Nature Search

Adenosine-to-inosine RNA editing controls cathepsin S expression in atherosclerosis by enabling HuR-mediated post-transcriptional regulation

RNA editing by the adenosine deaminase ADAR1 controls cathepsin S expression in endothelial cells, a mechanism that is implicated in determining cathepsin S levels in patients with atherosclerotic vascular diseases.

Konstantinos Stellos
Aikaterini Gatsiou
Stefanie Dimmeler
Research05 Sept 2016
Nature Medicine

Volume: 22, P: 1140-1150
Imidazole propionate is a driver and therapeutic target in atherosclerosis

Imidazole propionate produced by gut microbiota is associated with atherosclerosis in mouse models and in humans, and causes the development of atherosclerosis through activation of the imidazoline-1 receptor in myeloid cells.

Annalaura Mastrangelo
Iñaki Robles-Vera
David Sancho
ResearchOpen Access16 Jul 2025
Nature

Volume: 645, P: 254-261
Roadmap for alleviating the manifestations of ageing in the cardiovascular system

In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

Luca Liberale
Simon Tual-Chalot
Konstantinos Stellos
Reviews19 Feb 2025
Nature Reviews Cardiology

Volume: 22, P: 577-605
Amyloid beta is associated with carotid wall echolucency and atherosclerotic plaque composition

Dimitrios Delialis
Georgios Georgiopoulos
Kimon Stamatelopoulos
ResearchOpen Access28 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19

Kimon Stamatelopoulos
Georgios Georgiopoulos
Omer Mohammed
ResearchOpen Access12 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
RNA modifications in cardiovascular health and disease

In this Review, Gatsiou and Stellos summarize the current knowledge on RNA modifications in cardiovascular health and disease, discussing their effect on cardiovascular biology and function, and the potential for development and application of epitranscriptome-based prognostic, diagnostic and therapeutic tools for cardiovascular disease.

Aikaterini Gatsiou
Konstantinos Stellos
Reviews05 Dec 2022
Nature Reviews Cardiology

Volume: 20, P: 325-346
Unraveling the RNA code: a uridine RNA modification drives glycoRNA biogenesis

Marco Sachse
Konstantinos Stellos
Research HighlightsOpen Access27 Nov 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-2
Carfilzomib-induced endothelial dysfunction, recovery of proteasome activity, and prediction of cardiovascular complications: a prospective study

Efstathios Kastritis
Ageliki Laina
Meletios A. Dimopoulos
Research15 Feb 2021
Leukemia

Volume: 35, P: 1418-1427

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