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Showing 1–50 of 75 results

Advanced filters: Author: Jun Imamura Clear advanced filters

Host control of persistent Epstein–Barr virus infection

Axel Schmidt
T. Madhusankha Alawathurage
Kerstin U. Ludwig
Research19 Feb 2026
Nature

P: 1-5
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes

Here, Imamuraet al. conduct meta-analysis of genome-wide association studies to identify novel susceptibility loci for type 2 diabetes (T2D) in the Japanese population. By doing so, this study shows that both ethnicity-specific and ethnically-shared genetic loci can contribute to T2D risk.

Minako Imamura
Atsushi Takahashi
Takashi Kadowaki
ResearchOpen Access28 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Stomatal movements and ion fluxes within epidermis of Commelina communis L.

C. M. WILLMER
J. E. PALLAS JUN.
Research08 Nov 1974
Nature

Volume: 252, P: 126-127
Urea Cycle Enzyme Activities of Liver of the African Lion

G. W. BROWN jun.
Research01 Jun 1966
Nature

Volume: 210, P: 1367
Inhibition of DNA-dependent RNA Polymerase by 4-Nitroquinoline-N-oxide in Isolated Nuclei

J. S. PAUL
R. C. REYNOLDS
P. O'B. MONTGOMERY jun.
Research01 Aug 1967
Nature

Volume: 215, P: 749-750
Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks

The 24-hour circadian clocks in cartilage and intervertebral disc play key roles in regulating tissue physiology, yet how they are reset on a daily basis remains elusive. Here the authors show that daily patterns of mechanical loading and associated changes in osmolarity provide a tissue-type specific entrainment time cue for these skeletal clocks.

Michal Dudek
Dharshika R. J. Pathiranage
Qing-Jun Meng
ResearchOpen Access14 Nov 2023
Nature Communications

Volume: 14, P: 1-12
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Disruption of the BLM gene in ATM-null DT40 cells does not exacerbate either phenotype

Toshiyuki Fukao
Philip Chen
Martin F Lavin
Research26 Feb 2004
Oncogene

Volume: 23, P: 1498-1506
Smad6 inhibits signalling by the TGF-β superfamily

Takeshi Imamura
Masao Takase
Kohei Miyazono
Research09 Oct 1997
Nature

Volume: 389, P: 622-626
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

Harukazu Suzuki
Alistair R R Forrest
Yoshihide Hayashizaki
Research19 Apr 2009
Nature Genetics

Volume: 41, P: 553-562
Tocilizumab-induced hypofibrinogenemia in patients with systemic-onset juvenile idiopathic arthritis

Tingyan He
Jiayun Ling
Jun Yang
ResearchOpen Access03 Jun 2023
Scientific Reports

Volume: 13, P: 1-6
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Night home enteral nutrition as a novel enforced and physiologically effective nutrition therapy following total gastrectomy for gastric cancer

Shuhei Komatsu
Tomoki Konishi
Eigo Otsuji
ResearchOpen Access02 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
Highly porous nature of a primitive asteroid revealed by thermal imaging

Thermal imaging data obtained from the spacecraft Hayabusa2 reveal that the carbonaceous asteroid 162173 Ryugu is an object of unusually high porosity.

Tatsuaki Okada
Tetsuya Fukuhara
Yuichi Tsuda
Research16 Mar 2020
Nature

Volume: 579, P: 518-522
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Overexpression of JMJD6 drives immune evasion via the BRD4–IRF1–PD-L1 axis and promotes malignancy in gastric cancer

Ryo Ishida
Shuhei Komatsu
Atsushi Shiozaki
ResearchOpen Access08 Dec 2025
Scientific Reports

Volume: 16, P: 1-14
Spatially resolved gene expression profiling of tumor microenvironment reveals key steps of lung adenocarcinoma development

The role of immune-tumor cell interactions in lung adenocarcinoma (LUAD) development remains to be explored. Here, spatial transcriptomics and in situ RNA profiling of samples from 30 LUAD patients reveals changes in the phenotypic properties of tumors cells associated with changes in immune cell features.

Yuma Takano
Jun Suzuki
Ayako Suzuki
ResearchOpen Access06 Dec 2024
Nature Communications

Volume: 15, P: 1-17
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Multistep, site-selective noncovalent synthesis of two-dimensional block supramolecular polymers

Supramolecular structures are typically formed by the one-step self-assembly of building blocks. Now, a greater level of control has been achieved using stepwise non-covalent reactions under kinetic control. Two-dimensional block supramolecular polymers with tailored compositions and sequences were synthesized, and a site selectivity that is reminiscent of regioselectivity in covalent synthesis was observed.

Norihiko Sasaki
Jun Kikkawa
Kazunori Sugiyasu
Research01 Jun 2023
Nature Chemistry

Volume: 15, P: 922-929
Tumor localization by Prostate Imaging and Reporting and Data System (PI-RADS) version 2.1 predicts prognosis of prostate cancer after radical prostatectomy

Ayumi Fujimoto
Shinichi Sakamoto
Tomohiko Ichikawa
ResearchOpen Access21 Jun 2023
Scientific Reports

Volume: 13, P: 1-9
Effects of Monomer Sequence Alignment on Properties of p-Hydroxybenzoic Acid/Poly(ethylene terephthalate) Copolyester

Jun-ichi Suenaga
Masashi Kinugawa
Research01 Mar 1993
Polymer Journal

Volume: 25, P: 315-318
Absorption Spectra of Poly(L-vinylpyrene) in the Excited and Ionic States

Jun A Tanaka
Hiroshi Masuhara
Noboru Mataga
Research01 Feb 1986
Polymer Journal

Volume: 18, P: 181-184
Low-dose anti-thymocyte globulin for GVHD prophylaxis in HLA-matched allogeneic peripheral blood stem cell transplantation

Souichi Shiratori
Junichi Sugita
Mine Harada
Research05 Jul 2020
Bone Marrow Transplantation

Volume: 56, P: 129-136
Identification and characterization of a novel enhancer in the HTLV-1 proviral genome

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al. perform proviral DNA-capture followed by high-throughput sequencing and identify a yet unknown viral enhancer in the middle of the HTLV-1 provirus.

Misaki Matsuo
Takaharu Ueno
Yorifumi Satou
ResearchOpen Access03 May 2022
Nature Communications

Volume: 13, P: 1-16
Mutation spectrum of and founder effects affecting the PTS gene in East Asian populations

Yen-Hui Chiu
Ying-Chen Chang
Tze-Tze Liu
Research12 Jan 2012
Journal of Human Genetics

Volume: 57, P: 145-152
Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

Expression of Cas9 and gRNA from viral vectors in vivo may cause off-target activity. Here the authors present NanoMEDIC, which uses nanovesicles to transiently deliver editing machinery to hard-to-transfect cells.

Peter Gee
Mandy S. Y. Lung
Akitsu Hotta
ResearchOpen Access13 Mar 2020
Nature Communications

Volume: 11, P: 1-18
Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging

Min-Ju Kim
Soo-Jin Oh
Jae-Yong Lee
ResearchOpen Access01 Feb 2007
Experimental & Molecular Medicine

Volume: 39, P: 14-26
Association of common promoter polymorphisms of MCP1 with hepatitis B virus clearance

Byung Lae Park
Yoon Jun Kim
Hyoung Doo Shin
ResearchOpen Access01 Dec 2006
Experimental & Molecular Medicine

Volume: 38, P: 694-702
Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

Fujita et al. find that normal epithelial cells induce metabolic changes in adjacent transformed cells, causing their apical extrusion. The effect is conveyed non-cell-autonomously and relies on PDK4-mediated inhibition of mitochondrial function.

Shunsuke Kon
Kojiro Ishibashi
Yasuyuki Fujita
Research17 Apr 2017
Nature Cell Biology

Volume: 19, P: 530-541
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Re-examining the optimal extent of lymph node dissection for colon cancer using the lymphadenectomy index

Yuta Marunaka
Jun Kiuchi
Eigo Otsuji
ResearchOpen Access24 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Smad4 silencing in pancreatic cancer cell lines using stable RNA interference and gene expression profiles induced by transforming growth factor-β

Amarsanaa Jazag
Hideaki Ijichi
Masao Omata
Research13 Dec 2004
Oncogene

Volume: 24, P: 662-671
Layer-specific morphological and molecular differences in neocortical astrocytes and their dependence on neuronal layers

Several studies have suggested that astrocytes in the neocortex are more diverse than previously thought. Here, the authors describe layer-specific differences in morphology and molecular characteristics of astrocytes that depend on the neurons within those layers.

Darin Lanjakornsiripan
Baek-Jun Pior
Yukiko Gotoh
ResearchOpen Access24 Apr 2018
Nature Communications

Volume: 9, P: 1-15
TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

Epileptic seizures generate aberrant neurogenesis in the adult mouse hippocampal region but how animals cope with abnormal neurogenesis remains unknown. Here the authors show that microglia are activated through TLR9 signaling and that this leads to sustained expression of TNF-α which attenuates induced aberrant neurogenesis.

Taito Matsuda
Naoya Murao
Kinichi Nakashima
ResearchOpen Access09 Mar 2015
Nature Communications

Volume: 6, P: 1-10
OsSPL14 promotes panicle branching and higher grain productivity in rice

Motoyuki Ashikari and colleagues report the identification of OsSPL14 as a gene that regulates plant architecture in rice. OsSPL14 is regulated by miRNA156, promotes panicle branching and enhances rice grain yield.

Kotaro Miura
Mayuko Ikeda
Motoyuki Ashikari
Research23 May 2010
Nature Genetics

Volume: 42, P: 545-549
Germline gain-of-function mutations in RAF1 cause Noonan syndrome

M Abdur Razzaque
Tsutomu Nishizawa
Rumiko Matsuoka
Research01 Jul 2007
Nature Genetics

Volume: 39, P: 1013-1017
Author Correction: Altered kynurenine pathway metabolites in a mouse model of human attention-deficit hyperactivity/autism spectrum disorders: A potential new biological diagnostic marker

Yuki Murakami
Yukio Imamura
Jun Motoyama
Amendments and CorrectionsOpen Access28 Feb 2020
Scientific Reports

Volume: 10, P: 1
Low levels of tumor suppressor miR-3619 in plasma contribute to malignant outcomes and a target for nucleic acid therapy in esophageal cancer

Hiroshi Arakawa
Shuhei Komatsu
Eigo Otsuji
ResearchOpen Access27 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Highly concentrated trehalose induces prohealing senescence-like state in fibroblasts via CDKN1A/p21

Highly concentrated trehalose induces beneficial senescence-like state in fibroblasts and accelerates the proliferation of keratinocytes and angiogenesis to promote optimal wound repair, demonstrating its therapeutic potential in modulating fibroblast functions.

Jun Muto
Shinji Fukuda
Koji Sayama
ResearchOpen Access06 Jan 2023
Communications Biology

Volume: 6, P: 1-18
Sarcomere gene variants did not improve cardiac function in pediatric patients with dilated cardiomyopathy from Japanese cohorts

Keiichi Hirono
Yukiko Hata
Fukiko Ichida
ResearchOpen Access16 Dec 2024
Scientific Reports

Volume: 14, P: 1-14
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Dramatic improvement in genome assembly achieved using doubled-haploid genomes

Hong Zhang
Engkong Tan
Shuichi Asakawa
ResearchOpen Access27 Oct 2014
Scientific Reports

Volume: 4, P: 1-5
N-glycan-modified α-L-iduronidase produced by transgenic silkworms ameliorates clinical signs in a Japanese macaque with mucopolysaccharidosis I

Shinoda and Kitakaze et al. prepared recombinant hIDUA from transgenic silkworm cocoons and transglycosylated to mannose-6-phosphate- or α2,6-sialyl glycan-type using ENGases. These enzymes were administrated to a mucopolysaccharidosis type I macaque and succeeded in improving the clinical signs and reducing the urinary glycosaminoglycan levels.

Chika Shinoda
Keisuke Kitakaze
Kohji Itoh
ResearchOpen Access18 Apr 2025
Communications Medicine

Volume: 5, P: 1-14
Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIα

Atsushi Togawa
Jun Miyoshi
Yoshimi Takai
Research23 Sept 1999
Oncogene

Volume: 18, P: 5373-5380
Anti-tumor activity of antizyme which targets the ornithine decarboxylase (ODC) required for cell growth and transformation

Satoshi Iwata
Yuya Sato
Shuki Mizutani
Research19 Jan 1999
Oncogene

Volume: 18, P: 165-172
Efficacy of an orally active small-molecule inhibitor of RANKL in bone metastasis

Yuta Nakai
Kazuo Okamoto
Hiroshi Takayanagi
ResearchOpen Access03 Jan 2019
Bone Research

Volume: 7, P: 1-10
A new approach to the distribution and storage of genetic resources

Yoshihide Hayashizaki
Jun Kawai
Reviews01 Mar 2004
Nature Reviews Genetics

Volume: 5, P: 223-228
Comparison of antimicrobial therapy termination in febrile and afebrile patients with acute cholangitis after drainage

Sakue Masuda
Yoshinori Imamura
Kazuya Koizumi
ResearchOpen Access01 Aug 2024
Scientific Reports

Volume: 14, P: 1-8

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