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Showing 1–10 of 10 results
Advanced filters: Author: Kevin D. Raney Clear advanced filters

  • Efficient gas bubble removal is crucial for high-rate water electrolysis aimed at optimizing hydrogen production. Here, the authors show that integrating 3-D foam electrodes into a specially designed cell configuration enables alkaline water electrolysis to perform comparably to advanced systems, thereby enhancing overall efficiency.

    • Fernando Rocha
    • Christos Georgiadis
    • Joris Proost
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • G-quadruplexes (G4s) are stable structures that can disrupt genome stability and are dissolved by helicases. Here the authors present the structure of the yeast helicase Pif1 bound to a G4 and reveal a conserved G4 interacting region.

    • Zebin Hong
    • Alicia K. Byrd
    • Haiwei Song
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Hydrogen deuterium exchange (HDE) methods hold promise as relevant tools for the late-stage and one-step preparation of deuterium-labelled compounds, but they often fall short in achieving sufficient isotopic purity combined either with a site-selectivity or with a full deuteration process. Here, the authors report an approach to unlock the potential of HDE using the concept of iterative runs in continuous-flow technology.

    • Kevin Tatoueix
    • Marco Lepron
    • Sophie Feuillastre
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-9

  • This overview of the ENCODE project outlines the data accumulated so far, revealing that 80% of the human genome now has at least one biochemical function assigned to it; the newly identified functional elements should aid the interpretation of results of genome-wide association studies, as many correspond to sites of association with human disease.

    • Ian Dunham
    • Anshul Kundaje
    • Ewan Birney
    ResearchOpen Access
    Nature
    Volume: 489, P: 57-74

  • Pif1 plays multiple roles in maintaining genome stability and preferentially unwinds forked dsDNA. Here the authors solve the structure of Bacteroides sp Pif1 (BaPif1) in complex with a symmetrical double forked dsDNA and provide unprecedented insights into forked dsDNA unwinding by BaPif1.

    • Nannan Su
    • Alicia K. Byrd
    • Haiwei Song
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • This study describes the integrative analysis of 111 reference human epigenomes, profiled for histone modification patterns, DNA accessibility, DNA methylation and RNA expression; the results annotate candidate regulatory elements in diverse tissues and cell types, their candidate regulators, and the set of human traits for which they show genetic variant enrichment, providing a resource for interpreting the molecular basis of human disease.

    • Anshul Kundaje
    • Wouter Meuleman
    • Manolis Kellis
    ResearchOpen Access
    Nature
    Volume: 518, P: 317-330

  • A new crystal structure reveals the path taken by single-stranded (ss) DNA through the central channel of a hexameric helicase. The path resembles a spiral staircase and provides an answer to the question of how hexameric helicases translocate on ssDNA.

    • Kevin D Raney
    News & Views
    Nature Structural & Molecular Biology
    Volume: 13, P: 671-672