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Showing 1–3 of 3 results
Advanced filters: Author: Jason A. Carlyon Clear advanced filters

  • The protein p53 responds to DNA damage and intracellular infection by activating pathways that arrest the cell cycle, repair DNA, and elicit apoptosis. Here, Allen et al. show that the obligate intracellular bacterium Orientia tsutsugamushi inhibits p53 expression and protects host cells from DNA damage, thus delaying apoptosis and favouring bacterial replication.

    • Paige E. Allen
    • David L. Armistead
    • Jason A. Carlyon
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Viruses and bacteria are known to subvert the immune system using mimic or inhibitory proteins. Here the authors show that the protein Ank5 from the bacterium Orientia tsutsugamushi inhibits nuclear translocation and promotes proteasomal degradation of the MHC class I gene transactivator NLRC5.

    • Haley E. Adcox
    • Jason R. Hunt
    • Jason A. Carlyon
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-21

  • In this Review, Pedra and colleagues describe the advances and challenges in the genetic engineering of obligate intracellular bacteria, and highlight examples of how the use of genetically manipulated pathogens has improved our understanding of microbial pathogenesis and host–pathogen interactions.

    • Erin E. McClure
    • Adela S. Oliva Chávez
    • Joao H. F. Pedra
    Reviews
    Nature Reviews Microbiology
    Volume: 15, P: 544-558