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The Panoptes antiphage system defends bacteria by detecting phage-encoded counter-defences that sequester cyclic nucleotide signals, triggering membrane disruption and highlighting a broader strategy of sensing immune evasion through second-messenger surveillance.

The release of triplet or singlet oxygen is governed by individual Marcus normal and inverted region behaviour.

Achieving deep blue emission and high practical efficiency in organic light-emitting devices remains a considerable challenge. Here, the authors report late-stage double borylation of boron/nitrogen based multi-resonance frameworks, achieving maximum efficiency of over 32% in stable devices.

The quark structure of the f₀(980) hadron is still unknown after 50 years of its discovery. Here, the CMS Collaboration reports a measurement of the elliptic flow of the f₀(980) state in proton-lead collisions at a nucleon-nucleon centre-of-mass energy of 8.16 TeV, providing strong evidence that the state is an ordinary meson.

Spin-enhanced lateral flow tests use nanodiamonds for the sensitive, robust detection of disease biomarkers. Here, authors report a clinical evaluation of a test for SARS-CoV-2 antigen, finding 95.1% sensitivity (Ct ≤ 30) and 100% specificity, with detection 2.0 days earlier than conventional tests.

Although ice plays a crucial role in shaping our ecosphere, its microstructures formed by freezing water remain unclear. Here, the authors employ cryogenic liquid-cell TEM to gain atomic-level insights into ice defects frozen from liquid water.

Yamazoe et al. show that B cell-derived autoantibodies contribute to the development of atrial fibrillation, suggesting that targeting the humoral immune response may represent a viable therapeutic approach.

Squeezed light field microscopy (SLIM) combines ideas from tomography and compressed sensing with light field microscopy to enable volumetric imaging at kilohertz rates, as demonstrated in blood flow imaging in zebrafish and voltage imaging in leeches and mice.

A study of several longitudinal birth cohorts and cross-sectional cohorts finds only moderate overlap in genetic variants between autism that is diagnosed earlier and that diagnosed later, so they may represent aetiologically different conditions.

Nonaqueous redox flow batteries face challenges like costly membranes and unstable electrolytes. Here, authors develop a membrane-free battery using a polypropylene carbonate gel polymer electrolyte with Li anode and Tri-TEMPO catholyte, achieving a high voltage of 3.45 V, capacity retention of 96.8%, and efficiency of 98.4%.

Cancer cells can squeeze through confined spaces and undergo nuclear deformation, leading to changes in chromatin organisation. Here, the authors show that mechanical constriction in microcapillaries reprograms melanoma cells to a tumorigenic stem cell-like state through the mechanosensor PIEZO1.

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

Plasma proteomics plays a key role in advancing clinical research and biomarker discovery. Here, the authors show in a large MSCoreSys multicenter benchmark study that DIA outperforms DDA, delivering robust, precise, and reproducible label-free protein quantification across sites.

Understanding global methane trends remains limited, especially from a consumption view. This study shows rising emissions, limited decoupling, and shifting trade patterns involving more emerging and developing economies.

LRP8, an apolipoprotein E and reelin receptor with high expression in the brain, is a receptor for tick-borne encephalitis virus.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

Opposing forces generated by exopolysaccharide trail binding versus type IV pilus retraction generate a high cyclic diGMP–high cyclic AMP state in Pseudomonas aeruginosa that promotes social motility.

Understanding collective behaviour is an important aspect of managing the pandemic response. Here the authors show in a large global study that participants that reported identifying more strongly with their nation reported greater engagement in public health behaviours and support for public health policies in the context of the pandemic.

The LHCb experiment at CERN has observed significant asymmetries between the decay rates of the beauty baryon and its CP-conjugated antibaryon, thus demonstrating CP violation in baryon decays.

A purpose-built implantable system based on biomimetic epidural electrical stimulation of the spinal cord reduces the severity of hypotensive complications in people with spinal cord injury and improves quality of life.

Researchers observe directional strong coupling on the nanoscale between hyperbolic phonon polaritons and pentacene molecules.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

An amphiphilic mimotope vaccine can be used in tandem with Food and Drug Administration (FDA)-approved CD19 CAR-T cell products.

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Seeded growth methods are used to prepare highly ordered, crystalline semiconducting poly(di-n-hexylfluorene) platelet micelles, which exhibit long-range anisotropic exciton diffusion, particularly along the π–π-stacking direction.

A unified realization of the volt, ohm and ampere can be achieved by integrating a quantum anomalous Hall resistor and a programmable Josephson voltage standard in a single cryostat.

In this Stage 2 Registered Report, Buchanan et al. show evidence confirming the phenomenon of semantic priming across speakers of 19 diverse languages.

Low frequency brain waves convey information between regions. Here, the authors demonstrate that for patients with major depression, mood becomes more negative as low frequency waves increase intensity  across the prefrontal cortex.

Biofilm formation by Vibrio cholerae is regulated by c-di-GMP and requires the type IV MSHA pilus. Here, Floyd et al. show that the MSHA pilus is a dynamic system, and that both extension and retraction are directly controlled by c-di-GMP via regulation of activity of the extension ATPase MshE.

Electrified reactive capture converts CO₂ from carbonate solutions but suffers from low Faradaic efficiency. Here, the authors report a templated synthesis with defined pores and Ni single atoms to accumulate CO₂, achieving 46% energy efficiency to syngas at 300 mA/cm²

Cyclic diadenosine monophosphate (c-di-AMP) is a newly identified nucleotide second messenger in bacteria. Though protein receptors for c-di-AMP are known, the ydaO riboswitch has now been validated as a physiological sensor of cellular c-di-AMP levels.

mRNA-based therapies require efficient and selective delivery systems to advance clinical applications and overcome challenges posed by current formulations. Here, authors developed Discrete Immolative Guanidinium Transporters (DIGITs), chemically defined carriers that enable pHresponsive mRNA release with organ and reticulocyte selectivity, minimal toxicity, and scalable synthesis.

Sensorineureal hearing loss is a form of deafness when sensory cells cannot sense vibrations. Here the authors design a piezo-ionotropic polymer for multi-resonance acoustic sensing, driven by ion hitching-in cage effect.

Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.

Altermagnets, unlike their conventional collinear antiferromagnetic counterparts, allow for an anomalous Nernst response despite their collinear compensated magnetic ordering. Here, Badura et al find such an anomalous Nernst effect at zero magnetic field in the altermagnetic candidate, Mn₅Si₃.

Many bacteria use the second messenger cyclic diguanylate (c-di-GMP) to control motility, biofilm production and virulence. Here, the authors identify a thermosensitive enzyme that synthesizes c-di-GMP and modulates temperature-dependent motility, biofilm development and virulence in the opportunistic pathogen Pseudomonas aeruginosa.

The authors analyze rare coding variants in 1990 individuals with congenital kidney anomalies, finding diagnostic variants in 14.1% of cases. They identify two new causal genes, ARID3A and NR6A1, along with 38 candidate genes, providing evidence for shared genetics with other developmental disorders.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.