The functional role of the co-presence of aberrant long non-coding RNAs (lncRNAs) and coding genes in cancer remains poorly understood. Here, the transcriptional regulator Prohibitin 2 (PHB2) is shown to co-regulate the transcription of an oncogenic CASC15- New-Isoform 2 (CANT2) lncRNA and the tumour-suppressor gene CCBE1 accelerating tumorigenesis of melanoma.
- Tianyi Ding
- Haowen Xu
- He Zhang
