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Showing 1–50 of 516 results
Advanced filters: Author: Kevin Carl Clear advanced filters
  • 2D semiconductors hold promise for solution-processed circuits requiring low-cost components and manufacturing scalability. Here, the authors investigate the criteria for the electrochemical exfoliation of high aspect-ratio nanosheets from 28 different layered materials, identifying the most promising candidates and key bottlenecks for solution-processed complementary electronics and functional circuits.

    • Tian Carey
    • Kevin Synnatschke
    • Jonathan N. Coleman
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • tRNA modifications are essential for function, yet their timing relative to processing is unclear. Here, the authors show that queuosine and derivative modifications occur before splicing of pre-tRNA^Tyr, with cryo-EM confirming direct recognition by the QTRT1/2 complex.

    • Wei Guo
    • Igor Kaczmarczyk
    • Francesca Tuorto
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12
  • The EWSR1::FLI1 fusion protein is the oncogenic driver of Ewing sarcoma (EwS). Here, the authors find that EWSR1::FLI1 plays a non-canonical role in mRNA decay via interactions with the CCR4-NOT deadenylation complex and the RNA-binding protein HuR. This role uncovers a new therapeutic vulnerability of EwS to HuR inhibition.

    • Bartimée Galvan
    • Loïc Ongena
    • Franck Dequiedt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-24
  • Understanding the growth dynamics of GBMs can help expand therapeutic options. Here, authors use a cross-species computational approach to compare GBM cells to healthy neural stem cells, identifying predictors and modulators of tumour growth, including the Wnt antagonist, SFRP1, which stalls growth in preclinical xenograft models.

    • Leo Carl Foerster
    • Oguzhan Kaya
    • Ana Martin-Villalba
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Sarcomas are a group of mesenchymal malignancies which are molecularly heterogeneous. Here, the authors develop an in vivo muscle electroporation system for gene delivery to generate distinct subtypes of orthotopic genetically engineered mouse models of sarcoma, as well as syngeneic allograft models with scalability for preclinical assessment of therapeutics.

    • Roland Imle
    • Daniel Blösel
    • Ana Banito
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20
  • Lv et al. discover that homologous disordered regions of proteins linked to ALS/FTD and Parkinson’s, CHCHD10 and CHCHD2, form amyloid fibrils in vitro and that the structures of these fibrils are consistent with potential roles for them in disease.

    • Guohua Lv
    • Nicole M. Sayles
    • David Eliezer
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Contractile rings are formed from cytoskeletal filaments, specific crosslinkers and motor proteins during cell division. Here, authors form micron-scale contractile DNA rings from DNA nanotubes and synthetic crosslinkers, with both simulations and experiments showing ring contraction without motor proteins, offering a potential first step towards synthetic cell division machinery.

    • Maja Illig
    • Kevin Jahnke
    • Kerstin Göpfrich
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12
  • Cytoskeletons are essential components of cells that perform a variety of tasks, and artificial cytoskeletons that perform these functions are required for the bottom-up assembly of synthetic cells. Now, a multi-functional cytoskeleton mimic has been engineered from DNA, consisting of confined DNA filaments that are capable of reversible self-assembly and transport of gold nanoparticles and vesicular cargo.

    • Pengfei Zhan
    • Kevin Jahnke
    • Kerstin Göpfrich
    ResearchOpen Access
    Nature Chemistry
    Volume: 14, P: 958-963
  • An autophagy receptor, NDP52, is recruited to the nucleus where it can bind DNA. The authors show this promotes changes in chromatin accessibility which supports transcription initiation, providing a direct link between autophagy and transcription regulation.

    • Ália dos Santos
    • Daniel E. Rollins
    • Christopher P. Toseland
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-24
  • Carcinoma subtypes are normally linked to specific genetic alterations, but tissue mechanical changes also play a role. Now, aberrant morphologies resembling bladder carcinoma are shown to emerge from stiffness changes during epithelial overgrowth.

    • Franziska L. Lampart
    • Roman Vetter
    • Dagmar Iber
    ResearchOpen Access
    Nature Physics
    Volume: 21, P: 279-288
  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768
  • In vivo chimeric antigen receptor (CAR)-T cell engineering uses targeted delivery systems to generate CAR-T cells directly in patients, bypassing ex vivo manufacturing. This Review examines emerging viral and lipid nanoparticle platforms, early clinical proof of concept and potential applications beyond cancer.

    • Adrian Bot
    • Andrew Scharenberg
    • Carl H. June
    Reviews
    Nature Reviews Drug Discovery
    P: 1-22
  • This study showed that vagal sensory neurons in the nodose ganglia selectively encode specific cytokines, enabling real-time body-brain communication of immune signals. This neural encoding of cytokines is disrupted during inflammation associated with a colitis model.

    • Tomás S. Huerta
    • Adrian C. Chen
    • Eric H. Chang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • Nerve injury activates microglia to remove spinal synapses, disrupting spinal sensory processing and contributing to chronic pain. Blocking complement protein C1q preserves synapses, highlighting a potential therapeutic target for neuropathic pain.

    • Noosha Yousefpour
    • Shannon N. Tansley
    • Alfredo Ribeiro-da-Silva
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Large language models are increasingly used for diverse tasks, yet we have limited insight into their understanding of chemistry. Now ChemBench—a benchmarking framework containing more than 2,700 question–answer pairs—has been developed to assess their chemical knowledge and reasoning, revealing that the best models surpass human chemists on average but struggle with some basic tasks.

    • Adrian Mirza
    • Nawaf Alampara
    • Kevin Maik Jablonka
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 1027-1034
  • Apolipoprotein L1 genetic variants contribute to a subtype of proteinuric kidney disease referred to as APOL1-mediated kidney disease (AMKD). Here the authors report the discovery and characterization of potent and selective APOL1 ion channel inhibitors for the potential treatment of AMKD.

    • Brandon Zimmerman
    • Leslie A. Dakin
    • Mark E. Bunnage
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-13
  • Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methyltransferase, is an important regulator of recruitment and the pro-inflammatory phenotype of macrophages.

    • Gizem Günes Günsel
    • Thomas M. Conlon
    • Ali Önder Yildirim
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21
  • Urinary albumin-to-creatinine ratio (UCAR) is associated with various clinical outcomes such as kidney disease and cardiovascular disease. Here, the authors report genome-wide meta-analysis in over 500,000 individuals and find 68 UACR loci, followed by statistical fine-mapping, gene prioritization and experimental validation in flies.

    • Alexander Teumer
    • Yong Li
    • Anna Köttgen
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19
  • Mismatch repair-deficient colorectal cancer clones adapt their mutation landscape by toggling homopolymer sequences in MutS homolog 3 (MSH3) and MutS homolog 6 (MSH6). This increases the subclonal mutation rate and clonal diversity, favoring immune escape and tumor growth.

    • Hamzeh Kayhanian
    • William Cross
    • Marnix Jansen
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1420-1433
  • An expert-elicitation process identifies current methodological barriers for monitoring terrestrial biodiversity, and how technological and procedural development of robotic and autonomous systems may contribute to overcoming these challenges.

    • Stephen Pringle
    • Martin Dallimer
    • Zoe G. Davies
    ResearchOpen Access
    Nature Ecology & Evolution
    Volume: 9, P: 1031-1042
  • Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

    • Esther Rheinbay
    • Morten Muhlig Nielsen
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 102-111
  • A population of neutrophils in the skin produces extracellular matrix, providing a defence strategy by reinforcing the barrier properties of the skin and helping to block the entry of pathogens.

    • Tommaso Vicanolo
    • Alaz Özcan
    • Andrés Hidalgo
    Research
    Nature
    Volume: 641, P: 740-748
  • The in situ single-stranded open chromatin landscape is dynamically regulated in single cells. In their efforts to understand brain cells’ functional dynamics and to complement the other single-cell chromatin approaches, the authors present a method named CHEX-seq (CHromatin EXposed).

    • Youtao Lu
    • Jaehee Lee
    • James Eberwine
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-19
  • Surgery poses significant risks for patients, with attempts to mitigate these risks using multimodal perioperative care pathways. Here, the authors show that preoperative hypercaloric carbohydrate drinks not only alleviate surgical stress but also demonstrates the replicability of this protection using FGF21 treatment alone.

    • Thomas Agius
    • Raffaella Emsley
    • Alban Longchamp
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16
  • Controlled actuation is an important aspect of synthetic cellular systems. Here, the authors combine pH responsive DNA origami structures with light triggered proton pump engineered E. coli to trigger a change in pH and control the deformation of giant unilamellar vesicles by simple illumination.

    • Kevin Jahnke
    • Noah Ritzmann
    • Kerstin Göpfrich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-9
  • The connection between the molecular and physical control of embryonic tissues remains unclear. Here, the authors connect genetic mutations to changes in the physical state of posterior tissues during axis elongation, revealing a key role for dorsal tissues.

    • Georgina A. Stooke-Vaughan
    • Sangwoo Kim
    • Otger Campàs
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

    • Constance H. Li
    • Stephenie D. Prokopec
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-24
  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128
  • Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

    • Wei Jiao
    • Gurnit Atwal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

    • Marek Cmero
    • Ke Yuan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

    • Yulia Rubanova
    • Ruian Shi
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • The photoreceptor cilium contains an exclusive group of proteins responsible for capturing light and eliciting a visual response. Here, the authors show that the tectonic complex plays a role in the barrier that prevents unsolicited protein entry into the cilium.

    • Hanh M. Truong
    • Kevin O. Cruz-Colón
    • Jillian N. Pearring
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14