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Scientific Reports (26)
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Showing 1–50 of 89 results

Advanced filters: Author: Kazuhiko Inoue Clear advanced filters

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Recyclable Shape-memory and Mechanical Strength of Poly(lactic acid) Compounds Cross-linked by Thermo-reversible Diels-Alder Reaction

Midori Yamashiro
Kazuhiko Inoue
Masatoshi Iji
Research04 Jun 2008
Polymer Journal

Volume: 40, P: 657-662
Offspring production with sperm grown in vitro from cryopreserved testis tissues

As the fertility of pre-pubertal male patients undergoing chemotherapy cannot be preserved using semen cryopreservation, alternative approaches are needed. Here the authors generate live mouse offspring via assisted reproduction technologies, using round spermatids or sperm derived from neonatal mouse cryopreserved testis tissues.

Tetsuhiro Yokonishi
Takuya Sato
Takehiko Ogawa
Research01 Jul 2014
Nature Communications

Volume: 5, P: 1-6
A novel protein that participates in nonself discrimination of malignant cells by homologous complement

Misako Matsumoto
Junji Takeda
Tsukasa Seya
Research01 Nov 1997
Nature Medicine

Volume: 3, P: 1266-1270
Novel Shape Memory Using Delay and Thermal Hysteresis of Crystalline Phase Transition in Cross-Linked Polybutylene Succinate

Kazuhiko Inoue
Midori Yamashiro
Research24 Jun 2009
Polymer Journal

Volume: 41, P: 586-587
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Preparation of a New Class of Telechelic Polyamides with Amino Groups from Bicyclic Oxalactam

Kazuhiko Hashimoto
Hiroshi Sumitomo
Research01 Jul 1983
Polymer Journal

Volume: 15, P: 547-552
Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor

Kazuhiko Date
Kunio Matsumoto
Toshikazu Nakamura
Research09 Dec 1998
Oncogene

Volume: 17, P: 3045-3054
Asymmetric-Selective Polymerization of 2,3-Epoxypropyl Methacrylate with Grignard Reagent-(−)-Sparteine Systems in Toluene at −78°C

Yoshio Okamoto
Kazuhiko Urakawa
Heimei Yuki
Research01 Jul 1978
Polymer Journal

Volume: 10, P: 473-475
Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci

Chiea Chuen Khor, Tin Aung, Francesca Pasutto, Janey Wiggs and colleagues report a global genome-wide association study of exfoliation syndrome and a fine-mapping analysis of a previously identified disease-associated locus, LOXL1. They identify a rare protective variant in LOXL1 exclusive to the Japanese population and five new common variant susceptibility loci.

Tin Aung
Mineo Ozaki
Chiea Chuen Khor
Research29 May 2017
Nature Genetics

Volume: 49, P: 993-1004
Evolution of imprinting via lineage-specific insertion of retroviral promoters

Although many species-specific imprinted genes have been identified, how the evolutionary switch from biallelic to imprinted expression occurs is still unknown. Here authors find that lineage-specific ERVs active as oocyte promoters can induce de novo DNA methylation at gDMRs and imprinting.

Aaron B. Bogutz
Julie Brind’Amour
Louis Lefebvre
ResearchOpen Access12 Dec 2019
Nature Communications

Volume: 10, P: 1-14
Photocatalyst releasing hydrogen from water

Enhancing catalytic performance holds promise for hydrogen production by water splitting in sunlight.

Kazuhiko Maeda
Kentaro Teramura
Kazunari Domen
Research15 Mar 2006
Nature

Volume: 440, P: 295
An aposymbiotic primary coral polyp counteracts acidification by active pH regulation

Yoshikazu Ohno
Akira Iguchi
Takashi Nakamura
ResearchOpen Access18 Jan 2017
Scientific Reports

Volume: 7, P: 1-8
Effect of texture and color enhancement imaging on the visibility of gastric tumors

Hiroaki Sakai
Naoto Iwai
Yoshito Itoh
ResearchOpen Access18 Aug 2024
Scientific Reports

Volume: 14, P: 1-8
Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production

Mariko Kajiwara-Kubota
Kazuhiko Uchiyama
Yuji Naito
ResearchOpen Access28 Mar 2023
npj Science of Food

Volume: 7, P: 1-7
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Identification of nesfatin-1 as a satiety molecule in the hypothalamus

A secreted protein, nesfatin-1, is expressed in the hypothalamus and induces the feeling of being full. In rats, its injection into the brain decreases food intake, but blocking its action stimulates appetite.

Shinsuke Oh-I
Hiroyuki Shimizu
Masatomo Mori
Research01 Oct 2006
Nature

Volume: 443, P: 709-712
Transfusion ratios and survival in severe blunt trauma patients receiving massive transfusion

Toru Takiguchi
Tomohisa Seki
Shoji Yokobori
ResearchOpen Access15 Jul 2025
Scientific Reports

Volume: 15, P: 1-11
Rapid procedures for prenatal diagnosis of Cockayne syndrome

Kazuhiko Kawai
Mituo Ikenaga
Yuichi Kumahara
Research01 Sept 1983
Japanese journal of human genetics

Volume: 28, P: 223-229
Establishment of Cockayne syndrome fibroblast cell line belonging to complementation group B by SV40 transformation

Kiyoji Tanaka
Kazuhiko Kawai
Yoshio Okada
Research14 Jun 2005
Japanese journal of human genetics

Volume: 30, P: 21-29
Rat maf related genes: specific expression in chondrocytes, lens and spinal cord

Masaharu Sakai
Junko Imaki
Shinzo Nishi
Research13 Feb 1997
Oncogene

Volume: 14, P: 745-750
Preparation of Phospholipid Polymers and Their Properties as Polymer Hydrogel Membranes

Kazuhiko Ishihara
Tomoko Ueda
Nobuo Nakabayashi
Research06 Apr 2005
Polymer Journal

Volume: 22, P: 355-360
Single-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases

This analysis of single-cell RNA sequencing data from peripheral blood mononuclear cells for 474 individuals of diverse Asian ancestries in the Asian Immune Diversity Atlas links cell-type-specific splicing variation with autoimmune and inflammatory disease risk.

Chi Tian
Yuntian Zhang
Boxiang Liu
ResearchOpen Access03 Dec 2024
Nature Genetics

Volume: 56, P: 2739-2752
Association analyses confirming a susceptibility locus for intracranial aneurysm at chromosome 14q23

Yohei Mineharu
Kayoko Inoue
Akio Koizumi
Research01 Apr 2008
Journal of Human Genetics

Volume: 53, P: 325-332
Can Daily Walking Alone Reduce Pneumonia-Related Mortality among Older People?

Takaaki Ikeda
Sumito Inoue
Tsuyoshi Watanabe
ResearchOpen Access22 May 2020
Scientific Reports

Volume: 10, P: 1-7
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
TGF-β3-expressing CD4⁺CD25⁻LAG3⁺ regulatory T cells control humoral immune responses

B cells reactive against self antigens can cause autoimmune disease, but are normally suppressed by regulatory T cells (Tregs). Here the authors show that a subset of Tregs can suppress lupus in a mouse model by making TGF-β3 cytokine and by engaging an inhibitory PD-1 receptor on B cells.

Tomohisa Okamura
Shuji Sumitomo
Kazuhiko Yamamoto
ResearchOpen Access19 Feb 2015
Nature Communications

Volume: 6, P: 1-14
Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance

The gut is populated by a myriad of microorganisms and how the immune system tolerates their presence is of great interest. Here, by studying colon morphology in multiple knockout mice, the authors demonstrate a potential role for prostaglandin E2 and SOCS1 in mediating immune tolerance.

Takatoshi Chinen
Kyoko Komai
Akihiko Yoshimura
ResearchOpen Access08 Feb 2011
Nature Communications

Volume: 2, P: 1-11
Water-soluble cellulose acetate attenuates glucose intolerance through GLP-1 and PYY signal upregulation

Kohei Asaeda
Tomohisa Takagi
Yoshito Itoh
ResearchOpen Access02 Jul 2025
npj Science of Food

Volume: 9, P: 1-8
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction

The enzyme ACE2 is involved in cardiac pathology and can counteract heart failure and other cardio-pulmonary diseases. Here the authors show that bacteria produce an ACE2-like enzyme that is effective in suppressing cardiac hypertrophy and fibrosis in mice.

Takafumi Minato
Satoru Nirasawa
Keiji Kuba
ResearchOpen Access26 Feb 2020
Nature Communications

Volume: 11, P: 1-12
Comprehensive immunophenotyping reveals distinct tumor microenvironment alterations in anti-PD-1 sensitive and resistant syngeneic mouse model

Hiroyuki Inoue
Takayuki Hamasaki
Naoto Horai
ResearchOpen Access10 Mar 2025
Scientific Reports

Volume: 15, P: 1-12
Selective and Potent in Vitro Antitrypanosomal Activities of Ten Microbial Metabolites

Kazuhiko Otoguro
Aki Ishiyama
Satoshi Ōmura
Research01 Jun 2008
The Journal of Antibiotics

Volume: 61, P: 372-378
Synthesis and Properties of Segmented Poly(urethane-urea)s Containing Phosphorylcholine Moiety in the Side-Chain

Yu Nagase
Satoru Nakajima
Kazuhiko Ishihara
Research08 Oct 2008
Polymer Journal

Volume: 40, P: 1149-1156
Association between Obesity and Chronic Kidney Disease in Japanese: Differences in Gender and Hypertensive Status?

Nobukazu Ishizaka
Yuko Ishizaka
Minoru Yamakado
Research01 Nov 2007
Hypertension Research

Volume: 30, P: 1059-1064
Plasma Adiponectin Is Associated with Plasma Brain Natriuretic Peptide and Cardiac Function in Healthy Subjects

Takahiro Ohara
Jiyoong Kim
Masafumi Kitakaze
Research01 May 2008
Hypertension Research

Volume: 31, P: 825-831
Vinylbenzyl-Type Polyamide Macromer Synthesized from Bicyclic Oxalactam. Preparation and Characterization of Graft Copolymer Composed of Polystyrene as a Stock and Hydrophilic Polyamide as Branches

Kazuhiko Hashimoto
Hiroshi Sumitomo
Masaya Kawasumi
Research01 Sept 1985
Polymer Journal

Volume: 17, P: 1045-1054
Inhibition of Vascular Angiotensin-Converting Enzyme by Telmisartan via the Peroxisome Proliferator–Activated Receptor γ Agonistic Property in Rats

Shinji Takai
Denan Jin
Mizuo Miyazaki
Research01 Dec 2007
Hypertension Research

Volume: 30, P: 1231-1237
An Acyllactam-Type Growable End Group Formed in the Anionic Polymerization of a Bicyclic Oxalactam. The Isolation of the Polyamide and Its Use as an Activator in the Polymerization of 2-Pyrrolidone

Kazuhiko Hashimoto
Hiroshi Sumitomo
Housei Shinoda
Research01 Apr 1988
Polymer Journal

Volume: 20, P: 321-331
Status of Uric Acid Management in Hypertensive Subjects

Yasutaka Yamamoto
Koichi Matsubara
Ichiro Hisatome
Research01 Jun 2007
Hypertension Research

Volume: 30, P: 549-554
Urolithin A-mediated augmentation of intestinal barrier function through elevated secretory mucin synthesis

Takeshi Yasuda
Tomohisa Takagi
Yoshito Itoh
ResearchOpen Access08 Jul 2024
Scientific Reports

Volume: 14, P: 1-13
Correction: Corrigendum: A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome

Tin Aung
Mineo Ozaki
Chiea-Chuen Khor
Amendments and Corrections27 May 2015
Nature Genetics

Volume: 47, P: 689
Association of maternal home blood pressure trajectory during pregnancy with infant birth weight: the BOSHI study

Noriyuki Iwama
Mari S. Oba
Hirohito Metoki
Research10 Mar 2020
Hypertension Research

Volume: 43, P: 550-559
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line

The FANTOM4 study identified transcriptional start sites active during proliferation arrest and differentiation of the human monocytic cell line THP-1. Systematic knockdown of 52 transcription factors provide support for their model in which a complex transcriptional network regulates the differentiation process.

Harukazu Suzuki
Alistair R R Forrest
Yoshihide Hayashizaki
Research19 Apr 2009
Nature Genetics

Volume: 41, P: 553-562
Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer

Hiromi Sakamoto
Kimio Yoshimura
Setsuo Hirohashi
Research18 May 2008
Nature Genetics

Volume: 40, P: 730-740
Author Correction: Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production

Mariko Kajiwara-Kubota
Kazuhiko Uchiyama
Yuji Naito
Amendments and CorrectionsOpen Access22 Apr 2023
npj Science of Food

Volume: 7, P: 1
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

Yuta Kochi and colleagues report a meta-analysis of genome-wide association studies for rheumatoid arthritis in a Japanese population. They identify nine loci newly associated with rheumatoid arthritis in this population and consider overlap of associations with previous studies in European populations.

Yukinori Okada
Chikashi Terao
Kazuhiko Yamamoto
Research25 Mar 2012
Nature Genetics

Volume: 44, P: 511-516

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