Nature Search

Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution

The genome sequences of the neglected human-infective malaria species Plasmodium malariae and P. ovale provide new insights into their biology that are pertinent to understanding their epidemiology and to the broader agenda of malaria elimination.

Gavin G. Rutledge
Ulrike Böhme
Thomas D. Otto
ResearchOpen Access25 Jan 2017
Nature

Volume: 542, P: 101-104
Roadmap for alleviating the manifestations of ageing in the cardiovascular system

In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

Luca Liberale
Simon Tual-Chalot
Konstantinos Stellos
Reviews19 Feb 2025
Nature Reviews Cardiology

Volume: 22, P: 577-605
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

The Myocardial Infarction Genetics Consortium reports results of a genome-wide association study of early-onset myocardial infarction. The study analyzed common SNPs, common CNVs and rare CNVs and identified SNP alleles at three new loci associated with disease risk.

Sekar Kathiresan
Benjamin F Voight
David Altshuler
Research08 Feb 2009
Nature Genetics

Volume: 41, P: 334-341
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Georg B. Ehret
Patricia B. Munroe
Toby Johnson
Research11 Sept 2011
Nature

Volume: 478, P: 103-109
Genome analysis of the platypus reveals unique signatures of evolution

Platypuses are monotremes and combine aspects of both reptilian and mammalian behaviour. An international consortium reports the genome sequence and analysis of Ornithorhynchus anatinus and as expected, parts of the genome look more like mammals, whereas other parts more like reptiles or even chickens.

Wesley C. Warren
LaDeana W. Hillier
Richard K. Wilson
ResearchOpen Access08 May 2008
Nature

Volume: 453, P: 175-183
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Richard Trembath and colleagues report a meta-analysis of genome-wide association studies for psoriasis, including 2 cohorts genotyped on the custom Immunochip array, in a total of 10,588 cases and 22,806 controls. They identify 15 new susceptibility loci and refine signals in previously known loci, highlighting a role for innate host defense in susceptibility to psoriasis.

Lam C Tsoi
Sarah L Spain
Richard C Trembath
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1341-1348
Hemin-induced transient senescence via DNA damage response: a neuroprotective mechanism against ferroptosis in intracerebral hemorrhage

Transient senescence induced by DNA damage responses provide a neuroprotective mechanism against iron dysregulation seen during intracerebral haemorrhage, offering mechanistic insights and potential therapeutic avenues.

Vikas H. Malojirao
Velmarini Vasquez
Muralidhar L. Hegde
ResearchOpen Access17 Apr 2025
Communications Biology

Volume: 8, P: 1-18
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
A terrestrial planet candidate in a temperate orbit around Proxima Centauri

A small planet of at least 1.3 Earth masses is orbiting Proxima Centauri with a period of about 11.2 days, with the potential for liquid water on its surface.

Guillem Anglada-Escudé
Pedro J. Amado
Mathias Zechmeister
Research24 Aug 2016
Nature

Volume: 536, P: 437-440
Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis

Joana Carlevaro-Fita, Andrés Lanzós et al. present the Cancer LncRNA Census (CLC), a manually curated dataset of 122 long noncoding RNAs (lncRNAs) with experimentally-validated functions in cancer based on data from the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. CLC lncRNAs have unique gene features, and a number display evidence for cancer-driving functions that are conserved from humans to mice.

Joana Carlevaro-Fita
Andrés Lanzós
Christian von Mering
ResearchOpen Access05 Feb 2020
Communications Biology

Volume: 3, P: 1-16
A polygenic resilience score moderates the genetic risk for schizophrenia

Jonathan L. Hess
Daniel S. Tylee
Stephen J. Glatt
ResearchOpen Access06 Sept 2019
Molecular Psychiatry

Volume: 26, P: 800-815
Enhancing nucleotide sequence representations in genomic analysis with contrastive optimization

Scorpio enhances genomic language models with contrastive learning and hierarchical sampling to improve classification, generalization, and biological representation, enabling transferable embeddings to other domains.

Mohammadsaleh Refahi
Bahrad A. Sokhansanj
Gail L. Rosen
ResearchOpen Access29 Mar 2025
Communications Biology

Volume: 8, P: 1-18
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
2023 World Heart Federation guidelines for the echocardiographic diagnosis of rheumatic heart disease

A panel of experts from the World Heart Federation provide a revised set of guidelines for the echocardiographic detection of rheumatic heart disease (RHD) in patients living in RHD-endemic regions. The guidelines provide updated screening and confirmatory criteria, as well as a new stage-based classification of RHD based on risk of disease progression, which will improve the diagnosis and subsequent management of patients with RHD.

Joselyn Rwebembera
James Marangou
Bo Reményi
Reviews02 Nov 2023
Nature Reviews Cardiology

Volume: 21, P: 250-263
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Detecting iodine deficiency risks from dietary transitions using shopping data

Roberto Mansilla
Gavin Long
James Goulding
ResearchOpen Access10 Jan 2024
Scientific Reports

Volume: 14, P: 1-9
Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology

RE Banks
MA Forbes
PJ Selby
Research01 Mar 1998
British Journal of Cancer

Volume: 77, P: 956-964
CAR T cells for infection, autoimmunity and allotransplantation

This Review explores the challenges and opportunities of taking CARs down new therapeutic roads, in terms of developing chimeric antigen receptors (CARs) for treating infectious disease, autoimmunity and transplant rejection.

Colby R. Maldini
Gavin I. Ellis
James L. Riley
Reviews25 Jul 2018
Nature Reviews Immunology

Volume: 18, P: 605-616
Evaluating the neuroprotective impact of senolytic drugs on human vision

Nevin W. El-Nimri
Spencer M. Moore
Sally L. Baxter
ResearchOpen Access10 Dec 2020
Scientific Reports

Volume: 10, P: 1-8
PICRUSt2 for prediction of metagenome functions

Gavin M. Douglas
Vincent J. Maffei
Morgan G. I. Langille
Correspondence01 Jun 2020
Nature Biotechnology

Volume: 38, P: 685-688
Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

The International Multiple Sclerosis Genetics Consortium reports the discovery of 48 new susceptibility variants for multiple sclerosis through targeted follow-up of immune-related loci. They also report fine mapping of association signals at established susceptibility loci and provide insights into the immune system processes underlying this disease.

Ashley H Beecham
Nikolaos A Patsopoulos
Jacob L McCauley
Research29 Sept 2013
Nature Genetics

Volume: 45, P: 1353-1360
Ouvrai opens access to remote virtual reality studies of human behavioural neuroscience

The authors introduce Ouvrai, an open-source solution that facilitates the design and execution of remote virtual reality studies, capitalizing on the surge in virtual reality headset ownership.

Evan Cesanek
Sabyasachi Shivkumar
Daniel M. Wolpert
Research26 Apr 2024
Nature Human Behaviour

Volume: 8, P: 1209-1224
Publisher Correction: SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway

Brian J. Willett
Joe Grove
Emma C. Thomson
Amendments and CorrectionsOpen Access16 Sept 2022
Nature Microbiology

Volume: 7, P: 1709
From a genome-wide screen of RNAi molecules against SARS-CoV-2 to a validated broad-spectrum and potent prophylaxis

A genome-wide screen of 16,471 RNAi triggers targeting SARS-CoV-2 genome by Sens.AI. identifies hyper-potent RNAi candidates against SARS-CoV-2 that are further validated in vitro and in vivo.

Ohad Yogev
Omer Weissbrod
Yaniv Erlich
ResearchOpen Access16 Mar 2023
Communications Biology

Volume: 6, P: 1-12
Towards host-directed therapies for tuberculosis

The treatment of tuberculosis is based on combinations of drugs that directly targetMycobacterium tuberculosis. A new global initiative is now focusing on a complementary approach of developing adjunct host-directed therapies.

Alimuddin Zumla
Jeremiah Chakaya
Markus Maeurer
Comments & Opinion17 Jul 2015
Nature Reviews Drug Discovery

Volume: 14, P: 511-512
Patient-derived xenografts undergo mouse-specific tumor evolution

This large-scale analysis of copy number alterations (CNAs) in patient-derived xenografts (PDXs) across 24 cancer types shows that new CNAs accumulate quickly and that the specific CNAs acquired during passaging differ from those acquired during tumor evolution in patients, suggesting that PDX tumors are under distinct selection pressures from tumors in human hosts.

Uri Ben-David
Gavin Ha
Todd R Golub
Research09 Oct 2017
Nature Genetics

Volume: 49, P: 1567-1575
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

Richard Trembath, Peter Donnelly and colleagues report a genome-wide association study identifying six new psoriasis susceptibility loci. They also identify a statistical interaction between HLA-C and ERAP1 in psoriasis susceptibility.

Amy Strange
Francesca Capon
Richard C Trembath
Research17 Oct 2010
Nature Genetics

Volume: 42, P: 985-990
Patients with neurological or psychiatric complications of COVID-19 have worse long-term functional outcomes: COVID-CNS—A multicentre case–control study

Rajish S. K. Shil
Adam Seed
Hannah Stark
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-14
Genome-wide meta-analyses identify multiple loci associated with smoking behavior

The Tobacco and Genetics Consortium report meta-analyses of several smoking phenotypes across 16 cohorts including 74,053 individuals. They identify three loci associated with cigarettes smoked per day.

Helena Furberg
YunJung Kim
Patrick F Sullivan
Research25 Apr 2010
Nature Genetics

Volume: 42, P: 441-447
Correction: WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis

Carolyn B. McNabb
Ian D. Driver
Derek K. Jones
Amendments and CorrectionsOpen Access03 Jul 2025
Scientific Data

Volume: 12, P: 1
The genetic control of ribosomal RNA accumulation in flax genotrophs

Neasa Ni Ghogain
Henry Byrne
Jeremy Timmis
Research01 Apr 1982
Heredity

Volume: 48, P: 211-226
Aberrant CpG-island methylation has non-random and tumour-type–specific patterns

Joseph F. Costello
Michael C. Frühwald
Christoph Plass
Research01 Feb 2000
Nature Genetics

Volume: 24, P: 132-138
Metabolomic characterisation of the effects of oncogenic PIK3CA transformation in a breast epithelial cell line

Chung-Ho E. Lau
Gregory D. Tredwell
Hector C. Keun
ResearchOpen Access10 Apr 2017
Scientific Reports

Volume: 7, P: 1-12
Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data

James H. R. Farmery
Mike L. Smith
Andy G. Lynch
ResearchOpen Access22 Jan 2018
Scientific Reports

Volume: 8, P: 1-17
WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis

Carolyn B. McNabb
Ian D. Driver
Derek K. Jones
ResearchOpen Access06 Feb 2025
Scientific Data

Volume: 12, P: 1-19
Computational/experimental evaluation of liver metastasis post hepatic injury: interactions with macrophages and transitional ECM

Shanice V. Hudson
Hunter A. Miller
Hermann B. Frieboes
ResearchOpen Access21 Oct 2019
Scientific Reports

Volume: 9, P: 1-13
COVID-19 due to the B.1.617.2 (Delta) variant compared to B.1.1.7 (Alpha) variant of SARS-CoV-2: a prospective observational cohort study

Kerstin Kläser
Erika Molteni
Emma L. Duncan
ResearchOpen Access28 Jun 2022
Scientific Reports

Volume: 12, P: 1-17
Ultra Short Echo Time MRI of Iron-Labelled Mesenchymal Stem Cells in an Ovine Osteochondral Defect Model

Joshua D. Kaggie
Hareklea Markides
Frances Henson
ResearchOpen Access21 May 2020
Scientific Reports

Volume: 10, P: 1-10
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
COVID-19 vaccination, risk-compensatory behaviours, and contacts in the UK

John Buckell
Joel Jones
Helen Fryer
ResearchOpen Access25 May 2023
Scientific Reports

Volume: 13, P: 1-15
Genetic engineering of T cells for immunotherapy

This Review discusses strategies for the genetic engineering of adoptive T cell immunotherapies with a focus on approaches harnessing transgenic T cell receptors or chimeric antigen receptors to treat cancer. The authors also discuss the more complex levels of genetic regulation that will be needed to ensure both safety and efficacy.

Gavin I. Ellis
Neil C. Sheppard
James L. Riley
Reviews18 Feb 2021
Nature Reviews Genetics

Volume: 22, P: 427-447
Molecular diagnoses and candidate gene identification in the congenital heart disease cohorts of the 100,000 genomes project

Verity Hartill
Mitra Kabir
Colin A. Johnson
ResearchOpen Access26 Nov 2024
European Journal of Human Genetics

Volume: 33, P: 793-802
DYNC2H1 hypomorphic or retina-predominant variants cause nonsyndromic retinal degeneration

Anjali Vig
James A. Poulter
Elise Heon
ResearchOpen Access05 Aug 2020
Genetics in Medicine

Volume: 22, P: 2041-2051
Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning

Sema Nickbakhsh
Joseph Hughes
Alison Smith-Palmer
ResearchOpen Access19 Jul 2022
Scientific Reports

Volume: 12, P: 1-17
Changes in body weight, adherence, and appetite during 2 years of calorie restriction: the CALERIE 2 randomized clinical trial

James L. Dorling
Sai Krupa Das
Corby K. Martin
Research06 Mar 2020
European Journal of Clinical Nutrition

Volume: 74, P: 1210-1220
A randomised study to assess the nicotine pharmacokinetics of an oral nicotine pouch and two nicotine replacement therapy products

David Azzopardi
James Ebajemito
James Murphy
ResearchOpen Access28 Apr 2022
Scientific Reports

Volume: 12, P: 1-12
The United States COVID-19 Forecast Hub dataset

Estee Y. Cramer
Yuxin Huang
Nicholas G. Reich
ResearchOpen Access01 Aug 2022
Scientific Data

Volume: 9, P: 1-15
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

Stephen Sawcer
Garrett Hellenthal
Alastair Compston
Research10 Aug 2011
Nature

Volume: 476, P: 214-219
The molecular basis of thioalcohol production in human body odour

Michelle Rudden
Reyme Herman
Gavin H. Thomas
ResearchOpen Access27 Jul 2020
Scientific Reports

Volume: 10, P: 1-14

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