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Showing 1–50 of 75 results

Advanced filters: Author: Kazuhiro Otsuka Clear advanced filters

Archaean green-light environments drove the evolution of cyanobacteria’s light-harvesting system

Cyanobacteria use both chlorophylls and phycobilins to absorb light energy, and authors here use cultivation experiments, numerical simulations and protein phylogenetics to argue that cyanobacteria evolved in a green-light environment during the Archaean era in which green-specialized phycobilins would have been selectively advantageous.

Taro Matsuo
Kumiko Ito-Miwa
Hideaki Miyashita
ResearchOpen Access18 Feb 2025
Nature Ecology & Evolution

Volume: 9, P: 599-612
A radiation hybrid map of the rat genome containing 5,255 markers

Takeshi K. Watanabe
Marie-Therese Bihoreau
Michael R. James
Research01 May 1999
Nature Genetics

Volume: 22, P: 27-36
Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation

The glutamate transporter GLAST in astrocyte regulates synapse function by glutamate clearance. Here, the authors show that Down syndrome cell adhesion molecule (DSCAM) in Purkinje cells controls synaptogenesis through the intercellular association with GLAST in the developing cerebellum.

Ken-ichi Dewa
Nariko Arimura
Mikio Hoshino
ResearchOpen Access01 Feb 2024
Nature Communications

Volume: 15, P: 1-18
Impaired cortico-striatal excitatory transmission triggers epilepsy

Spike and wave discharge (SWD) activity is seen during absence seizures and is thought to be thalamocortical in origin. Here, the authors show that SWDs are initiated through the impaired corticostriatal excitatory transmissions onto striatal fast spiking interneurons.

Hiroyuki Miyamoto
Tetsuya Tatsukawa
Kazuhiro Yamakawa
ResearchOpen Access23 Apr 2019
Nature Communications

Volume: 10, P: 1-13
Depressive mixed state and anxious distress as risk factors for suicidal behavior during major depressive episodes

Kazuki Ota
Hotaka Shinzato
Yoshikazu Takaesu
ResearchOpen Access07 Apr 2025
Scientific Reports

Volume: 15, P: 1-7
Origin of rubber-like behaviour in metal alloys

Xiaobing Ren
Kazuhiro Otsuka
Research09 Oct 1997
Nature

Volume: 389, P: 579-582
Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

The role of cortical PV neurons in the regulation of sleep architecture and homeostatic sleep rebound is not fully understood. Here, the authors show that CaMKII-mediated control of cortical parvalbumin-neuron activity regulates the homeostatic sleep rebound in mice.

Kazuhiro Kon
Koji L. Ode
Hiroki R. Ueda
ResearchOpen Access18 Jul 2024
Nature Communications

Volume: 15, P: 1-19
Basal-shift transformation leads to EGFR therapy-resistance in human lung adenocarcinoma

Resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) is prevalent. Here the authors establish a biobank of patient-derived EGFR-mutant lung cancer organoids and identify a subgroup of EGFR-TKI-resistant lung adenocarcinoma organoids, which exhibit a basal-shift phenotype and vulnerability to CDK4/6 inhibitors.

Taro Shinozaki
Kazuhiro Togasaki
Toshiro Sato
ResearchOpen Access11 May 2025
Nature Communications

Volume: 16, P: 1-15
Polyesters of 2-Pyrone-4,6-dicarboxylic Acid (PDC) as Bio-based Plastics Exhibiting Strong Adhering Properties

Masakiyo Hishida
Kazuhiro Shikinaka
Kiyotaka Shigehara
Research18 Feb 2009
Polymer Journal

Volume: 41, P: 297-302
Synthesis of [²¹¹At]4-astato-L-phenylalanine by dihydroxyboryl-astatine substitution reaction in aqueous solution

Yoshifumi Shirakami
Tadashi Watabe
Koichi Fukase
ResearchOpen Access21 Jun 2021
Scientific Reports

Volume: 11, P: 1-7
An unbiased tissue transcriptome analysis identifies potential markers for skin phenotypes and therapeutic responses in atopic dermatitis

Atopic dermatitis (AD) with complex manifestations and genetic associations. Here the author profile the transcriptome of 951 skin samples from patients with AD to link skin phenotypes, clinical severity, and efficacy of dupilumab treatment to specific types of immune responses and gene features to serve clues for personalized medicine.

Ayano Fukushima-Nomura
Hiroshi Kawasaki
Masayuki Amagai
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-22
Genome sequencing provides high diagnostic yield and new etiological insights for intellectual disability and developmental delay

Kohei Hamanaka
Atsushi Fujita
Naomichi Matsumoto
ResearchOpen Access26 Aug 2025
npj Genomic Medicine

Volume: 10, P: 1-12
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior

Fagarasan and colleagues show that excessive activation of T cells in mice deficient in the inhibitory receptor PD-1 causes a systemic decrease in tryptophan and tyrosine, which leads to deficiency in serotonin and dopamine in the brain and behavioral changes.

Michio Miyajima
Baihao Zhang
Sidonia Fagarasan
Research23 Oct 2017
Nature Immunology

Volume: 18, P: 1342-1352
A lightweight strain glass alloy showing nearly temperature-independent low modulus and high strength

Temperature-independent (Elinvar) soft elasticity with high strength, which is technologically desired but scientifically challenging, is achieved in a lightweight strain glass Mg alloy.

Chang Liu
Yuanchao Ji
Xiaobing Ren
Research04 Jul 2022
Nature Materials

Volume: 21, P: 1003-1007
Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model

Hiroki Ueno
Yusuke Iyanaga
Atsushi Kasai
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
Rotigotine suppresses sleep-related muscle activity augmented by injection of dialysis patients’ sera in a mouse model of restless legs syndrome

Kazuhiro Muramatsu
Sachiko Chikahisa
Yuichi Inoue
ResearchOpen Access08 Nov 2019
Scientific Reports

Volume: 9, P: 1-9
Expansions of intronic TTTCA and TTTTA repeats in benign adult familial myoclonic epilepsy

This study identifies TTTCA- and TTTTA-repeat expansions in benign adult familial myoclonic epilepsy. Cortical neurons from affected people exhibit RNA foci containing these expanded repeats, suggesting RNA toxicity as the mechanism underlying disease pathogenesis.

Hiroyuki Ishiura
Koichiro Doi
Shoji Tsuji
Research05 Mar 2018
Nature Genetics

Volume: 50, P: 581-590
Long-term effects of ipragliflozin on blood pressure in patients with type 2 diabetes: insights from the randomized PROTECT trial

Yuichi Saito
Atsushi Tanaka
Kosuke Nishio
Research14 Nov 2023
Hypertension Research

Volume: 47, P: 168-176
Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage

Kiyomitsu Arai
Kazuhiro Morishita
Jun Yokota
Research12 Jun 1997
Oncogene

Volume: 14, P: 2857-2861
Radical Grafting from Carbon Black. Graft Polymerization of Vinyl Monomers Initiated by Azo Groups Introduced onto Carbon Black Surface

Kazuhiro Fujiki
Norio Tsubokawa
Yasuo Sone
Research01 Aug 1990
Polymer Journal

Volume: 22, P: 661-670
Structural basis for lysophosphatidylserine recognition by GPR34

GPR34 is a GPCR which has an immunomodulatory role and recognizes lysophosphatidylserine (LysoPS) as a putative endogenous ligand. Here, authors report two cryo-EM structures of human GPR34-Gi complex with one of two ligands bound: either the LysoPS analogue S3E-LysoPS, or its derivative M1.

Tamaki Izume
Ryo Kawahara
Osamu Nureki
ResearchOpen Access07 Feb 2024
Nature Communications

Volume: 15, P: 1-15
Multifaceted analysis of cross-tissue transcriptomes reveals phenotype–endotype associations in atopic dermatitis

Atopic dermatitis is an inflammatory skin disease featuring systemic involvement. Here authors show that the two major clinical manifestations of the disease, erythema and papulation, are distinguished by differential interplay between local skin and systemic immunity, uncovered by integrated transcriptomics.

Aiko Sekita
Hiroshi Kawasaki
Haruhiko Koseki
ResearchOpen Access02 Oct 2023
Nature Communications

Volume: 14, P: 1-16
Impact of HLA disparity on the risk of overall mortality in patients with grade II–IV acute GVHD on behalf of the HLA Working Group of Japan Society for Hematopoietic Cell Transplantation

Shigeo Fuji
Akitoshi Hakoda
Satoko Morishima
Research03 Sept 2021
Bone Marrow Transplantation

Volume: 56, P: 2990-2996
Multi-omics analysis of diabetic cardiomyopathy pathogenesis using a type 2 diabetic Zucker diabetic fatty rat model

Kazuhiro Tanabe
Qianqian Zheng
Makoto Nakamuta
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-16
Randomised phase II trial of mFOLFOX6 plus bevacizumab versus mFOLFOX6 plus cetuximab as first-line treatment for colorectal liver metastasis (ATOM trial)

Eiji Oki
Yasunori Emi
Yoshihiko Maehara
ResearchOpen Access09 Jul 2019
British Journal of Cancer

Volume: 121, P: 222-229
Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma

EGFR mutations in lung adenocarcinoma are more frequent in East Asians compared to other populations. Here, the authors carry out a genome-wide association study in EGFRmutant cancers and identify loci that are associated with risk of developing this molecular subtype of cancer.

Kouya Shiraishi
Yukinori Okada
Takashi Kohno
ResearchOpen Access09 Aug 2016
Nature Communications

Volume: 7, P: 1-7
Depletion of central memory CD8⁺ T cells might impede the antitumor therapeutic effect of Mogamulizumab

Elimination of regulatory T cells via the anti-CCR4 monoclonal antibody, mogamulizumab, is expected to augment anti-tumour immune response. Authors show here that although regulatory T cell targeting is successful, clinical improvement remains minimal in patients with solid tumours due to concomitant and unintended depletion of central memory CD8⁺ T cells.

Yuka Maeda
Hisashi Wada
Hiroyoshi Nishikawa
ResearchOpen Access14 Dec 2021
Nature Communications

Volume: 12, P: 1-13
Preparation of an amphiphilic diblock copolymer composed of polystyrene and hydrophilic alternating copolymer blocks

Hydrophilic alternating copolymers (P(11EO/MA)_m) of methoxy poly(ethylene glycol) allyl ether (11EO) and maleic anhydride (MA) were prepared via controlled radical polymerization. The MA units in P(11EO/MA)_m were hydrolyzed to prepare pendant carboxylic acid group-containing polymers (P(11EO/MH)_m). Furthermore, an amphiphilic diblock copolymer (P(11EO/MH)_m-PS_n) was prepared via block copolymerization of styrene using P(11EO/MH)_m as a macro-chain transfer agent. The association behavior of P(11EO/MH)_m-PS_n in water was also investigated.

Maho Ohshio
Yoko Mizoue
Shin-ichi Yusa
Research28 Oct 2019
Polymer Journal

Volume: 52, P: 189-197
Somatic inflammatory gene mutations in human ulcerative colitis epithelium

Whole-exome sequencing of colon organoids derived from patients with ulcerative colitis identifies somatic mutations in components of the IL-17 signalling pathway, which may confer a growth advantage to cells under inflammatory conditions.

Kosaku Nanki
Masayuki Fujii
Toshiro Sato
Research18 Dec 2019
Nature

Volume: 577, P: 254-259
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Metabolic Reprogramming in Leaf Lettuce Grown Under Different Light Quality and Intensity Conditions Using Narrow-Band LEDs

Kazuyoshi Kitazaki
Atsushi Fukushima
Miyako Kusano
ResearchOpen Access21 May 2018
Scientific Reports

Volume: 8, P: 1-12
Effects of renal denervation on blood pressure in patients with hypertension: a latest systematic review and meta-analysis of randomized sham-controlled trials

Yukako Ogoyama
Makiko Abe
Hisatomi Arima
Research03 Jun 2024
Hypertension Research

Volume: 47, P: 2745-2759
Hair zinc levels and psychosis risk among adolescents

Koichi Tabata
Mitsuhiro Miyashita
Makoto Arai
ResearchOpen Access25 Nov 2022
Schizophrenia

Volume: 8, P: 1-6
Combination Therapy with Renin-Angiotensin System Inhibitors and the Calcium Channel Blocker Azelnidipine Decreases Plasma Inflammatory Markers and Urinary Oxidative Stress Markers in Patients with Diabetic Nephropathy

Susumu Ogawa
Takefumi Mori
Sadayoshi Ito
Research01 Jun 2008
Hypertension Research

Volume: 31, P: 1147-1155
Fruit and Vegetable Consumption and the Risk of Hypertension Determined by Self Measurement of Blood Pressure at Home: The Ohasama Study

Megumi T Utsugi
Takayoshi Ohkubo
Yutaka Imai
Research01 Jul 2008
Hypertension Research

Volume: 31, P: 1435-1443
Pioglitazone Lowers Systemic Asymmetric Dimethylarginine by Inducing Dimethylarginine Dimethylaminohydrolase in Rats

Shu Wakino
Koichi Hayashi
Takao Saruta
Research01 Mar 2005
Hypertension Research

Volume: 28, P: 255-262
Resistance exercise has an antihypertensive effect comparable to that of aerobic exercise in hypertensive patients: a meta-analysis of randomized controlled trials

These authors contributed equally to this work:

Hidetaka Morita
Makiko Abe
Shin-ichiro Miura
Research28 Nov 2024
Hypertension Research

Volume: 48, P: 733-743
A disposable, ultra-fine endoscope for non-invasive, close examination of the intraluminal surface of the peritoneal dialysis catheter and peritoneal cavity

Masaaki Nakayama
Chieko Hamada
Toshio Miyata
ResearchOpen Access16 Oct 2020
Scientific Reports

Volume: 10, P: 1-6
Differences in the effects of exercise on blood pressure depending on the physical condition of the subject and the type of exercise: a systematic review and meta-analysis

Yasunori Suematsu
Hidetaka Morita
Shin-ichiro Miura
Research01 Nov 2024
Hypertension Research

Volume: 48, P: 720-732
TMPRSS4 as a prognostic biomarker after gastric cancer surgery in a multicenter retrospective study

Hirofumi Tazawa
Shinji Hato
Hirotaka Tashiro
ResearchOpen Access11 Mar 2025
Scientific Reports

Volume: 15, P: 1-12
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Relationship between body mass index and masticatory factors evaluated with a wearable device

Shogo Yoshimura
Kazuhiro Hori
Takahiro Ono
ResearchOpen Access08 Mar 2022
Scientific Reports

Volume: 12, P: 1-9
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Outcomes of allogeneic hematopoietic stem cell transplantation for relapsed or refractory diffuse large B-cell lymphoma

Koji Kato
Takeshi Sugio
Ritsuro Suzuki
Research15 Dec 2023
Bone Marrow Transplantation

Volume: 59, P: 306-314
Polymer heat-proofing using defibered plants obtained by wet-type bead milling of Japanese cedar

In this Note, the heat-proofing and anti-plasticizing nature of poly(ethylene carbonate) by the addition of a defibered plant (DP) is presented. The DP was obtained via simple wet-milling treatment for water-dispersed Japanese cedar. The presented results encourage us to use plants as functional fillers without a special chemical/biological reaction.

Kazuhiro Shikinaka
Ai Tsukidate
Yuichiro Otsuka
Research08 Mar 2021
Polymer Journal

Volume: 53, P: 841-845
Photonuclear reactions triggered by lightning discharge

Ground-based observations during a thunderstorm provide conclusive evidence of positrons being produced after lightning, confirming that lightning can trigger photonuclear reactions.

Teruaki Enoto
Yuuki Wada
Harufumi Tsuchiya
Research01 Nov 2017
Nature

Volume: 551, P: 481-484
Effects of renal denervation on blood pressures in patients with hypertension: a systematic review and meta-analysis of randomized sham-controlled trials

Yukako Ogoyama
Kazuhiro Tada
Kazuomi Kario
Research17 Oct 2021
Hypertension Research

Volume: 45, P: 210-220
Simultaneous assessment of endothelial function and morphology in the brachial artery using a new semiautomatic ultrasound system

Tomokazu Iguchi
Yasuhiko Takemoto
Minoru Yoshiyama
Research18 Apr 2013
Hypertension Research

Volume: 36, P: 691-697
Fingertip advanced glycation end products and psychotic symptoms among adolescents

Mitsuhiro Miyashita
Syudo Yamasaki
Makoto Arai
ResearchOpen Access12 Aug 2021
npj Schizophrenia

Volume: 7, P: 1-6
Utility of new FDG-PET/CT guidelines for diagnosing cardiac sarcoidosis in patients with implanted cardiac pacemakers for atrioventricular block

Subaru Tanabe
Yusuke Nakano
Tetsuya Amano
ResearchOpen Access03 Apr 2024
Scientific Reports

Volume: 14, P: 1-11

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