Meta-omic analyses are commonly used for large-scale studies of microbial eukaryotes. Here, Krinos et al. explore the potential pitfalls of common approaches to taxonomic annotation of protistan meta-omic datasets, highlighting the importance of database completeness and curation and proposing that precise taxonomic annotation of meta-omic data is a clustering problem rather than a feasible alignment problem.
- Arianna I. Krinos
- Margaret Mars Brisbin
- Harriet Alexander
