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Acta Pharmacologica Sinica (26)
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Showing 1–50 of 93 results

Advanced filters: Author: Jian-Hua Yang Clear advanced filters

Author Correction: Reproductive phasiRNAs regulate reprogramming of gene expression and meiotic progression in rice

Yu-Chan Zhang
Meng-Qi Lei
Yue-Qin Chen
Amendments and CorrectionsOpen Access22 Mar 2023
Nature Communications

Volume: 14, P: 1
Phenylphthalazines as small-molecule inhibitors of urea transporter UT-B and their binding model

Jian-hua Ran
Min Li
Bao-xue Yang
Research30 May 2016
Acta Pharmacologica Sinica

Volume: 37, P: 973-983
Author Correction: Topological Wannier cycles induced by sub-unit-cell artificial gauge flux in a sonic crystal

Zhi-Kang Lin
Ying Wu
Jian-Hua Jiang
Amendments and Corrections04 Mar 2024
Nature Materials

Volume: 23, P: 863
Benzoylaconine induces mitochondrial biogenesis in mice via activating AMPK signaling cascade

Xiao-hong Deng
Jing-jing Liu
Jian-hua Huang
Research12 Oct 2018
Acta Pharmacologica Sinica

Volume: 40, P: 658-665
Author Correction: Topological phenomena at defects in acoustic, photonic and solid-state lattices

Zhi-Kang Lin
Qiang Wang
Jian-Hua Jiang
Amendments and Corrections05 Dec 2023
Nature Reviews Physics

Volume: 6, P: 149
Prognostic nomogram for recurrence of hepatocellular carcinoma after liver transplantation for decision making on postoperative adjuvant therapy

Chen-Hao Gao
Qi-Jian Yu
Zhe Yang
ResearchOpen Access23 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Altered ATP-sensitive potassium channels may underscore obesity-triggered increase in blood pressure

Li-hong Fan
Hong-yan Tian
Yong-xiao Cao
Research01 Oct 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1167-1174
Landform and lithospheric development contribute to the assembly of mountain floras in China

An analysis of 140 floras from China reveals that high species diversity exists in granite and mixed landforms, while low species diversity is found in karst, Danxia, and desert landforms. Based on these findings, the authors provide new clues for understanding the assembly and differentiation of mountain floras, highlighting the role of bedrock and landform processes.

Wan-Yi Zhao
Zhong-Cheng Liu
Wen-Bo Liao
ResearchOpen Access17 Jun 2024
Nature Communications

Volume: 15, P: 1-13
Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity

Comprehensive analyses of Cas9 proteins shed light on the evolution of the CRISPR–Cas9 system, and identify a pro-CRISPR accessory protein in bacteria that boosts CRISPR-mediated immunity by enhancing the DNA binding and cleavage activity of Cas9.

Shouyue Zhang
Ao Sun
Jun-Jie Gogo Liu
Research29 May 2024
Nature

Volume: 630, P: 484-492
Reproductive phasiRNAs regulate reprogramming of gene expression and meiotic progression in rice

21-nucleotide phased secondary siRNAs are expressed in the developing rice anthers during meiosis. Here, the authors show that phasiRNAs can cleave target mRNA and act to ensure the progression of meiosis and fertility in rice.

Yu-Chan Zhang
Meng-Qi Lei
Yue-Qin Chen
ResearchOpen Access27 Nov 2020
Nature Communications

Volume: 11, P: 1-11
Observation of two-dimensional time-reversal broken non-Abelian topological states

Non-Abelian band topology reveals the global quantum geometry of multiple Bloch bands and unveils a new paradigm for topological physics. Here, authors find rich T-broken non-Abelian topological phases and their transitions with an unexpected connection to multigap antichiral edge states.

Yuze Hu
Mingyu Tong
Yihao Yang
ResearchOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-10
Angiotensin-Converting Enzyme Gene 2350 G/A Polymorphism Is Associated with Left Ventricular Hypertrophy but Not Essential Hypertension

Min Pan
Jian-Hua Zhu
Xiang-Jun Yang
Research01 Jan 2007
Hypertension Research

Volume: 30, P: 31-37
Author Correction: Observation of two-dimensional time-reversal broken non-Abelian topological states

Yuze Hu
Mingyu Tong
Yihao Yang
Amendments and CorrectionsOpen Access13 Jan 2025
Nature Communications

Volume: 16, P: 1
Machine learning based early warning system enables accurate mortality risk prediction for COVID-19

Methods to stratify patients according to mortality risk are essential to allocate limited heath resources during the COVID-19 crisis. Here, using machine learning methods, the authors present a mortality risk prediction model for COVID-19 that uses patients’ clinical data on admission to stratify patients by mortality risk.

Yue Gao
Guang-Yao Cai
Qing-Lei Gao
ResearchOpen Access06 Oct 2020
Nature Communications

Volume: 11, P: 1-10
Structure-based drug design of a novel family of chalcones as PPARα agonists: virtual screening, synthesis, and biological activities in vitro

Xiang-hua Li
Han-jun Zou
Jian-hua Shen
Research01 Dec 2007
Acta Pharmacologica Sinica

Volume: 28, P: 2040-2052
Harnessing virus flexibility to selectively capture and profile rare circulating target cells for precise cancer subtyping

The effective isolation of rare target cells, such as circulating tumor cells from whole blood is still challenging. Here, the authors utilize adaptable flexible M13 phage in constructing magnetic beads, forming a deformable surface that can tightly capture CTCs.

Hui-Da Li
Yuan-Qiang Chen
Chuanbin Mao
ResearchOpen Access12 Jul 2024
Nature Communications

Volume: 15, P: 1-17
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

Xuejun Zhang and colleagues report results of a genome-wide association study of systemic lupus erythematosus (SLE) in a Chinese Han population. Their work identifies nine new SLE susceptibility loci and reveals overlap in the spectrum of risk alleles shared between Chinese Han and European populations.

Jian-Wen Han
Hou-Feng Zheng
Xue-Jun Zhang
Research18 Oct 2009
Nature Genetics

Volume: 41, P: 1234-1237
Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy

Centromeres and kinetochores are important in maintaining chromosomal stability. Here, the authors show that overexpression of a subset of centromere and kinetochore genes is associated with chromosomal instability and mutation burden in cancer, and predict patient survival and response to genotoxic therapies.

Weiguo Zhang
Jian-Hua Mao
Gary H. Karpen
ResearchOpen Access31 Aug 2016
Nature Communications

Volume: 7, P: 1-15
Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers

Cross-linking mass spectrometry can provide insights into protein structures and interactions but its scope depends on the reactivity of the cross-linker. Here, the authors develop Arg-Arg and Lys-Arg cross-linkers, which provide structural information elusive to the widely used Lys-Lys cross-linkers.

Alexander X. Jones
Yong Cao
Meng-Qiu Dong
ResearchOpen Access02 Sept 2019
Nature Communications

Volume: 10, P: 1-11
Electrical tuning of branched flow of light

Here the authors experimentally realize the electrical tuning of branched flow of light in nematic liquid crystals. The statistical properties and the polarization effect of the branched flow of light in the film are systematically studied adding fundamental insights on branched flow of light.

Shan-shan Chang
Ke-Hui Wu
Jin-hui Chen
ResearchOpen Access03 Jan 2024
Nature Communications

Volume: 15, P: 1-8
Derivatives of (phenylsulfonamido-methyl)nicotine and (phenylsulfonamido-methyl)thiazole as novel 11β-hydroxysteroid dehydrogenase type 1 inhibitors: synthesis and biological activities in vitro

Xu Zhang
Yang Zhou
Jian-hua Shen
Research24 Aug 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1344-1350
Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation

Hong Wang
Man Yu
Kevin J. Tracey
Research22 Dec 2002
Nature

Volume: 421, P: 384-388
Acteoside-containing caffeic acid is bioactive functional group of antifibrotic effect by suppressing inflammation via inhibiting AHR nuclear translocation in chronic kidney disease

Yan-ni Wang
Xin Wu
Ying-yong Zhao
Research20 Jun 2025
Acta Pharmacologica Sinica

P: 1-14
Long-term increased grain yield and soil fertility from intercropping

Growing demand for food is confronting constraints to its sustainable production. This study finds that intercropping increases grain yields and their stability and that yield benefits increase over time.

Xiao-Fei Li
Zhi-Gang Wang
Long Li
Research04 Oct 2021
Nature Sustainability

Volume: 4, P: 943-950
Bulk–disclination correspondence in topological crystalline insulators

It is experimentally shown that topological states exist at crystallographic defects in the bulk and that disclination defects trap fractional charges characteristic of topological crystalline insulators.

Yang Liu
Shuwai Leung
Jian-Hua Jiang
Research20 Jan 2021
Nature

Volume: 589, P: 381-385
The extracellular domain of Staphylococcus aureus LtaS binds insulin and induces insulin resistance during infection

The extracellular domain of the cell wall protein LtaS is an insulin-binding protein and mediates insulin resistance during Staphylococcus aureus infection.

Yu Liu
Fang-Jie Liu
Guang Yang
Research16 Apr 2018
Nature Microbiology

Volume: 3, P: 622-631
A Pandas complex adapted for piRNA-guided transcriptional silencing and heterochromatin formation

Zhao et al. identify an unexpected role of the nuclear export factor Nxf2 as a partner of Panoramix in mediating piRNA-guided silencing. Nxf2 counteracts Nxf1-centred nuclear RNA transport to prevent the export of transposon transcripts.

Kang Zhao
Sha Cheng
Yang Yu
Research30 Sept 2019
Nature Cell Biology

Volume: 21, P: 1261-1272
Protective effects of iptakalim, a novel ATP-sensitive potassium channel opener, on global cerebral ischemia-evoked insult in gerbils

Hua Chen
Yong Yang
Gang Hu
Research01 Jun 2006
Acta Pharmacologica Sinica

Volume: 27, P: 665-672
Topological Wannier cycles induced by sub-unit-cell artificial gauge flux in a sonic crystal

Gauge fields are essential for detecting and controlling quantum dynamical systems, but their potential has yet to be fully exploited. Here, the authors insert a single-unit-cell synthetic gauge flux into a sonic crystal with the gauge phase ranging from 0 to 2π, leading to topological Wannier cycles.

Zhi-Kang Lin
Ying Wu
Jian-Hua Jiang
Research21 Mar 2022
Nature Materials

Volume: 21, P: 430-437
Mummified Oligocene fruits of Schima (Theaceae) and their systematic and biogeographic implications

Xiang-Gang Shi
Qiong-Yao Fu
Cheng Quan
ResearchOpen Access21 Jun 2017
Scientific Reports

Volume: 7, P: 1-9
Piezo Voltage Controlled Planar Hall Effect Devices

Bao Zhang
Kang-Kang Meng
Kai-You Wang
ResearchOpen Access22 Jun 2016
Scientific Reports

Volume: 6, P: 1-6
Preclinical assessment of the distribution, metabolism, and excretion of S-propargyl-cysteine, a novel H₂S donor, in Sprague-Dawley rats

Yuan-ting Zheng
Jian-hua Zhu
Wei-min Cai
Research30 Apr 2012
Acta Pharmacologica Sinica

Volume: 33, P: 839-844
Associations between Peripheral Thromboembolic Vascular Disease and Androgen Deprivation Therapy in Asian Prostate Cancer Patients

Yu-Chuan Lu
Chao-Yuan Huang
Chi-Jung Chung
ResearchOpen Access02 Oct 2019
Scientific Reports

Volume: 9, P: 1-8
Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect

Hua Cao
Zhi-Xiang Chen
Jian-Hua Shen
ResearchOpen Access24 Jun 2016
Scientific Reports

Volume: 6, P: 1-8
Research on object detection and recognition in remote sensing images based on YOLOv11

Lu-hao He
Yong-zhang Zhou
Jian-hua Ma
ResearchOpen Access23 Apr 2025
Scientific Reports

Volume: 15, P: 1-25
Evolutionary history of the angiosperm flora of China

A dated phylogeny and spatial distribution data for Chinese angiosperms show that eastern China has tended to act as a refugium for older taxa whereas western China has acted as a centre for their evolutionary diversification.

Li-Min Lu
Ling-Feng Mao
Zhi-Duan Chen
Research31 Jan 2018
Nature

Volume: 554, P: 234-238
Synthesis and Properties of Side-Chain Cholesteric Liquid Crystalline Elastomers Containing Tetra-Vinyl Crosslinking Units

Bao-Yan Zhang
Jian-She Hu
Jian-Hua Qian
Research01 Jun 2003
Polymer Journal

Volume: 35, P: 476-483
OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition

Shan-yao Ma
Meng-meng Ning
Ying Leng
Research06 Jun 2016
Acta Pharmacologica Sinica

Volume: 37, P: 1359-1369
K_ATP Channel Openers Facilitate Glutamate Uptake by GluTs in Rat Primary Cultured Astrocytes

Xiu-Lan Sun
Xiao-Ning Zeng
Gang Hu
Research04 Jul 2007
Neuropsychopharmacology

Volume: 33, P: 1336-1342
Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique

Shuai Chen
Li-li Chen
Hua-liang Jiang
Research01 Jan 2005
Acta Pharmacologica Sinica

Volume: 26, P: 99-106
Association analyses identify six new psoriasis susceptibility loci in the Chinese population

Xue-Jun Zhang and colleagues report genome-wide association analyses identifying six new susceptibility loci in the Chinese population.

Liang-Dan Sun
Hui Cheng
Xue-Jun Zhang
Research17 Oct 2010
Nature Genetics

Volume: 42, P: 1005-1009
p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo

Jesus Perez-Losada
Di Wu
Jian-Hua Mao
Research20 Jun 2005
Oncogene

Volume: 24, P: 5521-5524
Comprehensive analysis of Enterobacteriaceae IncX plasmids reveals robust conjugation regulators PrfaH, H-NS, and conjugation-fitness tradeoff

A detailed analysis of IncX plasmids identifies PrfaH as crucial for conjugation and H-NS as a regulator of the balance between conjugation and host fitness, highlighting PrfaH as a potential target for combating antimicrobial resistance.

Jun Yang
Yaoyao Lu
Jian-Hua Liu
ResearchOpen Access04 Mar 2025
Communications Biology

Volume: 8, P: 1-17
Effect of different courses and durations of invasive mechanical ventilation on respiratory outcomes in very low birth weight infants

Yang Yang
Xin-yue Gu
Joseph Ting
ResearchOpen Access03 Nov 2023
Scientific Reports

Volume: 13, P: 1-8
Tumor distribution affects bladder recurrence but not survival outcome of multifocal upper tract urothelial carcinoma treated with radical nephroureterectomy

Zai-Lin Sheu
Chi-Ping Huang
Hsin‑Chih Yeh
ResearchOpen Access24 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Visceral adipose tissue-derived extracellular vesicles promote stress susceptibility in obese mice via miR-140-5p

Hao Wang
Li Zhang
Gang Hu
Research10 Feb 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1221-1235
The marine-derived compound TAG alleviates Parkinson’s disease by restoring RUBCN-mediated lipid metabolism homeostasis

Pei Yang
Yang Liu
Gang Hu
Research27 Mar 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1366-1380
Topological thermal transport

This Perspective summarizes the recent progress of topological physics in thermal metamaterials and thus proposes a new research field, ‘topological thermotics’, which is inspired by topological photonics and topological acoustics in wave metamaterials.

Zhoufei Liu
Peng Jin
Jiping Huang
Reviews15 Aug 2024
Nature Reviews Physics

Volume: 6, P: 554-565
mTORC2 acts as a gatekeeper for mTORC1 deficiency-mediated impairments in ILC3 development

Ya-fei Deng
Shu-ting Wu
You-cai Deng
Research05 Jul 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2243-2252
Topological phenomena at defects in acoustic, photonic and solid-state lattices

Topological lattice defects in topological materials offer a platform to explore a diverse range of phenomena, including fractional charges, chiral and gravitational anomalies, topological lasers and non-Hermitian skin effects. This Perspective article surveys the impact of these phenomena on condensed matter physics, photonics, acoustics and materials science.

Zhi-Kang Lin
Qiang Wang
Jian-Hua Jiang
Reviews10 Jul 2023
Nature Reviews Physics

Volume: 5, P: 483-495

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