Nature Search

Microscopy analysis neural network to solve detection, enumeration and segmentation from image-level annotations

An important problem in microscopy analysis is to reduce the need for manual annotation of datasets. Bilodeau et al. develop a neural network method that can be trained on a simple main classification task using image-level annotations to solve more complex tasks such as semantic segmentation.

Anthony Bilodeau
Constantin V. L. Delmas
Flavie Lavoie-Cardinal
Research14 Apr 2022
Nature Machine Intelligence

Volume: 4, P: 455-466
The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson’s disease

Astrocytes are implicated in the maintenance of the blood-brain barrier (BBB). This study established a microfluidic BBB chip and found that astrocytes may play a role in cerebrovascular dysfunction in people with Parkinson’s disease.

A. de Rus Jacquet
M. Alpaugh
F. Cicchetti
ResearchOpen Access20 Jun 2023
Nature Communications

Volume: 14, P: 1-21
Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test

Jean-Philippe Rénéric
Manuel Bouvard
Luis Stinus
Research01 Apr 2001
Neuropsychopharmacology

Volume: 24, P: 379-390
A lactate-dependent shift of glycolysis mediates synaptic and cognitive processes in male mice

The molecular interplay between metabolic and synaptic functions of astrocytes is underexplored. Here, the authors show that astrocyte cannabinoid type-1 receptors integrate lactate and D-serine signaling to promote NMDA receptor-dependent cognition.

Ignacio Fernández-Moncada
Gianluca Lavanco
Giovanni Marsicano
ResearchOpen Access09 Aug 2024
Nature Communications

Volume: 15, P: 1-17
A genetically encoded fluorescent biosensor for extracellular l-lactate

l-lactate is an important intercellular energy currency. Here the authors report a genetically encoded biosensor eLACCO1.1 to monitor extracellular l-lactate; they use eLACCO1.1 to image extracellular l-lactate in cultured mammalian cells and brain tissue.

Yusuke Nasu
Ciaran Murphy-Royal
Robert E. Campbell
ResearchOpen Access06 Dec 2021
Nature Communications

Volume: 12, P: 1-12
The low-rank hypothesis of complex systems

Although using low-rank matrices is the go-to approach to model the dynamics of complex systems, its validity remains formally unconfirmed. An analysis of random networks and real-world data now sheds light on this low-rank hypothesis and its implications.

Vincent Thibeault
Antoine Allard
Patrick Desrosiers
Research10 Jan 2024
Nature Physics

Volume: 20, P: 294-302
Mitochondrial iron chelation ameliorates cigarette smoke–induced bronchitis and emphysema in mice

Reducing levels of mitochondrial iron by diet or pharmacological chelation ameliorates symptoms of cigarette smoke–induced chronic obstructive pulmonary disease in mice.

Suzanne M Cloonan
Kimberly Glass
Augustine M K Choi
Research11 Jan 2016
Nature Medicine

Volume: 22, P: 163-174
A Preliminary Neuroendocrine Study with Buspirone in Major Depression

Frederick G. Moeller
Joel L. Steinberg
Frederick Petty
Research01 Apr 1994
Neuropsychopharmacology

Volume: 10, P: 75-83
Rare variants and founder effect in the Beauce region of Quebec

Fine-scale population analysis combining deep genealogical data and whole-genome sequencing reveals a regional founder effect in Beauce (Quebec, Canada) leading to an increase in frequency for 36 rare pathogenic variants.

Mylène Gagnon
Claudia Moreau
Simon L. Girard
ResearchOpen Access08 Aug 2025
Communications Biology

Volume: 8, P: 1-10
Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice

Flanigan et al. show that activation of inhibitory neurons in the lateral habenula by the neuropeptide orexin (hypocretin) promotes both inter-male aggression and conditioned place preference for contexts associated with winning aggressive contests.

Meghan E. Flanigan
Hossein Aleyasin
Scott J. Russo
Research13 Apr 2020
Nature Neuroscience

Volume: 23, P: 638-650
Cocaine-Seeking Behavior in Response to Drug-Associated Stimuli in Rats: Involvement of D₃ and D₂ Dopamine Receptors

L Cervo
F Carnovali
T Mennini
Research22 Jan 2003
Neuropsychopharmacology

Volume: 28, P: 1150-1159
Social stress induces neurovascular pathology promoting depression

Chronic social defeat stress induces loss of protein claudin-5, leading to abnormalities in blood vessel morphology, increased blood brain barrier permeability, infiltration of immune signals and depression-like behaviors.

Caroline Menard
Madeline L. Pfau
Scott J. Russo
Research13 Nov 2017
Nature Neuroscience

Volume: 20, P: 1752-1760
Differential Roles of 5-HT Receptor Subtypes in Cue and Cocaine Reinstatement of Cocaine-Seeking Behavior in Rats

Jeffrey J Burmeister
Erin M Lungren
Janet L Neisewander
Research12 Nov 2003
Neuropsychopharmacology

Volume: 29, P: 660-668
Structural and functional multi-platform MRI series of a single human volunteer over more than fifteen years

Simon Duchesne
Louis Dieumegarde
Olivier Potvin
ResearchOpen Access31 Oct 2019
Scientific Data

Volume: 6, P: 1-9
Transition to chronic pain: opportunities for novel therapeutics

Although chronic pain is one of the most important medical problems facing society, there has been very limited progress in the development of novel therapies for this condition. Here, we discuss high-impact research priorities to reduce the number of people transitioning from acute to chronic intractable pain.

Theodore J. Price
Allan I. Basbaum
Robert H. Dworkin
Comments & Opinion15 May 2018
Nature Reviews Neuroscience

Volume: 19, P: 383-384
Adenosine A_2A Receptors in the Nucleus Accumbens Bi-Directionally Alter Cocaine Seeking in Rats

Casey E O'Neill
Mckenzie L LeTendre
Ryan K Bachtell
Research14 Dec 2011
Neuropsychopharmacology

Volume: 37, P: 1245-1256
Increases in Dopamine D₃ Receptor Binding in Rats Receiving a Cocaine Challenge at Various Time Points after Cocaine Self-Administration: Implications for Cocaine-Seeking Behavior

Janet L Neisewander
Rita A Fuchs
Jeffrey N Joyce
Research21 Apr 2004
Neuropsychopharmacology

Volume: 29, P: 1479-1487
Putting hornets on the genomic map

Emeline Favreau
Alessandro Cini
Seirian Sumner
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-12
Prolonged microgravity induces reversible and persistent changes on human cerebral connectivity

rs-fMRI is used to investigate human brain connectivity changes induced by prolonged microgravity in cosmonauts before and after spaceflight, with both persistent and reversible location specific changes in connectivity being observed.

Steven Jillings
Ekaterina Pechenkova
Floris L. Wuyts
ResearchOpen Access13 Jan 2023
Communications Biology

Volume: 6, P: 1-11
The Novel Dopamine D₃ Receptor Antagonist NGB 2904 Inhibits Cocaine's Rewarding Effects and Cocaine-Induced Reinstatement of Drug-Seeking Behavior in Rats

Zheng-Xiong Xi
Amy Hauck Newman
Eliot L Gardner
Research05 Oct 2005
Neuropsychopharmacology

Volume: 31, P: 1393-1405
Stimulation of Medial Prefrontal Cortex Serotonin 2C (5-HT_2C) Receptors Attenuates Cocaine-Seeking Behavior

Nathan S Pentkowski
Felicia D Duke
Janet L Neisewander
Research02 Jun 2010
Neuropsychopharmacology

Volume: 35, P: 2037-2048
Influence of Cocaine History on the Behavioral Effects of Dopamine D₃ Receptor-Selective Compounds in Monkeys

B L Blaylock
R W Gould
M A Nader
Research02 Feb 2011
Neuropsychopharmacology

Volume: 36, P: 1104-1113
Mice Lacking the Serotonin Transporter Exhibit 5-HT_1A Receptor-Mediated Abnormalities in Tests for Anxiety-like Behavior

Andrew Holmes
Rebecca J Yang
Dennis L Murphy
Research09 Jun 2003
Neuropsychopharmacology

Volume: 28, P: 2077-2088
Unifying turbulent dynamics framework distinguishes different brain states

A unifying turbulent dynamics framework using both model-free and modelbased measures of whole-brain information provides insights into brain states.

Anira Escrichs
Yonatan Sanz Perl
Gustavo Deco
ResearchOpen Access29 Jun 2022
Communications Biology

Volume: 5, P: 1-13
iPSC-derived cardiomyocytes from patients with myotonic dystrophy type 1 have abnormal ion channel functions and slower conduction velocities

Hugo Poulin
Aurélie Mercier
Mohamed Chahine
ResearchOpen Access28 Jan 2021
Scientific Reports

Volume: 11, P: 1-13
Facial representations of complex affective states combining pain and a negative emotion

Marie-Hélène Tessier
Jean-Philippe Mazet
Philip L. Jackson
ResearchOpen Access22 May 2024
Scientific Reports

Volume: 14, P: 1-21
Neuromodulatory effect of interleukin 1β in the dorsal raphe nucleus on individual differences in aggression

Aki Takahashi
Hossein Aleyasin
Scott J. Russo
Research30 Apr 2021
Molecular Psychiatry

Volume: 27, P: 2563-2579
Brain atrophy and patch-based grading in individuals from the CIMA-Q study: a progressive continuum from subjective cognitive decline to AD

Christine Marcotte
Olivier Potvin
Simon Duchesne
ResearchOpen Access19 Sept 2019
Scientific Reports

Volume: 9, P: 1-10
Deep learning of chest X-rays can predict mechanical ventilation outcome in ICU-admitted COVID-19 patients

Daniel Gourdeau
Olivier Potvin
Simon Duchesne
ResearchOpen Access13 Apr 2022
Scientific Reports

Volume: 12, P: 1-10
Autonomic nervous system modulation during self-induced non-ordinary states of consciousness

Victor Oswald
Audrey Vanhaudenhuyse
Olivia Gosseries
ResearchOpen Access22 Sept 2023
Scientific Reports

Volume: 13, P: 1-12
STEP-COVID: a pilot study of a prenatal intervention for pregnant women during the COVID-19 pandemic

Nicolas Berthelot
Julia Garon-Bissonnette
Thibaut Sériès
ResearchOpen Access20 Apr 2023
Scientific Reports

Volume: 13, P: 1-9
Stress-induced alterations of mesocortical and mesolimbic dopaminergic pathways

F. Quessy
T. Bittar
B. Labonté
ResearchOpen Access26 May 2021
Scientific Reports

Volume: 11, P: 1-13
Misfolded SOD1 pathology in sporadic Amyotrophic Lateral Sclerosis

Bastien Paré
Manuela Lehmann
François Gros-Louis
ResearchOpen Access21 Sept 2018
Scientific Reports

Volume: 8, P: 1-13
Deciphering the genetic structure of the Quebec founder population using genealogies

Laurence Gagnon
Claudia Moreau
Simon L. Girard
ResearchOpen Access04 Apr 2023
European Journal of Human Genetics

Volume: 32, P: 91-97
The effects of body position and actual execution on motor imagery of locomotor tasks in people with a lower-limb amputation

Arnaud Saimpont
Francine Malouin
Philip L. Jackson
ResearchOpen Access02 Jul 2021
Scientific Reports

Volume: 11, P: 1-11
Regulation of impulsive and aggressive behaviours by a novel lncRNA

Benoit Labonté
Khaled Abdallah
Gustavo Turecki
Research06 Jan 2020
Molecular Psychiatry

Volume: 26, P: 3751-3764
Natural human postural oscillations enhance the empathic response to a facial pain expression in a virtual character

Thomas Treal
Philip L. Jackson
Aurore Meugnot
ResearchOpen Access14 Jun 2021
Scientific Reports

Volume: 11, P: 1-10
Activation of the SDF1/CXCR4 pathway retards muscle atrophy during cancer cachexia

G B Martinelli
D Olivari
R Piccirillo
Research23 May 2016
Oncogene

Volume: 35, P: 6212-6222
MNI-FTD templates, unbiased average templates of frontotemporal dementia variants

Mahsa Dadar
Ana L. Manera
D. Louis Collins
ResearchOpen Access24 Aug 2021
Scientific Data

Volume: 8, P: 1-10
Apoptotic cell death in disease—Current understanding of the NCCD 2023

Ilio Vitale
Federico Pietrocola
Lorenzo Galluzzi
Reviews26 Apr 2023
Cell Death & Differentiation

Volume: 30, P: 1097-1154

Search

Filter By:

Search

Quick links