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Here, the authors introduce information isotopes, a novel framework for tracing unauthorized training data in black-box AI systems, offering a practical tool for auditing data provenance and protecting data rights.

Light-emitting diodes with suppressed efficiency roll-off can be created by intercalating oxygen plasma into few-layer molybdenum disulfide and tungsten disulfide.

Achieving complete coverage of 2-4 μm pyramids on industrial fully-textured silicon with solution processed perovskite film remains challenging. Here, authors spray-coat alumina particles on silicon for near-conformal deposition of perovskites, achieving efficiency of 32.74% for tandem solar cells.

Electronic metal-support interaction within Pd/TiO₂ are optimized for photocatalytic H₂O₂ evolution and furfural oxidation to furoic acid, realizing the simultaneous utilization of photogenerated electrons and holes for dual value-added products.

The heterogeneity of HSPCs in response to IR stress remains poorly characterized. Here, the authors provide insights into the molecular intricacies of IR-induced BM injury and reveal the roles of BMP4-BMPR2 signaling in radiation resistance of HSCs.

A bioinspired microneedle patch mimics the natural rhythm of human growth hormone secretion by combining burst-release and delayed-release modules to promote improved bone growth in mice and rats.

Organic memory devices, with small dimension, fast speed and long retention are promising candidates for data archiving. Here, the authors present a molecular hard-disk logic scheme capable of executing in-situ encryption of data in pW/bit power-consumption range.

Continuous directed evolution of base editors (BEs) has been successful in bacteria cells, but not yet in mammalian cells. Here, the authors report a Continuous Directed Evolution system in Mammalian cells (CDEM) enabling the BE evolution in a full-length manner with Cas9 nickase.

The search for active semiconductor photocatalysts that split water directly under visible-light irradiation remains challenging for solar applications. An orthophosphate semiconductor, Ag₃PO₄, which is capable of harnessing visible light to oxidize water as well as decompose organic contaminants in aqueous solution is now reported.

Implants made from patient-derived lyophilized lymph nodes loaded with chimeric antigen receptor T cells improve T cell delivery and inhibit tumour recurrence.

This study assesses the effects of working-from-home on vehicle miles traveled and transit ridership during the pandemic and finds a direct and negative relationship between them: a 1% decrease in onsite workers corresponds to a 0.99% decrease in vehicle miles traveled and a 2.26% decrease in transit ridership.

Type 1 diabetes (T1D) results from autoimmune destruction of pancreatic islet β cells. Here the author show, by comparing the diabetes-sensitive NOD mouse strain with its congenic, diabetes-resistant ALR strain, and by genomic analyses of T1D patients and control, that mutations in the Myo9b gene may alter dendritic cells to contribute to autoimmune diabetes onset.

Immune checkpoints are critical in maintaining self-tolerance and their therapeutic modulation can be achieved in autoimmune diseases. Here the authors present an in situ dual-anchoring approach that targets PD-L1 and show effects in animal models of autoimmunity.

A subcutaneous injection of a glucose-responsive formulation of insulin that does not trigger the formation of a fibrous capsule leads to week-long normoglycaemia in mice and minipigs with type 1 diabetes.

A thin elastic conductive nanocomposite that is formed by cryogenically transferring laser-induced graphene to a hydrogel film can be used to create multifunctional sensors for on-skin monitoring and cardiac patches for in vivo detection.

Fc–IL-4, a typical type 2 cytokine, reinvigorates exhausted CD8⁺ T cells in tumours, underscoring this fusion protein as a potent immunotherapy that synergizes effectively with type 1 immunity against cancer.

Here the authors develop a class of metasurfaces based on robust, unidirectional waves. Such metasurfaces, driven by guided one-way waves, may facilitate their on-chip integration, as well as the precise manipulation of wavefronts on deep-subwavelength scales.

Combining spin-resolved ultrafast spectroscopy and calculations, Zhou et al. report weak exciton-phonon interactions in 2D tin iodide perovskites, alleviating excited state polaronic screening effect and robust excitons, comparing to their lead counterparts.

Decoding the pathogenic genes of the inherited anemia could provide us with novel regulators of pathological and physiological erythropoiesis. Here, the authors show TLR8 is expressed by erythroid cells and regulates erythropoiesis through interacting with EPO signaling.

Welwitschia mirabilis is a unique plant that only has two leaves, but it can survive in hostile conditions of the African desert. Here, the authors report its chromosome-level genome assembly and discuss how gene function and regulation have given rise to its unique morphology and environmental adaptions.

Xuejun Zhang, Jun Wang, Liangdan Sun, Lennart Hammarström and colleagues sequence the MHC region in 20,635 Han Chinese individuals. Their Han-MHC database allows identification of new susceptibility loci for psoriasis and could serve as a tool for investigating the role of the MHC region in other complex diseases.

Many drugs contain tertiary and heteroaryl amines; however, these functional groups are difficult to reversibly crosslink to a carrier protein. Now, a method for conjugating anticancer and antibiotic drugs to antibodies via a quaternary ammonium salt has been developed. Cleavage of the linker results in the traceless release of the free drug and subsequent therapeutic activity.

Organic photoredox catalysts enable diverse chemical transformations, but predicting their activity is challenging due to complex properties. Now, a two-step data-driven approach is introduced for targeted organic photoredox catalysts synthesis and reaction optimization. Using Bayesian optimization, promising catalysts can be efficiently identified, yielding competitive results with iridium catalysts.

An efficient molecular nanojunction photocatalyst for hydrogen evolution is identified from a combinatorial molecular library, assisted by a materials acceleration platform, which is then scaled-up to the litre scale using flow synthesis.

Analysis of big Argo data reveals that model representation of global ocean circulation near 1000-m depth is substantially compromised by inaccuracies. Only 3.8% of the mid-depth ocean circulation can be considered accurately modelled.

A donor–acceptor molecule assembles with different molecular packing to form photocatalysts which selectively produce either H₂ or H₂O₂, depending on the aggregate structure, a proof-of-concept of photoactivity polymorphism.

Wireless bioelectronics integrates untethered controlled-release, wireless power and communication modules into drug delivery systems (DDSs), enabling dynamic, precise drug dosage and release adjustments and shaping the next generation of DDSs — wirelessly controlled DDSs (Will-DDSs).

Microneedle technologies for drug delivery and biosensing have progressed through the integration of material sciences, nanotechnologies and electronic devices. This Review discusses the development and clinical translation of microneedle biomedical devices.

This Perspective lays out the impetus and goals of the Cellular Senescence Network established to comprehensively identify and characterize senescent cells (SnCs) across tissues and lifespan, providing a publicly available SnC atlas.