Acetylation within the globular core domain of histone H3 on lysine 56 (H3K56) has been shown to have a critical role in packaging DNA into chromatin during DNA replication and repair in budding yeast, but has not been studied in multicellular eukaryotes. Here, the identification of multiple proteins regulating the levels of H3K56 acetylation in Drosophila and human cells allows future studies of this critical histone modulation which is implicated in cancer.
- Chandrima Das
- M. Scott Lucia
- Jessica K. Tyler
