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Trypanosoma cruzi, the protozoan parasite causing Chagas disease, encodes a miniature mechanosensitive channel critical for development and infectivity. Here, the authors reveal a direct lipid-mediated mechanical gating transition upon channel activation.

Materials with opposite signs of permittivity along the two orthogonal directions can support hyperbolic polaritons. Here, the authors demonstrate tunable broadband near-infrared hyperbolic plasmon polaritons in MoOCl₂.

Electronic components made from two-dimensional MoTe₂ can be chemically synthesized and integrated in a single step, creating devices in which each component in the active layer is connected via covalent bonds.

Hybrid organic-inorganic trihalide perovskites can make remarkable optoelectronic devices but their spin characteristics are less investigated. Here Wang et al. show spin-polarized carriers injection into methylammonium lead bromide films with long lifetime and realize spin LEDs and spin valves.

Identifying the crystallographic orientations of 2D materials is important, but methods to do so are typically destructive. Here, the authors show that the orientational dependency of self-assembled nanoribbons of oleamide molecules can be used to non-invasively probe the lattice orientations of various 2D substrates.

Rashan, Bartlett and colleagues show that mammalian 4-hydroxy fatty acids are primarily catabolized by ACAD10 and ACAD11 (atypical mitochondrial and peroxisomal acyl-CoA dehydrogenases, respectively) that use phosphorylation in their reaction mechanisms.

Rice coordinates recruitment of the root microbiota to optimize nitrogen acquisition from soil.

Photonic crystals (PhCs) are artificial periodic materials that can be used to manipulate the flow of light. Here, the authors report the realization of asymmetric PhCs based on in-plane hyperbolic phonon polaritons in perforated α-MoO₃, showing low-symmetry deep-subwavelength Bloch modes that are robust against lattice rearrangement in specific directions.

Fluorescence imaging in the near-infrared window between 1500–1700 nm (NIR-IIb window) offers superior spatial resolution and tissue penetration depth, but few NIR-IIb probes exist. Here, the authors synthesize rare earth down-converting nanocrystals as promising fluorescent probes for in vivo imaging in this spectral region.

Small cell lung cancer (SCLC) may evolve under treatment. But tumor tissues are often not available to study evolution of SCLC. Here, the authors utilize circulating tumor DNA to investigate the genomic evolution and subclonal architecture of SCLC during therapy.

Colorectal cancer patients with mismatch repair-deficient, but not MMR-proficient tend to benefit from immune checkpoint blockade therapy. Here, the authors identify interactions among tumor and immune cells that are associated with the responsiveness to immunotherapy in colorectal cancer.

Larger orbital polarization is highly desired in the nickelate-based superconductivity. Here, the authors report on the improved conduction and large in-plane polarization up to 35% in ultrathin LaNiO₃ layer with a distinct octahedron rotation.

Lu et al. demonstrate that allergens induce the formation of eosinophil extracellular traps, which activate pulmonary neuroendocrine cells to secrete neuropeptides and neurotransmitters as well as amplify allergic immune responses.

Coal–biomass co-firing power plants with retrofitted carbon capture and storage are seen as a promising decarbonization solution for coal-dominant energy systems. Framework with spatially explicit biomass sources, plants and geological storage sites demonstrate its effectiveness in China.

Attempts to extend the range of reversible intercalation stoichiometries in selenides are promising but challenging. Here, authors report a reversible controlled superstoichiometric intercalation in NbSe₂ with up to two copper-ions per molecule by triggering anionic redox.

Li et al. demonstrate mitochondrial fission in macrophages as key for phagocytosis induced by therapeutic antibodies. They identify overexpression of GFPT2 as an inhibitor of the process and phase transition of the phagocytic machinery as its regulator.

Using structural and electrophysiological analysis, authors demonstrated that the mitochondrial MRS2 channel is a calcium-regulated nonselective cation channel.

Imaging in the second near-infrared window has attracted attention due to superior penetration depth and low signal interference. Here, the authors describe a new organic nano fluorophore with high quantum yield and demonstrate its use for in vivo imaging.

The Arabidopsis mechanosensitive channel MSL10 plays a crucial role in hypo-osmotic shock adaptation and programmed cell death induction. Here, the authors reveal the structural mechanism underlying MSL10 channel gating.

Current methods to construct helical chiral molecules for asymmetric catalysis almost entirely rely on catalytic enantiocontrolled fused-ring system extension. Herein, the authors report a direct terminal peri-functionalization strategy, which allows for efficient assembling of substituted carbohelicenes via an organocatalyzed enantioselective amination reaction.

The application of Li-metal batteries (LMBs) is impeded by unstable solid electrolyte interphase (SEI) and uncontrollable Li dendrites growth. Here, the authors present an YF₃/PMMA composite layer to achieve high-performance LMBs via the synergetic regulation of SEI mechanics and Li crystallography.

Infectious respiratory viruses have been an everlasting threaten to public health. Here, authors report a wireless immunoassay technology based on immuno-responsive hydrogel-modulated resonant sensors, which facilitate on-site respiratory virus surveillance.

While the prognostic role of immunoglobulin heavy chain locus (IGH) rearrangement in minimal residual disease (MRD) in pediatric B-acute lymphoblastic leukemia (B-ALL) has been reported, the contribution of light chain loci (IGK/IGL) remains elusive. Here, the authors investigate it using a next generation sequencing approach.

High-speed atomic force microscopy single-molecule imaging and cryo-EM analysis discover and reveal the structure of a TRPV3 pentamer, providing evidence for a non-canonical pentameric TRP-channel assembly, laying the foundation for new directions in TRP channel research.

Active-state structures of the κ-opioid receptor in complexes with the G-protein heterotrimers G_i1, G_oA, G_z and G_g provide insights into the actions of hallucinogenic opioids and G-protein-coupling specificity at the κ-opioid receptor.

NaO^tBu — an alkoxide salt — enables simple access to low-oxidation-state catalysis using sustainable first-row transition metals (Fe, Co, Mn, Ni). The approach works across a wide range of reductive alkene and alkyne functionlization reactions including hydroboration, hydrosilylation, hydrogenation, hydrovinylation and [2π+2π] cyclization reactions.

Mechanosensitive channels transduce physical force into electrochemical signaling in processes such as hearing, touch, proprioception, osmoregulation, and morphogenesis. Here, authors use cryo-electron microscopy to provide structural insights into the mechanical gating mechanism.

Evolution- and structure-guided mutagenesis allows elucidation of the solution NMR structure of the N-terminal domain of APOBEC3G. Mapping of HIV-1 Vif binding to the APOBEC3G NTD reveals an interaction interface distinct from those in other APOBEC3 proteins.

China’s main rivers have experienced a 38.9% decline in free-flowing length and widespread fragmentation, especially in small and high-altitude headwater rivers, due to a surge in dam construction from 1970 to 2020, according to a newly developed high-resolution, spatio-temporal riverine reservoir inventory.

Identification of TRPV3 channel residues interacting with intracellular spermine and high resolution structure of a non-conducting TRPV3 in the presence of NASPM suggest a unifying molecular model to explain spermine block of TRPV1-4 channels.

Cultivating native bacteria from fresh plant roots is essential for understanding their interaction with the host plant. This protocol describes their isolation and accurate taxonomical identification using two-sided barcode polymerase chain reaction and Illumina sequencing.

Homology-directed DNA repair using RNA as a template enables precise gene replacement in rice.