Nature Search

Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Using well-calibrated statistical methods the authors jointly analyze Undiagnosed Diseases Network genomes, identifying known and novel disease genes. Software is publicly available to support future cross-cohort rare disease discovery efforts.

Shilpa Nadimpalli Kobren
Mikhail A. Moldovan
Shamil R. Sunyaev
ResearchOpen Access07 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Population dynamics and rapid spread of Cardinium, a bacterial endosymbiont causing cytoplasmic incompatibility in Encarsia pergandiella (Hymenoptera: Aphelinidae)

L R Harris
S E Kelly
S J Perlman
Research07 Oct 2009
Heredity

Volume: 104, P: 239-246
Cytoplasmic incompatibility in the parasitic wasp Encarsia inaron: disentangling the roles of Cardinium and Wolbachia symbionts

J A White
S E Kelly
M S Hunter
Research18 Feb 2009
Heredity

Volume: 102, P: 483-489
Reproductive interference and fecundity affect competitive interactions of sibling species with low mating barriers: experimental and theoretical evidence

M Gebiola
S E Kelly
M S Hunter
Research13 Sept 2017
Heredity

Volume: 119, P: 438-446
Quality over quantity: unraveling the contributions to cytoplasmic incompatibility caused by two coinfecting Cardinium symbionts

Matthew R. Doremus
Corinne M. Stouthamer
Martha S. Hunter
Research05 Feb 2022
Heredity

Volume: 128, P: 187-195
Endosymbiont costs and benefits in a parasitoid infected with both Wolbachia and Cardinium

J A White
S E Kelly
M S Hunter
Research07 Jul 2010
Heredity

Volume: 106, P: 585-591
Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes

Sex differences in brain transcriptomics have unknown cell type specificity. Here, authors show concordant cortical transcriptomic patterns in depression within individual cell types between sexes, but distinctly affected top cell types and genes.

Malosree Maitra
Haruka Mitsuhashi
Corina Nagy
ResearchOpen Access22 May 2023
Nature Communications

Volume: 14, P: 1-18
Development of a differential treatment selection model for depression on consolidated and transformed clinical trial datasets

Kelly Perlman
Joseph Mehltretter
Gustavo Turecki
ResearchOpen Access21 Jun 2024
Translational Psychiatry

Volume: 14, P: 1-9
Detection of cell–cell interactions via photocatalytic cell tagging

A new targeting modality-based transcellular labeling technology called photocatalytic cell tagging enables monitoring of cell–cell interactions when combined with multiomics single-cell sequencing.

Rob C. Oslund
Tamara Reyes-Robles
Olugbeminiyi O. Fadeyi
Research02 Jun 2022
Nature Chemical Biology

Volume: 18, P: 850-858
Development of the treatment prediction model in the artificial intelligence in depression – medication enhancement study

David Benrimoh
Caitrin Armstrong
Gustavo Turecki
ResearchOpen Access23 Jun 2025
npj Mental Health Research

Volume: 4, P: 1-12
Three is Better Than Two: Dose-related Efficacy of Dextrose Gel for Neonatal Hypoglycemia in At-Risk Infants, a Quality Improvement Initiative

Melanie Gao
Jenny Jin
Priyanka Tiwari
Research12 Apr 2025
Journal of Perinatology

Volume: 45, P: 1479-1485
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue

Automated pathotyping of synovial tissue in arthritis is a major unmet need. Here, the authors develop and demonstrate the efficacy of an automated tissue and cellular pathotyping tool for inflammatory arthritis.

Richard D. Bell
Matthew Brendel
Fei Wang
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-17
SARS-CoV-2 spike D614G change enhances replication and transmission

A SARS-CoV-2 variant containing a D614G substitution in the spike protein shows enhanced binding to human ACE2, increased replication in human cell cultures and a competitive advantage in animal models of infection.

Bin Zhou
Tran Thi Nhu Thao
Martin Beer
Research26 Feb 2021
Nature

Volume: 592, P: 122-127
Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

The Alpha variant of SARS-CoV-2 outcompetes progenitor SARS-CoV-2 in upper respiratory tract replication competition in vivo.

Lorenz Ulrich
Nico Joel Halwe
Charaf Benarafa
ResearchOpen Access22 Dec 2021
Nature

Volume: 602, P: 307-313
Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Nirmal K. Banda
Larry W. Moreland
V. Michael Holers
ResearchOpen Access04 Jun 2025
Scientific Reports

Volume: 15, P: 1-18
Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

A yeast-based synthetic genomics platform is used to reconstruct and characterize large RNA viruses from synthetic DNA fragments; this technique will facilitate the rapid analysis of RNA viruses, such as SARS-CoV-2, during an outbreak.

Tran Thi Nhu Thao
Fabien Labroussaa
Volker Thiel
Research04 May 2020
Nature

Volume: 582, P: 561-565
Accelerated CD8⁺ T-cell memory and prime-boost response after dendritic-cell vaccination

Vladimir P Badovinac
Kelly A N Messingham
John T Harty
Research12 Jun 2005
Nature Medicine

Volume: 11, P: 748-756
Genome-wide association study of peripheral artery disease in the Million Veteran Program

A genome-wide association study using electronic health record data in the Million Veteran Program uncovers new genetic loci associated specifically with peripheral artery disease, as compared to stroke or coronary artery disease.

Derek Klarin
Julie Lynch
Scott M. Damrauer
Research08 Jul 2019
Nature Medicine

Volume: 25, P: 1274-1279
Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

Single-nucleus transcriptomics reveal brain alterations associated with major depression. Deep layer excitatory cells and immature oligodendrocytes showed most changes, involving synaptic plasticity, immune function and steroid hormones.

Corina Nagy
Malosree Maitra
Gustavo Turecki
Research27 Apr 2020
Nature Neuroscience

Volume: 23, P: 771-781
Notch signalling drives synovial fibroblast identity and arthritis pathology

NOTCH3 signalling is shown to be the underlying driver of the differentiation and expansion of a subset of synovial fibroblasts implicated in the pathogenesis of rheumatoid arthritis.

Kevin Wei
Ilya Korsunsky
Michael B. Brenner
Research22 Apr 2020
Nature

Volume: 582, P: 259-264
Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Sacha Ferdinandusse
Kirsty McWalter
Frédéric M. Vaz
Amendments and CorrectionsOpen Access19 Oct 2021
Genetics in Medicine

Volume: 23, P: 2467
MHC class Ia–restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)–restricted memory response

Sara E Hamilton
Brandon B Porter
John T Harty
Research25 Jan 2004
Nature Immunology

Volume: 5, P: 159-168
An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Sacha Ferdinandusse
Kirsty McWalter
Frédéric M. Vaz
ResearchOpen Access26 Nov 2020
Genetics in Medicine

Volume: 23, P: 740-750
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Defining cell types and their activation status in rheumatoid arthritis (RA) is critical to understanding this disease. Raychaudhuri and colleagues leverage several single-cell -omics approaches to define the cellular processes and pathways in the human RA joint.

Fan Zhang
Kevin Wei
Soumya Raychaudhuri
Research06 May 2019
Nature Immunology

Volume: 20, P: 928-942
Decreased sound tolerance associated with blast exposure

Sarah M. Theodoroff
Kelly M. Reavis
James A. Henry
ResearchOpen Access15 Jul 2019
Scientific Reports

Volume: 9, P: 1-8
Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways

Milton Fernandes et al. combine single cell RNA-sequencing and functional assays to show that human oligodendrocytes exhibit an age-dependent resistance to apoptosis. Their findings have important implications for the pathology and treatment of myelination disorders like multiple sclerosis.

Milton Guilherme Forestieri Fernandes
Julia Xiao Xuan Luo
Jack P. Antel
ResearchOpen Access04 Jan 2021
Communications Biology

Volume: 4, P: 1-10
Initial recommendations for performing, benchmarking and reporting single-cell proteomics experiments

A community of researchers working in the emerging field of single-cell proteomics propose best-practice experimental and computational recommendations and reporting guidelines for studies analyzing proteins from single cells by mass spectrometry.

Laurent Gatto
Ruedi Aebersold
Nikolai Slavov
Reviews02 Mar 2023
Nature Methods

Volume: 20, P: 375-386
Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

An osteosarcoma-specific exosomal gene signature was developed using an orthotopic. xenograft model with a species-differentiating bioinformatics pipeline. The gene signature was validated in the serum of dogs with osteosarcoma, where it was able to detect minimal residual disease, and was therefore associated with prognosis following treatment.

Kelly M. Makielski
Alicia J. Donnelly
Jaime F. Modiano
Research06 Sept 2021
Laboratory Investigation

Volume: 101, P: 1585-1596
Association between non-medical cannabis legalization and emergency department visits for cannabis-induced psychosis

Daniel T. Myran
Michael Pugliese
Kelly K. Anderson
Research27 Jul 2023
Molecular Psychiatry

Volume: 28, P: 4251-4260
Child abuse associates with increased recruitment of perineuronal nets in the ventromedial prefrontal cortex: a possible implication of oligodendrocyte progenitor cells

Arnaud Tanti
Claudia Belliveau
Naguib Mechawar
ResearchOpen Access19 Nov 2021
Molecular Psychiatry

Volume: 27, P: 1552-1561
Fatty acid dysregulation in the anterior cingulate cortex of depressed suicides with a history of child abuse

Kelly Perlman
Raphaël Chouinard-Watkins
Naguib Mechawar
ResearchOpen Access18 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-8
Clinical, cortical thickness and neural activity predictors of future affective lability in youth at risk for bipolar disorder: initial discovery and independent sample replication

Michele A. Bertocci
Lindsay Hanford
Mary L. Phillips
Research19 Oct 2018
Molecular Psychiatry

Volume: 24, P: 1856-1867
Serum urate and cardiovascular events in the DCCT/EDIC study

Alicia J. Jenkins
Barbara H. Braffett
T. Woodfill
ResearchOpen Access09 Jul 2021
Scientific Reports

Volume: 11, P: 1-11

Search

Joint, multifaceted genomic analysis enables diagnosis of diverse, ultra-rare monogenic presentations

Population dynamics and rapid spread of Cardinium, a bacterial endosymbiont causing cytoplasmic incompatibility in Encarsia pergandiella (Hymenoptera: Aphelinidae)

Cytoplasmic incompatibility in the parasitic wasp Encarsia inaron: disentangling the roles of Cardinium and Wolbachia symbionts

Reproductive interference and fecundity affect competitive interactions of sibling species with low mating barriers: experimental and theoretical evidence

Quality over quantity: unraveling the contributions to cytoplasmic incompatibility caused by two coinfecting Cardinium symbionts

Endosymbiont costs and benefits in a parasitoid infected with both Wolbachia and Cardinium

Cell type specific transcriptomic differences in depression show similar patterns between males and females but implicate distinct cell types and genes

Development of a differential treatment selection model for depression on consolidated and transformed clinical trial datasets

Detection of cell–cell interactions via photocatalytic cell tagging

Development of the treatment prediction model in the artificial intelligence in depression – medication enhancement study

Three is Better Than Two: Dose-related Efficacy of Dextrose Gel for Neonatal Hypoglycemia in At-Risk Infants, a Quality Improvement Initiative

Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue

SARS-CoV-2 spike D614G change enhances replication and transmission

Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

Analysis of human factor H-related gene and protein expressed in rheumatoid arthritis synovium identifies a novel mechanism promoting dysregulated complement pathway activation

Rapid reconstruction of SARS-CoV-2 using a synthetic genomics platform

Accelerated CD8⁺ T-cell memory and prime-boost response after dendritic-cell vaccination

Genome-wide association study of peripheral artery disease in the Million Veteran Program

Single-nucleus transcriptomics of the prefrontal cortex in major depressive disorder implicates oligodendrocyte precursor cells and excitatory neurons

Notch signalling drives synovial fibroblast identity and arthritis pathology

Correction to: An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

MHC class Ia–restricted memory T cells inhibit expansion of a nonprotective MHC class Ib (H2-M3)–restricted memory response

An autosomal dominant neurological disorder caused by de novo variants in FAR1 resulting in uncontrolled synthesis of ether lipids

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

Decreased sound tolerance associated with blast exposure

Age-related injury responses of human oligodendrocytes to metabolic insults: link to BCL-2 and autophagy pathways

Initial recommendations for performing, benchmarking and reporting single-cell proteomics experiments

Development of an exosomal gene signature to detect residual disease in dogs with osteosarcoma using a novel xenograft platform and machine learning

Association between non-medical cannabis legalization and emergency department visits for cannabis-induced psychosis

Child abuse associates with increased recruitment of perineuronal nets in the ventromedial prefrontal cortex: a possible implication of oligodendrocyte progenitor cells

Fatty acid dysregulation in the anterior cingulate cortex of depressed suicides with a history of child abuse

Clinical, cortical thickness and neural activity predictors of future affective lability in youth at risk for bipolar disorder: initial discovery and independent sample replication

Serum urate and cardiovascular events in the DCCT/EDIC study

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