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The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex

PRPS enzymes are crucial for making nucleotides needed to build DNA, RNA, and proteins. This study shows how gene duplications and emergent innovations evolved an ancestral PRPS enzyme into a multi-protein complex in mammals, allowing fine-tuned metabolic regulation vital for growth and adaptation.

Bibek R. Karki
Austin C. MacMillan
John T. Cunningham
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-18
Correction: Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Jing Fang
Lyndsey C Bolanos
Daniel T Starczynowski
Amendments and Corrections22 Mar 2017
Nature Immunology

Volume: 18, P: 474
Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization

Eric J. Vick
Aishlin Hassan
Daniel T. Starczynowski
ResearchOpen Access16 Jul 2025
Leukemia

Volume: 39, P: 2163-2173
Publisher Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang
Hengyou Weng
Jianjun Chen
Amendments and Corrections27 Aug 2020
Nature Cell Biology

Volume: 22, P: 1288
Author Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang
Hengyou Weng
Jianjun Chen
Amendments and Corrections07 Jun 2018
Nature Cell Biology

Volume: 20, P: 1098
Multiplex Biomarker Screening Assay for Urinary Extracellular Vesicles Study: A Targeted Label-Free Proteomic Approach

Somchai Chutipongtanate
Kenneth D. Greis
ResearchOpen Access09 Oct 2018
Scientific Reports

Volume: 8, P: 1-8
Mouse models of neutropenia reveal progenitor-stage-specific defects

Mouse models of severe congenital neutropenia using patient-derived mutations in the GFI1 locus are used to determine the mechanisms by which the disease progresses.

David E. Muench
Andre Olsson
H. Leighton Grimes
Research22 Apr 2020
Nature

Volume: 582, P: 109-114
Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis

Osteoclasts are derived from circulating myeloid cells to mediate bone repair, maintenance and remodeling. Here, the authors show that the lung also recruits and reprograms monocytes and alveolar macrophages into osteoclast-like cells to clear pathogenic particles from the airspace.

Yasuaki Uehara
Yusuke Tanaka
Francis X. McCormack
ResearchOpen Access02 Mar 2023
Nature Communications

Volume: 14, P: 1-17
Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Starczynowski and colleagues show that overexpression of TRAF6 in HSCs induces ubiquitination of the RNA-binding protein hnRNPA1 and alternative splicing of Arhgap1, which accounts for the hematopoietic defects in myelodysplastic syndromes.

Jing Fang
Lyndsey C Bolanos
Daniel T Starczynowski
Research26 Dec 2016
Nature Immunology

Volume: 18, P: 236-245
Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huang et al. identify IGF2BPs as an additional class of N⁶-methyladenosine (m⁶A) reader proteins. They find that IGF2BPs selectively bind to m⁶A-containing mRNAs and promote their stability.

Huilin Huang
Hengyou Weng
Jianjun Chen
Research23 Feb 2018
Nature Cell Biology

Volume: 20, P: 285-295
Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome

Courtnee A. Clough
Claire Cunningham
Daniel Starczynowski
ResearchOpen Access30 Jun 2025
Leukemia

Volume: 39, P: 1997-2009
Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression

Isolation and characterisation of hepatic cytoplasmic (CM) and peridroplet mitochondria (PDM) from simple steatosis to advanced MASH. PDM showed higher pyruvate oxidation and OXPHOS, while CM favored fatty acid oxidation with MASH progression.

Noble Kumar Talari
Ushodaya Mattam
Karthickeyan Chella Krishnan
ResearchOpen Access18 Feb 2025
Communications Biology

Volume: 8, P: 1-13
Initial Validation of a Novel Protein Biomarker Panel for Active Pediatric Lupus Nephritis

Michiko Suzuki
Kristina Wiers
Hermine I Brunner
Research01 May 2009
Pediatric Research

Volume: 65, P: 530-536
FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome

Michael Schieber
Christian Marinaccio
John D. Crispino
ResearchOpen Access06 Oct 2020
Blood Cancer Journal

Volume: 10, P: 1-12
Ablation of miR-144 increases vimentin expression and atherosclerotic plaque formation

Quan He
Fangfei Wang
Andrew N. Redington
ResearchOpen Access09 Apr 2020
Scientific Reports

Volume: 10, P: 1-11
Time resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors

Pankaj Dwivedi
David E. Muench
Kenneth D. Greis
Research05 Jul 2018
Leukemia

Volume: 33, P: 75-87
Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors

Pankaj Dwivedi
David E. Muench
Kenneth D. Greis
ResearchOpen Access09 Apr 2019
Scientific Data

Volume: 6, P: 1-9

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The role of gene duplication and paralog specialisation in the evolution of the mammalian PRPS complex

Correction: Corrigendum: Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Targeting of IRAK4 and GSPT1 enhances therapeutic efficacy in AML via c-Myc destabilization

Publisher Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Author Correction: Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Multiplex Biomarker Screening Assay for Urinary Extracellular Vesicles Study: A Targeted Label-Free Proteomic Approach

Mouse models of neutropenia reveal progenitor-stage-specific defects

Insights into pulmonary phosphate homeostasis and osteoclastogenesis emerge from the study of pulmonary alveolar microlithiasis

Ubiquitination of hnRNPA1 by TRAF6 links chronic innate immune signaling with myelodysplasia

Recognition of RNA N⁶-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Characterization of E1 enzyme dependencies in mutant-UBA1 human cells reveals UBA6 as a novel therapeutic target in VEXAS syndrome

Functional compartmentalization of hepatic mitochondrial subpopulations during MASH progression

Initial Validation of a Novel Protein Biomarker Panel for Active Pediatric Lupus Nephritis

FBXO11 is a candidate tumor suppressor in the leukemic transformation of myelodysplastic syndrome

Ablation of miR-144 increases vimentin expression and atherosclerotic plaque formation

Time resolved quantitative phospho-tyrosine analysis reveals Bruton’s Tyrosine kinase mediated signaling downstream of the mutated granulocyte-colony stimulating factor receptors

Phospho serine and threonine analysis of normal and mutated granulocyte colony stimulating factor receptors

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