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Showing 101–150 of 153 results

Advanced filters: Author: James Duffy Clear advanced filters

Genome variation and evolution of the malaria parasite Plasmodium falciparum

Daniel C Jeffares
Arnab Pain
Matthew Berriman
Research10 Dec 2006
Nature Genetics

Volume: 39, P: 120-125
Complete Khoisan and Bantu genomes from southern Africa

Until now, fully sequenced human genomes of the indigenous hunter-gatherer peoples of southern Africa have been limited to recently diverged populations. The complete genome sequences of an indigenous hunter-gatherer from the Kalahari Desert and of a Bantu from southern Africa are now presented. The extent of whole-genome and exome diversity is characterized; the observed genomic differences may help to pinpoint genetic adaptations to an agricultural lifestyle.

Stephan C. Schuster
Webb Miller
Vanessa M. Hayes
ResearchOpen Access18 Feb 2010
Nature

Volume: 463, P: 943-947
Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya

Ashley Osborne
Emilia Manko
Taane G. Clark
ResearchOpen Access06 Oct 2021
Scientific Reports

Volume: 11, P: 1-11
Leveraging single-cell genomics to expand the fungal tree of life

Single-cell genome sequencing of eight uncultured fungal species provides insights into the phylogenetic placement of early-diverging lineages, highlights metabolic deficiencies and identifies gene expansions correlated with parasitism and unculturability.

Steven R. Ahrendt
C. Alisha Quandt
Igor V. Grigoriev
ResearchOpen Access08 Oct 2018
Nature Microbiology

Volume: 3, P: 1417-1428
Design of amidobenzimidazole STING receptor agonists with systemic activity

A small-molecule agonist for the cGAS–STING pathway has systemic activity in a mouse model of colon cancer.

Joshi M. Ramanjulu
G. Scott Pesiridis
John Bertin
Research07 Nov 2018
Nature

Volume: 564, P: 439-443
Maternal-foetal transfer of Plasmodium falciparum and Plasmodium vivax antibodies in a low transmission setting

Sarah C. Charnaud
Rose McGready
Freya J. I. Fowkes
ResearchOpen Access10 Feb 2016
Scientific Reports

Volume: 6, P: 1-10
Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma

Rebecca Fitzgerald and colleagues report whole-genome sequence analyses of 23 paired samples of Barrett's esophagus and esophageal adenocarcinoma. Their analyses of the clonal architecture of these lesions shows that copy number increases and heterogeneity persists during development of esophageal adenocarcinoma.

Caryn S Ross-Innes
Jennifer Becq
Sarah Dawson
Research20 Jul 2015
Nature Genetics

Volume: 47, P: 1038-1046
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
Desynchronizing the sleep–wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period

This protocol describes how to design, implement and analyze the data from a forced desynchrony protocol to assess endogenous circadian rhythmicity and to separate circadian from evoked components of daily rhythms in physiology and behavior.

Wei Wang
Robin K. Yuan
Charles A. Czeisler
Protocols14 Nov 2022
Nature Protocols

Volume: 18, P: 579-603
Predator-induced changes in the growth of eyes and false eyespots

Oona M. Lönnstedt
Mark I. McCormick
Douglas P. Chivers
ResearchOpen Access25 Jul 2013
Scientific Reports

Volume: 3, P: 1-5
How do retinoblastoma tumours form?

Brenda L Gallie
James M Dunn
Robert A Phillips
Research01 Mar 1992
Eye

Volume: 6, P: 226-231
Malaria is a cause of iron deficiency in African children

A genetic link suggests that interventions that halve the risk of malaria episodes could reduce the prevalence of iron deficiency in African children by nearly 50%.

John Muthii Muriuki
Alexander J. Mentzer
Sarah H. Atkinson
Research22 Feb 2021
Nature Medicine

Volume: 27, P: 653-658
Repeated Low-Level Formaldehyde Exposure Produces Cross-Sensitization to Cocaine: Possible Relevance to Chemical Sensitivity in Humans

Barbara A Sorg
James R Willis
Hal H Westberg
Research01 May 1998
Neuropsychopharmacology

Volume: 18, P: 385-394
CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration

James M. Fox
Fahima Kausar
James E. Pease
ResearchOpen Access21 Jun 2018
Scientific Reports

Volume: 8, P: 1-15
Parallel derivation of isogenic human primed and naive induced pluripotent stem cells

Derivation of human induced pluripotent stem cells (hiPSCs) produces primed hiPSCs that can in turn be converted to naive hiPSCs. Here, the authors directly reprogram somatic cells to form both naive and primed isogenic hiPSCs and confirm the similarity of naive hiPSCs to their in vivo counterparts.

Stéphanie Kilens
Dimitri Meistermann
Matthew L. Albert
ResearchOpen Access24 Jan 2018
Nature Communications

Volume: 9, P: 1-13
Sero-catalytic and Antibody Acquisition Models to Estimate Differing Malaria Transmission Intensities in Western Kenya

Grace E. Weber
Michael T. White
Arlene E. Dent
ResearchOpen Access04 Dec 2017
Scientific Reports

Volume: 7, P: 1-12
Revisiting the Plasmodium falciparum druggable genome using predicted structures and data mining

Karla P. Godinez-Macias
Daisy Chen
Elizabeth A. Winzeler
ResearchOpen Access04 Mar 2025
npj Drug Discovery

Volume: 2, P: 1-13
Characterization of the β-Adrenergic Receptor in Isolated Human Fetal Lung Type II Cells

Cynthia K Ewing
Diane M Duffy
James M Roberts
Research01 Sept 1992
Pediatric Research

Volume: 32, P: 350-355
Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

The Human BioMolecular Atlas Program (HuBMAP) presents its production phase: the generation of spatial maps of functional tissue units across organs from diverse populations and the creation of tools and infrastructure to advance biomedical research.

Sanjay Jain
Liming Pei
Michael P. Snyder
Reviews19 Jul 2023
Nature Cell Biology

Volume: 25, P: 1089-1100
IMI European Lead Factory — democratizing access to high-throughput screening

The European Lead Factory combines assets and experience from major pharma with innovation and agility of academia and SMEs in a collaborative platform to expand access to high-throughput screening. With many successes heading towards the clinic, the organization is broadening its approach to screening and partnering.

Philip S. Jones
Sylviane Boucharens
Jon S. B. de Vlieger
Comments & Opinion14 Dec 2021
Nature Reviews Drug Discovery

Volume: 21, P: 245-246
First results from five multidisciplinary diagnostic centre (MDC) projects for non-specific but concerning symptoms, possibly indicative of cancer

D. Chapman
V. Poirier
Brian Nicholson
ResearchOpen Access06 Jul 2020
British Journal of Cancer

Volume: 123, P: 722-729
A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

Whole-genome sequencing identifies a novel germline variant in the oncogene MITF, which is associated with the development of melanoma.

Satoru Yokoyama
Susan L. Woods
Kevin M. Brown
ResearchOpen Access13 Nov 2011
Nature

Volume: 480, P: 99-103
Transnational environmental crime threatens sustainable development

Transnational environmental crime has become the largest financial driver of social conflict, with severe implications for peace and security. Sustainable-development frameworks need to overtly recognize and mitigate the risks posed by transnational environmental crime to environmental security.

Meredith L. Gore
Patrick Braszak
Rob White
Comments & Opinion12 Aug 2019
Nature Sustainability

Volume: 2, P: 784-786
Biodiversity loss and its impact on humanity

Two decades ago the first Earth Summit raised the question of how biological diversity loss alters ecosystem functioning and affects humanity; this Review looks at the progress made towards answering this question.

Bradley J. Cardinale
J. Emmett Duffy
Shahid Naeem
Reviews06 Jun 2012
Nature

Volume: 486, P: 59-67
Bioinspired Breathable Architecture for Water Harvesting

Rowan M. von Spreckelsen
Matthew T. Harris
Jas Pal S. Badyal
ResearchOpen Access18 Nov 2015
Scientific Reports

Volume: 5, P: 1-6
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization

Klaus Bønnelykke and colleagues report results of a genome-wide association study of allergic sensitization. They identify ten loci influencing this phenotype and provide insight into the shared genetic basis of allergic sensitization and atopic diseases.

Klaus Bønnelykke
Melanie C Matheson
A John Henderson
Research30 Jun 2013
Nature Genetics

Volume: 45, P: 902-906
m⁶A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

The authors assess the role of N⁶-methyladenosine in T cell development and function, and show that RNA methylation controls T cell homeostasis by regulating IL-7-mediated STAT5 activation.

Hua-Bing Li
Jiyu Tong
Richard A. Flavell
Research09 Aug 2017
Nature

Volume: 548, P: 338-342
PTEX is an essential nexus for protein export in malaria parasites

This paper demonstrates that a protein complex known as PTEX translocates all malaria parasite proteins destined for export into the cytosol of their host red blood cell.

Brendan Elsworth
Kathryn Matthews
Tania F. de Koning-Ward
Research16 Jul 2014
Nature

Volume: 511, P: 587-591
High and Heterogeneous Prevalence of Asymptomatic and Sub-microscopic Malaria Infections on Islands in Lake Victoria, Kenya

Zulkarnain Md Idris
Chim W. Chan
Akira Kaneko
ResearchOpen Access14 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Genome-wide association study identifies three new melanoma susceptibility loci

Timothy Bishop and colleagues of the GenoMEL Consortium report a genome-wide association study for melanoma, identifying three new susceptibility loci.

Jennifer H Barrett
Mark M Iles
D Timothy Bishop
Research09 Oct 2011
Nature Genetics

Volume: 43, P: 1108-1113
Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3

Stuart MacGregor and colleagues report the results of a genome-wide association study for melanoma susceptibility in an Australian population. They identify a new melanoma susceptibility locus on chromosome 1.

Stuart MacGregor
Grant W Montgomery
Nicholas K Hayward
Research09 Oct 2011
Nature Genetics

Volume: 43, P: 1114-1118
The projected impact of the COVID-19 lockdown on breast cancer deaths in England due to the cessation of population screening: a national estimation

Stephen W. Duffy
Farah Seedat
Anne Mackie
ResearchOpen Access02 Feb 2022
British Journal of Cancer

Volume: 126, P: 1355-1361
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
A comparison of an immunological faecal occult blood test Fecatwin sensitive/FECA EIA with Haemoccult in population screening for colorectal cancer

N Armitage
J D Hardcastle
P D James
Research01 Jun 1985
British Journal of Cancer

Volume: 51, P: 799-804
Levels of interpopulation differentiation among different functional classes of immunologically important genes

A W Ryan
J Mapp
R McManus
Research13 Oct 2005
Genes & Immunity

Volume: 7, P: 179-183
Reducing stunting among children: the potential contribution of diagnostics

Stunting affects ~ 147 million children in developing countries. Studies have pointed to a relationship between stunting and different pathogens that are associated with diarrhoeal illness. New easy-to-use tools for diagnosing these pathogens could help to identify children at risk for growth shortfall, and reduce the prevalence of stunting and the large burden of disease associated with it.

Karen A. Ricci
Federico Girosi
Richard L. Guerrant
Research22 Nov 2006
Nature

Volume: 444, P: 29-38
Four consecutive yearly point-prevalence studies in Wales indicate lack of improvement in sepsis care on the wards

Maja Kopczynska
Harry Unwin
Judith E. Hall
ResearchOpen Access10 Aug 2021
Scientific Reports

Volume: 11, P: 1-12
¹⁸FDG uptake during induction chemoradiation for oesophageal cancer fails to predict histomorphological tumour response

C M Gillham
J A Lucey
J V Reynolds
ResearchOpen Access03 Oct 2006
British Journal of Cancer

Volume: 95, P: 1174-1179
A genome-wide scan for naevus count: linkage to CDKN2A and to other chromosome regions

Gu Zhu
Grant W Montgomery
David L Duffy
Research25 Oct 2006
European Journal of Human Genetics

Volume: 15, P: 94-102
Differential Distribution of Corticotropin-Releasing Hormone Immunoreactive Axons in Monoaminergic Nuclei of the Human Brainstem

Mark C Austin
James L Rhodes
David A Lewis
Research01 Nov 1997
Neuropsychopharmacology

Volume: 17, P: 326-341
Challenges for room temperature operation of electrically pumped GeSn lasers

A. R. Ellis
D. A. Duffy
S. J. Sweeney
ResearchOpen Access05 May 2024
Scientific Reports

Volume: 14, P: 1-11
The response of an arboreal mammal to livestock grazing is habitat dependant

Heather Neilly
Lin Schwarzkopf
ResearchOpen Access12 Dec 2017
Scientific Reports

Volume: 7, P: 1-9
Ixazomib with cyclophosphamide and dexamethasone in relapsed or refractory myeloma: MUKeight phase II randomised controlled trial results

Holger W. Auner
Sarah R. Brown
Gordon Cook
ResearchOpen Access01 Apr 2022
Blood Cancer Journal

Volume: 12, P: 1-8
Erosion of natural darkness in the geographic ranges of cacti

Maria Eugenia Correa-Cano
Bárbara Goettsch
Kevin J. Gaston
ResearchOpen Access12 Mar 2018
Scientific Reports

Volume: 8, P: 1-10
Strong trans-Pacific break and local conservation units in the Galapagos shark (Carcharhinus galapagensis) revealed by genome-wide cytonuclear markers

Diana A. Pazmiño
Gregory E. Maes
Lynne van Herwerden
Research11 Jan 2018
Heredity

Volume: 120, P: 407-421
Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition

Christos Mikropoulos
Christina G Hutten Selkirk
Rosalind A Eeles
ResearchOpen Access04 Jan 2018
British Journal of Cancer

Volume: 118, P: 266-276
WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions

Kendall H. Lee
J. Luis Lujan
Kevin E. Bennet
ResearchOpen Access28 Apr 2017
Scientific Reports

Volume: 7, P: 1-14
Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA

Weixin Wang
James L Abbruzzese
Paul J Chiao
Research18 Aug 1999
Oncogene

Volume: 18, P: 4554-4563
Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria

Hok Khim Fam
Kunho Choi
Cornelius F. Boerkoel
ResearchOpen Access09 Mar 2018
Scientific Reports

Volume: 8, P: 1-14
Increased concentrations of phosphatidate, diacylglycerol and ceramide in ras- and tyrosine kinase (fps)-transformed fibroblasts

Ashley Martin
Patricia A Duffy
David N Brindley
Research03 Apr 1997
Oncogene

Volume: 14, P: 1571-1580

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