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Organic electrochemical neurons typically require multiple components, limiting their integration density and scalability. Here, the authors develop a single-transistor organic electrochemical neuron mimicking biological spiking, sensing, and logic.

Glioblastoma is one of the most intractable tumors and presents a hypoxic and immunologically cold microenvironment. Lee and colleagues demonstrate that normalizing oxygen tension unleashes γδ T cell anti-glioblastoma function.

The synthesis of aziridines—three-membered nitrogen-containing heterocycles—is achieved by a new method involving the electrochemical coupling of alkenes and amines, via a dicationic intermediate.

Selective borylation of azines—nitrogen-containing aromatic heterocycles used in the synthesis of many pharmaceuticals—is made possible by forming a radical from an aminoborane using a photocatalyst.

Understanding how the immune system’s functionality declines with age is crucial for addressing aging-related health issues. Here, the authors demonstrate that activating TLR5 in the mucosal layer can significantly improve healthspan and longevity, suggesting a novel approach for aging interventions.

Through bioinformatic analyses of AML cohorts, Lee et al. explore the association between DNMT3A-destabilizing mutations and increased local concordance of DNA methylation patterns at bivalent domains, and bring insights into their pathological implications.

Liquid metals that have enormous surface tension are difficult to pattern into films. Here, authors report the spontaneous and selective wetting of a gallium-based liquid metal, which is induced by imbibition on a micro-structured metallized substrate.

The therapeutic success of CAR-T cells depends on the availability of selective and high-density targets, which limits their applicability due to on-target off-tumor toxicity. Here authors overcome this limitation in a mouse model of immune therapy in which an adaptor is an epitope-tagged single chain variable fragment targeting the tumour antigen, and the CAR-T cells are targeting the epitope, thus enabling a precise dose-switch.

It has been challenging to realize efficient and stable blue phosphorescent organic light-emitting diodes. Here, authors explore the effect of substitution position in platinum(II) dopants with suppressed metal-metal-to-ligand charge transfer features, resulting in prolonged lifetime in the devices.

Persistent antigen stimulation can cause exhaustion and unresponsiveness of CD8 cells, impairing the immune response. Here the authors show that increasing the number of CD8 cells, decreasing the antigen load or providing CD4 help can overcome the exhaustion and establish a memory response.

The proteins of the chromosomal passenger complex help chromosomes condense before cell division, but how this complex arrives at chromosomes was not known. Here the authors show that PRMT6 methylates histone H3 to recruit the chromosomal passenger complex.

Designing robust blue organic light-emitting diodes is a long-standing challenge in the display industry. Here, the authors show that electron-induced degradation reactions play a more critical role in the short lifetime of devices with iridium-based emitters under real operational conditions.

Anti-PD-1 therapy could induce a durable response in patients with gastric cancer, however biomarkers to predict response to immunotherapy are generally lacking. Here the authors report that openness of chromatin in circulating CD8⁺ T cells predicts treatment outcome in patients with metastatic gastric cancer treated with pembrolizumab.

Polo-like kinase 1 (PLK1) regulates the spindle assembly checkpoint and is recruited to prometaphase kinetochores. Kim et al.show that the condensin subunit NCAPG2 is required for stable interaction of PLK1 with kinetochores and for proper chromosome segregation.

The use of organic photoactive materials in direct solar water-splitting devices has been limited by recombination losses and their instability in aqueous media. Daboczi et al. report that stable and efficient devices based on organic photoactive layers can be achieved through the application of catalyst-functionalized protective graphite sheets.

Using an intrinsically stretchable nanocomposite of quantum dots, an elastomer and a hole transport polymer as an emissive layer, stretchable light-emitting diodes can be fabricated that exhibit high brightness even under 50% strain.

Clonal haematopoiesis (CH) has been associated with altered inflammatory profiles and increased risk of cardiovascular and malignant diseases. Here, the authors analyze patient data from two different cohorts and show that CH is associated with severe infections and severe Covid19.

Here the authors demonstrate a scalable and durable minimodule size artificial leaf with a solar-to-hydrogen efficiency of >10% using a metal-halide perovskite-based photoelectrodes encapsulated with metal foil deposited co-catalysts.

Detection of Alzheimer’s disease (AD) biomarkers from patients’ blood is challenging because these are present in very low concentrations in the plasma. Here the authors develop a sensor array of densely aligned single-walled carbon nanotubes for clinically accurate detection of femtomolar AD biomarkers in human plasma samples.

To maximize composite reinforcing efficiency, a semi-infinite reinforcement should be aligned in the matrix. Here, the authors report a float-stacking strategy for graphene-PMMA laminate with precisely aligned monolayer graphene in a polymer matrix.

A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.

Most genetic studies have been done on European cohorts, which affects the efficacy of polygenic risk scores in non-European populations. Here, the authors demonstrate that a colorectal cancer PRS including Asian and European ancestries has improved performance over the European-centric PRS across racial and ethnic groups.

Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.

Adult human tissues from diverse sites around the body are used to reconstruct cellular phylogenies from early development, using somatic mutations as an internal barcode.

Senescenct cells are shown to accumulate cholesterol in lysosomes, which upregulates mTORC1 signaling, thereby supporting the senescence-associated secretory phenotype and promoting senescence-associated inflammation.

Symbiosis should be maintained during the oral regeneration period. Herein, authors develop an occlusive membrane that induces symbiosis, thereby improving the performance of guided bone generation therapy.

Spatial genomics offers insights into cellular interactions within tissues. Here, the authors develop barcoded multiple displacement amplification, achieving high-coverage sequencing to map complex genomic variations within cellular landscapes.

An integrated electronic platform with site-specific sensitivity is highly needed for medical applications. Here, Kim et al.report a stretchable prosthetic skin composed of ultrathin single crystalline silicon nanoribbon array, which can sense strain, pressure and temperature spontaneously.

Exome sequencing of 851 trios from more than 2,500 individuals finds 187 genes with de novo mutations that contribute to meningomyelocele (spina bifida) and highlights critical pathways required for neural tube closure.

Ha and colleagues show that loss of PD-1 expression on regulatory T cells in the tumor environment reduces their metabolic fitness and proliferative capacity.

Occurrence of DNA double-strand break (DSB) repair is important for genome integrity. Here, the authors reveal that Pellino1 is a DSB-responsive ubiquitin ligase required for promoting the accumulation of ATM and MRN complex at DSB sites via NBS1 ubiquitination.

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial role for it in maintaining brown adipocyte mitochondrial OXPHOS and thermogenesis upon cold stimulus.

The naïve CD4 T cell compartment is traditionally deemed as homogenous. Here, by leveraging scRNA-seq analysis, the authors reveal the role of naive CD4 T cell heterogeneity in disease states and therapeutic outcomes by characterizing a Th1-poised naive CD4 T cell subpopulation, linked to anti-tumor immunity in mice and responsiveness to anti-PD-1 therapy in humans.

A polymerization method for converting elemental sulfur into a chemically stable, processable and electrochemically active copolymer has been described. This methodology — termed inverse vulcanization — is conducted by a one-step process using liquid sulfur, as both reaction medium and reactant, and vinylic comonomers to form polymeric materials with a high content of sulfur (50–90 wt%).

Tiny copolymer micelles can effectively restore locomotion in rats after spinal cord injury.

By using optoelectronic device arrays for chip-to-chip communication and neuromorphic cores based on memristor crossbar arrays for highly parallel data processing, reconfigurable and stackable hetero-integrated chips can be created for use in edge computing applications.