Nature Search

Aaaargh, no! – in lights

Peter J. Herring
Research08 May 1997
Nature

Volume: 387, P: 140
RAF inhibitors activate the integrated stress response by direct activation of GCN2

Three BRAF inhibitors are used to treat melanoma and colorectal cancer. Here, the authors demonstrate that these drugs bind and activate the protein kinase GCN2, a previously unappreciated off-target effect that may modulate tumour cell responses.

Rebecca Gilley
Andrew M. Kidger
Simon J. Cook
ResearchOpen Access17 Nov 2025
Nature Communications

Volume: 16, P: 1-19
Inadequacy of effective CO₂ as a proxy in simulating the greenhouse effect of other radiatively active gases

Wei-Chyung Wang
Michael P. Dudek
J. T. Kiehl
Research18 Apr 1991
Nature

Volume: 350, P: 573-577
Streptomycin Sensitivity of Oral Lactobacilli

H. C. DE KLERK
J. N. COETZEE
Research11 Aug 1962
Nature

Volume: 195, P: 624-625
Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

Jürgen K. Naggert
Lloyd D. Fricker
Edward H. Leiter
Research01 Jun 1995
Nature Genetics

Volume: 10, P: 135-142
Cation interdiffusion control for 2D/3D heterostructure formation and stabilization in inorganic perovskite solar modules

The formation of 2D perovskites in inorganic perovskite solar cells is hindered by the strong binding affinity of caesium ions. Liu et al. engineer the functional groups of a large organic cation to facilitate its exchange with caesium ions and form a stable 2D perovskite.

Cheng Liu
Yi Yang
Mohammad K. Nazeeruddin
Research16 Jul 2025
Nature Energy

Volume: 10, P: 981-990
Colorectal cancer cells with the BRAF^V600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM

J A Wickenden
H Jin
S J Cook
Research22 Sept 2008
Oncogene

Volume: 27, P: 7150-7161
Two-dimensional perovskitoids enhance stability in perovskite solar cells

We find that 2D–3D perovskitoid passivation applied to perovskite solar cells impedes cation migration and decreases carrier recombination at the interface, providing enhanced operating stability at elevated temperatures and increased power conversion efficiencies.

Cheng Liu
Yi Yang
Mercouri G. Kanatzidis
Research08 Jul 2024
Nature

Volume: 633, P: 359-364
Emplacement of Taupo ignimbrite

C. J. N. Wilson
Research23 Jan 1997
Nature

Volume: 385, P: 306-307
MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF^V600E amplification whereas KRAS^G13D amplification promotes EMT-chemoresistance

Colorectal cancer cells can acquire resistance to MEK inhibition due to BRAF or KRAS amplification. Here, the authors show that while MEK inhibitor withdrawal in BRAF mutant cells restores sensitivity to the inhibitor through the loss of BRAF amplification mediated by a p57-dependent mechanism, drug withdrawal from KRAS mutant cells does not restore sensitivity but results in EMT and chemoresistance.

Matthew J. Sale
Kathryn Balmanno
Simon J. Cook
ResearchOpen Access02 May 2019
Nature Communications

Volume: 10, P: 1-22
Expression of telomerase in normal and malignant rat hepatic epithelia

Vita M Golubovskaya
Sharon C Presnell
William K Kaufmann
Research04 Sept 1997
Oncogene

Volume: 15, P: 1233-1240
Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

BRAF or MEK1/2 inhibitors are cytostatic in melanoma and the surviving cells develop drug resistance. This study shows that the pro-survival pool is biased towards MCL1 in melanoma so that BRAF or MEK1/2 inhibitors are synthetic lethal with the MCL1 inhibitor AZD5991, improving tumour growth inhibition.

Matthew J. Sale
Emma Minihane
Simon J. Cook
ResearchOpen Access14 Nov 2019
Nature Communications

Volume: 10, P: 1-19
Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma

R M'kacher
A Bennaceur
A G Turhan
Research11 Sept 2003
Oncogene

Volume: 22, P: 7905-7912
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells

Abdelkader Essafi
Silvia Fernández de Mattos
Eric W-F Lam
Research31 Jan 2005
Oncogene

Volume: 24, P: 2317-2329
Programmed axon degeneration: mechanism, inhibition and therapeutic potential

Programmed axon degeneration (PAxD) is activated by axotomy to execute the self-destruction of a severed distal axon. It may also be activated by some non-axotomy insults, suggesting it has a role in some neurodegenerative diseases. Here, Loreto and Neukomm review the molecular mechanisms of PAxD, its involvement in disease and its potential as a therapeutic target.

Andrea Loreto
Lukas J. Neukomm
Reviews12 Nov 2025
Nature Reviews Neuroscience

Volume: 27, P: 44-60
Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS

Jun-Wei Liu
Dhyan Chandra
Dean G Tang
Research24 Jan 2005
Oncogene

Volume: 24, P: 2020-2031
The life and death of DNA-PK

Spencer J Collis
Theodore L DeWeese
Antony R Parker
Reviews13 Dec 2004
Oncogene

Volume: 24, P: 949-961
FOXOs, cancer and regulation of apoptosis

Z Fu
D J Tindall
Reviews07 Apr 2008
Oncogene

Volume: 27, P: 2312-2319
Telomere maintenance mechanisms as a target for drug development

David J Bearss
Laurence H Hurley
Daniel D Von Hoff
Reviews27 Dec 2000
Oncogene

Volume: 19, P: 6632-6641
Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage

H D Chae
B M Kim
D Y Shin
Research17 Mar 2008
Oncogene

Volume: 27, P: 4115-4121
Metabolic and fecal microbial changes in adult fetal growth restricted mice

Stephanie P. Gilley
Miguel A. Zarate
Kartik Shankar
ResearchOpen Access07 Nov 2023
Pediatric Research

Volume: 95, P: 647-659
Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1

Hongyan Guo
Ryan P. Gilley
William J. Kaiser
ResearchOpen Access26 Jul 2018
Cell Death & Disease

Volume: 9, P: 1-11
BH3-only proteins: key regulators of neuronal apoptosis

J Ham
E Towers
R Randall
News03 Jun 2005
Cell Death & Differentiation

Volume: 12, P: 1015-1020
NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons

R Hughes
M Kristiansen
J Ham
Research17 Dec 2010
Cell Death & Differentiation

Volume: 18, P: 937-947
Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia

Norberto Gonzalez-Juarbe
Kelley M. Bradley
Carlos J. Orihuela
ResearchOpen Access11 Apr 2018
Scientific Reports

Volume: 8, P: 1-10
A practical workflow for the 3D reconstruction of complex historic sites and their decorative interiors: Florence As It Was and the church of Orsanmichele

George R. Bent
David Pfaff
John Delaney
ResearchOpen Access28 Jul 2022
Heritage Science

Volume: 10, P: 1-17
Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19

Annemarie Gilley
Timothy J. Boly
Jennifer Bermick
Research10 Nov 2023
Pediatric Research

Volume: 95, P: 1483-1492
A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

M Di Stefano
I Nascimento-Ferreira
L Conforti
ResearchOpen Access17 Oct 2014
Cell Death & Differentiation

Volume: 22, P: 731-742
Effectiveness of a multi-disciplinary family-based programme for treating childhood obesity (The Family Project)

D F Coppins
B M Margetts
S Huelin
Research13 Apr 2011
European Journal of Clinical Nutrition

Volume: 65, P: 903-909
Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

R Ley
K E Ewings
S J Cook
News10 Jun 2005
Cell Death & Differentiation

Volume: 12, P: 1008-1014

Search

Aaaargh, no! – in lights

RAF inhibitors activate the integrated stress response by direct activation of GCN2

Inadequacy of effective CO₂ as a proxy in simulating the greenhouse effect of other radiatively active gases

Streptomycin Sensitivity of Oral Lactobacilli

Hyperproinsulinaemia in obese fat/fat mice associated with a carboxypeptidase E mutation which reduces enzyme activity

Cation interdiffusion control for 2D/3D heterostructure formation and stabilization in inorganic perovskite solar modules

Colorectal cancer cells with the BRAF^V600E mutation are addicted to the ERK1/2 pathway for growth factor-independent survival and repression of BIM

Two-dimensional perovskitoids enhance stability in perovskite solar cells

Emplacement of Taupo ignimbrite

MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAF^V600E amplification whereas KRAS^G13D amplification promotes EMT-chemoresistance

Expression of telomerase in normal and malignant rat hepatic epithelia

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

Multiple molecular mechanisms contribute to radiation sensitivity in mantle cell lymphoma

Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells

Programmed axon degeneration: mechanism, inhibition and therapeutic potential

Induction of prosurvival molecules by apoptotic stimuli: involvement of FOXO3a and ROS

The life and death of DNA-PK

FOXOs, cancer and regulation of apoptosis

Telomere maintenance mechanisms as a target for drug development

Deregulation of Cdk2 causes Bim-mediated apoptosis in p53-deficient tumors following actin damage

Metabolic and fecal microbial changes in adult fetal growth restricted mice

Species-independent contribution of ZBP1/DAI/DLM-1-triggered necroptosis in host defense against HSV1

BH3-only proteins: key regulators of neuronal apoptosis

NF-Y is essential for expression of the proapoptotic bim gene in sympathetic neurons

Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia

A practical workflow for the 3D reconstruction of complex historic sites and their decorative interiors: Florence As It Was and the church of Orsanmichele

Neonatal immune cells have heightened responses following in-utero exposure to chorioamnionitis or COVID-19

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

Effectiveness of a multi-disciplinary family-based programme for treating childhood obesity (The Family Project)

Regulatory phosphorylation of Bim: sorting out the ERK from the JNK

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