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Here, the authors develop a microneedle system that converts 5-ALA photodynamic byproducts into therapeutic fuel, enhancing ferroptosis and improving hypertrophic scar treatment.

The authors find that electric-field gating-controlled lithium intercalation can switch FeSe reversibly between a nonmagnetic superconducting state and a high-temperature superconducting ferromagnetic state. Further, scanning-SQUID magnetometry reveals that the ferromagnetic domains survive deep in the Meissner state and coexist spatially.

The topological surface states usually appear in pairs in a topological insulator, with one on the top surface and the other on the bottom surface. Here, Zhang et al. utilize Co cluster to induce a Zeeman gap on one surface through antiferromagnetic exchange coupling, and observe a quasi-half-integer plateau, suggesting the parity anomaly of Dirac fermions.

Commonly used opioids for pain management primarily target the mu opioid receptor. However, mu opioid receptor agonists often come with harmful side effects. Here, the authors report the results of two phase 3 trials of HSK21542 (anrikefon), a highly selective activator of peripheral kappa opioid receptor agonists, for postoperative pain treatment following abdominal surgery.

Current DNA computational systems are constrained by integration efficiency, device structures and limited functions. Here the authors design a DNA arithmetic logic unit that uses polymerase-mediated strand displacement.

Spectroscopic signatures of magnetic response in topological materials remain very limited. Here, the authors observe a quasi-linear field dependent transverse magnetization and a non-saturating parallel magnetization in a Weyl semimetal TaAs under strong magnetic field, suggesting a signature of relativistic quasiparticles in topological materials.

Monolayers of transition metal dichalcogenides have many of the properties required for applications in spintronics and valleytronics. Here, the authors experimentally observe intervalley quantum interference involving conduction band Q-valleys in tungsten diselenide.

Enzyme-catalyzed biodegradation is an emerging green strategy for environmental remediation, although challenged by high cost and poor robustness. Here, the authors report a cellulose derived hydrogel with immobilized laccase for water remediation.

This study reveals that E. coli lipoate-protein ligase A (LplA) exhibits reversible phase separation and forms condensates in cells, which can be specifically regulated by small molecules, offering chemical tools for synthetic biology and biomedicine.

Use of immobilized enzymes in bioremediation has potential in water treatment, but limited enzymatic activity and stability can cause issues. Here, the authors report the development of a strategy to immobilize enzymes within a hydrogel while maintaining good activity against a range of pollutants.

In-depth transcriptomic analyses of 56,636 single cells from monkey embryos revealed transcriptional features of major perigastrulation cell types, and comparative analyses with mouse embryos and human embryoids uncovered conserved and divergent features of perigastrulation development across species.

Hashimoto’s thyroiditis (HT) is the main cause of hypothyroidism. Here the authors develop a deep learning model for diagnosis of HT on a large multi-site dataset including image and video data.

Biomaterials have potential in treating periodontitis in diabetes, but addressing the range of issues with one material is challenging. Here, the authors report the development of a redox-active hydrogel for reducing inflammation and promoting tissue regeneration in diabetic periodontitis.

The design of programmable artificial photosynthetic cells is hindered by the requirement for cofactor generation for the biocatalytic module. Here, the authors report on the design of artificial photosynthetic cells using biotic–abiotic thylakoid–CdTe as hybrid energy modules, which enhance the regeneration of NADPH, NADH and ATP cofactors without external supplements by promoting proton-coupled electron transfer.

Topological flat bands offer a solid-state platform for studying the interplay between topology and electron correlations. Here, the authors demonstrate that a prototypical 3D Dirac material can host topological flat bands under magnetic fields due to polar-distortion-assisted Rashba splitting.

Advancements in methods that enable in vitro culture of mammalian embryos have become an essential way of investigating mammalian early embryonic development and modeling developmental and pregnancy-related disorders. Here, we discuss the recent method development in this space and analyze current challenges and future directions.

In three-dimensional metals, topological objects known as Weyl nodes can arise from a crossing of the conduction and valence bands. Experiments under high magnetic fields show how Weyl nodes of opposite chiralities can move together to annihilate.

The energy density of dielectric ceramic capacitors is limited by low breakdown fields. Here, by considering the anisotropy of electrostriction in perovskites, it is shown that <111>-textured Na_0.5Bi_0.5TiO₃–Sr_0.7Bi_0.2TiO₃ ceramics can sustain higher electrical fields and achieve an energy density of 21.5 J cm⁻³.

Using the lifespan brain chart and two large-scale cross-cultural consortia (ABIDE and CABIC), we disentangle the heterogeneity of brain morphology in ASD into two structural impairment pathways that could disrupt sensory to association functions.

Despite of the high demand of chiral allenes, their asymmetric synthesis remains a challenge for organic chemists. Here, the authors report a stereodivergent synthesis of trisubstituted allenes via asymmetric additions of oxazolones to activated 1,3-enynes enabled by modification of chiral phosphoric acid catalysts.

Only a few relaxors can be grown into crystals, which show high piezoelectricity, but their operable temperature range is limited by the low phase transition temperature. Here, the authors develop an approach to fabricate textured relaxor ceramics with elevated phase transition temperatures.

DNA 5-hydroxymethylcytosine (5hmC) is mapped in mouse preimplantation embryos, postimplantation epiblasts, primordial germ cells (PGCs) and gametes. Nlrp14 maternal depletion perturbs DNA-replication-coupled passive demethylation and impairs 5hmC deposition.

Mobile excitons in metals have been elusive, as screening usually suppresses their formation. Here, the authors demonstrate such mobile bound states in quasi-one-dimensional metallic TaSe₃, taking advantage of its low dimensionality and carrier density.

A new type of cyclotron orbit combining surface Fermi arcs and bulk states in topological semimetals has recently been proposed as Weyl orbit. Here, Zhang et al. report the evolution of Shubnikov-de Haas oscillations in Dirac semimetal Cd₃As₂ nanoplates along with a quantum Hall state possibly arising from such Weyl orbit.

Functional peptides can be encoded by short open reading frames in non-coding RNA. Here, the authors identify a 87aa peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT) that can reduce glioblastoma proliferation via interaction with PAF1 which sequentially inhibits the transcriptional elongation of some oncogenes.

This protocol describes the in vitro culture of cynomolgus monkey embryos from blastocyst to early organogenesis. Given the ethical limitations restricting the use of human embryos beyond 14 days, nonhuman primate embryos are an ideal model.

Pregnant corin- or ANP-deficient mice have impaired trophoblast invasion and uterine spiral artery remodelling, and patients with pre-eclampsia have lower uterine corin messenger RNA and protein levels than normal pregnancies, suggesting that defects in corin and ANP function may contribute to pre-eclampsia.