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Showing 1–18 of 18 results
Advanced filters: Author: Jeremy M. Baskin Clear advanced filters

  • Cellular membranes contain numerous lipids, and efforts to understand the biological functions of individual lipids demand approaches for controlled modulation of membrane composition in situ. Now, click chemistry-based directed evolution of a microbial phospholipase within mammalian cells affords an editor for optogenetic, targeted modification of phospholipids in cell membranes.

    • Reika Tei
    • Saket R. Bagde
    • Jeremy M. Baskin
    Research
    Nature Chemistry
    Volume: 15, P: 1030-1039

  • Natural products and synthetic bifunctional molecules enable the development of new chemical probes that target oxysterol-binding protein (OSBP), a key player in intracellular cholesterol homeostasis and Golgi complex integrity and a potential target for metabolic disease and cancer.

    • Po-Hsun Brian Chen
    • Jeremy M. Baskin
    News & Views
    Nature Chemical Biology
    Volume: 21, P: 160-161

  • Chemoproteomics-enabled identification of the targets of a hydroxylated cholesterol metabolite, 20(S)-hydroxycholesterol, reveals it to be the first reported endogenous ligand of the sigma-2 receptor, a drug target for neurodegeneration and neuropathic pain.

    • Weizhi Yu
    • Jeremy M. Baskin
    News & Views
    Nature Chemical Biology
    Volume: 17, P: 1214-1216

  • Phosphoinositide signalling regulates cellular processes and is hijacked by pathogens. Classically, phosphoinositides are produced by kinase- and phosphatase-catalysed reactions. A study now reveals an unprecedented, kinase- and ATP-free synthesis of PtdIns(3,4)P2 via a phosphotransferase mechanism during bacterial infection.

    • Xiaofu Cao
    • Jeremy M. Baskin
    News & Views
    Nature Cell Biology
    Volume: 24, P: 604-606

  • PI3K–Akt signalling downstream of cell-surface receptor activation has long been thought to occur at the plasma membrane. However, surprising evidence now reveals activation of PI3Kα-mediated PI(3,4,5)P3 synthesis on endosomal membranes that is dependent upon the interaction of PI3Kα with the microtubule-associated protein MAP4.

    • Alex G. Batrouni
    • Jeremy M. Baskin
    News & Views
    Nature Cell Biology
    Volume: 22, P: 1292-1294

  • Roots bend towards water. The root cortex in the elongation zone is the site of perception during hydrotropism but also the site of differential root growth, which is different from gravitropism.

    • Daniela Dietrich
    • Lei Pang
    • Malcolm J. Bennett
    Research
    Nature Plants
    Volume: 3, P: 1-8

  • Jones et al. examine the generalizability of the valence–dominance model of social judgements of faces in 41 countries across 11 world regions. They find evidence of both generalizability and variation, depending on the analytical method.

    • Benedict C. Jones
    • Lisa M. DeBruine
    • Nicholas A. Coles
    Research
    Nature Human Behaviour
    Volume: 5, P: 159-169

  • How accurate are social scientists in predicting societal change, and what processes underlie their predictions? Grossmann et al. report the findings of two forecasting tournaments. Social scientists’ forecasts were on average no more accurate than those of simple statistical models.

    • Igor Grossmann
    • Amanda Rotella
    • Tom Wilkening
    Research
    Nature Human Behaviour
    Volume: 7, P: 484-501

  • Off-targets identified by whole-genome sequencing of CRISPR-treated mouse embryos and their genetic parents are compared to predictions from GUIDE-seq and computational methods.

    • Keith R. Anderson
    • Maximilian Haeussler
    • Søren Warming
    Research
    Nature Methods
    Volume: 15, P: 512-514