Adipose tissue macrophages are intimately involved with adipocytes to orchestrate whole-body energy metabolism. Qiu and colleagues show that myeloid-specific deletion of the homeobox protein IRX3 protects against diet-induced obesity, excessive proinflammatory cytokine secretion and metabolic diseases via increasing adaptive thermogenesis.
- Jingfei Yao
- Dongmei Wu
- Yifu Qiu
