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Relatively few lncRNAs have been shown to regulate animal behavior. Here, Saha et al. use mouse genetic methods to show that the lncRNA Pnky can underlie specific mouse behavior by functioning in trans.

Inorganic–organic hybrid dye-sensitized solar cells featuring a perovskite compound as a light harvester and a polymer as a hole transporter provide an open-circuit voltage of almost 1 V and a power conversion efficiency of 12% under standard illumination conditions.

A Ca–O₂ battery that relies on a highly reversible two-electron redox to form chemically reactive calcium peroxide as the discharge product is reported to be stable in air and rechargeable for 700 cycles at room temperature.

Genome-wide association studies (GWAS) have improved our understanding of the genetic basis of lung adenocarcinoma but known susceptibility variants explain only a small fraction of the familial risk. Here, the authors perform a two-stage GWAS and report 12 novel genetic loci associated with lung adenocarcinoma in East Asians.

Sensing internal body states is crucial for physiological homeostasis. Here, the authors show that the C. elegans PIEZO channel regulates swallowing by detecting intestinal food buildup and triggering pharyngeal movements to aid ingestion.

Transplanted older livers are prone to injury through unclear mechanisms, precluding effective treatment development. Here, the authors show that decreased FTO expression in older livers inhibits Acsl4 and Tfrc mRNA stability in an m6A-dependent manner, increasing cell death in older donor livers.

Kim and colleagues perform a phase 2 clinical trial (ELM-2) of odronextamab monotherapy in patients with relapsed/refractory diffuse large B cell lymphoma and report on the primary analyses of the efficacy and safety profile.

It is generally believed that quantum tunneling cannot occur when the distance is larger than the particle’s wavelength. This paper reveals that a long-range quantum tunneling of the atom to the remote trapping potentials mediated by its emitted matter wave occurs as long as bound states are present in the energy spectrum of the total system formed by the atom and its matter-wave.

GPCR dynamics are critical for signal transmission into the cell. Here, the authors probe receptor plasticity using molecular dynamics simulations, enabling the detection of allosteric sites and drug entry gateways for a broad range of GPCR types.

Here, the authors develop a PMO-based heteroduplex oligonucleotide technology that enhances PMO delivery to tissues and normalizes motor/cardiac function and CNS symptoms in a mouse model of Duchenne muscular dystrophy.

Here the authors identify distinct mechanisms by which domain-specific p53 mutations activate cancer cell growth via the epidermal growth factor receptor (EGFR). These mechanisms affect sensitivity to EGFR inhibitors, opening avenues for targeted therapy.

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

O2-type Li-rich layered cathodes suppress voltage decay and aid in oxygen redox research. Here, the authors report trilateral relationship among anionic redox utilization, bulk chemo-mechanical degradation, and electrochemical fading, which can be mitigated by balancing the redox center capabilities.

Pseudokinase ILK is essential for dynamic communication between focal adhesion complexes and F-actin filaments. Here, the authors show that ILK regulates such communication by complexing with PINCH and Parvin to trigger F-actin filament bundling through previously unrecognized actin binding motifs in PINCH and Parvin

Identifying crystallographic phases in solution is not possible with standard diffraction methods. Here, Limet al. demonstrate the in situidentification of cubic and hexagonal phases of cadmium selenide nanocrystals using optical methods based on first-principles electronic theory.

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Whole-genome sequencing identifies noncoding CGG repeat expansions in neuronal intranuclear inclusion disease, oculopharyngodistal myopathy and oculopharyngeal myopathy with leukoencephalopathy, three disorders with overlapping clinical features and neuroimaging findings.

TGF-β is thought to be important for group 2 innate lymphoid cell (ILC2) function. Here the authors show that TGF-β drives expression of ST2 specifically in ILC2 progenitors and thereby is also important for the development of ILC2s in the bone marrow.

Water thermodynamics drive changes in macromolecular assembly that rapidly restore intracellular water availability in response to physiological fluctuations in temperature, pressure and osmotic strength.

Compact localized states constitute an auxiliary state representation for a flat-band lattice system with wave functions non-zero only in a finite portion of the lattice. Here, the authors show that in some flat-band systems, these states can be partially “hidden”; surprisingly, these ghost flat bands present an obstruction to be represented as maximally localized Wannier functions.

Spin-polarized defects in 2D materials are attracting attention for future quantum technology applications, but their controlled fabrication is still challenging. Here, the authors report the creation and characterization of effective spin 1/2 defects via the atomically-precise generation of magnetic carbon radical ions in 2D WS₂.

As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during aging in healthy individuals.

Here, the authors use cryo-EM to show that phosphorylating or O-GlcNAcylating α-synuclein on serine 87 leads to the formation of two distinct fibril structures. Both structures display reduced neurotoxicity and propagation activity.

Mesoscale connectomic mapping of the cortico–basal ganglia–thalamic network reveals key architectural and information processing features.

Potential synergism between BTK inhibitor and lenalidomide in treating aggressive B-cell lymphoma has been suggested. Here, the authors report a single-arm phase II clinical trial of combination of acalabrutinib, lenalidomide and rituximab in patients with aggressive Relapsed/Refractory aggressive B-cell non-Hodgkin lymphoma.

Here, the authors provide detailed analyses of viral RNA structure in virions and in infected cells for four dengue virus serotypes and four Zika virus strains, and identify conserved structures that are important for virus replication.

A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.

Studying the cell composition of acral melanoma at the single-cell level could provide some clues about its poor response to immunotherapy. Here, the authors analyse acral and cutaneous melanoma patient samples using single-cell RNA-sequencing, and reveal a severe immunosuppressive state in acral melanomas

The anti-freezing property of electrolyte is crucial for aqueous batteries under extreme conditions. Here authors explore the relationship between tetrahedral entropy and the freezing behavior of aqueous electrolyte, and further develop anti-freezing electrolyte for aqueous zinc ion batteries.

Difficulties in elucidating active sites and the role of the support hamper the development of high-efficiency two-electron oxygen reduction electrocatalysts. Here, the authors develop hybrid single-atom catalysts by rational experimental and theoretical screening for hydrogen peroxide production.

Receptor Interacting Protein Kinase 3 (RIPK3) has a key role in TNF-induced necroptosis. Here, the authors combine solid state NMR measurements, MD simulations and cell based assays to characterize mouse RIPK3 and they present the structure of the RIPK3 amyloid core.

The authors report here that talin and kindlin, the two key integrin binders and activators, are bridged by paxillin to induce microclustering of integrins to potently bind to multivalent extracellular ligand and trigger rapid cell attachment.

Tan and colleagues conducted a single-cell multiomic analysis of T cell acute lymphoblastic leukemia and identified a treatment-resistant subpopulation of bone marrow progenitor-like blasts associated with poor outcomes.

Simultaneous control of the direction and polarization of quantum emission using photonic nanostructures is a long-standing challenge in photonics. Here, the authors experimentally demonstrate unidirectional chiral emission from a twisted bilayer metasurface with multi-dimensional control.

This work establishes a prime editing platform for high-throughput interrogation of small genetic variants (up to tens of thousands) with negative selection phenotypes.

Colloidal semiconductor core-shell nanocrystals are sought after for photonic applications. Here, the authors report coherent heteroepitaxial growth of Ag(In,Ga)S₂ core-shell nanocrystals with near-unity photoluminescence quantum yield across almost the full visible range.

No effective pharmacological treatments exist for nonalcoholic fatty liver disease (NAFLD). Here, the authors show that serotonin concentration in the portal blood is increased in nine human subjects and in mice fed a high-fat diet, and that local serotonin signaling ablation, either genetically or with an antagonist, prevents hepatic steatosis in mice.