The meiocyte-specific histone reader MMD1 competes with the C-terminal domain of the histone demethylase JMJ16 for binding to its catalytic domain, expanding the substrate specificity of JMJ16 from H3K4 alone in somatic cells to both H3K4 and H3K9 in meiocytes.
- Jun Wang
- Chaoyi Yu
- Yingxiang Wang