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Showing 1–50 of 57 results

Advanced filters: Author: Jun-jie Liu Clear advanced filters

Comprehensive assessment of the contribution of wastewater treatment to urban greenhouse gas and ammonia emissions

Extensive measurements of the emissions of methane, nitrous oxide and ammonia from wastewater treatment facilities in the USA present higher values than are currently stated in national inventories. The results of this analysis show that greenhouse gas and nitrogenous emissions from the wastewater sector are often overlooked and that their impact on climate should be reassessed.

Daniel P. Moore
Nathan P. Li
Mark A. Zondlo
ResearchOpen Access08 Oct 2025
Nature Water

P: 1-11
Engineering a xylose fermenting yeast for lignocellulosic ethanol production

The sodium salts in corn stover hydrolysates have been identified as important inhibitors for cellulosic ethanol production. Adaptive evolution generated a robust yeast that converted both glucose and xylose into biofuel. Subsequent reverse engineering created a genetically defined yeast with equivalent performance to the evolved strain.

Yi-Wen Zhang
Jun-Jie Yang
Sheng Yang
Research04 Nov 2024
Nature Chemical Biology

Volume: 21, P: 443-450
Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble

Type III CRISPR-Cas systems are able to target transcriptionally active DNA sequences in phages and plasmids. Here, the authors reveal the mechanism of the target nucleic acid preference of Type III-A CRISPR-Cas complexes at the transcription bubble by a combination of structural and biochemical approaches.

Tina Y. Liu
Jun-Jie Liu
Jennifer A. Doudna
ResearchOpen Access05 Jul 2019
Nature Communications

Volume: 10, P: 1-13
Cas12e orthologs evolve variable structural elements to facilitate dsDNA cleavage

CRISPR-Cas12e systems exhibit robust genome editing capabilities, yet their phylogenetic diversity remains underexplored. Here, authors elucidate the biochemical diversity and structural variations of newly identified Cas12e proteins, offering critical insights into structure-activity relationships.

Danyuan Li
Shouyue Zhang
Jun-Jie Gogo Liu
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-14
CasX enzymes comprise a distinct family of RNA-guided genome editors

CRISPR–CasX represents a distinct RNA-guided platform that is functionally separate from Cas9 and Cas12a and is active for bacterial and human genome modification.

Jun-Jie Liu
Natalia Orlova
Jennifer A. Doudna
Research04 Feb 2019
Nature

Volume: 566, P: 218-223
Author Correction: Cryo-EM structure of the exocyst complex

Kunrong Mei
Yan Li
Wei Guo
Amendments and Corrections05 Nov 2018
Nature Structural & Molecular Biology

Volume: 25, P: 1137
Visualization of distinct substrate-recruitment pathways in the yeast exosome by EM

A combination of single-particle EM and biochemical analyses provides direct evidence for two distinct, substrate-specific recruitment pathways that channel RNAs for degradation by the eukaryotic exosome.

Jun-Jie Liu
Matthew A Bratkowski
Hong-Wei Wang
Research15 Dec 2013
Nature Structural & Molecular Biology

Volume: 21, P: 95-102
Pro-CRISPR PcrIIC1-associated Cas9 system for enhanced bacterial immunity

Comprehensive analyses of Cas9 proteins shed light on the evolution of the CRISPR–Cas9 system, and identify a pro-CRISPR accessory protein in bacteria that boosts CRISPR-mediated immunity by enhancing the DNA binding and cleavage activity of Cas9.

Shouyue Zhang
Ao Sun
Jun-Jie Gogo Liu
Research29 May 2024
Nature

Volume: 630, P: 484-492
Daptomycin exerts rapid bactericidal activity against Bacillus anthracis without disrupting membrane integrity

Yu-hua Xing
Wei Wang
Hui-peng Chen
Research23 Dec 2013
Acta Pharmacologica Sinica

Volume: 35, P: 211-218
CHMFL-26 is a highly potent irreversible HER2 inhibitor for use in the treatment of HER2-positive and HER2-mutant cancers

Jiang-yan Cao
Shuang Qi
Qing-song Liu
Research28 Feb 2022
Acta Pharmacologica Sinica

Volume: 43, P: 2678-2686
Author Correction: CasX enzymes comprise a distinct family of RNA-guided genome editors

Jun-Jie Liu
Natalia Orlova
Jennifer A. Doudna
Amendments and Corrections03 Apr 2019
Nature

Volume: 568, P: E8-E10
Gate-controlled reversible rectifying behaviour in tunnel contacted atomically-thin MoS₂ transistor

Van der Waals heterostructures of atomically thin materials hold promise for nanoelectronics. Here, the authors demonstrate a reverted stacking fabrication method for heterostructures and devise a vertical tunnel-contacted MoS₂ transistor, enabling gate tunable rectification and reversible pn to np diode behaviour.

Xiao-Xi Li
Zhi-Qiang Fan
Zhi-Dong Zhang
ResearchOpen Access17 Oct 2017
Nature Communications

Volume: 8, P: 1-7
Super-strong dislocation-structured high-carbon martensite steel

Jun-jie Sun
Yong-ning Liu
Xiao-bing Ren
ResearchOpen Access26 Jul 2017
Scientific Reports

Volume: 7, P: 1-7
Auxin transport and activity regulate stomatal patterning and development

Stomata regulate gas exchange between plants and the atmosphere but whether the plant hormone auxin regulates stomatal development has not been investigated. Here, the authors reveal dynamic changes of auxin activity levels during stomatal development and show that auxin transporters are required for stomatal patterning.

Jie Le
Xu-Guang Liu
Fred Sack
Research27 Jan 2014
Nature Communications

Volume: 5, P: 1-8
Theranostic near-infrared-IIb emitting nanoprobes for promoting immunogenic radiotherapy and abscopal effects against cancer metastasis

Hypoxia and immunosuppression contribute to tumor resistance to radiotherapy (RT). Here the authors design a nanoprobe based on NIR-IIb emitting quantum dots for image-guided RT and modified with catalase to relieve hypoxia in the tumor microenvironment, enhancing the precision and efficacy of RT and promoting anti-tumor immune responses.

Hao Li
Meng Wang
Zhi-Jun Sun
ResearchOpen Access09 Dec 2021
Nature Communications

Volume: 12, P: 1-17
Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China

Wei Tang
Jun-jie Zou
Yong-quan Shi
Research05 Sept 2011
Acta Pharmacologica Sinica

Volume: 32, P: 1381-1386
Cryo-EM structure of the exocyst complex

The structure of the fully assembled yeast exocyst complex, which mediates the tethering of secretory vesicles to the plasma membrane during exocytosis, provides new insights to hierarchical complex assembly and the mechanism of vesicle tethering.

Kunrong Mei
Yan Li
Wei Guo
Research15 Jan 2018
Nature Structural & Molecular Biology

Volume: 25, P: 139-146
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a

Doudna and colleagues determine the mechanisms used by type V anti-CRISPR proteins. AcrVA1 is a multiple-turnover inhibitor that triggers cleavage of the Cas12a-bound guide RNA, while AcrVA4 and AcrVA5 inhibit recognition of dsDNA.

Gavin J. Knott
Brittney W. Thornton
Jennifer A. Doudna
Research01 Apr 2019
Nature Structural & Molecular Biology

Volume: 26, P: 315-321
A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates

A programmable polymer library that responds to external and internal stimuli has been developed and used to fabricate a series of nanocarriers for drug release. The carriers respond to disease biomarkers, triggering self-immolative motifs and leading to the site-specific release of therapeutics both in vitro and in vivo.

Penghui Zhang
Di Gao
Weihong Tan
Research09 Mar 2020
Nature Chemistry

Volume: 12, P: 381-390
Activation of MST1 protects filtration barrier integrity of diabetic kidney disease in mice through restoring the tight junctions of glomerular endothelial cells

Ting-ting Yang
Ying Liu
Xiao-xing Yin
Research06 Dec 2024
Acta Pharmacologica Sinica

Volume: 46, P: 1345-1360
Association of CYP2D6 and CYP1A2 gene polymorphism with tardive dyskinesia in Chinese schizophrenic patients

Yan Fu
Chang-he Fan
Xin-qiao Lu
Research01 Mar 2006
Acta Pharmacologica Sinica

Volume: 27, P: 328-332
Influences of CYP2D6^*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis

Qi Pei
Lu Huang
Guo-ping Yang
Research26 Sept 2016
Acta Pharmacologica Sinica

Volume: 37, P: 1499-1508
Diverse activation mechanisms of PI3Ks

The class II phosphatidylinositol 3-kinases (PI3Ks) serve important roles in diverse cellular processes. The lab of Volker Haucke has now determined high-resolution structures of mouse PI3KC2α in both active and inactive conformations, elucidating the autoregulatory mechanism of class II PI3K activation.

Pujuan Deng
Jun-Jie Gogo Liu
News & Views07 Mar 2022
Nature Structural & Molecular Biology

Volume: 29, P: 185-187
The role of halophyte-induced saline fertile islands in soil microbial biogeochemical cycling across arid ecosystems

Halophyte shrubs serve as hotspots for halophilic microbes, enhancing microbial nutrient transformation in saline soils.

Shuai Zhao
Marcel G. A. van der Heijden
Chang-yan Tian
ResearchOpen Access29 Aug 2024
Communications Biology

Volume: 7, P: 1-13
Targeting METTL3 mitigates venetoclax resistance via proteasome-mediated modulation of MCL1 in acute myeloid leukemia

Chang-qing Jiao
Chen Hu
Jian Ge
ResearchOpen Access01 Apr 2025
Cell Death & Disease

Volume: 16, P: 1-14
Author Correction: Laparoscopic Versus Open Liver Resection for Colorectal Liver Metastases: A Comprehensive Systematic Review and Meta-analysis

Si-Ming Xie
Jun-Jie Xiong
Xu-Bao Liu
Amendments and CorrectionsOpen Access18 Apr 2018
Scientific Reports

Volume: 8, P: 1
Laparoscopic Versus Open Liver Resection for Colorectal Liver Metastases: A Comprehensive Systematic Review and Meta-analysis

Si-Ming Xie
Jun-Jie Xiong
Xu-Bao Liu
ResearchOpen Access21 Apr 2017
Scientific Reports

Volume: 7, P: 1-10
YY1/HIF-1α/mROS positive-feedback loop exacerbates glomerular mesangial cell proliferation in mouse early diabetic kidney disease

Ting-ting Yang
Yu-ting Shao
Qian Lu
Research04 Mar 2025
Acta Pharmacologica Sinica

Volume: 46, P: 1974-1989
Emerging regulated cell death mechanisms in bone remodeling: decoding ferroptosis, cuproptosis, disulfidptosis, and PANoptosis as therapeutic targets for skeletal disorders

Hai-Ting Hu
Zhen-Yu Zhang
Feng-Lai Yuan
ReviewsOpen Access21 Jul 2025
Cell Death Discovery

Volume: 11, P: 1-24
SOX7 co-regulates Wnt/β-catenin signaling with Axin-2: both expressed at low levels in breast cancer

Huidi Liu
Emilio Mastriani
Shu-Lin Liu
ResearchOpen Access18 May 2016
Scientific Reports

Volume: 6, P: 1-14
Starvation during pregnancy impairs fetal oogenesis and folliculogenesis in offspring in the mouse

Jun-Jie Wang
Xiao-Wei Yu
Wei Shen
ResearchOpen Access18 Apr 2018
Cell Death & Disease

Volume: 9, P: 1-13
The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis

Jun-Jie Wu
Zi-Li Sun
Feng-Lai Yuan
ResearchOpen Access06 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-14
Subtyping-based platform guides precision medicine for heavily pretreated metastatic triple-negative breast cancer: The FUTURE phase II umbrella clinical trial

Yin Liu
Xiu-Zhi Zhu
Zhi-Ming Shao
ResearchOpen Access27 Mar 2023
Cell Research

Volume: 33, P: 389-402
The compact Casπ (Cas12l) ‘bracelet’ provides a unique structural platform for DNA manipulation

Ao Sun
Cheng-Ping Li
Jun-Jie Gogo Liu
Research17 Jan 2023
Cell Research

Volume: 33, P: 229-244
LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway

Jun Lu
Liang-min Fu
Jun-hang Luo
ResearchOpen Access25 Mar 2023
Oncogene

Volume: 42, P: 1543-1557
Diabetes downregulates peptide transporter 1 in the rat jejunum: possible involvement of cholate-induced FXR activation

Li-min Liang
Jun-jie Zhou
Xiao-dong Liu
Research27 Apr 2020
Acta Pharmacologica Sinica

Volume: 41, P: 1465-1475
Circ-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4–β-catenin complex and downregulation of SOX9

Circular RNA Circ0075305 hinders gastric cancer stem cells by indirectly increasing the expression of RPRD1A. In turn, RPRD1A disrupts TCF4-β-catenin complex formation and promotes downregulation of SOX9 transcription.

Qi-Yue Chen
Kai-Xiang Xu
Chang-Ming Huang
ResearchOpen Access07 May 2024
Communications Biology

Volume: 7, P: 1-16
Feasibility study of ⁶⁸Ga-labeled CAR T cells for in vivo tracking using micro-positron emission tomography imaging

Xin-yu Wang
Yan Wang
Min Yang
Research08 Sept 2020
Acta Pharmacologica Sinica

Volume: 42, P: 824-831
Soil pH is equally important as salinity in shaping bacterial communities in saline soils under halophytic vegetation

Shuai Zhao
Jun-Jie Liu
Chang-Yan Tian
ResearchOpen Access14 Mar 2018
Scientific Reports

Volume: 8, P: 1-11
High-efficiency backward four-wave mixing by quantum interference

Zi-Yu Liu
Jian-Ting Xiao
Yong-Fan Chen
ResearchOpen Access17 Nov 2017
Scientific Reports

Volume: 7, P: 1-9
Electrochemiluminescence energy transfer-promoted ultrasensitive immunoassay using near-infrared-emitting CdSeTe/CdS/ZnS quantum dots and gold nanorods

Lingling Li
Ying Chen
Jun-Jie Zhu
ResearchOpen Access25 Mar 2013
Scientific Reports

Volume: 3, P: 1-10
In vitro oogenesis from murine premeiotic germ cells using a new three-dimensional culture system

Lu Wang
Zi-Hui Yan
Wei Shen
ResearchOpen Access31 Jul 2023
Cell Death Discovery

Volume: 9, P: 1-10
CryoEM structure of yeast cytoplasmic exosome complex

Jun-Jie Liu
Chu-Ya Niu
Hong-Wei Wang
Research13 May 2016
Cell Research

Volume: 26, P: 822-837
A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis

Shulin Li
Rui Yan
Liang Ge
Research24 Sept 2021
Cell Research

Volume: 32, P: 119-138
Collagen I-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression

Yi-xiao Xiong
Xiao-chao Zhang
Wan-guang Zhang
Research28 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1648-1665
Gene expression profile analysis of ileum transcriptomes in pigs fed Gelsemium elegans plants

Chong-Yin Huang
Kun Yang
Zhao-Ying Liu
ResearchOpen Access31 Oct 2019
Scientific Reports

Volume: 9, P: 1-8
Immunogenic hypofractionated radiotherapy sensitising head and neck squamous cell carcinoma to anti-PD-L1 therapy in MDSC-dependent manner

Liang Mao
Jun-Jie Zhou
Zhi-Jun Sun
Research28 Mar 2023
British Journal of Cancer

Volume: 128, P: 2126-2139
Immunosuppressive effect of arsenic trioxide on islet xenotransplantation prolongs xenograft survival in mice

Bin Zhao
Jun-jie Xia
Ben-hua Zhao
ResearchOpen Access14 Mar 2018
Cell Death & Disease

Volume: 9, P: 1-11
Author Correction: Cryo-EM structure and biochemical analysis reveal the basis of the functional difference between human PI3KC3-C1 and -C2

Meisheng Ma
Jun-Jie Liu
Hong-Wei Wang
Amendments and Corrections13 Apr 2020
Cell Research

Volume: 30, P: 551-552
New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity

Qiu-Yue Qi
Er-Wei Li
Hong-Wei Liu
ResearchOpen Access19 May 2015
Scientific Reports

Volume: 5, P: 1-7

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