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Advanced filters: Author: Juliet Mwirigi Clear advanced filters

A cryptic pocket in CB1 drives peripheral and functional selectivity

A peripherally restricted CB1 agonist (VIP36) targeting a cryptic receptor pocket was developed, showing high efficacy in mouse pain models with minimal side effects and tolerance, potentially revolutionizing chronic pain treatment and GPCR drug design.

Vipin Ashok Rangari
Evan S. O’Brien
Susruta Majumdar
Research05 Mar 2025
Nature

Volume: 640, P: 265-273
Genetic editing of primary human dorsal root ganglion neurons using CRISPR-Cas9

Seph M. Palomino
Katherin A. Gabriel
Amol Patwardhan
ResearchOpen Access01 Apr 2025
Scientific Reports

Volume: 15, P: 1-13
Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK

Stephanie Shiers
Juliet Mwirigi
Theodore J. Price
Research07 Oct 2019
Neuropsychopharmacology

Volume: 45, P: 524-533