Search

A type I secretion effector, TesG, suppresses host immune response to promote chronic Pseudomonas aeruginosa infection.

Anlló et al. show that context effects on reward value encoding are found across 11 diverse countries, suggesting that this may be a basic feature of human decision-making.

We developed a technique to fabricate atomically precise quantum antidots with unprecedented robustness and tunable quantum hole states through self-assembled single vacancies in a two-dimensional transition metal dichalcogenide.

CDK4/6 inhibition is a promising therapeutic approach to treat cancer, but it is challenged by resistance development. Here, the authors show that the RNA binding protein LRPPRC forms a positive feedback loop with CDK6 and inhibiting LRPPRC with the FDA-approved gossypol acetate overcomes CDK4/6 inhibition resistance.

Dry reforming of methane is an attractive route to convert greenhouse gases into valuable syngas. Here, the authors demonstrate design strategy to prepare efficient catalysts towards activation of both C–H and C = O bonds and provide atomic-level insights into interfacial synergistic catalysis.

Heterogeneous geminal-atom catalysts, which pair single-atom sites in specific coordination and spatial proximity, offer a new avenue for the sustainable manufacture of fine chemicals.

Toxoplasma gondii acquires host cytosolic materials, yet the mechanism remains unknown. Wan et al. reveal the micropore as an essential organelle at the plasma membrane for endocytosis of host cytosolic proteins and biotin, and Golgi ceramide.

By using nuclear pore complex mimics, the authors demonstrate that the cytoplasm-facing Nup358 provides a dock for the HIV-1 capsid, and the nucleoplasm-facing Nup153 positions the capsid for NPC entry. Nup358 and Nup153 thus create an affinity gradient which regulates capsid penetration, whereas Nup62 constitutes a final NPC gatekeeper against HIV-1 capsid entry.

Here, the authors show that single upconversion nanoparticles can generate position-sensitive patterns in the spatial domain when placed on a mirror. They attribute this to the single emitter’s interference with its own mirror image and show how this can be used to obtain axial localisation of the particle.

Cocrystal engineering combined with macrocycle chemistry has allowed the development of materials with vapochromic characteristics. Here, the authors report the development of a macrocycle cocrystal for the separation of trace solvents.

Though BiCuSeO is a promising thermoelectric material, further study of its electronic structure-property relationship and compositing effect is required to optimize the performance. Here, the authors observe three power factor maxima in BiCuSeO with the increasing Pb-doping content.

Messenger RNAs and their associated proteins are transported from the nucleus through highly selective nuclear pore complexes. Using ultrahigh resolution single-molecule imaging, the authors visualise the path taken by each messenger RNA as it negotiates the pore’s selectivity filter.

Intact single crystals of the enzyme lysozyme can be used to study the time-dependent, protein-directed growth of gold nanoparticles.

The development of precious-metal-free catalysts to promote the sustainable production of fuels and chemicals from biomass challenging. Here the authors report a unique core-shell structured Co@CoO catalyst which exhibits excellent performance in the hydrogenolysis of biomass-derived compounds.

Mapping the spatial distribution of interaction sites between FG nucleoporins and nuclear transport receptors within the native NPC through SPEED microscopy reveals the 3D configuration of the FG-nucleoporin barrier and competition among transport receptors.

A mild electrochemical exfoliation method has been developed to obtain large-size two-dimensional superconductor monolayers with high crystallinity and production yield, which enables the easy fabrication of twisted van der Waals heterostructures and printed films.

A general versatile approach combining wet-chemistry impregnation and two-step annealing is devised for the scalable synthesis of a library of ultra-high-density single-atom catalysts with drastically enhanced reactivity.

Muntjac deer underwent rapid species radiation and dramatic chromosome fusions within a short period of time. Here the authors reveal that repeat sequences likely mediated illegitimate recombination to result in chromosome fusions and that 3D chromatin architecture around fusion sites have no significant change, while significant interactions across fusion sites were gradually established after speciation.

Aliovalent doping affects the electrical properties of semiconductors, but its effect on phonons is unclear. Now, strong softening and deceleration of phonons, causing a significant reduction in lattice thermal conductivity, is reported for Hf-doped NbFeSb.

A deep-learning algorithm can detect polyps in the colon in real time and with high sensitivity and specificity, according to validation studies with prospectively collected images and videos from colonoscopies performed in 1,138 patients.

It has been a long-standing challenge to produce air-stable few- or monolayer phosphorene. Here, the authors demonstrate a new highly controllable method for fabricating high quality, air-stable mono- and few-layer phosphorene films, enabling precise defect engineering in monolayer phosphorene.

Unusual properties arise in transition metal dichalcogenides as dimensionality decreases. Here, the authors introduce a templated growth approach to precisely control the width of MoS₂nanowires on a substrate, allowing them to reveal a relationship between size and electronic properties.

The solidification of liquid metal alloys drives phase separation and pattern formation. Now, it emerges that the solidification of liquid metal alloys on a surface follows unique solidification patterns that reveal alternating convergent and divergent growth habits, leading to oscillatory bifurcation patterns.

During a liquid-to-solid phase transition, a Bi–Ga alloy forms ordered nanostructured patterns on its surface.

A ‘click’ reaction is developed for the simple and rapid formation of azides from primary amines, and is used to prepare a library of over 1,200 azides for subsequent use in the existing triazole annulation click reaction.

The role and mechanism of Srsf1 in GC-induced osteoblast apoptosis reveals that Srsf1 may serve as a target for treating GC-induced osteoporosis and osteonecrosis.

Chemical doping plays an important role in tuning carrier concentration of materials, but its influence on other aspects of electrical properties is less known. Here, the authors find that chemical doping brings strong screening effects to ionized impurities, grain boundary, and polar optical phonon scattering.

The combination of metallurgy concepts and nanotechnology with liquid metal processing has been largely unexplored. Here the authors use liquid-phase ultrasonication to produce a model system of catalytically active nano-alloys, demonstrating electrocatalysis and photocatalysis.

The presence of strong inter-layer interactions has hindered the synthesis efforts towards large-area and highly crystalline monolayer SnS. Here, the authors report synthesis of large-area monolayer SnS using a liquid metal-based technique, and fabricate piezoelectric nano-generators with average peak output voltage of 150 mV at 0.7% strain.

The structural modification of inactive materials to effectively engineer active catalysts is very attractive. Here, layered crystalline Pd₃P₂S₈ is transformed by electrochemical lithiation into amorphous Li-incorporated nanodots. This process turns the inert parent material into a highly active and stable hydrogen-evolving catalyst.

Mixed ionic–electronic conductors are limited by material decomposition. Here the authors reveal the mechanism for atom migration and deposition in Cu_2–δ(S,Se) materials based on a critical chemical potential difference and propose electronically conducting, ion-blocking interfaces to enhance stability.

Mercury (Hg) is a global neurotoxic pollutant and has a long chain from economic activities to human health risks. Here the authors presented a map of Hg-related health risks in China and found significant impacts of interprovincial trade on health risks, such as the prevention of deaths from fatal heart attacks by the trade induced by final consumption.

How extramedullar cytokines regulate hematopoietic stem cell (HSC) homeostasis is unclear. Here, the authors show that the cytokine leukocyte cell-derived chemotaxin 2 regulates HSC expansion and mobilisation via tumour necrosis factor and interaction with CD209a in macrophages.