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Using vortices trapped inside a superconductor that repel each other it can be demonstrated that particle–particle interactions can lead to multiple drift reversal of a ratchet effect, very different from the single particle behaviour.

Vascularization remains a significant challenge in organoid technology. Here, the authors develop a microfluidic platform that enhances organoid growth, function and maturation, by establishing functional perfusable vascular networks.

The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle transport, and that loss of VAMP7 leads to reduced cold avoidance in vivo.

An extensive analysis of the JWST-NIRSpec spectrum of GN-z11 shows a supermassive black hole of a few million solar masses in a galaxy 440 million years after the Big Bang.

A phosphorus dopant qubit is positioned within a vertically gated single-electron transistor with <5 nm alignment precision and its spin is read with 97.9% fidelity.

Laurent Fasano and colleagues identify TSHZ3 deletions in patients with autism spectrum disorder. Tshz3-mutant mice show functional changes at synapses established by cortical projection neurons and exhibit autism-like behavioral patterns.

As part of the JWST Advanced Deep Extragalactic Survey (JADES), NIRSpec has spectroscopically confirmed four young and metal-poor galaxies at redshift 10.3–13.2, from an early epoch of galaxy formation.

Three transient receptor potential channels (TRPA1, TRPV1 and TRPM3) mediate sensitivity to acute noxious heat in mice in a redundant system; mice lacking all three show severe deficits in heat sensing, whereas double-knockout mice do not.

The authors develop a machine learning approach to find structurally related chemicals in mass spectral libraries. Their method boosts the annotation rate and aids in assessing novelty in metabolomics datasets.

A crystalline cluster exhibits thorium–thorium bonding, adding to our knowledge of actinide–actinide bonding.

Analysis of the JWST/NIRSpec spectrum of the recently observed Lyman-break galaxy JADES-GS+53.15508-27.80178 revealed a redshift of z = 7.3, a Balmer break and a complete absence of nebular emission lines, indicating that quenching occurred only 700 million years after the Big Bang.

Stress granules are non-membranous organelles connected to stress responses and age-related disease. Here, the authors identify a conserved yeast protein, Lsm7, that facilitates stress granule formation through dynamic liquid-liquid phase separation condensates upon 2-deoxy-D-glucose-induced stress.

Quantum circuits are constructed from various superconducting components such as qubits and quantum logic gates and each come with their own challenges in terms of efficient operation. Here, the authors investigate the effects of magnetic field penetration on superconducting coplanar waveguide resonators and suggest ways to improve their magnetic resilience.

Analysis of outcomes of over 800 patients with relapsed/refractory diffuse large B cell lymphoma, treated with commercially available CAR T cell therapy, supports higher efficacy and also a higher toxicity of axicabtagene ciloleucel compared to tisagenlecleucel as the third or more treatment line for this type of tumor.

Strong spin–electric coupling related to modulation of magnetic coupling has now been observed in polar spin chains. This is a first step towards switching quantum bit interactions by localized electric fields.

An (ultraviolet) dust attenuation feature at 2,175 Å, attributed to carbonaceous dust grains in the Milky Way and nearby galaxies, also exists in galaxies up to a redshift of 7.

The authors demonstrate the negative role of GOLVEN peptides during lateral root initiation in Arabidopsis, at the very early stage of the first asymmetric cell division of lateral root founder cells, and identify the receptors for these peptides.

Plant-parasitic nematodes are a threat to crop production. Combining bioinformatics, genetic and biochemical approaches, the authors show that the plant pathogen beet cyst nematode possesses an incomplete vitamin B5 synthesis pathway, of potential prokaryotic origin, complemented by its plant host.

Frequencies of rare variants fluctuate over populations, hampering gene discovery. Here the authors use a population-specific reference panel, the Genome of the Netherlands, to discover four novel loci involved in lipid metabolism, including an exonic variant in ABCA6.

Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor Lp(a).

The skin of the African bush elephant features micrometer-wide channels whose function is water and mud retention for thermal regulation and protection from parasites. Here authors use microscopy and modelling to show that the channels are fractures of the animal thick and brittle skin outermost layer.

The cardiac autonomic nervous system produces various neuropeptides, such as neurokinin substance-P (Sub-P), whose function remains largely unclear. Here, authors show that Sub-P causes a receptor-mediated prolongation of the atrial action potential through a reduced background potassium current, and prevents atrial fibrillation.

Transient metallonitrenes (M–N) have been proposed as key intermediates in nitrogen atom transfer reactions, but well-defined examples have remained elusive. Now, a platinum complex with an atomic nitrogen ligand, best described as a subvalent nitrogen diradical singly bonded to a platinum(ii) ion (Pt–N), has been isolated and shows ambiphilic reactivity.

The enzyme glutamine synthetase is active in endothelial cell migration during angiogenesis, through autopalmitoylation and the regulation of RHOJ signalling.

In this Comment, Veltman and Tüttelmann call on geneticists to further study male infertility and help to develop diagnostic strategies using state-of-the-art genomic approaches.

Journals, funders and scholars must work together to create an infrastructure to study peer review.

Including participants from 45 countries, Bago et al. find that the situational factors that affect moral reasoning are shared across countries, with diminished observed cultural variation.

A revised date for the Laacher See eruption using measurements of subfossil trees shifts the chronology of European varved lakes relative to the Greenland ice core record, synchronizing the onset of the Younger Dryas across the North Atlantic–European sector.

Plasmodium vivax generally accounts for a low proportion of malaria cases in Africa, but population-level data on the distribution of infections is limited. Here, the authors use data from the Democratic Republic of the Congo and show that the prevalence is low (~3%) and diffusely spread.

Mislocalisation of tau occurs in several neurodegenerative diseases and is thought to contribute to synaptic function. The authors show that presynaptically, tau binds to synaptic vesicles via the N-terminus which contributes to synaptic dysfunction.

Scientists demonstrate an optically pumped InP-based distributed feedback laser array monolithically grown on (001)-silicon operating at room temperature that is suitable for wavelength-division multiplexing applications.

Many aging-related phenotypes share a common genetic component, but to disentangle disease-specific variants from aging-specific ones has been challenging. Here Timmers et al. combined several genetics studies of aging-related traits to identify common underlying genetic factors that contribute to aging.

Capacity for carbon capture and storage in forests may not be monolithic but instead a function of complex dynamics of forest strata and age. The smaller trees that make up the understory in African tropical forests store their carbon longer as compared to sub-canopy and canopy trees and they represent a disproportionately large share of the carbon sink, in spite of their small size.

Red giants are evolved stars that have exhausted the supply of hydrogen in their cores and instead burn hydrogen in a surrounding shell. Once a red giant is sufficiently evolved, the helium in the core also undergoes fusion. However, it is difficult to distinguish between the two groups. Asteroseismology offers a way forward. This study reports observations of gravity-mode period spacings in red giants using high precision photometry obtained by the Kepler spacecraft. It is found that the stars fall into two clear groups, making it possible to distinguish unambiguously between hydrogen-shell-burning stars and those that are also burning helium.

Aviation contributes to climate change and ways to reduce its emissions are widely debated. Here, the authors assess the effects of technology improvements and the use of sustainable aviation fuels and find that even when these are considered aviation is unlikely to meet emissions goals in line with the Paris Agreement.

As of yet, no clear structure–performance descriptors have been developed to tune the catalytic activity of zeolitic methanol-to-olefin catalysts. Now it has been shown that introducing Lewis acidity into Brønsted acidic zeolites boosts their performance. Although Brønsted acidity is found to define propylene selectivity, Lewis acidity is responsible for prolonging lifetime.

As resident macrophages of the brain, microglia are important for neuroinflammatory responses. This work shows that nuclear factor kappa B regulatory protein A20 is important for microglia activation and regulation during inflammation of the central nervous system.

The vitamin B₁₂ importer BtuCD-F is a type II ATP-binding cassette transporter. Here the authors use single-molecule fluorescence techniques to analyse ATP hydrolysis and substrate transport in individual BtuCD-F complexes embedded in liposomes, and propose a transport model.

A combination of crosslinking, X-ray crystallography, NMR, and mutagenesis provide a detailed visualization of the interactions between an acyl carrier protein and β-ketoacyl-ACP-synthase I in the Escherchia coli fatty acid synthase complex.