Nature Search

Discovery and characterization of a novel inhibitor of CDC25B, LGH00045

Xu Feng
Li-na Wang
Jia Li
Research01 Oct 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1268-1274
Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

Mei Zhang
Zhi-fu Xie
Jing-ya Li
Research24 May 2018
Acta Pharmacologica Sinica

Volume: 39, P: 1622-1632
Discovery of novel PTP1B inhibitors with antihyperglycemic activity

Zhang Liu
Qian Chai
Jing-kang Shen
Research05 Aug 2010
Acta Pharmacologica Sinica

Volume: 31, P: 1005-1012
Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening

Lei Shi
Hai-ping Yu
Jia Li
Research01 Feb 2008
Acta Pharmacologica Sinica

Volume: 29, P: 278-284
Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids

Yi-ping Zhu
Kun Xiao
Jing-kang Shen
Research26 Jan 2009
Acta Pharmacologica Sinica

Volume: 30, P: 259-269
2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

Jin Zhang
Li-na Zhang
Jing-ya Li
Research16 Mar 2015
Acta Pharmacologica Sinica

Volume: 36, P: 483-496
LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation

Yu-bo Zhou
Xu Feng
Jia Li
Research04 Sept 2009
Acta Pharmacologica Sinica

Volume: 30, P: 1359-1368
Discovery of a novel inhibitor of NAD(P)⁺-dependent malic enzyme (ME2) by high-throughput screening

Yi Wen
Lei Xu
Jia Li
Research31 Mar 2014
Acta Pharmacologica Sinica

Volume: 35, P: 674-684
Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells

Yue-peng Cao
Jing-ya Sun
Xiang Yan
Research14 Feb 2019
Acta Pharmacologica Sinica

Volume: 40, P: 1076-1084
Live-cell synthesis of biocompatible quantum dots

Quantum dots can be synthesized in live yeast, bacterial and mammalian cells by controlling the temporal and spatial pattern of specific metabolic reactions via the timed supply of chemicals.

An-An Liu
Ran Cui
Dai-Wen Pang
Protocols17 Mar 2025
Nature Protocols

Volume: 20, P: 1884-1914
Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH

Yu-feng Li
Zhi-fu Xie
Jing-ya Li
Reviews01 Feb 2022
Acta Pharmacologica Sinica

Volume: 43, P: 1141-1155
Precise tracking of nanoparticles in plant roots

This protocol for the precise tracking of nanoparticles in plant roots uses CLSM for macroscopic tissue examination and TEM for cellular-level analysis and provides methodologies for preparing plant materials before imaging.

Xiao-Dong Sun
Jing-Ya Ma
Xian-Zheng Yuan
Protocols05 Sept 2024
Nature Protocols

Volume: 20, P: 248-271
Latency period of PROM at term and the risk of neonatal infectious diseases

Lu Zhuang
Zhan-Kui Li
Zhi-Chun Feng
ResearchOpen Access18 Jul 2022
Scientific Reports

Volume: 12, P: 1-9
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain

Teng-teng Li
Cheng Peng
Jing-ya Li
Research14 Dec 2021
Acta Pharmacologica Sinica

Volume: 43, P: 2147-2155
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue

Bo-han Li
Mei Zhang
Jing-ya Li
Research15 Sept 2020
Acta Pharmacologica Sinica

Volume: 42, P: 964-974
Single cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch

Fa-Li Zhang
Yan-Qin Feng
Wei Shen
ResearchOpen Access17 Feb 2023
Cell Death & Disease

Volume: 14, P: 1-12
AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models

Shui-mei Sun
Zhi-fu Xie
Jing-ya Li
Research28 Jul 2020
Acta Pharmacologica Sinica

Volume: 42, P: 585-592
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice

Yan-yan Yu
Shi-chao Cui
Jing-ya Li
Research22 Jul 2020
Acta Pharmacologica Sinica

Volume: 42, P: 272-281
Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

Yu-ting Lu
Yu-feng Xiao
Jing-ya Li
Research18 Dec 2018
Acta Pharmacologica Sinica

Volume: 40, P: 908-918
Effects of physical activity and stress on the relationship between social capital and quality of life among breast cancer survivors

Jie Zhao
Yong Ma
Jin-Ming Yu
ResearchOpen Access20 Oct 2020
Scientific Reports

Volume: 10, P: 1-12
CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

In the glioma microenvironment, tumor-associated macrophages secrete large amounts of chemokine (C-C motif) ligand 8 CCL8, which contributes to pseudopodia formation of glioblastoma cells and promotes progression of glioma. CCL8 induces invasion and stem-like traits of glioblastoma cells via CCR1/ CCR5-mediated ERK1/2 activation.

Xiang Zhang
Lu Chen
Xiu-wu Bian
Research20 Nov 2019
Laboratory Investigation

Volume: 100, P: 619-629
Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria

Xiao-Qing Xie
Yi Yang
Xiu-Wu Bian
ResearchOpen Access10 Jan 2023
Cell Research

Volume: 33, P: 215-228
High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas

The authors identified tissue inhibitor of metalloproteinase-1 (TIMP1) as an important regulator of tissue stiffness in isocitrate dehydrogenase (IDH)-wild type (WT) gliomas. TIMP1 knockdown decreases tissue stiffness, inhibited the expression of tenascin C and fibronectin, and suppressed tumor progression. These results suggest that TIMP1 could be a potential therapeutic target for IDH-WT gliomas.

Chun-Hua Luo
Yu Shi
Yi-Fang Ping
Research26 Jul 2022
Laboratory Investigation

Volume: 102, P: 1304-1313
Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells

Yi Liu
Ke-xin Zhu
Fa-jun Nan
Research16 Jan 2020
Acta Pharmacologica Sinica

Volume: 41, P: 813-824

Search

Discovery and characterization of a novel inhibitor of CDC25B, LGH00045

Novel substituted pyrazolone derivatives as AMP-activated protein kinase activators to inhibit lipid synthesis and reduce lipid accumulation in ob/ob mice

Discovery of novel PTP1B inhibitors with antihyperglycemic activity

Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening

Discovery of potent β-secretase (bace-1) inhibitors by the synthesis of isophthalamide-containing hybrids

2-(3-Benzoylthioureido)-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid ameliorates metabolic disorders in high-fat diet-fed mice

LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation

Discovery of a novel inhibitor of NAD(P)⁺-dependent malic enzyme (ME2) by high-throughput screening

Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells

Live-cell synthesis of biocompatible quantum dots

Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH

Precise tracking of nanoparticles in plant roots

Latency period of PROM at term and the risk of neonatal infectious diseases

Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain

Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue

Single cell epigenomic and transcriptomic analysis uncovers potential transcription factors regulating mitotic/meiotic switch

AMPK activator C24 inhibits hepatic lipogenesis and ameliorates dyslipidemia in HFHC diet-induced animal models

Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice

Sulfuretin protects hepatic cells through regulation of ROS levels and autophagic flux

Effects of physical activity and stress on the relationship between social capital and quality of life among breast cancer survivors

CCL8 secreted by tumor-associated macrophages promotes invasion and stemness of glioblastoma cells via ERK1/2 signaling

Targeting ATAD3A-PINK1-mitophagy axis overcomes chemoimmunotherapy resistance by redirecting PD-L1 to mitochondria

High levels of TIMP1 are associated with increased extracellular matrix stiffness in isocitrate dehydrogenase 1-wild type gliomas

Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells

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