Nature Search

Nature of the Scrapie Agent: Self-replication and Scrapie

J. S. GRIFFITH
Research02 Sept 1967
Nature

Volume: 215, P: 1043-1044
Natural Occurrence of Thymine and Three Methylated Adenine Bases in Several Ribonucleic Acids

J. W. LITTLEFIELD
D. B. DUNN
Research25 Jan 1958
Nature

Volume: 181, P: 254-255
Nature of the Defect in Alcaptonuria

V. G. ZANNONI
J. E. SEEGMILLER
B. N. La DU
Research10 Mar 1962
Nature

Volume: 193, P: 952-953
Prospective multicenter study of ctDNA versus tumor tissue guiding FGFR-targeted therapy in metastatic urothelial cancer

Plasma ctDNA testing for FGFR alterations in metastatic urothelial carcinoma shows high concordance with tissue testing and identifies additional patients with actionable alterations. Here, the authors show that clinical uptake of ctDNA FGFR testing can be combined with tissue-based approaches.

David C. Müller
Andrew J. Murtha
Bernhard J. Eigl
ResearchOpen Access27 Feb 2026
Nature Communications

P: 1-10
Nature of Nucleotoxic Substances

J. A. V. BUTLER
Research01 Jul 1950
Nature

Volume: 166, P: 18-19
Obsidian forms by slow cooling

Obsidian has long been thought to be formed by rapidly quenching of lava. This study shows that, on the contrary, slow cooling over weeks to decades is required to resorb bubbles and produce this dense, glassy material.

E. W. Llewellin
F. B. Wadsworth
C. Allgood
ResearchOpen Access27 Feb 2026
Nature Communications

P: 1-7
Nature of the Non-Haem Iron in Ferredoxin and Rubredoxin

R. D. GILLARD
E. D. MCKENZIE
J. E. STANGROOM
Research20 Nov 1965
Nature

Volume: 208, P: 769-771
Nature of the Lunar Mascons

J. J. GILVARRY
Research22 Feb 1969
Nature

Volume: 221, P: 732-736
Nature of the Circulating Thyroid Hormone - Plasma Protein Complex

A. H. GORDON
J. GROSS
ROSALIND PITT-RIVERS
Research05 Jan 1952
Nature

Volume: 169, P: 19-20
Nature and Origin of Initial Bodies in Lymphogranuloma Venereum

J. A. ARMSTRONG
SYLVIA E. REED
Research25 Jan 1964
Nature

Volume: 201, P: 371-373
Natural Occurrence of Ubichromenol

D. MCHALE
J. GREEN
A. T. DIPLOCK
Research29 Dec 1962
Nature

Volume: 196, P: 1293-1294
Naturally Occurring Alpha-Activity of Drinking Waters

R. C. TURNER
J. M. RADLEY
W. V. MAYNEORD
Research04 Feb 1961
Nature

Volume: 189, P: 348-352
Nature of Argillaceous Odour

I. J. BEAR
R. G. THOMAS
Research07 Mar 1964
Nature

Volume: 201, P: 993-995
Tumor-informed circulating tumor DNA stratifies recurrence risk and survival in anal squamous cell carcinoma

Prediction of tumour recurrence in anal squamous cell carcinoma can be challenging. Here, the authors use a tumour-informed ctDNA assay to show concordance with relapse in patients following failed definitive-intent chemoradiation.

Paul B. Romesser
Aron Bercz
Richard Tuli
ResearchOpen Access26 Feb 2026
Nature Communications

P: 1-9
Nature and Relationships of the Specific Products of the Human Blood-Group and Secretor Genes

W. T. J. MORGAN
Research19 Aug 1950
Nature

Volume: 166, P: 300-302
Nature of Impulse Origin and Conduction in the Mammalian Heart

C. J. G. WENSING
Research12 Mar 1966
Nature

Volume: 209, P: 1108-1109
Male obesity causes adipose mitochondrial dysfunction in F₁ mouse progeny via a let-7-DICER axis

Paternal obesity impacts offspring health, though the underlying mechanisms remain poorly understood. Here, the authors show that male obesity drives adipose mitochondrial dysfunction in F₁ mouse progeny via a let-7-DICER axis, identifying a pathway for intergenerational metabolic inheritance

Chien Huang
Joo-Hyun Park
Jan-Wilhelm Kornfeld
ResearchOpen Access24 Feb 2026
Nature Communications

P: 1-19
Nature of the Ribosomes Present in Bacteria and Yeast: A Re-Appraisal

T. J. BOWEN
S. DAGLEY
D. G. WILD
Research25 Feb 1961
Nature

Volume: 189, P: 638-640
Natural Configuration of the Purine Nucleotides in Ribonucleic Acids: Enzymatic Splitting of Purine Internucleotide Linkages

LEON A. HEPPEL
ROY MARKHAM
R. J. HILMOE
Research27 Jun 1953
Nature

Volume: 171, P: 1152
Natural Occurrence of Amino-Acids in Dolomitic Limestones Containing Algal Growths

J. S. HARINGTON
P. D. TOENS
Research07 Dec 1963
Nature

Volume: 200, P: 947-948
Nature of χ-Iron Carbide

M. J. DUGGIN
L. J. E. HOFER
Research15 Oct 1966
Nature

Volume: 212, P: 248
Evaluating spatially targeted HIV interventions and harm reduction services among people who inject drugs in a high-burden setting

Spatial targeting of HIV services may improve their effectiveness. Here, the authors use data on locations frequented by people who inject drugs in New Delhi, India to model different service prioritisation strategies.

Jasmine Wang
Steven J. Clipman
Amy Wesolowski
ResearchOpen Access24 Feb 2026
Nature Communications

P: 1-8
Nature of the ‘Infective Ribonucleic Acid Component’ in Cells Infected with Encephalomyocarditis Virus and the ‘Virosome’ Concept

A. J. D. BELLETT
A. T. H. BURNESS
Research15 Apr 1961
Nature

Volume: 190, P: 235-237
ERCC6L2 ensures repair fidelity for staggered-end DNA double-strand breaks

Structural features of DNA double-strand break (DSB) ends play key roles in determining DNA repair pathway usage and outcomes. Here, the authors identify ERCC6L2, a poorly characterized ATPase, as playing a minimal role in blunt end DSB repair but crucial for repair of staggered end DSBs.

Eric J. Aird
Almudena Serrano-Benitez
Stephen P. Jackson
ResearchOpen Access25 Feb 2026
Nature Communications

P: 1-19
Nature and Infectivity of Granular Forms of the Bovine Tubercle Bacillus

E. M. BRIEGER
J. A. R. MILES
R. W. HORNE
Research21 Jul 1951
Nature

Volume: 168, P: 96-98
Nature of Glass in New Zealand Ignimbrites

R. C. MARTIN
J. F. LEWIS
Research23 Mar 1963
Nature

Volume: 197, P: 1166-1167
Nature of Orientational Defects in Ice

J. D. DUNITZ
Research02 Mar 1963
Nature

Volume: 197, P: 860-862
Native iron reduces CO₂ to intermediates and end-products of the acetyl-CoA pathway

The acetyl-CoA pathway is the most ancient CO₂ fixation pathway in nature. Here, the authors show that metals selectively reduce CO₂ to the intermediates and end-products of the acetyl-CoA pathway, which is consistent with a prebiotic origin of this pathway.

Sreejith J. Varma
Kamila B. Muchowska
Joseph Moran
Research23 Apr 2018
Nature Ecology & Evolution

Volume: 2, P: 1019-1024
Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase

Here, the authors investigate the mechanism by which human aspartate/asparagine-β-hydroxylase (AspH), a 2OG-dependent oxygenase with an atypical Fe(II) coordination environment, catalyses hydroxylation of aspartate and asparagine residues in epidermal growth factor-like domains.

Mariska de Munnik
Amelia Brasnett
Patrick Rabe
ResearchOpen Access25 Feb 2026
Nature Communications

P: 1-16
FATE-MAP predicts teratogenicity and human gastrulation failure modes by integrating deep learning and mechanistic modeling

Human gastrulation and AI are often treated as black boxes. Here, the authors provide interpretability to both by combining stem cell models with AI and mechanistic modeling to understand how gastrulation can fail and to predict teratogenic risk.

Joseph Rufo
Chongxu Qiu
Maxwell Z. Wilson
ResearchOpen Access19 Feb 2026
Nature Communications

P: 1-19
Q4ddPCR: a flexible, 4-target assay for high-resolution HIV reservoir profiling

Here, the authors develop Q4ddPCR, a high-throughput assay to quantify genetically intact HIV reservoirs by targeting four regions, and demonstrate that it reduces assay dropout to 5%, tracks reservoir decay, and closely correlates with viral outgrowth.

Rachel Scheck
Mark Melzer
Christian Gaebler
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-14
Normative growth trajectories of fetal brain regions validated by satisfactory maturation of neurodevelopmental domains at 2 years of age

This study mapped normative growth trajectories of 28 fetal brain phenotypes derived from 4,205 3D ultrasound scans collected across 7 international sites. The low variance between sites reinforces the principle that the brain develops similarly when environmental constraints are minimal.

Madeleine K. Wyburd
Stephen H. Kennedy
Ana I. L. Namburete
ResearchOpen Access23 Feb 2026
Nature Communications

P: 1-17
Nature of the Vibrato and the Control Loop in Singing

J. A. DEUTSCH
J. K. CLARKSON
Research17 Jan 1959
Nature

Volume: 183, P: 167-168
Regional nonsense constraint offers biological and clinical insights into genetic disease

Nonsense variants can disrupt gene function, but regional intolerance is poorly defined. Here, the authors develop a map of regional intolerance to nonsense mutations, improving loss‑of‑function variant interpretation and prioritising novel genes in rare disease.

Alexander J. M. Blakes
Nicola Whiffin
Siddharth Banka
ResearchOpen Access25 Feb 2026
Nature Communications

P: 1-15
Homochiral toroidal spin state in Dy(III)-based single-molecule toroics

Achieving toroidal magnetic moments in molecular systems is challenging. Now homochiral toroidal magnetic ground states have been realized in propeller-shaped chiral Dy(III)-based single-molecule toroics, enabling toroidal spin states to be detected through magneto-chiral dichroism.

Zhenhua Zhu
Xu Ying
Jinkui Tang
Research23 Feb 2026
Nature Chemistry

P: 1-10
Co-transcriptional folding orchestrates sequential multi-effector sensing by a glycine tandem riboswitch

Riboswitches are RNA elements that regulate gene expression through dynamic changes in secondary structure. Here, the authors reveal how the glycine tandem riboswitch integrates sequential signals via stepwise folding and binding of ligands to orchestrate gene regulation during transcription.

Rosa A. Romero
Adrien Chauvier
Nils G. Walter
ResearchOpen Access14 Feb 2026
Nature Communications

P: 1-20
Multi-modal skin atlas identifies a multicellular immune-stromal community associated with disrupted cornification and specific T cell expansion in atopic dermatitis

In atopic dermatitis (AD), skin barrier disruption leads to chronic inflammation. Here, the authors use single-cell sequencing to map human skin, uncovering AD-specific cell states and populations involved in immune responses and cell differentiation.

Evgenij Fiskin
Gökcen Eraslan
Ramnik J. Xavier
ResearchOpen Access25 Feb 2026
Nature Communications

P: 1-20
Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool

How embryonic hematopoietic stem and progenitor cells proliferate while maintaining multipotency remains unclear. Here they show that Bnip3lb-regulated mitophagy reduces ROS levels, enabling sustained HSPC proliferation.

Eleanor Meader
Morgan T. Walcheck
Trista E. North
ResearchOpen Access24 Feb 2026
Nature Communications

P: 1-20
Switching speed limits in electrically driven VO₂ structural Mott–Peierls transition

Ultrafast electron microscopy reveals how conductive paths in VO₂ form and dissolve under rapid electrical pulses, uncovering switching mechanisms relevant for brain-inspired and next generation electronics.

Alexandre Pofelski
Chuhang Liu
Yimei Zhu
ResearchOpen Access24 Feb 2026
Nature Communications

P: 1-11
Allosteric and energetic remodeling of a PDZ domain by protein domain extensions

Independently folding domains can be seen as the functional and evolutionary structural units of proteins. Here, the authors assess effects of >7000 mutations in a model PDZ domain, to quantify how two small extensions to a protein domain reshape its energetic and allosteric landscape.

Cristina Hidalgo-Carcedo
Andre J. Faure
Ben Lehner
ResearchOpen Access19 Feb 2026
Nature Communications

P: 1-18
Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis

Sepsis is a heterogeneous inflammatory disease and it is believed treatment requires suitable stratification based on the underlying disease pathology and immunology. Here the authors show genetic variation in the regulatory elements of MTOR can impact neutrophil-T cell cross talk in the context of pneumonia associated sepsis, highlighting a genetic framework for targeted patient stratification.

Ping Zhang
Patrick MacLean
Julian C. Knight
ResearchOpen Access25 Feb 2026
Nature Communications

P: 1-15
Immunometabolic determinants of long-term response in leukemia patients receiving CD19 CAR T cell therapy

Most patients with B-cell leukemia respond to chimeric antigen receptor T cell (CAR T) therapy, yet many relapse due to loss of CAR T function. Here, the authors show that the metabolism of CAR T from short- and long-term responders is different, which may explain why CAR T lose functionality.

Lior Goldberg
Eric R. Haas
Xiuli Wang
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-14
Phosphorylation of Runx protein controls helper CD4⁺ T cell versus cytotoxic CD8⁺ T cell lineage choice

Taniuchi and colleagues show that differential phosphorylation of the terminal Y residue in Runx proteins connect MHC restriction with the helper versus cytotoxic T cell lineage choice.

Chihiro Ogawa
Kazuki Okuyama
Ichiro Taniuchi
ResearchOpen Access19 Feb 2026
Nature Immunology

P: 1-13
Activated ATF6α is a hepatic tumour driver restricting immunosurveillance

ATF6α activation in human and preclinical models of hepatocellular carcinoma is significantly associated with an aggressive tumour phenotype characterized by reduced survival, glycolytic reprogramming and local immunosuppression.

Xin Li
Cynthia Lebeaupin
Mathias Heikenwälder
ResearchOpen Access04 Feb 2026
Nature

P: 1-12
Correlative molecular-to-mesoscale evolution in conjugated polymers for intrinsically stretchable organic photovoltaics

Mechanical response of semiconducting polymers affects their electrical properties, yet the detail remains elusive. Zhong et al. examine the multiscale structural evolution of conjugated polymer thin films during uniaxial deformation and link it to mechanical resilience and solar cell performance.

Wenkai Zhong
Guillaume Freychet
Feng Liu
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-11
Natural Resources in the United States

J. J. MacGREGOR
Research09 Nov 1963
Nature

Volume: 200, P: 518-520
Natural nanoparticle complexes at water-water interfaces

Aqueous two-phase systems have potential as biomimetic materials, but often lack stability and are prone to collapse. Here, the authors use interfacial assembly of chitin nanofibres and cellulose nanocrystals to prepare a biobased system with permeability and switchable motility.

Han Wang
Yi Lu
Orlando J. Rojas
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Evolving epigenomics of immune cells at single-nucleus resolution in children en route to type 1 diabetes

Islet autoimmunity in patients with Type 1 Diabetes (T1D) emerges months to years before clinical disease manifestation. However, the precise drivers of T1D remain elusive. Here, the authors leverage longitudinal samples collected within the context of the TRIGR trial and, by performing single-cell transcriptomics and epigenomics, reveal heightened pro-inflammatory cytokine signaling in the myeloid lineage before autoantibody seroconversion, suggesting that genomic differences influence immune regulation and predisposition to T1D.

Tomi Pastinen
Elin Grundberg
Mikael Knip
ResearchOpen Access25 Feb 2026
Nature Communications

P: 1-14
Crystal-facet-directed all-vacuum-deposited perovskite solar cells

The vacuum process is scalable and solvent free, yet all-vacuum-deposited perovskite solar cells still trail solution-processed counterparts. Facet-directed co-evaporation yields (100)-oriented mixed-halide wide-bandgap films for efficient, stable single-junction cells and perovskite–silicon tandem cells.

Xinyi Shen
Wing Tung Hui
Henry J. Snaith
ResearchOpen Access23 Feb 2026
Nature Materials

P: 1-12
Deviation in development of dorsal association tracts during preadolescence links to concurrent and future cognitive performance and transdiagnostic psychopathology

Using diffusion MRI data from over 10,000 youth, the authors develop 30 tract-specific brain age models and show that developmental deviations in association and limbic tracts are linked to concurrent and future cognition and psychiatric risks.

Danni Wang
Christopher J. Hammond
Yihong Yang
ResearchOpen Access19 Feb 2026
Nature Communications

P: 1-21

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