Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Advertisement

Nature

View all journals
Search
Log in

nature
search

Search

Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Journal of Human Genetics (16)
Scientific Reports (15)
Nature (7)
Nature Communications (6)
Hypertension Research (4)

Choose more journals

Article type Check one or more article types to show results from those article types only.

Research (61)
Amendments and Corrections (3)
Reviews (3)

Subject Check one or more subjects to show results from those subjects only.

Biochemistry
Biological techniques
Cancer
Cell biology
Computational biology and bioinformatics
Developmental biology
Diseases
Endocrinology
Gastroenterology
Genetics
Health care
Immunology
Medical research
Microbiology
Molecular biology
Neurology
Neuroscience
Physiology
Rheumatology
Zoology

Date Choose a date option to show results from those dates only.

Today
Last 7 days
Last 30 days
Last 12 months
Last 2 years
Last 5 years

Custom date range

Clear all filters

Sort by:

Relevance

Date published (new to old)

Date published (old to new)

Showing 1–50 of 67 results

Advanced filters: Author: Kiyoshi Hashimoto Clear advanced filters

Thyroid Hormones in Human Milk and their Influence on Thyroid Function of Breast-Fed Babies

Hitoshi Mizuta
Nobuyuki Amino
Kiyoshi Miyai
Research01 Jun 1983
Pediatric Research

Volume: 17, P: 468-471
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Eosinophils as a predictive marker of treatment-related adverse events in mRCC patients treated with first-line immune-checkpoint inhibitor combination therapy

Tatsushi Kawada
Satoshi Katayama
Motoo Araki
ResearchOpen Access25 Jul 2025
Scientific Reports

Volume: 15, P: 1-8
Antibody against T cell-replacing factor acceptor site(s) augments in vivo primary IgM responses to suboptimal doses of heterologous erythrocytes

Kiyoshi Takatsu
Yoshimi Sano
Toshiyuki Hamaoka
Research23 Jul 1981
Nature

Volume: 292, P: 360-362
Study on the Phase Separation Process of Poly(methyl methacrylate)/Poly(styrene-co-acrylonitrile) Blend by SR-SAXS

Kiyoshi Ikawa
Akio Uemura
Yoshiyuki Amemiya
Research01 Nov 1991
Polymer Journal

Volume: 23, P: 1291-1296
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Five familial hypercholesterolemic kindreds in Japan with novel mutations of the LDL receptor gene

Tsunenori Hirayama
E. Yamaki
M. Emi
Research01 Dec 1998
Journal of Human Genetics

Volume: 43, P: 250-254
Missense mutation of rhodopsin gene codon 15 found in Japanese autosomal dominant retinitis pigmentosa

Keiko Fujiki
Yoshihiro Hotta
Atsushi Kanai
Research01 Sept 1995
Japanese journal of human genetics

Volume: 40, P: 271-277
Extremotolerant tardigrade genome and improved radiotolerance of human cultured cells by tardigrade-unique protein

Tardigrades are resistant to extreme environmental conditions including dehydration, radiation and the vacuum of space. Here the authors present a high-quality genome which displays minimal horizontal gene transfer, and identify the unique tardigrade protein Dsup which suppresses DNA damage.

Takuma Hashimoto
Daiki D. Horikawa
Takekazu Kunieda
ResearchOpen Access20 Sept 2016
Nature Communications

Volume: 7, P: 1-14
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Partial 18q trisomy and 18p monosomy resulting from a maternal pericentric inversion, inv(18)(p11.2q21.3)

Takeshi Asano
Tatsuro Ikeuchi
Kiyoshi Hashimoto
Research24 Jun 2005
Japanese journal of human genetics

Volume: 36, P: 257-265
Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo

Hiroshi Inoue
Wataru Ogawa
Masato Kasuga
Research11 Jan 2004
Nature Medicine

Volume: 10, P: 168-174
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
The red sweat of the hippopotamus

The red and orange pigments in this secretion account for its protective properties.

Yoko Saikawa
Kimiko Hashimoto
Teruyuki Komiya
Research27 May 2004
Nature

Volume: 429, P: 363
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Arterial Stiffness and QT Interval Prolongation in a General Population: The Hisayama Study

Daisuke Maebuchi
Hisatomi Arima
Yutaka Kiyohara
Research01 Jul 2008
Hypertension Research

Volume: 31, P: 1339-1345
Spinocerebellar ataxia 1 (SCA1) in the Japanese: Analysis of CAG trinucleitide repeat expansion and instability of the repeat for paternal transmission

Yoshihiro Suzuki
Hidenao Sasaki
Takeshi Hamada
Research01 Mar 1995
Japanese journal of human genetics

Volume: 40, P: 131-143
Association of a single nucleotide polymorphism in TNIP1 with type-1 autoimmune hepatitis in the Japanese population

Shomi Oka
Takashi Higuchi
Kiyoshi Migita
Research20 Mar 2018
Journal of Human Genetics

Volume: 63, P: 739-744
Synthesis and Properties of Syndiotactic Graft Copolymer of Styrene with Polyisoprene Macromonomer by CpTiCl₃–Methylaluminoxane Catalyst

Kiyoshi Endo
Kazunobu Senoo
Research01 Oct 1999
Polymer Journal

Volume: 31, P: 817-821
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Liver group 2 innate lymphoid cells regulate blood glucose levels through IL-13 signaling and suppression of gluconeogenesis

Besides hepatocytes, resident immune cells of the liver are also contributing to the body’s energy homeostasis. Here authors show that group 2 innate lymphoid cells interact with a specific set of hepatocytes in suppressing gluconeogenesis and regulate blood glucose levels via Interleukin-13 signalling.

Masanori Fujimoto
Masataka Yokoyama
Tomoaki Tanaka
ResearchOpen Access15 Sept 2022
Nature Communications

Volume: 13, P: 1-21
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Role of deleterious single nucleotide variants in the coding regions of TNFAIP3 for Japanese autoimmune hepatitis with cirrhosis

Takashi Higuchi
Shomi Oka
Kiyoshi Migita
ResearchOpen Access28 May 2019
Scientific Reports

Volume: 9, P: 1-5
Microbe-dependent CD11b⁺ IgA⁺ plasma cells mediate robust early-phase intestinal IgA responses in mice

Intestinal plasma cells contribute to the delicate balance between immunity against pathogens and tolerance of intestinal microflora. Kunisawa et al. identify a subpopulation of plasma cells whose proliferation depends on stimulation by microbes and IL-10, and which mediate early-phase responses to oral antigens.

Jun Kunisawa
Masashi Gohda
Hiroshi Kiyono
ResearchOpen Access23 Apr 2013
Nature Communications

Volume: 4, P: 1-10
TRAM is specifically involved in the Toll-like receptor 4–mediated MyD88-independent signaling pathway

Masahiro Yamamoto
Shintaro Sato
Shizuo Akira
Research12 Oct 2003
Nature Immunology

Volume: 4, P: 1144-1150
The critical monosomic segment involved in 4p- syndrome: A high-resolution banding study on five inherited cases

Kouji Narahara
Yusuke Himoto
Hiroshi Kimoto
Research01 Dec 1984
Japanese journal of human genetics

Volume: 29, P: 403-413
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IκBζ

Masahiro Yamamoto
Soh Yamazaki
Shizuo Akira
Research08 Jul 2004
Nature

Volume: 430, P: 218-222
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Essential function for the kinase TAK1 in innate and adaptive immune responses

Shintaro Sato
Hideki Sanjo
Shizuo Akira
Research25 Sept 2005
Nature Immunology

Volume: 6, P: 1087-1095
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

Masahiro Yamamoto
Toru Okamoto
Shizuo Akira
Research23 Jul 2006
Nature Immunology

Volume: 7, P: 962-970
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c⁺ lamina propria cells

Satoshi Uematsu
Myoung Ho Jang
Shizuo Akira
Research09 Jul 2006
Nature Immunology

Volume: 7, P: 868-874
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
The medaka draft genome and insights into vertebrate genome evolution

The medaka fish (Oryzias latipes) has long been a popular pet in Japan and more recently a laboratory model organism; it now has its genome sequenced and analysed by a Japanese consortium.

Masahiro Kasahara
Kiyoshi Naruse
Yuji Kohara
ResearchOpen Access07 Jun 2007
Nature

Volume: 447, P: 714-719
The new preparation method for paraffin-embedded samples applying scanning electron microscopy revealed characteristic features in asthma-induced mice

Ken Wakai
Kazuhiko Azuma
Yuzuru Ikehara
ResearchOpen Access31 May 2022
Scientific Reports

Volume: 12, P: 1-11
The roles of tertiary lymphoid structures in chronic diseases

Here, the authors discuss tertiary lymphoid structure (TLS) development, maintenance and function, with a focus on the roles of TLSs in autoimmune disease, cancer, infection and chronic age-related inflammatory diseases. They also discuss the clinical implications of TLSs in various tissues and diseases.

Yuki Sato
Karina Silina
Motoko Yanagita
Reviews12 Apr 2023
Nature Reviews Nephrology

Volume: 19, P: 525-537
Long-term outcomes in patients with primary biliary cholangitis complicated with CREST syndrome

Kazumichi Abe
Manabu Hayashi
Hiromasa Ohira
ResearchOpen Access19 Jun 2024
Scientific Reports

Volume: 14, P: 1-10
Antiproliferative Action of an Angiotensin I-Converting Enzyme Inhibitory Peptide, Val-Tyr, via an L-Type Ca²⁺ Channel Inhibition in Cultured Vascular Smooth Muscle Cells

Toshiro Matsui
Takao Ueno
Kiyoshi Matsumoto
Research01 Jun 2005
Hypertension Research

Volume: 28, P: 545-552
Association of NCF1 polymorphism with systemic lupus erythematosus and systemic sclerosis but not with ANCA-associated vasculitis in a Japanese population

Nozomi Yokoyama
Aya Kawasaki
Naoyuki Tsuchiya
ResearchOpen Access08 Nov 2019
Scientific Reports

Volume: 9, P: 1-8
POGLUT1, the putative effector gene driven by rs2293370 in primary biliary cholangitis susceptibility locus chromosome 3q13.33

Yuki Hitomi
Kazuko Ueno
Minoru Nakamura
ResearchOpen Access14 Jan 2019
Scientific Reports

Volume: 9, P: 1-11
Association of a single nucleotide polymorphism upstream of ICOS with Japanese autoimmune hepatitis type 1

Takashi Higuchi
Shomi Oka
Kiyoshi Migita
Research15 Dec 2016
Journal of Human Genetics

Volume: 62, P: 481-484
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Satoshi Umemura
Hisatomi Arima
Nobuhito Hirawa
Reviews02 Aug 2019
Hypertension Research

Volume: 42, P: 1235-1481
Immunohistochemical Distribution and Quantitative Biochemical Detection of Advanced Glycation End Products in Fetal to Adult Rats and in Rats with Streptozotocin-Induced Diabetes

Xia Ling
Ryoji Nagai
Kiyoshi Takahashi
Research01 Jun 2001
Laboratory Investigation

Volume: 81, P: 845-861
Association of neonatal hyperbilirubinemia in breast-fed infants with UGT1A1 or SLCOs polymorphisms

Hiroko Sato
Toshihiko Uchida
Kiyoshi Hayasaka
Research13 Nov 2014
Journal of Human Genetics

Volume: 60, P: 35-40
A founder haplotype of APOE-Sendai mutation associated with lipoprotein glomerulopathy

Kentaro Toyota
Taeko Hashimoto
Kiyoshi Hayasaka
Research14 Feb 2013
Journal of Human Genetics

Volume: 58, P: 254-258
Molecular diagnosis and clinical onset of Charcot–Marie–Tooth disease in Japan

Akiko Abe
Chikahiko Numakura
Kiyoshi Hayasaka
Research17 Feb 2011
Journal of Human Genetics

Volume: 56, P: 364-368
De novo polyalanine expansion of PHOX2B in congenital central hypoventilation syndrome: unequal sister chromatid exchange during paternal gametogenesis

Hiroko Arai
Tesshu Otagiri
Kiyoshi Hayasaka
Research11 Oct 2007
Journal of Human Genetics

Volume: 52, P: 921-925
Correlation of postoperative recurrence in hepatocellular carcinoma with demethylation of repetitive sequences

Osamu Itano
Masakazu Ueda
Masaki Kitajima
Research11 Feb 2002
Oncogene

Volume: 21, P: 789-797

Previous page
page 1
page 2
Next page

Search

Search articles by subject, keyword or author

Show results from

Advanced search

Quick links

Explore articles by subject
Find a job
Guide to authors
Editorial policies

Nature.com

nature.com sitemap

About Nature Portfolio

About us
Press releases
Press office
Contact us

Discover content

Journals A-Z
Articles by subject
protocols.io
Nature Index

Publishing policies

Nature portfolio policies
Open access

Author & Researcher services

Reprints & permissions
Research data
Language editing
Scientific editing
Nature Masterclasses
Research Solutions

Libraries & institutions

Librarian service & tools
Librarian portal
Open research
Recommend to library

Advertising & partnerships

Advertising
Partnerships & Services
Media kits
Branded content

Professional development

Nature Awards
Nature Careers
Nature Conferences

Regional websites

Nature Africa
Nature China
Nature India
Nature Japan
Nature Middle East

Privacy Policy
Use of cookies
Legal notice
Accessibility statement
Terms & Conditions
Your US state privacy rights

© 2025 Springer Nature Limited