Nature Search

Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities

Genotype-phenotype data from over 450,000 individuals was analyzed to discover 205 genomic loci where an allele associated with increase adiposity was associated with a lower cardiometabolic disease risk to an individual.

Nathalie Chami
Zhe Wang
Ruth J. F. Loos
ResearchOpen Access12 Sept 2025
Nature Medicine

P: 1-12
Plasma proteome variation and its genetic determinants in children and adolescents

This mass spectrometry-based proteomic study profiles the plasma proteome in 2,147 children and adolescents and reveals its association with age, sex, puberty, body mass index and genetics.

Lili Niu
Sara Elizabeth Stinson
Matthias Mann
ResearchOpen Access19 Feb 2025
Nature Genetics

Volume: 57, P: 635-646
Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity

A combination of cross-sectional study and lifestyle intervention program uncovered altered lipid profiles in children and adolescents with obesity and demonstrated that a personalized obesity management program can restore a healthy lipid profile.

Yun Huang
Karolina Sulek
Torben Hansen
ResearchOpen Access20 Sept 2024
Nature Medicine

Volume: 31, P: 294-305
Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Molecular pharmacological characterization and association testing of human GIPR genetic variants with follow-up analysis in mice shows that β-arrestins regulate GIPR signalling and thereby strongly contribute to metabolic outcomes.

Hüsün S. Kizilkaya
Kimmie V. Sørensen
Mette M. Rosenkilde
ResearchOpen Access13 Jun 2024
Nature Metabolism

Volume: 6, P: 1268-1281
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

An expanded GWAS of birth weight and subsequent analysis using structural equation modeling and Mendelian randomization decomposes maternal and fetal genetic contributions and causal links between birth weight, blood pressure and glycemic traits.

Nicole M. Warrington
Robin N. Beaumont
Rachel M. Freathy
Research01 May 2019
Nature Genetics

Volume: 51, P: 804-814
Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children

Genome-wide association studies indicate a strong genetic susceptibility to acute lymphoblastic leukaemia in children, though the effect on protein-coding genes is not fully understood. Here Xu and Zhang et al. identify a missense variant in CDKN2Awhich reduces tumour suppression.

Heng Xu
Hui Zhang
Jun J. Yang
ResearchOpen Access24 Jun 2015
Nature Communications

Volume: 6, P: 1-7
Genome-wide associations for birth weight and correlations with adult disease

Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.

Momoko Horikoshi
Robin N. Beaumont
Rachel M. Freathy
Research28 Sept 2016
Nature

Volume: 538, P: 248-252
Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations

Cæcilie Trier
Mette Hollensted
Torben Hansen
ResearchOpen Access13 Sept 2020
International Journal of Obesity

Volume: 45, P: 66-76
Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

Anna Viitasalo
Theresia M. Schnurr
Tuomas O. Kilpeläinen
ResearchOpen Access22 Jul 2019
International Journal of Obesity

Volume: 43, P: 2007-2016
Global barriers to decision makers for prioritizing interventions for obesity

Lars Holger Ehlers
Nicoline Weinreich Reinstrup
Carel W. Le Roux
ReviewsOpen Access16 Oct 2024
International Journal of Obesity

Volume: 49, P: 246-253
Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans

Li Zhang
Martin Iain Bahl
Tine Rask Licht
Research18 Nov 2016
The ISME Journal

Volume: 11, P: 676-690

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Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities

Plasma proteome variation and its genetic determinants in children and adolescents

Lipid profiling identifies modifiable signatures of cardiometabolic risk in children and adolescents with obesity

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors

Inherited coding variants at the CDKN2A locus influence susceptibility to acute lymphoblastic leukaemia in children

Genome-wide associations for birth weight and correlations with adult disease

Obesity treatment effect in Danish children and adolescents carrying Melanocortin-4 Receptor mutations

Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents

Global barriers to decision makers for prioritizing interventions for obesity

Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans

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