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TOI-500 hosts at least four planets, the innermost of which is an Earth-sized ultra-short-period body with a density similar to Earth. The architecture of the TOI-500 system can be explained by a slow, secular, low-eccentricity migration scenario.

Metabolomics is improved by using a reference library of both known and unknown molecules.

Individual variation in fMRI-derived brain networks is reproduced in a model using only the smoothness (autocorrelation) of the fMRI time series. Smoothness has implication for aging and can be causally manipulated by psychedelic serotonergic drugs.

Mixed responses to targeted therapy within a patient are a clinical challenge. Here the authors show that TP53 loss-of-function cooperates with whole genome doubling which increases chromosomal instability. This leads to greater cellular diversity and multiple routes of resistance, which in turn promotes mixed responses to treatment.

Two doses of the coronavirus disease 2019 vaccine ChAdOx1 nCoV-19 boost antibody responses and functions in phase 1/2 trial participants.

Observations of the super-massive Neptune-sized transiting planet TOI-1853 b show a mass almost twice that of any other Neptune-sized planet known so far and a bulk density implying that heavy elements dominate its mass.

An exciting genome-wide association study in the British population for seven common diseases. This analysis confirms previously identified loci and provides strong evidence for many novel disease susceptibility loci.

Very early observations of a type Ia supernova—from within one hour of explosion—show a red colour that develops and rapidly disappears. These data provide information on the initial explosion mechanism: surface nuclear burning on the white dwarf or extreme mixing of the nuclear burning process.

The SPECULOOS project detected an Earth-sized planet in a short orbit around a nearby Jupiter-sized star. This planet, SPECULOOS-3 b, is one of the most promising rocky exoplanets for detailed emission spectroscopy characterization with JWST.

Genome-wide analysis identifies 32 loci associated with breast cancer susceptibility, accounting for estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 status and tumor grade.

TSPO PET imaging is widely used to quantify microglial activation. Here, the authors show that TSPO expression increases in activated rodent but not human microglia, implying that in humans TSPO informs on microglial density rather than activation status.

A cryo-EM structure of the Dbf4-dependent kinase (DDK) in the act of phosphorylating an Mcm2-7 helicase complex reveals how DDK selectively targets DNA-loaded MCM double hexamers to trigger replication origin activation. Checkpoint kinase Rad53 blocks origin firing by impairing double hexamer engagement by DDK.

Current experimental monoclonal antibodies (mAbs) for Ebola virus (EBOV) post-exposure immunotherapy are ineffective against Sudan (SUDV) or Marburg virus (MARV). Here, authors develop cocktails of mAbs that protect nonhuman primates against EBOV, SUDV, and MARV infection when given four days post infection.

The edematous form of severe acute childhood malnutrition (ESAM) presents with more severe multi-organ dysfunction than non-edematous SAM (NESAM). Here the authors assess genome-wide DNA methylation in buccal cells of SAM children and find that ESAM is characterized by hypomethylation at genes associated with disorders of nutrition and metabolism, including fatty liver and diabetes.

The crystal structure of a broadly neutralizing monoclonal antibody against Ebola virus glycoprotein isolated from a human survivor allows the engineering of variant antibodies with expanded activity and has implications for vaccine design.

Identifying driver genes in unstable, heterogenous tumour types can be challenging. Here, Mourikis, Benedetti, Foxall and colleagues present a machine learning algorithm to tackle this problem in esophageal adenocarcinoma.

Stellar data from the Kepler spacecraft are used to infer the existence of a sub-Mercury-sized exoplanet, the smallest yet discovered, in orbit around a Sun-like star.

Multi-instrument detection of a nearby type 1a supernova shows that the exploding star was probably a carbon–oxygen white dwarf star in a binary system with a main-sequence companion.

The expression of each of the roughly 22,000 genes of the mouse genome has been mapped, at cellular resolution, across all major structures of the mouse brain, revealing that 80% of all genes appear to be expressed in the brain.

The interleukin-15 superagonist N-803, combined with the depletion of CD8⁺ lymphocytes, induced a robust and persistent reactivation of the virus in vivo in both antiretroviral-therapy-treated SIV-infected macaques and HIV-infected humanized mice.

The entanglement of squeezed light beams is critical for quantum optical applications, but has so far been achieved with only two light beams. Now, researchers have surpassed this restriction and achieved entanglement with three beams of different colours. They also report a finite loss level for disentanglement of one beam from the other two.

The spectroscopic and photometric observations of a high-mass, transiting warm Jupiter, TIC 241249530 b, with an orbital eccentricity of 0.94, provide evidence that hot Jupiters may have formed by means of a high-eccentricity tidal-migration pathway.

Dobrzycki et al delete a conserved enhancer that drives endothelial expression of the transcription factor Gata2a in Zebrafish and find that it is required for programming of haemogenic endothelium and for maintenance of haematopoietic stem cells in the adult. These data may help understanding Gata2 deficiency syndromes in humans.

Steel is employed ubiquitously throughout human society thanks to its outstanding mechanical properties, however over time degradation can lead to a loss in performance. Here, the authors show that creating liquid-infused surfaces via electrodeposition of a tungstite film endows steel with a durable coating which inhibits corrosion and fouling.

Using large-scale data, Kraemer et al. find that human mobility patterns vary across the globe and in scale by environmental and sociodemographic contexts. There are tenfold differences in mobility patterns depending on the countries’ economic development.

Components for flexible electronics capable of both bending and stretching have been reported but the fabrication of similarly pliable power sources remains challenging. Here, the authors present stretchable lithium ion batteries exploiting segmented layouts and deformable electrical interconnects.

The SIGNAL Phase 2 study of pepinemab immunotherapy in early Huntington’s disease (HD) did not meet its coprimary clinical efficacy endpoints, but had a favorable safety profile and showed a significant treatment-related reduction in caudate brain atrophy and reversal of the characteristic decline in brain metabolic activity that is typical of HD progression.

Sun et al. investigate the effects of current ambient and potential future oxygen levels on phytoplankton growth and photosynthesis with field observations and mesocosm and lab experiments. Their results demonstrate positive effects of low O₂ on phytoplankton growth, photosynthesis, and inorganic carbon acquisition at current and future high levels of CO₂.

Genome-wide meta-analysis of SARS-CoV-2 susceptibility and severity phenotypes in up to 756,646 samples identifies a rare protective variant proximal to ACE2. A 6-SNP genetic risk score provides additional predictive power when added to known risk factors.

Circadian rhythms can alter inflammatory state and activity of inflammatory diseases such as rheumatoid arthritis. Here the authors show that extrinsic signals confer a circadian rhythm to regulatory T cell activity, which in turn drives rhythmic inflammation in collagen-induced arthritis.

Kepler-107 b and c have the same radius but, contrary to expectations, the outermost Kepler-107 c is much denser. This difference cannot be explained by photoevaporation by stellar high-energy particle flux and it suggests that Kepler-107 c experienced a giant impact event.