Nature Search

Design of facilitated dissociation enables timing of cytokine signalling

A fresh approach to protein design that incorporates excited intermediate states enables precise control over the lifetime of protein interactions, with potential applications in cell-signalling modulation and in biosensors and synthetic circuits.

Adam J. Broerman
Christoph Pollmann
David Baker
ResearchOpen Access24 Sept 2025
Nature

P: 1-8
Reactivation of basement faults and crustal shortening in orogenic belts

J. A. Jackson
Research24 Jan 1980
Nature

Volume: 283, P: 343-346
Covariation MS uncovers a protein that controls cysteine catabolism

A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

Haopeng Xiao
Martha Ordonez
Edward T. Chouchani
ResearchOpen Access17 Sept 2025
Nature

P: 1-9
Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

CAR-T cells have been found to be less effective as treatment for solid tumours. Here the authors, utilising B7H3 as an antigen, consider how changes in B7H3 binders lead to functional changes of CAR-T cells and differences in tumour outcomes in humanised mouse tumour models.

Marta Barisa
Henrike P. Muller
John Anderson
ResearchOpen Access05 Aug 2025
Nature Communications

Volume: 16, P: 1-20
A New Compound Active Against Trypanosoma Congolense and T. Vivax

W. C. AUSTIN
H. O. J. COLLIER
E. P. TAYLOR
Research19 Jan 1957
Nature

Volume: 179, P: 143-144
Motion impact score for detecting spurious brain-behavior associations

Head motion is an artifact in structural and functional MRI signals, and some traits or groups are more strongly correlated with motion than others. Here the authors describe a method to attribute a motion impact score to specific trait-functional connectivity relationships.

Benjamin P. Kay
David F. Montez
Nico U. F. Dosenbach
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-15
The human ribosome modulates multidomain protein biogenesis by delaying cotranslational domain docking

By studying dynamic folding intermediates on the human ribosome, Pellowe et al. show that newly made domains help each other to fold but do not stably interact until synthesis is complete, avoiding interdomain misfolding.

Grant A. Pellowe
Tomas B. Voisin
David Balchin
ResearchOpen Access19 Sept 2025
Nature Structural & Molecular Biology

P: 1-12
Geochemistry of Andesites and the Growth of Continents

S. R. TAYLOR
A. J. R. WHITE
Research16 Oct 1965
Nature

Volume: 208, P: 271-273
Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase

Koen H. G. Verschueren
Frank Seljée
Bauke W. Dijkstra
Research24 Jun 1993
Nature

Volume: 363, P: 693-698
Broad-line high-excitation gas in the elliptical galaxy NGC5128

M. M. Phillips
Keith Taylor
R. N. Hook
Research16 Aug 1984
Nature

Volume: 310, P: 554-557
Vesiculation of mafic magma during replenishment of silicic magma reservoirs

J. C. Eichelberger
Research04 Dec 1980
Nature

Volume: 288, P: 446-450
High-precision timing observations of the millisecond pulsar PSR1937 + 21

M. M. Davis
J. H. Taylor
D. C. Backer
Research13 Jun 1985
Nature

Volume: 315, P: 547-550
Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines

Expanding the complexity of genetically encoded peptides is a long-standing challenge at the intersection of chemistry and biology. Now it has been shown that linear peptides with a reactive N-terminal β- or γ-keto amide can be synthesized ribosomally and elaborated to generate atropisomeric and/or macrocyclic peptides with embedded pharmacophores.

Isaac J. Knudson
Taylor L. Dover
Scott J. Miller
Research17 Sept 2025
Nature Chemistry

P: 1-12
High-Energy Nuclear Physics at Harwell

T. G. PICKAVANCE
J. M. CASSELS
Research29 Mar 1952
Nature

Volume: 169, P: 520-523
Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Distinct roles for B cell-derived LTα3 and LTα1β2 in TNF-mediated ileitis

Erlich et al. show that soluble LTα and membrane-bound LTα1β2 lymphotoxins expressed by B cells play distinct roles to attenuate the pathology observed in ileitis.

Emma C. Erlich
Quazim A. Alayo
Gwendalyn J. Randolph
ResearchOpen Access08 Sept 2025
Nature Immunology

Volume: 26, P: 1781-1793
Mycoplasma capping on lymphocytes

Eric J. Stanbridge
Richard L. Weiss
Research07 Dec 1978
Nature

Volume: 276, P: 583-587
Prof. A. E. Taylor, F.B.A.

J. LAIRD
Comments & Opinion16 Feb 1946
Nature

Volume: 157, P: 186-187
Interstellar scintillation and compact sources in supernova remnants

J. M. Cordes
J. M. Dickey
Research01 Sept 1979
Nature

Volume: 281, P: 24-27
DNA methylation cooperates with genomic alterations during non-small cell lung cancer evolution

Integrated multi-omic analyses using samples from the TRACERx study highlight cross-talk between DNA hypermethylation and genomic lesions in non-small cell lung cancer.

Francisco Gimeno-Valiente
Carla Castignani
Nnennaya Kanu
ResearchOpen Access10 Sept 2025
Nature Genetics

Volume: 57, P: 2226-2237
Behavioural dynamics

L. R. Taylor
R. A. J. Taylor
J. N. Perry
Research30 Jun 1983
Nature

Volume: 303, P: 801-804
Resolving discrepancies between chimeric and multiplicative measures of higher-order epistasis

Epistasis can be quantified using the chimeric formula, which mixes additive and multiplicative scales. Here, the authors show that this formula does not appropriately quantify higher-order epistasis.

Uthsav Chitra
Brian Arnold
Benjamin J. Raphael
ResearchOpen Access17 Feb 2025
Nature Communications

Volume: 16, P: 1-20
Designing soft materials with interfacial instabilities in liquid films

Interfacial instabilities can be damaging as they may lead to fabrication defects. Here the authors harness a fluid instability to their advantage to produce thin polymeric films with drop-shaped structures which have tailored geometrical properties.

J. Marthelot
E. F. Strong
P.-T. Brun
ResearchOpen Access26 Oct 2018
Nature Communications

Volume: 9, P: 1-7
Genetic suppression features ABHD18 as a Barth syndrome therapeutic target

The enzyme ABHD18 is shown to have a key role in cardiolipin metabolism in mitochondria, offering a potential route for a small-molecule treatment of the rare genetic disease Barth syndrome.

Sanna N. Masud
Anchal Srivastava
Jason Moffat
Research03 Sept 2025
Nature

Volume: 645, P: 1029-1038
Measuring the semantic priming effect across many languages

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Erin M. Buchanan
Kelly Cuccolo
Savannah C. Lewis
Research24 Sept 2025
Nature Human Behaviour

P: 1-20
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
Periodic Intensity Fluctuations in Pulsars

J. H. TAYLOR
M. JURA
G. R. HUGUENIN
Research23 Aug 1969
Nature

Volume: 223, P: 797-799
Characterising acute and chronic care needs: insights from the Global Burden of Disease Study 2019

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

Cecilia Anza-Ramirez
J. Jaime Miranda
Yves Miel H. Zuniga
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-36
A New ‘Wedge’ Type Instability Observed in a ‘Theta’ Pinch

J. K. WRIGHT
R. D. MEDFORD
R. C. POTTINGER
Research09 Sept 1961
Nature

Volume: 191, P: 1054-1056
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Tamoxifen induces PI3K activation in uterine cancer

Sequencing analysis of tamoxifen-associated uterine cancers and further in vivo analyses suggest that the drug tamoxifen can activate the PI3K pathway in the absence of oncogenic mutations.

Kirsten Kübler
Agostina Nardone
Rinath Jeselsohn
ResearchOpen Access22 Aug 2025
Nature Genetics

Volume: 57, P: 2192-2202
Electrohydrodynamic tip streaming and emission of charged drops from liquid cones

Robert T. Collins
Jeremy J. Jones
Osman A. Basaran
Research02 Dec 2007
Nature Physics

Volume: 4, P: 149-154
Titration of Some Common Cold Viruses (Rhinoviruses) and Their Antisera by a Plaque Method

J. S. PORTERFIELD
Research16 Jun 1962
Nature

Volume: 194, P: 1044-1047
Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates

Molecular glue degraders eliminate cellular proteins by promoting their interaction with E3 ubiquitin ligases. Here, the authors identify molecular glue degraders targeting the E3 ligase TRIM21 and synthesize a heterobifunctional degrader that recruits TRIM21 to degrade an engineered protein aggregate.

Marc A. Scemama de Gialluly
Anthony R. Allen
Drew J. Adams
ResearchOpen Access16 Jul 2025
Nature Communications

Volume: 16, P: 1-14
Origin of Methyl Ketones Found in Steam Distillates of Milk Fat

R. C. LAWRENCE
J. C. HAWKE
Research30 Mar 1963
Nature

Volume: 197, P: 1276-1277
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Spermadsorption and Spermagglutination by Mycoplasmas

D. TAYLOR-ROBINSON
R. J. MANCHEE
Research01 Jul 1967
Nature

Volume: 215, P: 484-487
Finding of a sex pheromone source by gypsy moths released in the field

C. T. David
J. S. Kennedy
A. R. Ludlow
Research30 Jun 1983
Nature

Volume: 303, P: 804-806
Deposition of Strontium and Calcium in Snail Shell

G. M. ROSENTHAL Jun.
D. J. NELSON
D. A. GARDINER
Research03 Jul 1965
Nature

Volume: 207, P: 51-54
Hydrogen isotopic evidence of rhyolitic magma degassing during shallow intrusion and eruption

B. E. Taylor
J. C. Eichelberger
H. R. Westrich
Research08 Dec 1983
Nature

Volume: 306, P: 541-545
Two New Pulsating Radio Sources

J. H. TAYLOR
G. R. HUGUENIN
Research01 Mar 1969
Nature

Volume: 221, P: 816-817
Pleistocene bimodal response of Antarctic ice

David J. Drewry
Research18 Sept 1980
Nature

Volume: 287, P: 214-216
Density-dependent network structuring within and across wild animal systems

The number of individuals in a given space influences animal interactions and network dynamics. Here the authors identify general rules underlying density dependence in animal networks and reveal some fundamental differences between spatial and social dynamics.

Gregory F. Albery
Daniel J. Becker
Shweta Bansal
Research04 Sept 2025
Nature Ecology & Evolution

P: 1-12
Nature bingo?

S.J. PUBLICOVER
Correspondence04 Oct 1984
Nature

Volume: 311, P: 406
The promise and limitations of using GenAI to reduce climate scepticism

ChatGPT provides a way of teaching people about climate change. This research reveals that conversations between climate sceptics and ChatGPT reduced climate scepticism, but these effects are modest, inconsistent across studies and prone to decay over time.

Matthew J. Hornsey
Samuel Pearson
Saphira Rekker
Research19 Sept 2025
Nature Climate Change

P: 1-7
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
Experiments in catastrophe

J. M. T. Thompson
Research03 Apr 1975
Nature

Volume: 254, P: 392-395
Rift-induced disruption of cratonic keels drives kimberlite volcanism

Most kimberlites erupting in the past billion years on Earth did so about 30 million years after continental breakup, with dynamical and analytical models suggesting a control from rifting-related mantle delamination.

Thomas M. Gernon
Stephen M. Jones
Anne Glerum
ResearchOpen Access26 Jul 2023
Nature

Volume: 620, P: 344-350
Invasive swamp eels reduce aquatic animal diversity and disproportionately reduce prey for nesting wading birds

Matthew R. Pintar
Nathan J. Dorn
ResearchOpen Access23 May 2025
Scientific Reports

Volume: 15, P: 1-14
Release of ³H-γ-Aminobutyric Acid from the Brain during Synaptic Inhibition

J. F. MITCHELL
VASANTA SRINIVASAN
Research15 Nov 1969
Nature

Volume: 224, P: 663-666

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