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The researchers showcase nonvolatile multilevel tunable SO(m) holonomy in heterogeneous integrated photonics, merging static geometric-phase control with programmability for robust and adaptable “all-geometric” classical and quantum information processing.

ELA induced by social deprivation on postnatal days 10–20 impairs looming-evoked innate defensive behaviors via decreased oxytocin receptor mRNA levels in the intermediate and deep layers of the superior colliculus.

TAK1 is a key mediator of human inflammatory bowel diseases (IBD) through the NF-kB pathway. Here, the authors show that TAK1 phosphorylates TRADD, which cooperates with RIPK1 to intestinal pathology and inflammation in a mouse model of IBD.

This study reveals that the TRPC3 channel is essential for HPV-driven cervical cancer. TRPC3 promotes malignant transformation by regulating the RASA4/MAPK pathway and EMT. Targeting TRPC3 could be a new therapeutic strategy.

Necrosomes formed by RIPK1–RIPK3 mediate necroptosis. Super-resolution microscopy identifies the architectural features of necrosomes and provides mechanistic insights into the signalling from RIPK1 to RIPK3 when RIPK1 is activated to mediate necroptosis, and from RIPK3 to RIPK1 when RIPK3 is inhibited to mediate apoptosis.

Liu and colleagues examine how severe acute respiratory syndrome coronavirus 2 variants evade CD8⁺ T cell epitope recognition.

StrucGP offers a de novo glycan mapping method to determine detailed N-glycan structures at the site-specific level.

Adult zebrafish possess the ability to regenerate injured hearts through a complex orchestration of molecular and cellular activities. Here, the authors present a single cell and spatially-resolved atlas of the regenerating zebrafish heart, which serves as a valuable resource for research on heart regeneration.

ERα^vlVMH neurons mediate the inhibitory role of 17β-oestradiol on prolactin production, and this inhibition is lifted in lactating mice to promote lactation-associated metabolic adaptations.

Using exome sequencing data from one of the largest cohorts of children with cerebral palsy, the genetic diagnostic rates of single-nucleotide and copy number variants were assessed and a sizeable fraction found to be clinically actionable.

Oncogene-induced senescence (OIS) occurs in premalignant lung adenomas, but infrequently in malignant adenocarcinomas. Here the authors show that USP5-Beclin 1 axis overcomes OIS in Kras-driven lung cancer by enhancing MDM2-mediated p53 degradation.

Strain engineering is promising for improving catalytic capability of biocatalysts, but it is challenging to modify the atomic-scale strain for specific enzyme-like reactions. Here, the authors report the biocatalysts with atomically-resolved Pt clusters laminated on PdAu nanocrystals and show that the tensile strains contribute to the enzyme-like activities greater than that of natural enzymes.

When an order parameter has multiple components, fluctuations can suppress the ordering partially, leaving behind vestigial order. Here the authors show that nematic superconductivity in electron-doped Bi₂Se₃ gives way to a vestigial nematic phase driven by fluctuating Cooper pairs.

The discrepancy between the short half-life of ketamine and its long-lasting effects is due to ketamine being trapped in NMDA receptors, and its release depends on neural activity in the lateral habenula.

MHC-I mediated antigen presentation is an important element of the anti-tumour immune response. Here authors identify a tumour immune escape mechanism by which the cancer cells express the ubiquitin E3 ligase UHRF1 in the cytoplasm instead of the nuclear expression pattern observed in normal tissues, and this results in degradation of MHC-I and thus diminished antigen presentation and anti-tumour T cell response.

Iron–rhodium is a promising material for antiferromagnetic (AFM) spintronics applications. Here, the authors demonstrate a strong enhancement of damping during the ferromagnetic (FM) to AFM phase transition caused by lateral spin pumping from FM domains to the AFM matrix.

Designing an efficient activation function for optical neural networks remains a challenge. Here, the authors demonstrate a modulator-detector-in-one graphene/silicon heterojunction ring resonators enabling on-chip reconfigurable activation function devices with phase activation capability for optical neural networks.

The foundry-compatible platform could facilitate integration of phase change materials for reconfigurable photonics and open up the possibility of integrating excellent optoelectronic materials into future silicon photonic process design kits.

The zinc finger-containing transcription factor KLF5 drives cell proliferation and migration. Here, the authors show that the debuquitinase BAP1 directly stabilizes KLF5, thus promoting basal-like breast cancer cell-cycle progression and metastasis.

Resistance to anti-HER2 therapy in breast cancer remains a major obstacle in the clinic. Here the authors performed a CRISPR-selective vulnerability screen to identify transaldoloase as a target that is synthetically lethal with HER2 inhibition in breast cancer cells.

The issue that whether single-atom sites possess similar catalytic properties to the interfacial sites of nanocatalysts remains unresolved. Here, the authors demonstrate a large H₂O promotional effect on CO oxidation over Au single-atom sites due to their unique local atomic structure and electronic properties.

Immunoglobulin A protects against infectious disease and contributes to autoimmune and inflammatory disorders. Here, the authors perform a genome-wide association study for serum IgA levels, identifying 20 genome-wide significant loci, providing new insights into the genetic regulation of IgA levels.

The authors show that stimulus strength-dependent effects of DA on 5-HT^DRN neurons bidirectionally regulate feeding in mice. DRD1-mediated activation of 5-HT^DRN neurons contributes to activity-based anorexia, and this can be prevented by blocking DRD1.

Ilamycin E/F target the ClpC1P1P2 protease, disrupting mycobacterial protein homeostasis and causing cell death. ClpX mutation of ClpXP1P2 protease confer resistance to ilamycin E/F, highlighting Clp proteases as key vulnerability/resistance nodes.

The molecular mechanisms underlying Benzbromarone’s interference with the Hsp90-Aha1 system advance the understanding of Aha1’s interaction with Hsp90 and shed light on the rational design of chemical modulators with high specificity towards Aha1.