaeozoic

The cause of animal diversification in the Cambrian is unclear. Here, the authors use a biogeochemical model to argue that diel benthic oxygen fluctuations on expanding Cambrian shallow marine shelves promoted animal adaptive radiation.

Emma U. Hammarlund
Anuraag Bukkuri
Kasper Hancke
ResearchOpen Access21 Mar 2025
Nature Communications

Volume: 16, P: 1-12
Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

Marco W. Schilham
Mariëtte A. Oosterwegel
Hans Clevers
Research25 Apr 1996
Nature

Volume: 380, P: 711-714
Drug reinforcement impairs cognitive flexibility by inhibiting striatal cholinergic neurons

Addictive substances may impair cognitive flexibility. Here the authors show that in rodents, increased activity of striatal direct-pathway medium spiny neurons (dMSNs) in response to cocaine inhibits cholinergic interneurons (CINs), reducing cognitive flexibility.

Himanshu Gangal
Xueyi Xie
Jun Wang
ResearchOpen Access30 Jun 2023
Nature Communications

Volume: 14, P: 1-15
Lack of evidence for the transitional cerebellar progenitor

Kyle S. Smith
Yiran Li
Paul A. Northcott
Research09 Jul 2025
Nature

Volume: 643, P: E1-E8
Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains

Bradford J. Graves
Robert L. Crowther
Daniel K. Burns
Research10 Feb 1994
Nature

Volume: 367, P: 532-538

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