Nature Search

DeepSeek-R1 incentivizes reasoning in LLMs through reinforcement learning

A new artificial intelligence model, DeepSeek-R1, is introduced, demonstrating that the reasoning abilities of large language models can be incentivized through pure reinforcement learning, removing the need for human-annotated demonstrations.

Daya Guo
Dejian Yang
Zhen Zhang
ResearchOpen Access17 Sept 2025
Nature

Volume: 645, P: 633-638
Near-visible integrated soliton microcombs with detectable repetition rates

Integrated optical frequency combs are powerful tools for optical spectroscopy. Here, authors demonstrate low-power, detectable-rate soliton microcombs from telecom to visible bands, including wavelength-multiplexed operation, using ultra-low-loss silicon nitride waveguides.

Peng Liu
Qing-Xin Ji
Kerry J. Vahala
ResearchOpen Access22 May 2025
Nature Communications

Volume: 16, P: 1-6
Obesity-associated macrophages dictate adipose stem cell ferroptosis and visceral fat dysfunction by propagating mitochondrial fragmentation

Obesity induces adipose stem cell (ASC) exhaustion and impairs adipose function. Here, the authors reveal that macrophages in visceral fat lose TIPE2 in obesity, which drive ASC ferroptosis via mitochondrial transfer, thereby disrupting adipose homeostasis and metabolic health.

Yan Tao
Jinhao Zang
Qun Wang
ResearchOpen Access14 Aug 2025
Nature Communications

Volume: 16, P: 1-20
A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma

Thyroidectomy is frequently the treatment offered to patients with low-risk papillary thyroid microcarcinoma (PTMC). Here, the authors perform a multicentre online survey to a cohort of patients with PTMC showing that heightened regret may not be an experience of a minority of clinically low-risk PTMC patients and is primarily due to lower postoperative quality of life.

Genpeng Li
Ruicen Li
Jianyong Lei
ResearchOpen Access08 Mar 2025
Nature Communications

Volume: 16, P: 1-11
Response of the gut microbiota to changes in the nutritional status of red deer during winter

Jinhao Guo
Zheng Li
Minghai Zhang
ResearchOpen Access23 Oct 2024
Scientific Reports

Volume: 14, P: 1-12
Systemic and dynamic risk analysis of drilling construction based on bayesian network and system dynamics model

Jinhao Zhang
Lirong Wu
Dun Wu
ResearchOpen Access31 Jul 2025
Scientific Reports

Volume: 15, P: 1-20
Deciphering cell–cell communication at single-cell resolution for spatial transcriptomics with subgraph-based graph attention network

cell–cell communication (CCC) is crucial for understanding biological processes. Here, authors present DeepTalk, which combines single-cell RNA sequencing and spatial transcriptomics data to infer cell–cell communication at single-cell resolution, revealing intricate intercellular dynamics within tissues.

Wenyi Yang
Pingping Wang
Qinghua Jiang
ResearchOpen Access18 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Topological segregation of stress sensors along the gut crypt–villus axis

Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of the gut.

Kouki K. Touhara
Nathan D. Rossen
David Julius
Research12 Feb 2025
Nature

Volume: 640, P: 732-742
Silent magnetic resonance angiography diagnostic value of intracranial unruptured aneurysms

Bin Lv
Tingyang Zhang
Chenglin Tian
ResearchOpen Access07 Feb 2025
Scientific Reports

Volume: 15, P: 1-8
Soft robotic hand with tactile palm-finger coordination

Robotic hands with tactile sensing hold potential for interactive operations, yet palm sensing remains underexplored. Here, authors present a robotic hand that integrates a high-density tactile palm with soft, dexterous fingers, enhancing palm-finger coordination for improved robotic operation and perception.

Ningbin Zhang
Jieji Ren
Xiangyang Zhu
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-14
Multimaterial cryogenic printing of three-dimensional soft hydrogel machines

Hydrogel-based machines have potential in a range of applications, but it can be challenging to prepare multimaterial devices with complex structures. Here, the authors report the development of a multimaterial cryogenic printing technique that can be used to prepare three-dimensional structures with geometries such as overhanging, thin-walled and hollow.

Jinhao Li
Jie Cao
Guoying Gu
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-9
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59
Maternal circadian rhythm disruption affects neonatal inflammation via metabolic reprograming of myeloid cells

In mice, disruption of circadian rhythms during pregnancy aggravates neonatal inflammation via metabolic reprograming of myeloid cells in the offspring.

Zhaohai Cui
Haixu Xu
Jie Zhou
Research01 Apr 2024
Nature Metabolism

Volume: 6, P: 899-913
Consensus statement on Brillouin light scattering microscopy of biological materials

Brillouin scattering microscopy is prone to artefacts and inconsistencies. This Consensus statement provides recommendations for measuring and reporting relevant parameters with the aim of standardizing protocols and improving the comparability of studies.

Pierre Bouvet
Carlo Bevilacqua
Kareem Elsayad
Reviews03 Jul 2025
Nature Photonics

Volume: 19, P: 681-691
Astrocyte-derived CXCL10 exacerbates endothelial cells pyroptosis and blood–brain barrier disruption via CXCR3/cGAS/AIM2 pathway after intracerebral hemorrhage

Wenqianjun Sheng
Zhangyi Wu
Qinghua Wang
ResearchOpen Access08 Aug 2025
Cell Death Discovery

Volume: 11, P: 1-15
Brainstem Dbh⁺ neurons control allergen-induced airway hyperreactivity

Mapping a full allergen circuit from the lung to the brainstem and back, repeated exposure of mice to inhaled allergen activated the nuclei of solitary tract neurons in a mast cell-, interleukin-4- and vagal nerve-dependent manner.

Yujuan Su
Jinhao Xu
Xin Sun
ResearchOpen Access10 Jul 2024
Nature

Volume: 631, P: 601-609
Stretchable surface electromyography electrode array patch for tendon location and muscle injury prevention

Stretchable surface electromyography electrodes with high signal-to-noise ratios and stable recordings are challenging to develop. Here, Yang et al. design a gel-free metal-polymer electrode array patch for long-term continuous monitoring of tendon displacement and muscle stress for injury prevention.

Shuaijian Yang
Jinhao Cheng
Xingyu Jiang
ResearchOpen Access14 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Robustly printable freeform thermal metamaterials

Thermal metamaterials can be used to manipulate heat flow but experimental fabrication is challenging. Here, the authors report robustly printable freeform thermal metamaterials to tackle this challenge by topology optimization and 3D printing.

Wei Sha
Mi Xiao
Run Hu
ResearchOpen Access10 Dec 2021
Nature Communications

Volume: 12, P: 1-8
Theoretical analysis of dynamic sliding mechanism of rock slope with a bedding structural plane based on stress wave propagation

Shaobo Chai
Boyang Song
Jiehui Shi
ResearchOpen Access28 Feb 2025
Scientific Reports

Volume: 15, P: 1-17
Biomimetic high performance artificial muscle built on sacrificial coordination network and mechanical training process

Artificial muscles have a wide range of applications yet truly mimetic designs remain a challenge. Here, the authors use dynamic sacrificial bonds which are rearranged via a mechanical training process to optimise the characteristics of self-strengthening, strain-adaptive stiffening and actuation.

Zhikai Tu
Weifeng Liu
Hongming Lou
ResearchOpen Access18 May 2021
Nature Communications

Volume: 12, P: 1-11
Biomechanical and neuromuscular adaptations in joint contributions during loaded countermovement jumps

Xin Zhang
Xin Zhang
Chenxuan Feng
ResearchOpen Access31 May 2025
Scientific Reports

Volume: 15, P: 1-12
A N7-methylguanosine modified circular RNA, circIPP2A2, promotes malignant behaviors in hepatocellular carcinoma by serving as a scaffold in modulating the Hornerin/PI3K/AKT/GSK3β axis

Zeyi Guo
Zhongzhe Li
Shunjun Fu
ResearchOpen Access30 Nov 2024
Cell Death & Disease

Volume: 15, P: 1-14
Deciphering the impact of genomic variation on function

The Impact of Genomic Variation on Function Consortium is combining single-cell mapping, genomic perturbations and predictive modelling to investigate relationships between human genomic variation, genome function and phenotypes and will provide an open resource to the community.

Jesse M. Engreitz
Heather A. Lawson
Ella K. Samer
Reviews04 Sept 2024
Nature

Volume: 633, P: 47-57
3D-printed PEDOT:PSS for soft robotics

Combining poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) with 3D-printing techniques enables the customization of compliant conductive materials for soft robotics, towards the goal of merging humans and robots. This Review discusses the fundamentals of 3D-printed PEDOT:PSS for soft robotics, from printable ink design and evaluation to printing strategies and promising soft robotic systems.

Jinhao Li
Jie Cao
Guoying Gu
Reviews24 Aug 2023
Nature Reviews Materials

Volume: 8, P: 604-622
Original vegetation condition and precipitation growth rate bifurcate sediment flux trend on the Qinghai-Tibet Plateau

Multivariate climate elasticity modelling of pathway-specific contributions to sediment dynamics in the Qinghai-Tibet Plateau suggest sediment trend bifurcations are driven by interactions among precipitation, temperature, and vegetation under climate change

Jinhao Guo
Yao Yue
Zhonghua Yang
ResearchOpen Access07 Feb 2025
Communications Earth & Environment

Volume: 6, P: 1-10
Talaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing

The study explores immune evasion mechanisms of T. marneffei infection, highlighting the role of alternative splicing (AS). T. marneffei triggers the upregulation of NCOR2-013, inhibiting pro-inflammatory cytokine production via histone acetylation. TUT1 regulates NCOR2-013, contributing to immune evasion. This sheds light on T. marneffei’s immune evasion at the molecular level, offering potential talaromycosis therapy targets.

Wudi Wei
Gang Wang
Hao Liang
ResearchOpen Access16 Oct 2023
Communications Biology

Volume: 6, P: 1-16
Correction: TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas

Jiabo Li
Xuya Wang
Xuejun Yang
Amendments and CorrectionsOpen Access26 Jan 2024
Cancer Gene Therapy

Volume: 31, P: 495-496
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma

Xuya Wang
Xisen Wang
Xuejun Yang
ResearchOpen Access25 Nov 2022
Cancer Gene Therapy

Volume: 30, P: 345-357
Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases

Xian Zhang
Jun Yang
Junping Li
ResearchOpen Access27 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
CRP and IHF act as host regulators in Royal Jelly's antibacterial activity

Zhenyu Xia
Yunchang Li
Yue Hao
ResearchOpen Access21 Aug 2024
Scientific Reports

Volume: 14, P: 1-15
Discovery of an OTUD3 inhibitor for the treatment of non-small cell lung cancer

Yonghui Zhang
Tongde Du
Peiyu Li
ResearchOpen Access27 Jun 2023
Cell Death & Disease

Volume: 14, P: 1-14
TMEM158 promotes the proliferation and migration of glioma cells via STAT3 signaling in glioblastomas

Jiabo Li
Xuya Wang
Xuejun Yang
ResearchOpen Access06 Jan 2022
Cancer Gene Therapy

Volume: 29, P: 1117-1129
Lingering shadows: the negative effects of incivility on volunteers

Qing Miao
Jinhao Huang
Hui Yin
ResearchOpen Access20 Dec 2023
Humanities and Social Sciences Communications

Volume: 10, P: 1-8
Biomolecule sensors based on organic electrochemical transistors

Zhongyou Lu
Kun Xu
Wei Huang
ReviewsOpen Access13 Feb 2025
npj Flexible Electronics

Volume: 9, P: 1-30
FAM201A encodes small protein NBASP to inhibit neuroblastoma progression via inactivating MAPK pathway mediated by FABP5

The long non-coding RNA FAM201A encodes a short peptide NBASP that suppresses neuroblastoma carcinogenesis by down-regulating FABP5 to inactivate the MAPK pathway.

Mujie Ye
Runnan Gao
Kuiran Dong
ResearchOpen Access12 Jul 2023
Communications Biology

Volume: 6, P: 1-12
Synergistic inhibition effects of andrographolide and baicalin on coronavirus mechanisms by downregulation of ACE2 protein level

Lina Wan
Yuchen Li
Jianyuan Tang
ResearchOpen Access21 Feb 2024
Scientific Reports

Volume: 14, P: 1-10
Electronic exoneuron based on liquid metal for the quantitative sensing of the augmented somatosensory system

Jin Shang
Lixue Tang
Xingyu Jiang
ResearchOpen Access15 Sept 2023
Microsystems & Nanoengineering

Volume: 9, P: 1-13
Chinese diabetes datasets for data-driven machine learning

Qinpei Zhao
Jinhao Zhu
Congrong Wang
ResearchOpen Access19 Jan 2023
Scientific Data

Volume: 10, P: 1-8
Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and universal influenza vaccines

Pan Huang
Lujia Sun
Chungen Pan
ReviewsOpen Access16 Jun 2023
Cell Discovery

Volume: 9, P: 1-13
The role of microRNAs in bone remodeling

Dian Jing
Jin Hao
Zhi-He Zhao
ReviewsOpen Access24 Jul 2015
International Journal of Oral Science

Volume: 7, P: 131-143

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