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PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation

Hereditary deafness lacks effective biological treatments. Here, the authors develop a base editing therapy that corrects a common MPZL2 deafness gene mutation in a humanized mouse model and restores hearing, highlighting base editing as a potential treatment for hereditary deafness.

Shao Wei Hu
Sohyang Jeong
Yilai Shu
ResearchOpen Access05 Aug 2025
Nature Communications

Volume: 16, P: 1-18
Dural arteriovenous fistula masquerading as pulsatile tinnitus: radiologic assessment and clinical implications

Yong-Hwi An
Sungjun Han
Jae-Jin Song
ResearchOpen Access04 Nov 2016
Scientific Reports

Volume: 6, P: 1-8
The impact of circulatory arrest with selective antegrade cerebral perfusion on brain functional connectivity and postoperative cognitive function

Tae-Hoon Kim
Jooyoung Oh
Jae-Jin Kim
ResearchOpen Access23 Aug 2023
Scientific Reports

Volume: 13, P: 1-10
Correction: Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology

Yunseon Yang
Min-Jong Seok
Sang-Hun Lee
Amendments and Corrections11 Jul 2023
Molecular Psychiatry

Volume: 28, P: 5375-5377
Thalamocortical dysrhythmia detected by machine learning

Thalamocortical dysrhythmia has been proposed to occur in a number of neurological and psychiatric disorders. Here, the authors use a data-driven approach to demonstrate thalamocortical dysrhythmia occurs in individuals with Parkinson’s disease, neuropathic pain, tinnitus, and depression.

Sven Vanneste
Jae-Jin Song
Dirk De Ridder
ResearchOpen Access16 Mar 2018
Nature Communications

Volume: 9, P: 1-13
Correction to: Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology

Yunseon Yang
Min-Jong Seok
Sang-Hun Lee
Amendments and Corrections05 Apr 2023
Molecular Psychiatry

Volume: 28, P: 5378-5379
Gene signatures and genotype-phenotype correlations of sensorineural hearing loss in Noonan syndrome and related RASopathies

Seung Jae Lee
Sohyang Jeong
Sang-Yeon Lee
ResearchOpen Access09 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology

Yunseon Yang
Min-Jong Seok
Sang-Hun Lee
Research29 Jul 2022
Molecular Psychiatry

Volume: 28, P: 5359-5374
Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination

In-Kang Song
Jae-Jin Lee
Kong-Joo Lee
ResearchOpen Access05 Oct 2016
Scientific Reports

Volume: 6, P: 1-15
Functional pathogenicity of ESRRB variant of uncertain significance contributes to hearing loss (DFNB35)

Won Hoon Choi
Yeijean Cho
Sang-Yeon Lee
ResearchOpen Access11 Sept 2024
Scientific Reports

Volume: 14, P: 1-13
Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis

Seon-A Choi
Young-Hyun Kim
Kyu-Tae Chang
ResearchOpen Access21 Nov 2018
Cell Death & Differentiation

Volume: 26, P: 1582-1599
Phenotypic and molecular basis of SIX1 variants linked to non-syndromic deafness and atypical branchio-otic syndrome in South Korea

Somin Lee
Yejin Yun
Sang-Yeon Lee
ResearchOpen Access21 Jul 2023
Scientific Reports

Volume: 13, P: 1-15
Quantitative three-dimensional image analysis of the superior canal after surgical plugging to treat superior semicircular canal dehiscence

Sang-Yeon Lee
Yein Lee
Ja-Won Koo
ResearchOpen Access09 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
Longitudinal analysis of surgical outcome in subjects with pulsatile tinnitus originating from the sigmoid sinus

Sang-Yeon Lee
Min-Kyung Kim
Jae-Jin Song
ResearchOpen Access23 Oct 2020
Scientific Reports

Volume: 10, P: 1-10
Contralateral spreading of substances following intratympanic nanoparticle-conjugated gentamicin injection in a rat model

Sang-Yeon Lee
Jeonghyo Kim
Ja-Won Koo
ResearchOpen Access29 Oct 2020
Scientific Reports

Volume: 10, P: 1-9
Small molecule activator of Nm23/NDPK as an inhibitor of metastasis

Jae-Jin Lee
Hwang Suk Kim
Kong-Joo Lee
ResearchOpen Access19 Jul 2018
Scientific Reports

Volume: 8, P: 1-13
The molecular etiology of deafness and auditory performance in the postlingually deafened cochlear implantees

Sang-Yeon Lee
Ye Ji Shim
Byung Yoon Choi
ResearchOpen Access01 Apr 2020
Scientific Reports

Volume: 10, P: 1-12
Neural substrates predicting short-term improvement of tinnitus loudness and distress after modified tinnitus retraining therapy

Shin Hye Kim
Ji Hye Jang
Jae-Jin Song
ResearchOpen Access06 Jul 2016
Scientific Reports

Volume: 6, P: 1-10
Typewriter tinnitus revisited: The typical symptoms and the initial response to carbamazepine are the most reliable diagnostic clues

Woongsang Sunwoo
Yung Jin Jeon
Jae-Jin Song
ResearchOpen Access06 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
In vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns

Taeho Kim
Jae-Jin Song
Sang-Hun Lee
ResearchOpen Access10 Mar 2017
Experimental & Molecular Medicine

Volume: 49, P: e300

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PAM-flexible adenine base editing rescues hearing loss in a humanized MPZL2 mouse model harboring an East Asian founder mutation

Dural arteriovenous fistula masquerading as pulsatile tinnitus: radiologic assessment and clinical implications

The impact of circulatory arrest with selective antegrade cerebral perfusion on brain functional connectivity and postoperative cognitive function

Correction: Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology

Thalamocortical dysrhythmia detected by machine learning

Correction to: Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology

Gene signatures and genotype-phenotype correlations of sensorineural hearing loss in Noonan syndrome and related RASopathies

Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology

Degradation of Redox-Sensitive Proteins including Peroxiredoxins and DJ-1 is Promoted by Oxidation-induced Conformational Changes and Ubiquitination

Functional pathogenicity of ESRRB variant of uncertain significance contributes to hearing loss (DFNB35)

Novel crosstalk between Vps26a and Nox4 signaling during neurogenesis

Phenotypic and molecular basis of SIX1 variants linked to non-syndromic deafness and atypical branchio-otic syndrome in South Korea

Quantitative three-dimensional image analysis of the superior canal after surgical plugging to treat superior semicircular canal dehiscence

Longitudinal analysis of surgical outcome in subjects with pulsatile tinnitus originating from the sigmoid sinus

Contralateral spreading of substances following intratympanic nanoparticle-conjugated gentamicin injection in a rat model

Small molecule activator of Nm23/NDPK as an inhibitor of metastasis

The molecular etiology of deafness and auditory performance in the postlingually deafened cochlear implantees

Neural substrates predicting short-term improvement of tinnitus loudness and distress after modified tinnitus retraining therapy

Typewriter tinnitus revisited: The typical symptoms and the initial response to carbamazepine are the most reliable diagnostic clues

In vitro generation of mature midbrain-type dopamine neurons by adjusting exogenous Nurr1 and Foxa2 expressions to their physiologic patterns

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